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16 18 (-16,
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). , 91
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()
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-16 -18
. 73 -
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.
.

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: _______________
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, , ,
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31 2004 .
( / ) .
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(76,6 vs 27,2%; <0,001). .,
. . ,
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() . .,
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, . ;
2004 . 2005 . 340
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36% (95%:4-57). ,
<6 . 63% 1/3
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, . (), , ductus Venosis
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39 404 (9,7%). 15,4% (6/39; 2,7;
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<790 ( 74,4%; 72,9%; <0,0001)
32,2 . ( 94,9%; 45,8%;
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.
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.
,
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52 - ( 1,5
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. .
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. 170 ,
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( 17,4; 95%:4,6-64,9),
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, , ().
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,
2000 ., 0,95 11,2 /1 . .
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1979 2003 . , 500
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=0,0058). ( 42%
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1990 . 2 . .
: (50/254; 20%) ,
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.
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8
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1997-2003 .
1 7047
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,
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, 105 . HELLP- ,
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.
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11
2000 . 2005 .
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27. 1 : ,
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322 .,
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. . 137 131 . 14 21 .
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. 343871,5 355572,9 (=0,091). 37,6 vs 37,4 .
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12
5749 .
, ., >1 ,
., ( 0,09;
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., 24%- ( 0,76;
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,
. .
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, , .
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, 8,2 . . 53% - -
., . 1,4 ( .
1,9 ). (8%) ,
. 34% >1,0 .
( , ) 53% -
>1,5 .
. 62%
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- ( 32%
24% ). 1-.
10% .
,
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14
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. . -
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76,2%, . 92,1 88,7% ( , ,
; ; <0,001). ,
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( 1,84; 95%:1,62-2,10).

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-
- -
-
- -
3.
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(, , , , )
, ,
. ,
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, .
853 (51,5%) 1657 6 ; 13 (1,5%)
, 41 (5,1%)
, >6 . in situ
22 (2,6%) 853 , 6 62 (7,7%) 804 ,
15
>6 . ,
>6
, , ,
. , Dept. Dermatol., New York Univ. Sch.
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- -
4. :
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, ().
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12-.
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200 ; 2 . 100 . 12
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, S 75%
8-16 . (S-75). (S75) ().
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(=24%; 95%:19-30%), , 50 /2 .
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(=30%; 95%:25-35%).
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. .
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17
. .
. , 1-4, 5-19
20 -, . 0,93 (95%:0,76-1,13); 1,10 (95%:0,971,24) 1,10 (95%:1,01-1,20) , .
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-
. , -
; . - 2 .
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- -
- -
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,
. .
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(2 /.) 8 .

() -.
,
18
. ,
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-
- -
- - -
10.
. Mazoyer E., Enjolras O., Bisdorff A., et al. Coagulation disorders in patients with
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2-. 118 ( 27 .)
() ,
.
, . 30, 58 36%
. , ; 22%
. , , ,
65, 73, 13, 12 9% - . (58% )
D- (>0,5 /),
, ,
. 84 -
. -
/
.
,
58% -, .

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-
- -
- -
- - -
11. g 180
. Iwata Y., Komura K., Kodera M., et al. Correlation of IgE
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,
(), g, 180 230
(). . - (n=37) . . (26
). G (gG) -180 -230
. 35 (95%) 26 (70%) ( 37 - ).
gG1 gG4 32 (87%) 25 (68%) 180 , 16 (44%) 26 (70%) -230 . g 180 -230 22% -.
19
g -180 .
, g -180
, , g
-230 . g -180 , gG -180
. , g 180 .

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-
- - g
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-
-. ()
(). / 1 /4 .
40 /2; .
( )
56% (5 4 ).
43,7 .
. 5 . ,
- 60 50% .

, - .
, 20 /2,
40 /2 ,
( ). , Dept. Dermatol., Cent.
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- -
- - -
- - - -
13.
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(), Clostridium tetani,
. ,
20

, . -
G Clostridium tetani . (n=100)
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. , ,
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.
() ,
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14. -2 . Lysitsa S., Samson
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() ,
.
. , () 1 2
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- .
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. -2
, -2
. ,
-2
. , Lab. Histopath., Oral
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15.
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()
- ()
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21
: 218-472).
. 1319843 686171 /; =0,024. -
611160 531167 / .,
. ,
.
, Dept. Dermatol., Chonnam Natl. Univ. Med. Sch., Clin. Trial Cent.,
Gwangju. . 20.
-
- - -
- - -
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16.

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AEGIS 5772/5
(). . - (n=30)
, .
- ,
.
7, 14, 21 28 . SCORAD,
. ,
14 . .;
.,
. . - .
AEGIS
5772/5 , - . , Dept. Clin. Experim.
Pathol., Med., Inst. Dermatol., Inst. Hyg., Epid., Univ. Udine, Udine. . 16.
-
- -
- - -
17. ,
. Pitarch G., Sanchez-Carazo J/L/. Mahiques L., et al.
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- (),
.
, -
/ .
22
, 54 ., 25% - PASI
75%. 24 .
PASI 75% 75% -.
. - ,

. , Serv. de Dermat., Hosp. Gener. Univ., Valencia. . 19.
-
-
- -
18.
. Sheth V.M., Weitzul S. Postoperative topical antimicrobial use //Dermatitis.-2008.Vol.19, N4.-P.181-189.-.
()
-,
().
-
. (11%) -
, ;
8% .
.
(1-2%)
(1,6-2,3%).
- ; .
, . , Dept. Dermatol., Divis. Derm. Surg.,
Univ. Texas Southwest. Med. Cent., Dallas. . 53.
-
- -
- - -
19. : . Brenninkmeijer E.E.A., Schram M.E., Leeflang M.M.G., et al. Diagnostic criteria for atopic
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() ,
. ,
.
27 .
. , Hanifin Rajka
87,9-96,0 77,6 93,8% .
10 100%, 89,3 99,1%.
Diepgen . 83,3-87,7 83,9-87,0%.
Kang Tian, ,
100%, 95,5%.
23
(ISAAC) ,
48,8 91,1% .
, ,
1997 . Williams et al. , Dept.
Dermatol., Dept. Clin. Epidemiol., Biostat., Bioinform., Dutch Cochrane Centre,
Amsterdam. . 58.
-
- -
20.
. Dompmartin A., Acher A., Thibon P., et al. Association of
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,
. . (n=140)
- - .
, 42%
-, 61% . 1,0 /.
6 .
,
-. (),
, . ,
/
- , , ,
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. -
( ), ,
. ,
,
- . , Dept. Dermat.,
Hygiene, Hematol., Pl. Surg., Univ. C.B. Normandie, Caen.
-
- -
- - -
24

: ..
: _______________
: _______________
21. . Cassarino D.S., Cabral E.S., Kartha R.V. Primary
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,
,
(), ,
() ().
, , ,
- .
9,6 . 2
, 1
, 1 - . ,
44 . 92%.
,
: 53 (=0,02), 67 ( 1),
(=0,002), 1 (=0,001) ( 2-40) (<0,001),
. ,
- - .
, Dept. Pathol., Dermatol., Stanf. Univ. Med. Cent., Stanford.
(. : http://archderm.ama-assn.org)
25

-
- -
- - -
22. , D240, . Niakosari F., Khn H.J., McCready D., et al.
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//Arch.Dermatol.-2008.-Vol.144, 4.-P.462-467.-.
, ,
() D2-40,
.
-.
,
1 , , ,
D2-40,
(<0,001),
(=0,01). - 24%
. ,
,
-. , 3
, 13%,
61%. ,
D2-40
,
-. , Dept. Pathol., Gen.Surg., Dermatol., Sunnybrook Hlth Sci.
Centre, Ontario. .34
(. : http://ontent.karger.com)
-
- -
- - - -
23. . Lecluse L.L.A., Piskin G., Mekke J.R., et al. Review and expert
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(, ) -
, / -
, , , , .
- 3-22%
.
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26
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Acad. Med. Center, Univ.Ansterdam. 46.
(. : http://ontent.karder.com)
-
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- - -
- - - -
24.
,
. Lu Y.-P., Lou Y.-R., Xie J.-G., et al. Tumorigenic effect of some
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SKH-1
(30j-2) 2 /. 20 . 17 .
5 /. 100 Dermabase,
Dermovan, Eucerin Vanicream. ,
69 (<0,0001), 95 (<0,0001), 24
(< 0,01) 58 % (<0,0001), . ,
,
.

. , Sus. Lehman Cullman Lab.Canc.Res., Dept Chem Biol.,
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- -
25. - ,
, 2001-2002 .
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-
() - .
- . . , ,
, . ,
- . .
, , ,
1,20 - .

, .
. , Harv. Med. Sch., Boston. .33
27

- -
- -
26. .
, Mayo Clinic 2001-2005
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,

. . (n=3854) 55,1
.; 66,8% . 69,3. 2664
1 -, 1933 (50,2%) 2 .
. : , ,
, , ,
, ,
, . ,
. , Mayo Clinic
Cont. Derm. Group, Dept. Dermatol., Divis. Biostat., Rochester.
(. : http://archderm.ama-assn.org)
-
- -
27. , .
- , 2001-2004 .
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()
- . (n=391) (n=9670). ,
1 - . (51,2%) (54,1%)
. . (28,3%),
(17,9%), (15,3%), (8,0%)
- (7,7%) (5,1%).
- . . 34,0% . 11,2%
(<0,001). 15%
39% . ,
,
TRUE test. ,
.
. , Set. Dermatol., Dartmouth-Hitchcock Med. Cent., Lebanon, New
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(. : http://www.medscape.com)
-
- -
28
28.
() in vivo :
. Kowatzki D., Macholdt C., Krull K., et al. ffect of
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() , , . . 20-49 ,
, . .
() , ,
p . , ,
2 15 . 80 ,
, p . ,
-
. ,
.
,
p .
, Skin Phys. Lab., Dermatol., Inst. Clin. Chem., Berlin. .29.
-
- -
29
: ..
: _______________
: _______________
3.
-, .
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, ()
. 64 , 41
() 1) - (6 . 2
., 3 /.) (100 /.) 24 . 28 .
(n=30) 2) 52 . .
8 .
< = 7 log / (90 vs 33%, =0,013) 24 .
(75 vs 40%, =0,080). . 52
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.
,
24 . .
( , ,
). 68 45 23 5 (3-10) .
. 4
(10 .) : SAPS <50,
LODS . 3<6, - <0,5 //.,
30
>50 g. , , - 0,5 //.

