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    Peptic Ulcer Disease Patho

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    chelle_asenjo
    Peptic ulcer disease is caused by an imbalance between aggressive and defensive factors in the stomach and duodenum, leading to damage of the mucosal barrier. Key predisposing factors include age, gender, lifestyle, and family history, while precipitating factors include H. pylori infection, smoking, NSAID use, and stress. Damage to the mucosal cells results in decreased mucus production and acid exposure, causing erosions and ulcers that can bleed and scar over time.

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    Peptic Ulcer Disease Patho

    Uploaded by

    chelle_asenjo
    490 views1 page
    Peptic ulcer disease is caused by an imbalance between aggressive and defensive factors in the stomach and duodenum, leading to damage of the mucosal barrier. Key predisposing factors include age, gender, lifestyle, and family history, while precipitating factors include H. pylori infection, smoking, NSAID use, and stress. Damage to the mucosal cells results in decreased mucus production and acid exposure, causing erosions and ulcers that can bleed and scar over time.

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    Peptic Ulcer Disease patho

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    Peptic ulcer disease is caused by an imbalance between aggressive and defensive factors in the stomach and duodenum, leading to damage of the mucosal barrier. Key predisposing factors include age, gender, lifestyle, and family history, while precipitating factors include H. pylori infection, smoking, NSAID use, and stress. Damage to the mucosal cells results in decreased mucus production and acid exposure, causing erosions and ulcers that can bleed and scar over time.

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    Download as DOCX, PDF, TXT or read online from Scribd
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    Download as docx, pdf, or txt
    490 views1 page

    Peptic Ulcer Disease Patho

    Uploaded by

    chelle_asenjo
    Peptic ulcer disease is caused by an imbalance between aggressive and defensive factors in the stomach and duodenum, leading to damage of the mucosal barrier. Key predisposing factors include age, gender, lifestyle, and family history, while precipitating factors include H. pylori infection, smoking, NSAID use, and stress. Damage to the mucosal cells results in decreased mucus production and acid exposure, causing erosions and ulcers that can bleed and scar over time.

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    PATHOPHYSIOLOGY OF PEPTIC ULCER DISEASE

    Predisposing Factors y Age (40-60) y Gender y Lifestyle (Alcohol Ingestion) y Familial tendency Precipitating Factors y Malignant tumors y Gastric Hyperacidity y Stress y Irritating Foods

    Damage to mucosa with alcohol abuse, smoking, use of aspirin & NSAID s

    Acid & pepsinogen release with chronic vagal response to increased stress

    Infection with Helicobacter Pylori

    Damaged mucosal barrier

    Imbalance of aggressive & defensive factor

    Low function of mucosal cells; low quality of mucous; less of tight junction between cells

    Infection gives increased gastrin & decreased somatostatin production

    Erosive gastritis: inflammation >> decreased acid and intrinsic factor

    Mucosal ulcerations, possible bleeding and scarring

    A damage mucosa could not secrete enough mucus to act as a barrier against gastric acid

    Severe ulcerations: Signs and symptoms: Epigastric pain Hematemesis Dyspepsia Pyrosis

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