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    Diagnostic Procedures: Stem Cell Transplant Methods

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    Dememar Jill Payot
    There are four main types of stem cell transplants: autologous, allogeneic, syngeneic, and cord blood. An autologous stem cell transplant (AutoSCT) involves harvesting a patient's own stem cells, treating the patient with high-dose chemotherapy to clear cancer cells, then returning the harvested stem cells to rebuild the immune system. The AutoSCT process has four phases - induction, mobilization/harvesting, conditioning, and engraftment. Potential advantages are using high doses to decrease disease recurrence and cure aggressive cancers, while risks include the harvested cells possibly still containing cancer contamination.

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    Diagnostic Procedures: Stem Cell Transplant Methods

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    Dememar Jill Payot
    10 views9 pages
    There are four main types of stem cell transplants: autologous, allogeneic, syngeneic, and cord blood. An autologous stem cell transplant (AutoSCT) involves harvesting a patient's own stem cells, treating the patient with high-dose chemotherapy to clear cancer cells, then returning the harvested stem cells to rebuild the immune system. The AutoSCT process has four phases - induction, mobilization/harvesting, conditioning, and engraftment. Potential advantages are using high doses to decrease disease recurrence and cure aggressive cancers, while risks include the harvested cells possibly still containing cancer contamination.

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    There are four main types of stem cell transplants: autologous, allogeneic, syngeneic, and cord blood. An autologous stem cell transplant (AutoSCT) involves harvesting a patient's own stem cells, treating the patient with high-dose chemotherapy to clear cancer cells, then returning the harvested stem cells to rebuild the immune system. The AutoSCT process has four phases - induction, mobilization/harvesting, conditioning, and engraftment. Potential advantages are using high doses to decrease disease recurrence and cure aggressive cancers, while risks include the harvested cells possibly still containing cancer contamination.

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    10 views9 pages

    Diagnostic Procedures: Stem Cell Transplant Methods

    Uploaded by

    Dememar Jill Payot
    There are four main types of stem cell transplants: autologous, allogeneic, syngeneic, and cord blood. An autologous stem cell transplant (AutoSCT) involves harvesting a patient's own stem cells, treating the patient with high-dose chemotherapy to clear cancer cells, then returning the harvested stem cells to rebuild the immune system. The AutoSCT process has four phases - induction, mobilization/harvesting, conditioning, and engraftment. Potential advantages are using high doses to decrease disease recurrence and cure aggressive cancers, while risks include the harvested cells possibly still containing cancer contamination.

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    DIAGNOSTIC PROCEDURES

    Stem Cell Transplant Methods

    The different types of stem cell transplants:


    autologous - stem cells harvested from self allogeneic - stem cells harvested from donor (following reduced for full intensity therapy) syngeneic - stem cells harvested from identical twin cord blood - stem cells from saved cord blood, from self or donor

    About Autologous Stem Cell Transplant (AutoSCT)

    Phases:
    1. Induction phase - conventional doses of chemo are used to clear the blood of circulating tumor cells and to reduce tumor burden. 2. Mobilization/harvesting phase is the use of growth factor and specific types of chemotherapy agents. This treatment leads to the proliferation and mobilization of stem cells from the bone marrow into the bloodstream.

    3. Conditioning phase comes next, and according to some sources about a month after harvesting. 4. Engraftment phase is the process by which the stem cells are given back to the patient to reconstitute the immune system.

    Potential Advantages of Auto Transplants:


    High dose therapies made possible by prior harvesting and subsequent engraftment may: decrease risk of disease recurrence and/or curing aggressive component of the disease. produce a durable remission.

    Potential Problems with Auto Transplants:


    Engrafted cells can be contaminated with disease (compared to allogeneic SCT)

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