48 .
>50 g. . , Assistance PubliqueHpitaux de Paris.
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- -
- - -
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,
.

,
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.
, .
, , CD4
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. , Instituto Superiore di
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6.
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4
(, , ).
,
, ,
.
1 .,
.
.
.
(1 ., 10-27%; 2 ., 37-48%; 4 ., 60-65%) (1 . 0%; 2 ., 3%; 5
31
., 29%) (1 ., 3-4%; 2 ., 9-22%).

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- -
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. Duvalov X., Leport C. Prophylaxis of infective endocarditis: current
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,
. ,
,
,
.
,
,

, .
, , ,

. , Paris 7 Diderot University.
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- -
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, ,
Helicobacter spp . , ,
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- Staphylococcus aureus (MRSA).
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4,6 5,1% .
, , MRSA.

MRSA . 63 (93%)
68 . MRSA 449 (88%) 510
.
.
MRSA
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10. ,
. Piersimoni C., Scarparo C. Pulmonary infections
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()
(). ,
,

.

, .
, , ,
, ,
.
, ,
.
,
. , .
, ,
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11.
:
. Morrison J., Pai M., Hopewell P.C. Tuberculosis
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,
( )
. , , ,
, .

.
.
( )
4,5% (95%:4,3-4,8) ,
2,3% (95% :2,1-2,5). 51,4%
(95%:50,6-52,2) .
,
. ,
,
. ,
University of California San Francisco.
-
- -
12. . Bechah Y., Capo C., Mege J.L., Raoult D. Epidemic typhus
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,
, .
, , ,
, . , R.
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.

. , University of Mediterranean.
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13.
. Nash K.L., Alexander G.J. The case for combination antiviral therapy for
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.
,
,
.
,

.

. , ,
,
, , , .
,
,

. ,
. , University department of Medicine, Cambridge.
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- -
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14. Acinetobacter baumannii: ,
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Acinetobacter baumannii () ,
.
.
.
, , , ,
.
, , ,
.
,
,
,
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35
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15. - .
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-., - CD4(+),
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. .
, , ,
.
. , .
. ,
-. . ,
. , University of Manitoba.
-
-
- - -
16. - ,
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Staphylococcus aureus ()
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. 50 90%
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4 ( ,
, ,
,
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, ) (17
vs 12%), . , Denver Health
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17. . DuPont A.W. Postinfectious
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- ,

(). , ,

, .
, ,
,
. , ,
,
. , University of Texas Medical Branch. Galveston.
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- -
18. :
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,
. , ,
- . ,
(
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, ,
. ,

.
.
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19. ,
. Colmenero J.D., Ruiz-Mesa J.D., Plata A. Clinical
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. , ,
96 , 1982-2005 .
3 . 3 . 2-.
6 . 10,4%,
-12,7 .
37
( 94,8% )
(91,7%). 8,3% .
, , 45,8;
27,1; 10,4%; . 63 (65,6%) ,
33 (34,4%) . 20%
. 2,1%,
6,2%. - . , Carlos Haya
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20. .
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,
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. , , 6
.,
.
(., ), , ,
. .
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.
, ,
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. , , 4219
.

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52 2388 . .
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, 90% ) 25% >5,5
/ (, , , ) 31% . -
38
< = 1 / (6 13, 5
, 4 6 //.),
>1 / (15 39 ). >1/
6 . 16
>5,5 /, 5 (31%) , 4 / 8 //. 4
. ,
. ,
University of Lausanne.
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4
(, , ) 2001-2004 . 1422
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23. . Alp E.,
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,
.
. ,
.
.
, (,
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39
3 . ) .
(, , -) ,

(, , ..). , Erciyes University.
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24.
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(>1010(9) ./) -
(), - ()
(). . .
: . ,
. ,
, ,
. 173 , 99 (57%)
. 0,5 /, -
0,57; 0,85; 0,59
0,84 .
. ,
, .
,
0,5 /. , Hospital de la ville.
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25. ,
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() . .,
.-. .
.
290 . 18-44 . 6 .
15,5 . 52,8%
-, 31,7% 30,0% . 12-.
29,2%.
6,11,16 18 2,8; 0,5; 4,8 0,8 1000 -., ..
- 5,9 . (95%:5,7-6,1),
- . 12 .
- , 75% . .
. . , .
40
. , H.
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26. , 2: H5N1. Lee S.M., Cheung C.Y.,
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H5N1 .
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, H5N1. ,
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n vitro , H5N1.
, H5N1-
, , ,
. , -2
, -2.

H5N1 .
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- - -2
- - -
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. Castelain S., Schnuriger A., Franois C., et al. Low levels of
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() 37
37 -.
. ,
, .
(1,6130,416) ,
(1,9120,578).
. ,
, . , CHHHospital Snd. Amies.
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, 5-10% (> =10 m IU/ml)
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24
(Twinrix) 0, 1 6 . - -
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- 26 (59%) 42 (95%) .
. . 10 100%.
. - - .

.
, ,
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29. Clostridium difficile
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Clostridium dfficile (CD)
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.
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CD : Meridian
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1,0; Remel Xpect 0,82 i 0,96; Meridian Immunocard 0,9 i 0,99; BioMerieux VIDAS 0,76 i
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(., <50%
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,
.
TCD
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42
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. ,
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, ,
, ,

. ,
,
. ,
( )
. ,
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. , McGill Univers. Health Centre.
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43

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: _______________
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1. 1 .
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() ()
() 1 .
322 ., 1
. (1 .) (2, ., .). -
3 . b1 7,0 10,0%.
b1 26 . b1
. - (=0,003),
- 25 ., (
-0,53%; 95%:-0,71-0,35; <0,001). .
- 15 24 . ( 0,08; 95%:-0,17
0,33; =0,52) . 8 14 . ( 0,13; 95%: -0,38
0,11;= 0,29). 6./. 83% -
25 ., 30% - 15 24 . 50% . 8 14 .
., ,
. ,
1
. , ,
. . , Jaeb Cent. Hlth. Res., Tampa. .31.
(. )
-
- - 1
- - -
2. GAD
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- 65 (GAD)
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, GAD (GAD-alum)
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GAD-, 18 . . 1 . (35
-) / 20 GAD-alum, 2 . (35 -) (
alum) 1- 30- . . 1- . 3, 9, 15, 21 30 . -

( -). GAD-alum
. .
44
- 15 . (
). 30 . -
1 ., 2 . (-0,21 vs -0,27 / [-0,62
vs -0,81/], =0,045), ,
(-0,72 vs -1,02 //2. [-2,20 vs -3,08 //2.], =0,04).
-, 6 . .
, .
GAD-alum GAD- -. ,
GAD-alum -
1 ,
. , Linkoping Univ., Linkoping. . 32.
(. )
-
- - 1
- - -
3. 2 .
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Copenhagen, Copenhagen. .43
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45
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5.
2 . Patel A., et al. Intensive blood glucose control and vascular outcomes in patients
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6.
2 . Holman R.R., Paul S.K., Bethel M.A., et al. Longterm follow-up after tight control of blood pressure in type 2 diabetes //N.Engl.J.Med.2008.-Vol.359, 15.-P.1565-1576.-.

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Churchill Hosp., Oxford. .25
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7. 10- 2 .
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, Oxford Cent. Diabetes, Endocrinol. a. Metabolism, Churchill Hosp., Oxford.
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Inst.
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/. Riedel-Baima B., Riedel A. Female pattern hair
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49
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. , , ,
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NOD2, TLR (Toll-like reeptors), -, .,
, . ,
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. , Massachusetts General Hosp., Boston, MA.
-
10. . Modlin
I.M., Moss S.F. Symptom evaluation in gastroesophageal reflux disease
//J.Clin.Gastroenterol.-2008.-Vol.42, 5.-P.558-563.-.
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Re Quest, (
) . . Yale
Univers. New Haven.
-
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B.E., Weiser K. Esophageal motility disorders: medical therapy //J.Clin.Gastroenterol.2008.-Vol.42, 5.-P.652-658.-.
.

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68
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. , Dartmouth-Hitchcock Med. Centr.
-
12. . Kamisawa T. Diagnostic
criteria for autoimmune pancreatitis //J.Clin.Gastroenterol.-2008.-Vol.42, 4.-P.404-407..
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-
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13. 4943 . Talamini
G., Tommasi M., Amadei V., et al. Risk factors of peptic ulcer in 4943 inpatients
//J.Clin.Gastroenterol.-2008.-Vol.42, 4.-P.373-380.-.

. , 2001-2004 .
,
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. 4947 .
2 .
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2001-2004 . : 6,5%
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(22/702) 2004 . : ,
, , ,
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. ,
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, .
. , Univ. of Verona.
-
- -
14. :
. Domenech E., Maosa M., Navarro M., et al.
Long-term methotrexate for Crohns disease: safety and efficacy in clinical practice
//J.Clin.Gastroent.-2008.-Vol.42, 4.-P.395-399.-.
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1169 784 . 39% ,
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5 (11%) . -
77% .
7 ,
39% 3 . . , Hosp. Univers.
Germans Trias i Pujol.
-
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15. . Sheibani S., Gerson L.B. Chemical colitis //J.Clin.Gastroent.-2008.Vol.42, 2.-P.115-121.-.
()
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-
16. ,
() . Lopasso F.P., Sakai P.,
Gazi B.M., et al. A pilot study to evaluate the safety, tolerance, and efficacy of a novel
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150 o 30 7

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(8,1 ), <90 (4,5 ). 9 ,
6 . 11,5 4,6 . 1 3
. ,
. ,
,
. , Sao Paulo Univ. Sch. of Med.
-
17. .
Ebert E.C. Gastric and enteric involvement in progressive systemic sclerosis
//J.Gastroenterol.-2008.-Vol.42, 1.-P.5-12.-.
()
,

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, UMDNJ- Robert Wood Johnson Med. School.
-
18. . Tahara T.,
Arisawa T., Shibata T., et al. Association of endoscopic appearances with dyspeptic
symptoms //J.Gastroenterol.-2008.-Vol.43, 3.-P.208-215.-.
Helicobacter
pylor,
. 87 93
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.
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mura-Takemoto. Helicobacter pylori
H. pylori,
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.
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H pylori .
, Fujita Hlth. Univ. Sch. of Medicine.
72
-
- -
19. , . Hori K., Ikeuchi H., Nakano
H., et al. Gastroduodenitis associated with ulcerative colitis //J.Gastroenterol.-2008.Vol.43, 3.-P.193-201.-.

