Chinese General Hospital College of Nursing Drug Study DRUG DOSE ROUTE IV push INDICATIONS Short-term treatment of active

duodenal ulcer Short-term treatment of active, benign gastric ulcer Maintenance therapy for duodenal ulcer at reduced dosage. Short-term treatment for GERD. Pathologic hypersecretory conditions (Zollinger-Ellison syndrome) Treatment of erosive esophagitis Treatment of heartburn, acid indigestion, sour stomach CONTRAINDICATION Use cautiously with impaired renal or hepatic function. Adjust dosage in patients with impaired renal function. Contraindicated to patients that are hypersensitive to drug and those with acute porphyria. ACTION Competitively inhibits the action of histamine at the H2 receptors of the parietal cells of the stomach, inhibiting basal gastric acid secretion and gastric acid secretion that is stimulated by food, insulin, histamine, cholinergic agonists, gastrin and pentagastrin. SIDE EFFECT CNS: headache, malaise, dizziness, somnolence, insomnia, vertigo CV: tachycardia, bradycardia Dermatologic: rash, alopecia GI: constipation, diarrhea, nausea and vomiting, abdominal pain, hepatitis GU: impotence or decreased libido Hematologic: leucopenia, granulocytopenia, thrombocytopenia, pancytopenia NURSING CONSIDERATIONS Assessment: 1. History: allergy to ranitidine, impaired renal or hepatic function, lactation, pregnancy. 2. Physical: skin lesions, orientation, affect, liver evaluation, abdominal examination, normal output, renal function tests, CBC 3. Assess patients with abdominal pain. Note presence of blood n stool or vomitus. Interventions: 1. Administer oral drug with meals and at bedtime. 2. Decrease doses in renal and liver failure. 3. Provide concurrent antacid therapy to relieve pain.. 4. Arrange for regular follow-up including blood test, to evaluate effects. 5. Advise patients to report abdominal pain and blood in stool.

Generic 40 mg q 8 Name: hrs Ranitidine Hydrochloride Brand Name: Zantac Class: Histamine2 antagonists

Name: Carl S. Ibasco Section B Group II