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.; 42 .; 162 , 163 )
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-
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20.
:
. Kasahara A., Kita K., Tomita E., et al.
Repeated administration of recombinant human serum albumin caused no serious allergic
reactions in patients with liver cirrhosis: a multicenter clinical study //J.Gastroenterol.2008.-Vol.43, 6.-P.464-472.-.

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,
gE i IgG .
73
(<0,0001),
(<0,0001). , Osaka Univ. Grad. Sch. of Med.
-
- -
- - -
21.
,
-,
-
2-
. Hongo M., Kinoshita Y., Haruma
K. A randomized, double-blind, placebo-controlled clinical study of the histamine H2receptor antagonist famotidine in Japanese patients with nonerosive reflux disease
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, 2-
() ,
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( 10 20 ) 2 . 8 .
. , 528
. . ( )
62% 40 , 59% 20 55% (=0,001).
40
8 . . , Tohoku Univ. Hosp.
Aoba.
-
- - y
- - -
22. 1
. Perez-Calle J.L., Marin-Jimenez I., Lopez-Serrano P., et al. Prevalence of
macrocreatinkinase type 1 in patients with inflammatory bowel disease //Dig.Dis.Sci.2008.-Vol.53, 2.-P.486-489.-.
() () 2
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. , Fundacion Hosp. Alcorcon.
-
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- - -
- - - -
23.
. -1. Maconi G., Dominici R.,
Molteni M., et al. Prevalence of pancreatic insufficiency in inflammatory bowel diseases.
Assessment by fecal elastase-1 //Dig.Dis.Sci.-2008.-Vol.53, 1.-P.262-270.-.
()
().
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12 -.
. (=5,4), (= 5,7),
(=4,2).
. , L. Sacco Univ. Hosp.
-
- -
- - - -1
24. : ,
. Okazaki K., Uchida K., Fukui T. Recent advances in autoimmune pancreatitis:
concept, diagnosis, and pathogenesis //J.Gastroenterol.-2008.-Vol.43, 6.-P.409-418..
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-. () - 1 (1),
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). -,
- 2-. .
IgG1 . , Kansai Univ. Osaka
-
25. -6 , -6
. Nancey S., Hamzaoui N., Moussata D. et al. Serum interleukin-6,
soluble interleukin-6 receptor and Crohns disease activity //Dig.Dis.Sci.-2008.Vol.53, 1.-P.242-247.-.
- -6 (-6)
() () .
20 94 (44 50
). - -6 (80 9 /)
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-6 -6 ,
. , Hospices Civil
de Lyon.
-
- - -6
- - -
26. : . Bellicini N., Molloy P.J., Caushaj P., Kozlowski P. Fecal
incontinence: a review //Dig.Dis.Sci.-2008.-Vol.53, N1.-P.41-46.-.
,
.
. , ,
.
47%.
76
,
. . The Western Pennsylvania Hosp.
-
27. ,
: . Zhang X.P., Wang L., Zhou Y.F. The
pathogenic mechanism of severe acute pancreatitis complicated with renal injury: a
review of current knowledge //Dig.Dis.Sci.-2008.-Vol.53, N5.-P.1434-1435.-.
() ,

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. , Hangzhou First Peoples Hosp.
-
- -
28. -:
. Lichtenstein G.R., Deren J.J., Katz S., et
al. Bowman-Birk inhibitor concentrate: a novel therapeutic agent for patients with active
ulcerative colitis //Dig.Dis.Sci.-2008.-Vol.53, N1.-P.175-180.-.
- (), ,
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Sutherland ,
( > = 3) ( < = 1
) , 12 . .
, , ,
(p=0,067). (p=0,082)
(p=0,22). .
, ,
77
,
. , Univ. of Pennsylvania Sch. of Med.
-
- -
29. ,
. Cappell M.S., Turkieh A. Chronic pericarditis and pericardial
tamponade associated with ulcerative colitis //Dig.Dis.Sci.-2008.-Vol.53, N1.-P.149-154..
. (),
9
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-
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- - -
30. : , : Geeraerts B., Tack. J.
Functional dyspepsia: past, present, and future //J.Gastroenteral.-2008.-Vol.43, N4.-P.251255.-.
()
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. , Center for Gastroenterological Research.
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: _______________
: _______________
1. , :
. Peters R., Peters J., Warner J., et al. Alcohol, dementia and
cognitive decline in the elderly: a systematic review //Age and Ageing.-2008.-Vol.37, N5.P.505-512.-.
() () () . , ()
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95%:0,67-1,17). , ,
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. , Imperial Coll., London.
-
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2.
. Di Meo F., Pedone C., Lubich S., et al.
Age does not hamper the response to pulmonary rehabilitation of COPD patients //Age and
Ageing.-2008.-Vol.37, N5.-P.530-535.-.
()
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-
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- - -
3.
. Bartali B., Frongillo E.A., Guralnik J.M., et al. Serum
micronutrient concentrations and decline in physical function among older
persons //JAMA.-2008.-Vol.299, N3.-P.308-315.-.

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.) (.
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. , Cornell Univ., Ithaca.
(. http:/ www.jama.org)
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4.
. Burr M.L., Dolan E., OBrien E.W., et al. The value of ambulatory blood
pressure in older adults: the Dublin outcome study //Age and Ageing.-2008.-Vol.37, N2.P.201-206.-.
, () ()
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1,09 (95%:1,04-1,14; <0,001) .
. ,
-
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. , Cambridge Univ. Hosp.
NHS Foundation Trust, Cambridge.
-
- -
- - -
5. : .
Delerme S., Ray P. Acute respiratory failure in the elderly: diagnosis and prognosis //Age
and Ageing.-2008.-Vol.37, N3.-P.251-257.-.
. () - >65 .
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6. , - 65
. Shah R., Wang Y., Foody
J.A.M. Effect of statins, angiotensin-converting enzyme inhibitors, and beta blockers on
survival in patients 65 years of age with heart failure and preserved left ventricular
systolic function //Am.J.Cardiol.-2008.-Vol.101, 2.-P.217-222.-.
- ()
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. , Yale Univ. Sch. Medic., New Haven. . 25.
(. )
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82
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- - -
7. 80 . Beckett N.S., Peters
R., Fletcher A.E., et al. Treatment of hypertension in patients 80 years of age or
older //N.Engl.J.Med.-2008.-Vol.358, N18.-P.1887-1898.-.
, - 80 .
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(95%:42-78; <0,001). - 1 .
, 2 . (358 vs
448, =0,001). , (
) 80 . . , Imperial Coll. London and
London Sch. Hygiene and Tropical Med., London. . 35.
(. )
-
- -
8.
1987-2001 . Puts
M.T.E., Deeg D.J.H., Hoeymans N., et al. Changes in the prevalence of chronic disease and
the association with disability in the older Dutch population between 1987 and 2001 //Age
and Ageing.-2008.-Vol.37, N2.-P.187-193.-.

()
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1987 . 2708 , 2001 . 3474;
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Univ. Medic. Cent., Amsterdam.
-
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9.
? . Marsden J., Gibson L.M., Lightbody C.E., et
al. Can early onset bone loss be effectively managed in post-stroke patients? An integrative
review of the evidence //Age and Ageing.-2008.-Vol.37, N2.-P.142-150.-.
() () ()
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. 2006 . 99
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Lancashire, Preston.
-
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10. ;
? Roderick P.J., Atkins R.J., Smeeth L., et al. Detecting chronic kidney disease
84
in older people; what are the implications? //Age and Ageing.-2008.-Vol.37, N2.-P.176186.-.

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() (),
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(95%:1,37-2,32) 1,10 (95%:0,92-1,32). :
eGFR <60; eGFR <45
. ,

(., ). ,
eGFR >45. , Univ. Southampton, Southampton.
-
- -
11.
. Foss N.B., Kristensen M.T., Kehlet H. Anaemia impedes functional
mobility after hip fracture surgery //Age and Ageing.-2008.-Vol.37, N2.-P.173-178.-.
()
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(/) .
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/ . 487
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Cumulated
85
Ambulation Score (CAS). 170, 132 116 -,

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.
Hb. , ,
, ,
3- / . ( 0,41; 95%:0,14-0,73;
=0,002). ,
/ -,
/.
- . , Hvidovre Univ. Hosp., Hvidovre.
-
- -
- - -
12. .
Chipperfield J.G. Everyday physical activity as a predictor of late-life mortality //The
Gerontologist.-2008.-Vol.48, N3.-P.349-357.-.
, () ()
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. 198
80 98 .
actigraph.
, ,
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2 .
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2- ., .
, , .
, Univ. Manitoba, Manitoba.
-
- -
- - -
13. ,
. Mezuk B., Eaton W.W., Golden S.H., et al. Depression, antidepressants, and bone
mineral density in a population-based cohort //J.Gerontology.-2008.-Vol.63, 12.-P.14101415.-.
() ()
()
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>18 . .
1982 . (2768 ), 1993-1996 .
(1920 ) 2004-2005 . (1071 ). 2004-2005 . 398
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.
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, Univ. Michigan Sch. Public Hlth., Ann Arbor.
-
- -
14. ,
-1 100 . Arai Y., Takayama M.,
Gondo Y., et al. Adipose endocrine function, insulin-like growth factor-1 axis, and
exceptional survival beyond 100 years of age //J.Gerontology.-2008.-Vol.63, 11.-P.12091218.-.
, >100 .,
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-1 (IGF-1).
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- (TNF-),
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(), ( . 1,6; 95%:1,142,35 1,45; 95%:1,00-2,08). IGF-1, IGF-1 -3 (IGFBP 3) .
87
,
; ; ; , ,
, - , -6 IGF-1
. ,
IGF-1
. , Keio Univ. Sch. Medic., Tokyo.
- 100
- -
15. 100 :
. Hagberg B., Samuelsson G. Survival after 100 years of age: a
multivariate model of exceptional survival in Swedish centenarians //J.Gerontology.-2008.Vol.63, 11.-P.1219-1226.-.
()
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- 100
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16.
, . Goldman S.E., Ancoli-Israel S., Boudreau R., et al. Sleep
problems and associated daytime fatigue in community-dwelling older individuals
//J.Gerontology.-2008.-Vol.63, 10.-P.1069-1075.-.
() .
() ( , )
, . 2264 .
. 75 84 . ( 77,5 ., [ ] 2,9 .).
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, 7 ./. ,
, 5,5% , , .

. 6 .
,
. , Vanderbilt Univ. Medic. Cent.,
Nashville.
-
- -
17. :
. Ruggiero C., Metter E.J., Melenovsky V., et al.
High basal metabolic rate is a risk factor for mortality: the Baltimore longitudinal study of
aging //J.Gerontology.-2008.-Vol.63, 7.-P.698-706.-.
()
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, 31,3-33,9 /2/.
.
; ,
. , Natl. Inst. Aging, Natl. Inst. Hlth., Baltimore.
-
- -
- - -
89
18.
. Abbatecola
A.M., Barbieri M., Rizzo M.R., et al. Arterial stiffness and cognition in elderly persons with
impaired glucose tolerance and microalbuminuria //J.Gerontology.-2008.-Vol.63, 9.P.991-996.-.
(),
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Mini-Mental State Examination (MMSE)
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. MMSE ,
. , MMSE
. --
, MMSE . ~20%
(. MMSE ) .
, .
, ,
. , Second Univ. Naples,
Naples.

-
- -
- - -
19. 65
:
. La Croix A.Z., Gray S.L., Aragaki A., et al. Statin use and incident frailty in women
aged 65 years or older: prospective findings from the Womens Health initiative
Observational Study //J.Gerontology.-2008.-Vol.63, 4.-P.369-375.-.
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S. , Fred Hutchinson Cancer Res. Cent., Seattle.
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20. ,
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91

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21. . Vaz Fragoso C.A., Araujo
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6 . Lauretani F., Semba R.D., Bandinelli
S., et al. Low plasma carotenoids and skeletal muscle strength decline over 6 years
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Tuscany Regional Hlth., Agency, Florence.
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: . Andel R., Crowe
M., Pedersen N.L., et al. Physical exercise at midlife and risk of dementia three decades
93
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: _______________
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()
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Dhaka.
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,
. Alvarez-Pedrerol M.,
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on thyroid function in preschool children //Occup.Environ.Med.-2008.-Vol.65, 7..452-457.-A.

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Epid.-IMIM, Barcelona.

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3.
. Navas-Acien A., Silbergeld E.K., Pastor-Barriuso R. et ol. Arsenic exposure and
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Environ. Health Sci, Dept. Epidem., Johns Hopkins Bloomberg Sch. Publ. Health,
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(. http://jama.ama-assn.org)
-
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- - -
4. 4-- : 2003-2004 .
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Divis. Lab. Sci, Nat. Cent. Environ. Health, CDC, Atlanta. . 59.
(. http://www.ehponline.org)
- 4--
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5. 50 .:
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Perspect.-2008.-Vol.116, N10.-P.1338-1343.-.
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. 50 . . , Grad. Prog.
Publ. Health, Stony Brook Univ. Med. Cent., New York. . 42.
-
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6. ,
. Turner P.C., Rothwell J.A., White K.L.M., et al.
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Kingdom //Environ. Health Perspect.-2008.-Vol.116, N1.-P.21-25.-.
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Biostat., Univ. Leeds, Leeds. . 29.
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7. ,
, . Suglia S.F., Gryparis A., Schwartz
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Harv. Sch. Publ. Health, Boston. . 41.
(. http://www.ehponline.org )

-
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8.
:
(NHANES) 2001-2004 . Braun J.M., Froehlich
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- 962.-.
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- - -
9.
, . Hirshon J.M., Shardell M., Alles S., et al. Elevated ambient air
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. . , Dept. Emerg. Med.,
Univ. Maryland Sch. Med., Baltimore. .36.
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- -
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10.
. Franco Suglia S., Gryparis A., Wright R.O., et al. Association
of black carbon with cognition among children in a prospective birth cohort study
//Am.J.Epidemiol.-2008.-Vol.167, N3.-P.280 - 286.-.
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(-5,4; 95%) (-3,9; 95%)
WRAML. , -
. , Dept. Environ. Health, Harv. Sch. Publ. Health, Boston.
(. http://www.medscape.om)
-
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11. ,

GSM. Barth A., Winker R., Pononcy-Seliger E., et al. A meta-analysis for
99
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phones //Occup.Environ.Med.-2008.-Vol.65, 5.-.342-346.-.
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(. : http://www.joem.org)
-
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- - -
12.
: 18- . Moore K.,
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Biostat., Sch. Publ. Health, Univ. Calif., Berkeley. . 43.
(. : http://www.ehponline.org)
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100
13. - , ,'
, . Gao J., Liu L., Liu X., et
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Beijing.
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-
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- - - -
14.
. Cocco P., Brennan P., Ibba A., et al. Plasma polychlorobiphenyl and
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and
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of
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101
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- -
- - -
- - - -
15.
. Lang I.A., Galloway T.S., Scarlett A., et al. Association of urinary
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//JAMA.-2008.-Vol.300, N11.-P.1303-1310.-.
()
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1 1,29; 95%; <0,001) (
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. , Epid. Publ.Health
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-
- -
- - -
16. -3,
, :
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//Environ.Health Perspect.-2008.-Vol.116, N7.-P.893-897.-.
-3 (-3) -
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- 95 . ,
-3 2003-2004 . , Div. Lab.
Sci., Natl. Cent. Envir. Health, CDC, Atlanta. . 44.
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-
- -
17. : 2003-2004 . Calafat
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() ,
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6 .
(NHANES), 2003-2004 .
2517
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- 95 . 13,0 / (12,7 / )
459,0 / (363,8 / ).

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. , (
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18. , :
. Meeker J.D.,
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(,
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103
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.
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14,4 13,7 -
. . , Dept.
Environ. Health Sci, Univ. Michigan Sch. Publ. Health, Ann Arbor. . 46.
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- -
- - -
- - - -
- - - - -
19.
. Chevrier J., Eskenazi B.,
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334 ., ( ).
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Hlth. Res., Sch. Publ. Hlth., Univ. Calif., Berkeley.
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-
- -
- - -
- - - -
20. - :
. Pathak N., Khandelwal Sh. Impact of
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, (d) ,
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D4+
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, d -.
. . , Ind. Toxical. Res. Cent., Lucknow.
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-
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21.
(). Siriwardhana N., Wang H.-Ch.R. Precancerous
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//Molecular Carcinogen.-2008.-Vol.47, 5.- .338-348.-.
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Lab., Dept. Pathobiol., Knoxville.
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22.
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. Peng R.D., Chang H.H., Bell M.L., et al. Coarse particulate matter air
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2,5 .
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( 10-2,5). 108 1999-2005 . 3,7 .
105
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. - 10-2,5 10 /3
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2,5 , .
- 10-2,5 10 /3
0,33%,
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. , Dept. Biostat. Epidem., John Hopkins
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- -
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23.
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,
2,5 (2,5) . .
1999-2005 . 202 .

2,5.
, . -
1,05% - 2,5 10 /3
. . 1,49% 2,5 10 /3.
. . 2,5
,
. , Yale Univ., New Haven.
(. : http://aje.oxfordjournals.org)
-
- -
- - -
24. , - : . Opler M.G.A., Buka S.L., Groeger J., et al.
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, - Pb,
,
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106
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,
. , Dept. Psych., Col. Phys., Surgeon, Columb.
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25. ;
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() .
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.
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. , Dept. Publ. Health, Prim. Health Care, Sect. Occup.
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26.
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-
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12 . , .,
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107
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Technic. Univ. Denmark, Dept. Mechan. Engin., Internat. Centre Indoor Environ., Energy,
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27. , ,
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, ()
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(1988-1994 .) -
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. 16% (.
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17%.
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- -
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28.
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70- 80- .
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108
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. , Paijat-Hame Soc.
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- - -
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,
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1400 , 1996-2002 .
. ,
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0,069 (95% :0,024-0,113)
0,059 (95%:0,012-0,106).
.

. , Dept. Epidemiol., Sch. Publ. Health, Univ. Calif., Los Angeles.

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- -
30. . Zhang Ya., Sanjose S., Bracci P.M., et al. Personal use of hair
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() (), ,
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1980 . ,
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109
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/ . ,
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- -
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: ..
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: _______________
1. - . Olive D.L.
Gonadotropin-releasing hormone agonists for endometriosis //N.Engl.J.Med.-2008.Vol.359, N11.-P.1136-1142.-.
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. , Wisconsin Fertility Inst., Middleton. .
37.
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2. . Cummings
S.R., Ettinger B., Delmas P.D., et al. The effects of tibolone in older postmenopausal
women //N.Engl.J.Med.-2008.-Vol.359, N7.-P.697-708.-.
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0,32; 95%:0,13-0,80; =0,02) ( 0,31; 95%:0,10-0,96; =0,04).
, . 1 . ( 2,19; 95%:1,14-4,23;
=0,02), 2006 .
. .
, , , ,
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, . , Univ. Florida Coll.
Medic., Jacksonville. . 54.
(. )
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112

: ..
: _______________
: _______________
4.
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()
() () ( 250 )
LigaSure (Valleylab, Boulder, CO).
102 ,
( ) 250 .
LigaSure,
- (-) ,
. 102 99 (97,1%; 95%:91,6-99,4%);
3- .
455 ( 241 1913 ). ,
, 1600 , ,
. 50 .
, ,
250 . , Unit.
Minimally Invasive Gynecol.-Ginteam, Torino.
(. )
-
- -
5. Gardnerella Vaginalis ()
, .
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Vaginalis infection and cervical (pre)neoplasia as established in population-based cervical
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()
() () .,
Gardnerella Vaginalis. 800 498
.,
113
. () , G.Vaginalis
.
G.Vaginalis 0,6/1 . ()
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( 10,3; 95%:6,6-16,1). ,
G.Vaginalis ()
.
() . ,
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(. )
-
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6. ,
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,
() () ().
24 -,
1994 . 2006 .
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. , Charles Nicolle Hosp., Tunis.
(. )
-
- -
- - -
- - - -
7.
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()
., (), .,
. .,
, , ,
114
. 1 . 6 .
. 277 . 102
( ); 129
; 46 .
28 . 74 - (27%). 36-.
-, , .
94%, . ., 51% (<0,001).
,
. , Univ. Milan, Milan.
(. )
-
- -
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8. ,
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() . 2 .
- () () () (
) .,
. 608 ., 17
6 . 24 .
,
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( 0,7), ( 0,5), ( 0,6), ( 0,4),
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( 2,3), >20 . ( 13,4) ( 96,9).
. ,
, ,

. , Cent. Interdisciplinary Res. Womens Hlth, Univ. Texas Medic.
Branch, Galveston.
(. )
-
- -
- -
- - -
9. :
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()
(). 39 . ,
115
, 20-. ,
4-. (1 ), 12 .
(2 ), 3- ,
4 . .
. 16 . 1 20- . (
1107 ). Nugent 7.
.
,
0,76 (95%:0,33-1,76). ., ,
,
( 0,23; 95%:0,12-0,44).
, . , John Hopkins
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(. )
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- -
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10.
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() .
. ,
. 488 .,
800 ; 78 (1 .)
( ), 410 (2 .). .
, 2 . .
, .
(72 vs 69%; =0,64)
30 . (85 vs 82%; =0,50) . , ,
. 1 2 . .
.
. , Univ. Pittsburgh Sch. Medic. A. Madee-Womens Res.
Inst., Pittsburgh.
(. )
-
- -
- - -
11.
? Rizzo M., Berneis K., Carmina E., Rini G.B. How should we manage
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dyslipidemia
in
women
with
polycystic
ovary
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, . ()
- .
- (),
116
, -
. , .
, ,
. ,
(),
- .
. .
- , ,
- . -
, . -
,
; ,
. , Univ. Palermo,
Palermo.
(. )
-
- -
- - -
- - - -
12. . Chavarro J.E., Rich-Edwards
J.W.,
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B.A.,
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() (). 18 555
. . ; , .
8-. .
. 438 . .

1,39 (95%:1,011,90; 0,03). 0,78
(95%:0,54-1,12; 0,07). , 5%
, ,
> 50% (=0,007). ,
. , Harvard Sch.
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- -
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13.
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, , ., ,
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in vivo in vitro per os
()
()
/ () .
PubMed., Scopus, Web of Science Cochrane Library;
6 , 1092 /
, .
1- 2-
- (. CI 0,94 [95%:0,6-1,48] 1,09 [95%:0,68-1,75]).
1- 2-
(. CI 0,73 [95%:0,31-1,7] 0,71 [95%:0,49-1,03]),
,
. ,
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. Tuomikoski P., Aittoki K., Mikkola T.S. et al. Effect of oral and trausdermal
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() ()
() . .
- - (),
.
(1 ., 20 .) (2 ., ., 20 .).
118
. ()
2,0 /.) 2 . ,
. ( 10,9 15,4%). 4,0 /.
, ()
( 11,0 10,7%).
(50 ) ( 3,2%) . . .
, .
, / - .
. ,
. , Helsinki Univ. Cent.
Hosp., Helsinki.
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- -
16. 1
. Thys-Jacobs S., McMahon D.,
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,
.,
() ().
() .
, ()
(1 .) ., (2, ., .).
, N-, -
-1 (IGF-1) . .
2-. ;
1 . - IGF-1 ( )
. (205,756,8 vs 240,276,9 /, =0,01)
5 . 1 . . . . -
IGF-1 , N-
. ( )
. . 1 .
, - IGF-1 . .
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Medic. Cent., New York.
-
- - -1
17. Trichomonas Vaginalis
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() (). () ,
. ,
.
. ,
. . ,

,
. 2003 . 2006 .
59 . -
(47%) (11%) 15 . (25,4%)
, . 17 . (28,8%)

: 5 17 (29,4%).
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,
. ()
. . , .
() 2 ,
,
2-. (75 ).
- ,
, .
, ,
. , ,
() ,
,
, (., 2 ).
.
. , Cedars-Sinai Medic. Cent., Los Angeles.
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. 1 . 30 . 2 . 72.
1 . 44,90,8., 2 . 44,60,6. 1 .
- , , (11,31,9 vs 5,60,6 ; =0,003;
95:1,9-8,5). 1 . , 2 . (20 vs 1,4%; =0,002;
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20.
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- . , . ().
- OPG . .
-, 40 - 40
., .
; - OPG
(ELISA). ,
- OPG . . .
(304120 vs 363105 /; F=7,641, p=0,007) .

- (RANKL) RANKL/OPG.
(R2=0,208 F=6,579, p=0,001) , (=0,281, p=0,008), (=-0,245, p=0,022), (=0,296, p=0,006),
- OPG . , -
- OPG .
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21.
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. ()
,
() ,
, .
, ,
136 . . 600 ()
. 117 . : 200 /.
6 ., - .
.
6 . 1 /2 .
6 .
,
. 3 .,
, 101 . (90%) 6 .
, 80 . (77%) 1 .
0,5%
, ,
, 1% / . .,
( ),
( 4,9; 95%:1,8-13,7; =0,002),
(6,5 vs 3,7 .; =0,06) Candida nonalbicans (=0,001).
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per os
. . , Univ. Hosp. Gasthuisberg, Leuven.
-
- -
22.
. Karim R., Hodis H.W.,
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()
- . ,
- ,
. -
180 . ; 91 17- 89
( .
intima media ()
>2 . . - (=0,02),
(=0,01), (=0,02) ,
(SHBG) (=0,005)
( ). SHBG
122

( <0,0001), ()
(<0,003).
, .
SHBG
8,534,72 /., . SHBG
(-5,452,77
/., =0,3). , SHBG
. .
. .,
,
SHBG . ,
Univ. Southern California, Los Angeles.
-
- -
23.

in vitro. Kovacs P., Kovats T., Bernard A., et al. Comparison of serum and
follicular fluid hormone levels with recombinant and urinary human chorionic
gonadotropin during in vitro fertilization //Fertil.Steril.-2008.-Vol.90, N6.-P.2133-2137..

()
(hCG) ()
in vitro (IVF).
., IVF/ (ICSI)

(FSH). 250 hCG (1 .) 7500
hCG (2 .) IVF.
. 2, (), hCG
(). , 2, , hCG
. , >14 ,
, .
, hCG
.
IVF .
. , Kaali Inst. IVF Cent., Budapest.
-
- -
24. -,
: 24-
. Cromer B.A., Bonny A.E., Stager M., et al. Bone mineral density in
123
adolescent females using injectable or oral contraceptives: a 24-month prospective

study //Fertil.Steril.-2008.-Vol.90, N6.-P.2060-2067.-.
, ()
. .
433 - 12-18 .
1 . 58
(D), 2 . (187 ) , 100
20 2, 3 . (188 ) .

6-. 24 . 24 . %
: 1 .: -1,5%, 2 .: +4,2%, 3, ., .: +6,3%.
% : 1 .: -5,2%, 2 .: +3,0%, 3
.: +3,8%. 1 . . .
1 . % 12 . -1,4%;
-0,1% 12 . .
, -, D,
2 3 .; ,
, 1- .
D,
.
-
- - -
25. . Sbaragli C., Morgante G., Goracci
A., et al. Infertility and psychiatric morbidity //Fertil.Steril.-2008.-Vol.90, N6.-P.21072111.-.
()
(). -,
: 81 70 . .
, .;

(16 vs 2%), , (8 vs 0%).
, -
.

-
. , Univ. Siena Sch. Medic., Siena.
-
26. in vitro
. McCormick B., Thomas M.,
Maxwell R., et al. Effects of polycystic ovarian syndrome on in vitro fertilization embryo
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124

() in vitro (IVF) () ()
() ().
. . 4 .
: 1 . 52 . , 2 . 6 . , 3 . 18 .
4 . 10 . . 94 IVF .
, . . 2 .
(12,26,0 vs 7,73,6),
(22,29,2 vs 12,65,8) (54,6 vs 1,42,6), . 1 . . 2 .
(18,86,0 vs 29,214,2),
, . 4 . (22,29,2 vs 14,34,9). . 3 .
, . 4 . (2,40,6 vs 2,90,6),
, 1 . (3,23,2 vs 1,42,6).
. 4 ., . . , -
, , ,
,
. , Univ. Cincinnati Coll. Medic., Cincinnati.
-
- - in vitro
27. . Sun W., Stegmann B.J.,
Henne M., et al. A new approach to ovarian reserve testing //Fertil.Steril.-2008.-Vol.90,
N6.-P.2196-2202.-.
() ()
().
PubMed.
;
. ,
. 30 45 .
. .
,
. , ,
, 2 .:
() () .
- ,
.

(FSH) / .
,
, .
() .
, Wake Forest Univ. Baptist Medic. Cent., Winston-Salem.
-
- -
125
28.
/
? Berkkanoglu M., Isikoglu M., Arici F., Ozgur K.
What is the best time to perform intracytoplastic sperm injection/embryo transfer cycle
after hysteroscopic surgery for an incomplete uterine septum? //Fertil.Steril.-2008.-Vol.90,
N6.-P.2112-2115.-.
,
(ICSI)/ ()
() ().
282 ., ICSI/
6 2003 . 1 2006 . 133 (1 .)
ICSI/ 9 . , 93 (2 .) 10 16 .
56 (3 .) >17 . .
2,
(FSH), , () (),
hCG; ( ),
. 1, 2 3 . . 52,6; 52,6
46,4%; . 45,8; 43,1 41,1%. . 21,1;
17,6 22,1%. . 6,4; 7,9 5,1%.
. ,
, ; - 2,
FSH, , , ,
. ,
ICSI/ -
10 .
. , Antalya IVF, Antalya.
-
- -
29. ,
in vitro :
. Serna J., Cholquevilque J.L., Cela V., et al. Estradiol
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(2) in vitro (IVF)/
(ICSI).
176 , . ()
() (200 ,
), 2 , 2
(100 /.) /., . .
() ()/; ()/,
, , 2 .
., 2+P.
(34,9% [51 146] vs 28,9% [41 142]), , (42% [34 81] vs 41,8 [33
126
79]), (15% [6 40] vs 13,2% [5 38])

(28,6% [12 42] vs 24,4% [10 41]).
2 IVF. ,
IVI-Madrid, Madrid.
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- - in vitro
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30.
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() in vitro (IVF)
(ICSI).
, 1960 .
2007 .; 10 .
., IVF ICSI
- (GnRH), GnRH,
hMG (FSH)
.
(4), 4 .
\ .

. 2 4 . 4.
, 2 4
IVF/ICSI . ,
.

2 IVF. , St. Marys
Hosp., Cent. Manchester a. Manchester Childrens Univ. Hosp., Manchester.
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- - in vitro
- - -
31. -
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,
.,
() () () .
127
in vitro (IVF)
587 .-, 973
886 .
, , , ,
, 0,7% (6 886 ).
, , .-
, 8,5%; 9% .
, ,
.
, ; ,

., IVF.
,
.-. ,
.- . , Coll. Physicians a. Surgeons Columbia Univ.,
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-
- -
- - -

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.
27 33 -, 6 - .
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.
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(. )
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12 . . , . . , ; .
. . - . ,
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4 . 8 .
5 ; , .
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()
.
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130
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( 83%). 28 ., 23
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(86% ), 9 (31%) . .
3-22 . . ,

. , - .
( <20%),
, , . ,

,
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(. )
-
- -
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(). 170 -; 1995-1998 .
33 -. Visick-
2003 2007 .; . 69 117 .
2003 . 29 (90%), 2007 . 31 (97%). 1 -
2003 .
117 . ( 99 144 .).
- (Visick 1-2) 93% - 2003 .
97% 2007 . 97% - 10 .
. - . 1 -
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,
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; - ,
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1,16; 95%:0,91-1,49; =0,23). 3,1% (70 -)
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, . ,
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traditional risk factors with cardiovascular death across 0 to 10, 10 to 20, and >20 years
follow-up in men and women //Am.J.Cardiol.-2008.-Vol.101, N1.-P.89-94.-.
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. 28.
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. Roy D., Talajic M., Nattel S., et al. Rhythm control versus rate
control for atrial fibrillation and heart failure //N.Engl.J.Med.-2008.-Vol.358, N25.-P.26672677.-.
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15.
ST-. Ellis S.G., Tendera M., de Belder M.A., et al. Facilitated PCI
in patients with ST-elevation myocardial infarction //N.Engl.J.Med.-2008.-Vol.358, N21.P.2205-2217.-.
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. , Cleveland Clinic, Cleveland. . 42.
(. )
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16. . Chan P.S.,
Krumholz H.M., Nichol G., Nallamothu B.K. Delayed time to defibrillation after in-hospital
cardiac arrest //N.Engl.J.Med.-2008.-Vol.358, N1.-P.9-17.-.
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Kansas City. . 18.
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ST-,
. Ndrepepa G., Kastrati A., Mehilli J., et al.
One-year clinical outcomes with abciximab vs placebo in patients with non-ST-segment
elevation acute coronary syndromes undergoing percutaneous coronary intervention after
pre-treatment with clopidogrel: results of the ISAR-REACT 2 randomized trial //Eur. Heart
J.-2008.-Vol.29, N4.-P.455-461.-.
, 1 .
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Deutsches Herzzentrum, Munich. . 23.
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Cardoso G., Trancas B., Luenco A., et al. Heart failure and depression: an association with
clinical importance //Rev.Port.Cardiol.-2008.-Vol.27, N1.-P.91-109.-.
1/5 - () (),
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, . Young J.B., Abraham W.T.,
Albert N.M., et al. Relation of low hemoglobin and anemia to morbidity and mortality in
patients hospitalized with heart failure (Insight from the OPTIMIZE-HF
Registry) //Am.J.Cardiol.-2008.-Vol.101, N2.-P.223-230.-.
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Cleveland. . 17.
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20. . Hung J., Knuiman M.W.,

Divitini M.L., et al. Prevalence and risk factor correlates of elevated C-reactive protein in
an adult Australian population //Am.J.Cardiol.-2008.-Vol.101, N2.-P.193-198.-.
- (CRP)
. CRP
, .
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1994/1995 . CRP >3 / . 25
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CRP .: ( 3,5; 95%:2,4-5,0), ( 3,1;
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, CRP
. , Sch. Medic. a. Pharmacol., Sir Charles
Gairdner Hosp. Unit, Univ. Western Australia, Perth. . 18.
(. )
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- - - -
21.
. Mark D.B., Anstrom K.J., Sun J.L., et al. Quality of
life with defibrillator therapy or amiodarone in heart failure //N.Engl.J.Med.-2008.Vol.359, N10.-P.999-1008.-.
()
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(. )
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22. -
. Messerli F.H., Pinto L., Tang S.S.K., et al. Impact
of systemic hypertension on the cardiovascular benefits of statin therapy a metaanalysis //Am.J.Cardiol.-2008.-Vol.101, N3.-P.319-325.-.
()
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St. Lukes-Roosevelt Hosp., New York. . 29.
(. )
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23. .
Truong T., Slavin L., Kashani R., et al. Prevalence of migraine headaches in patients with
congenital heart disease //Am.J.Cardiol.-2008.-Vol.101, N3.-P.396-400.-.
159
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UCLA, Los Angeles. . 21.
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24.
. Rosseb A.B., Pedersen T.R., Boman K., et al. Intensive lipid lowering with
simvastatin and ezetimibe in aortic stenosis //N.Engl.J.Med.-2008.-Vol.359, N13.-P.13431356.-.
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, - .
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- , , . , Aker Univ.
Hosp., Oslo. . 42.
(. )
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25.
ST- 5-
. Tadel-Kcjancic S., Zorman S., Jazbec A., et al. Effectiveness of primary
percutaneous coronary intervention for acute ST-elevation myocardial infarction from a 5year single-center experience //Am.J.Cardiol.-2008.-Vol.101, N2.-P.162-168.-.
()
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2000 . 31 2004 . 2393 - ;
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. 13.
(. )
-
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- - -
26.
(ADHERE). Fonarow
G.C., Peacock W.F., Horwich T.B., et al. Usefulness of B-type natriuretic peptide and
cardiac troponin levels to predict in-hospital mortality from ADHERE //Am.J.Cardiol.2008.-Vol.101, N2.-P.231-237.-.
, (BNP)
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Tn ( 5,10; <0,0001).
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. -, ,
. , Univ. California, Los Angeles Medic. Cent.,
Los Angeles. . 25.
(. )
-
- -
- - -
27.
ST-,
. Chong J.J.H.,
Ganesan A.N., Eipper V., et al. Comparison of left ventricular ejection fraction and
inducible ventricular tachycardia in ST-elevation myocardial infarction treated by primary
angioplasty versus thrombolysis //Am.J.Cardiol.-2008.-Vol.101, N2.-P.153-157.-.

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162
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21.
(. )
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28. - ,
? Wng T.J. New cardiovascular risk factors exist, but
are they clinically useful? //Eur. Heart J.-2008.-Vol.29, N4.-P.441-444.-.
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- . Ridker P.M., Danielson E., Fonseca
F.A.H., et al. Rosuvastatin to prevent vascular events in men and women with elevated Creactive protein //N.Engl.J.Med.-2008.-Vol.359, N21.-P.2195-2207.-.
163
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95%:0,67-0,97; =0,02). 1 .
, .
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. 29.
(. )
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30. .
Shaw A.D., Stafford-Smith M., White W,D. The effect of aprotinin on outcome after
coronary-artery bypass grafting //N.Engl.J.Med.-2008.-Vol.358, N8.-P.784-793.-.
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, 285- /- - , 285- , 285- - , 285, 285- - , 285
, 286- - - , 286
, 287- - - S100, 287
, 288- - - 12/23- - - - - - , 288
, 289- - - , 289
, 290- -, 290- , 290- - , 290
, 291- - - , 291- - , 291
, 292- - - - - - , 292
, 293- - - , 293- - , 293- - - , 293
, 294- - - g, 294
, 295- - - - - - - - - - , 295
, 296- - - , 296
, 297- - - -2- - - - , 297
178
, 298- - - -- - - - - - , 298
, 299- - - - - - , 299
, 300- , 300- , 300- - , 300
, 301- - - - - - , 301
, 302- - - , 302
, 303- - - - - - , 303
, 304- - - - - - , 304
, 305- - - - - - -, 305
, 306- - - - - - - - - - , 306
, 307- - - , 307
, 308- -- - , 308
, 309- - - , 309
, 310- - - , 310
, 311- - - , 311
V. .
, 312- - - - - - , 312
, 313- - - 2- - - - - - -
, 313
, 314- - - - - - , 314
, 315- - - - - - , 315
, 316- , 316
, 317- - - , 317
, 318- - - , 318
Helicobacter spp., 319
, 320- -- - , 320
179
, 321- - - , 321
, 322- - - , 322
, 323- - - , 323
, 324- - - - - - , 324
Acinetobacter, 325- , 325
, 326- , 326- , 326- - -, 326
, 327- , 327
, 328- - - , 328
, 329
, 330- , 330
, 331- c - - , 331
, 332- - - - - - , 332
, 333- , 333
, 334- , 334
, 335- , 335
, 336- - - , 336
, 337- - - -2- - - , 337
, 338- - - - - - , 338
, 339- - - , 339
Clostridium dfficile, 340- -- - - - - , 340
, 341- - - - - - , 341
, 342
.
, 343- - - , 343
, 344- - - , 344
180
, 345- - - , 345
, 346- - - , 346
, 347- - - , 347
, 348- - - , 348
, 349- - - , 349
, 350- - - , 350
, 351- -
, 351
, 352- -- - , 352
, 353- - - - - - , 353
, 354- - - , 354
, 355- - - , ,
355
, 356- - - , 356
, 357- - - , 357
, 358- - - - , 358
, 359- - - , 359
, 360- - - , 360
, 361- - - - - - , 361
, 362- , 362
, 363- - - , 363
, 364- - - , 364
, 365- 6- - - , 365
, 366- - - - - - - - - - ,
366
181
D, 367- - -
1 , 367
, 368- - - , 368
, 369- - - - , 369
, 370- - - - - - , 370
, 371- - - - - - , 371
, 372- - - - - - , 372
. .
, 373- , 373- , 373

, 374- - - - - - , 374
, 375- - - - - -
, 375
, 376- - - - - - ,
376
, 377- - - , 377
, 378- - - - - - , 378
, 379- - - , 379
, 380- - - - - - , 380
, 381- - - , 381
, 382- - - , 382
, 383- - - - - - , 383
, 384- - - - - - , 384
, 385- - - , 385
, 386- 100 - -
, 386
, 387- 100 - - , 387
, 388- - - , 388
182
, 389- - - - - - , 389
, 390- - - - - , 390
, 391- - - , 391
, 392- - - - - - ,
, , 392
, 393- - - , 393
, 394- - - - - -
, 394
, 395- - - , 395
, 396- - -
, 396
.
, 397- - - - - -
, 397
, 398- - - , 398
, 399- - - , 399
, 400- - - - - - , 400
, 401- - - , 401
, 402- - - , 402
, 403- - - - - - ,
, 403
, 404- - - , 404
, 405- - - , 405
, 406- - - - - - - - - , 406
, 407- - - - - - , 407
, 408- - - , 408
183
, 409- - - - - - , 409
, 410- - - , 410
, 411- - , 411
, 412- - - , 412
, 413- - - , 413
, 414- - - , 414
, 415- - - , 415
, 416- - - 1979-2003 , 416
, 417- - - - - - -
, 417
, 418- - - - - - , 418
, 419- , 419
, 420- - - , 420
, 421- - - , 421
, 422- - - , 422
, 423- 1 - - - - -
, 423
, 424- , 424
, 425- - - - - - ,
425
, 426- - - - - -
, 426
.
, 427- - - - , 427
, 428- - - , 428
, 429- - - , 429
, 430- , 430
184
, 431- Gardnerella vaginalis- - , 431

, 432- - - - - - , 432
, 433- - -
, 433
, 434- - - - ,
434
, 435- - - , 435
, 436- - - , 436
, 437- - - - - - , 437
, 438- - - , 438
, 439- , 439
, 440- - - , 440
, 441- - - , 441
, 442- - - -1, 442
, 443- - - , 443
, 444- - - , 444
, 445- - - , 445
, 446- - - , 446
, 447- - - , 447
, 448- - -
, 448
, 449- - - - - , 449- - - , 449- - - - , 449
, 450- - - -, 450
, 451- , 451
, 452- - - in vitro, 452
185
, 453- - - , 453
, 454- - -
, 454
, 455, 456- - - in vitro- - , 455, 456
, 457- - - - - - , 457
. .
, 458- - - - - - , 458
, 459- - - - - - , 459
, 460- - - , 460
, 461- - - - - - - - - - , 461
, 462- - - , 462
, 463- , 463
, 464- - - - - - - - - - , 464
, 465- - - - - - - - - - , 465
, 466- - - - - - - - - - , 466
, 467- - - , 467
, 468- - - - - - , 468
, 469- - - - - - - - - - ABCD, 469
, 470- - - , 470
, 471- - - - - - ,
471- - - , 471
, 472- - - - - - , 472
, 473- - - , 473- -
, 473
, 474- - - - - - , 474
186
, 475- - - -- - -
, 475
, 476- - - - - - , 476
, 477- - - - - - , 477
, 478- - - , 478
, 479- - - - - - , 479
, 480- - - - - - - - - , 480
, 481- - - - - - , 481
, 482- , 482- , 482- - D, 482
, 483- , 483
, 484
, 485- , 485
, 486- - - , 486
, 487- - - - - - , 487
V.
, 488- - - , 488- - , 488- - - - - - , 488

, 489- , 489
, 490- - - , 490
, 491- - - - - - ,
491
, 492- - - - - - , 492
, 493- - - , 493
, 494- , 494
, 495- - - , 495
, 496- - - - - - , 496
187
, 497- , 497
, 498- -- - , 498
, 499- - - - - -
, 499
, 500- , 500
, 501- , 501
, 502- c- - , 502
, 503- - - , 503
, 504- , 504
, 505- - - , 505
, 506- - - , 506
, 507- , 507
, 508 - - - , 508
, 509- , 509- , 509
, 510- - - - - - , 510
, 511- , 511
, 512- , 512
, 513- - - , 513
, 514
, 515
, 516- - - - - - , 516
, 517- - - , 517
V.
, 518- - - - - - , 518
, 519- - - , 519
188
, 520- - - - - - , 520
, 521- 4--- - , 521
, 522- - - , 522
, 523- , 523
, 524- - - , 524
, 525- - - - - - , 525
, 526- - - - - - , 526
, 527- - - - - - , 527
, 528- - - - - - , 528
, 529- - - - - - , 529
, 530- - - - - - ,' - - - - , 530
, 531- -- - - - - - - - , 531
, 532- - - - - - , 532
-3, 533- - - , 533
, 534- , 534
, 535- - - - - - - - - - - - - - , 535
, 536- - - - - - - - - -
, 536
, 537- - - , 537
, 538- - - (), 538
, 539- - - - - - , 539
, 540- - - - - - , 540
, 541- - - , 541
189
, 542- , 542
, 543- - - , 543
, 544- - - , 544
, 545- - - -- - - , 545
, 546- - - , 546
, 547- -- - - - - , 547
V. .
, 548- , 548
, 549- , 549
, 550- - - , 550
, 551- , 551
, 552- , 552
, 553- , 553
, 554- , 554
, 555- - - , 555
, 556- - - , 556
, 557- - - , 557- - , 557- - , 557
(1) , 558- - - - - - - - - - ,
558
, 559
, 560- - - - - - - , 560
, 561- - - - - -
, 561
, 562- -- - , 562
, 563- , 563
, 564- , 564
190
, 565- - - , 565
, 566- , 566
, 567- - - , 567
, 568- - - 210Pb, 568
, 569- - - , 569
, 570- - - RANDO, 570
, 571- , 571
, 572- - - , 572- - , 572- - -
, 572
, 573- , 573 , 573- - , 573
, 574- - - , 574
, 575- - - , 575
, 576- - - , 576
, 577- , 577
V.
, 578- - - - - - []- - - -
, 578
, 579- - - - - - - - - - , 579
, 580- - - , 580
, 581- - - - - - , 581
, 582- - - - - - - - - - , 582
, 583- - - , 583
, 584- - - , 584
, 585- , 585
, 586- - - , 586
191
, 587- - - , 587
, 588- - - - - - , 588
, 589- - - 2-- - - -- - - - -, 589
, 590- - - 2--4 - - - ,
590
, 591- - - - - - - - - -
, 591
, 592- - - - - - 1-- - - , 592
, 593- - - - - - , 593
, 594- - - - - -
- - - - , 594
, 595- - - - - - , 595
, 596- - - - - - ,
596
, 597- - - , 597
, 598- - - - - - - - - - , 598
, 599- , 599- , 599- - , 599
, 599- , 599- , 599- - , 599
, 600- - - - - - , 600
, 601- - - , 601
, 602- - - , 602
, 603- - - , 603
, 604- , 604
, 605- - - - - - - - - - , 605
, 606- - - , 606
192
, 607- - - , 607
, 409
-
- -
- - - , 409
, 239, 511
- , 239
- , 239
- , 511
, 192, 581, 596
-
- - , 192
-
- -
- - - , 581
-
- -
- - - , 596
, 467
-
- - , 467
, 579, 580
-
- - , 580
-
- -
- - -
- - - - , 579
Acinetobacter, 325
- , 325
, 131, 135, 137
- , 135
-
- - , 137
- , 131
, 384
-
- -
193
- - - , 384
, 309
-
- - , 309
, 19, 20, 23, 24
-
- - , 20
- , 23, 24
- -
- - - , 23
- - - , 23
- - , 24
-
- - , 19
- - , 19
, 21, 22, 373
- , 21, 22
- -
- - - , 22
- -
- - - , 21
- - - , 21
- - - - , 21
- , 373
- , 373
, 118
-
- - /, 118
, 195
-
- -
- - - , 195
, 164
-
- - , 164
, 223
-
- - , 223
, 560, 562
- -
194
- -
- - - , 560
- -
- - , 562
, 201, 202, 203, 218, 471
- , 471
- -
- - - , 471
- - - , 471
- , 201, 202, 203, 218
- - , 202, 218
- - - , 202
- - - , 218
, 410
-
- - , 410
, 249
-
- - , 249
, 516
-
- -
- - - , 516
, 485
- , 485
, 65, 66
- , 65, 66
- - , 65, 66
- - - , 65
- - - , 66
, 395
-
- - , 395
, 604
- , 604
, 174
-
- -
- - - , 174
195
, 259, 275, 280, 281, 282, 283, 550

-
- - , 280
- , 282, 283
- - , 282, 283
- - - , 283
- - - , 282
- - - - , 282
-
- - , 550
-
- - , 275
-
- -
- - - , 281
-
- -
- - - , 259
, 62, 63, 349, 357, 368, 526, 529, 591
-
- -
- - -
- - - - , 591
- , 62, 63
- - , 62
- , 349, 357, 368, 526, 529
- -
- - - , 529
- -
- - - , 526
- - , 349, 368
- - , 357
, 469
-
- -
- - -
- - - - ABCD, 469
, 484
, 240
-
- - , 240
, 372
196
-
- -
- - - , 372
, 327
- , 327
, 117
-
- - , 117
, 438, 451, 542
-
- - , 438
- , 542
- , 451
-3, 533
-
- - , 533
-, 219
- , 219
, 241
-
- - , 241
, 602
-
- - , 602
, 521
- 4--
- - , 521
, 330, 334
- , 330
- , 334
, 435
-
- - , 435
, 566, 601
-
- - , 601
- , 566
197
, 397, 398, 399, 401, 403, 406, 411, 414, 417, 423, 424, 436
-
- - , 398
- - , 411
-
- - , 399
- 1
- -
- - - , 423
-
- - , 436
- -
- -
- - - , 417
- , 397, 401, 403, 406, 414
- - , 414
- - , 397, 403, 406
- - - , 397
- - - - , 406
- - - , , 403
- - , 401
- , 424
, 366, 407, 412, 418
- , 366, 407, 412, 418
- - , 412
- -
- - -
- - - - , 366
- - , 407, 418
- - - , 418
- - - , 407
, 316
- , 316
, 354
-
- - , 354
, 91
-
- - , 91
, 342
, 313, 314, 324, 338
198
- , 314, 324
- -
- - - , 324
- -
- - - , 314
- , 313, 338
- -
- - - , 338
- - 2
- - -
- - - - , 313
D, 367
-
- - 1 , 367
, 388
-
- - , 388
, 586
-
- - , 586
, 578, 592
- , 578, 592
- -
- - - 1-
- - - - , 592
- -
- - - []
- - - - , 578
, 524
-
- - , 524
, 97
-
- - , 97
, 328, 341
-
- - , 328
-
- -
- - - , 341
199
, 470
-
- - , 470
, 317, 339
-
- - , 339
-
- - , 317
, 120
- , 120
, 128
- , 128
, 127, 197, 214, 221
- , 197, 214
- - 1985-2005 , 214
- , 127, 221
- - , 127
- -
- - - , 221
, 379
-
- - , 379
, 147
-
- -
- - -
- - - - , 147
, 124
-
- - , 124
, 121, 213
-
- - , 121
-
- - , 213
, 126, 356
-
- - L-, 126
-
200
- - , 356
, 364
-
- - , 364
, 430
- , 430
, 489, 494
- , 494
- , 489
, 599
- , 599
- , 599
- - , 599
, 150, 151, 160
-
- -
- - - 2-
- - - - , 150
-
- -
- - - , 151
- - - , 151
- - - -
- - - - - , 151
- - - - - g, 151
- - - - - -
- - - - - - - , 151
- , 160
, 142, 157, 166
- g
- -
- - - , 166
-
- -
- - - , 142
-
- -
- - -
- - - - , 157
- , 157
, 362
201
- , 362
, 199, 216
-
- - , 199
-
- - , 216
, 337
-
- - -2
- - - , 337
, 488
-
- - , 488
- - , 488
- - -
- - - - , 488
, 523
- , 523
, 419
- , 419
, 468, 483
- , 483
-
- -
- - - , 468
, 385, 459
-
- - , 385
-
- -
- - - , 459
, 299, 301, 302, 310
- , 299, 302
- -
- - - , 299
- - , 302
- , 301, 310
- - , 310
- -
- - - , 301
202
, 40
-
- - , 40
, 96, 108, 606
-
- - , 96
- , 108, 606
- -
- - - , 606
, 254
-
- -
- - - , 254
, 89
- , 89
, 79, 109, 110, 111, 112, 113, 114, 115, 400, 408, 520, 600
-
- - , 408
-
- - , 79
-
- -
- - - , 520
- , 109, 110, 111, 112, 113, 114, 115, 400, 600
- - 1 , 109, 110
- - - , 109, 110
- - 2 , 111, 112, 113, 114, 115
- - - , 111, 112, 113
- - - - , 112, 113, 114, 115
- - - - - , 114
- - - - - , 112, 113, 115
- - - - - - , 113
- -
- - - , 400
- -
- - - , 600
, 278
- , 278
, 386, 387
- 100 , 386, 387
- - , 386
203
- - , 387
, 570, 571
- , 571
-
- - RANDO, 570
, 12
-
- -
- - - , 12
, 8
-
- - , 8
, 81, 86
-
- - , 86
-
- -
- - - , 81
, 568
-
- - 210Pb, 568
, 217
-
- - , 217
, 58, 59
- , 58, 59
- - , 59
- - , 58
, 35, 318
- , 35, 318
- - , 318
- - , 35
, 427
-
- - - , 427
, 433
-
- - , 433
204
, 355
-
- - , , 355
, 1
-
- -
- - - , 1
, 125, 536
- , 125, 536
- -
- - - , 125
- -
- - -
- - - - , 536
, 72
-
- - , 72
, 532
-
- -
- - - , 532
, 3, 37, 46, 52, 53, 67, 73, 144, 193, 353, 374, 382
-
- -
- - - , 353
- , 67, 73, 374
- - , 67, 73, 374
- - - , 67
- - - , 73
- - - , 374
- , 144, 382
- -
- - -
- - - - , 144
- -
- - - , 382
-
- -
- - -
- - - - , 193
- -, 3, 37, 46, 52, 53
- -
205
- - - , 53
- -
- - - , 46
- - , 3, 37
- - -
- - - - , 3
- - - , 37
- - , 52
, 4, 11, 14, 17, 18, 375, 380
- , 11, 14, 17, 18, 375, 380
- - , 17
- -
- - - , 18
- -
- - -
- - - - , 11
- - , 375, 380
- - - , 375
- - - , 380
- -
- - - , 14
-
- -
- - - , 4
, 26
- , 26
, 402
-
- - , 402
, 363
-
- - , 363
, 204
- -
- - in vitro, 204
, 381, 462, 465, 466, 474, 475, 479, 481, 486, 487
-
- -
- - - , 481
-
- - , 381
-
206
- -
- - -
- - - - , 466
-
- -
- - - , 487
- , 465, 474, 475, 486
- -
- - - , 474
- -
- - - , 486
- - -
- - - , 475
- -
- - -
- - - - , 465
-
- -
- - - , 479
-
- - , 462
, 33, 39, 49, 51, 464
- , 33, 39, 49, 51
- - , 33, 39, 49
- - - , 33, 39, 49
- - ST-
- - - , 51
-
- -
- - -
- - - - , 464
, 476
-
- -
- - - , 476
, 321, 326
- , 326
- - -, 326
-
- - , 321
- , 326
, 277, 331, 431
-
- - , 277
207
- c
- - , 331
- Gardnerella vaginalis
- - , 431
, 198, 461
-
- -
- - -
- - - - , 461
-
- -
- - - , 198
, 537
-
- - , 537
, 246, 440, 447
-
- - , 440
-
- - , 447
- , 246
, 554
- , 554
, 544
-
- - , 544
, 394
-
- -
- - - , 394
, 538
-
- - (), 538
, 190, 191, 555
-
- - , 555
- , 190, 191
- -
- - - , 190
- -
208
- - -
- - - - , 191
, 508
-
- - , 508
, 350
-
- - , 350
, 492, 493, 495, 502
-
- - , 493
-
- -
- - - , 492
-
- - , 495
-
- - , 502
, 515
, 244
-
- - , 244
Clostridium dfficile, 340
- -
- -
- - - , 340
, 303
-
- -
- - - , 303
, 93, 106, 107
- , 106, 107
- - , 106
- -
- - - , 107
- , 93
, 513
-
- - , 513
209
, 429, 434, 450

-
- - -, 450
-
- - , 429
-
- - , 434
- , 434
, 505
-
- - , 505
, 84
-
- -
- - - , 84
- - - , 84
, 61
-
- - , 61
, 335
- , 335
, 297
-
- - -2
- - - - , 297
, 531, 547
- -, 531, 547
- -
- - -
- - - - , 531
- -
- - - , 547
, 263
, 369
-
- - - , 369
, 293, 504
- , 504
210
-
- - , 293
- - , 293
- - - , 293
, 587, 595
- , 587, 595
- -
- - - , 595
- - , 587
, 284, 285, 286, 287, 304, 305, 510
- /
- - , 285
-
- - , 286
- , 285
- - , 285
-
- - S100, 287
- , 285
- - , 285
-
- -
- - - , 510
- , 284, 304, 305
- -
- - - , 304
- -
- - - -, 305
- - , 284
, 599
- , 599
- , 599
- - , 599
, 134
-
- -
- - - , 134
, 573
- , 573
- , 573
- - , 573
, 47
211
- , 47
, 188
-
- -
- - - , 188
, 295
-
- -
- - -
- - - - , 295
, 332
-
- -
- - - , 332
, 143
- -
- - -2-, 143
, 501
- , 501
, 477
-
- -
- - - , 477
, 478
-
- - , 478
, 551
- , 551
, 548
- , 548
, 549
- , 549
, 577
- , 577
, 245, 500
- , 245
212
- , 500
- , 60
- -
- - - , 60
, 496
-
- -
- - - , 496
, 351
- - , 351
, 420
-
- - , 420
, 27, 29, 42, 43, 45, 50, 65, 101, 133, 136, 163, 165, 208, 210, 361, 371,
377, 378
- , 136, 208
- - , 136
- -
- - - , 208
-
- -
- - - , 133
- , 163, 165
- -
- - -
- - - -
- - - - - , 165
- -
- - - , 163
-
- -
- - - -1, 101
- , 210, 361
- -
- - - -, 210
- -
- - - , 361
-
- - , 377
- , 27, 29, 42, 43, 45, 50, 65, 371, 378
- - , 27, 50
- - - , 27
- - - , 50
- - , 42
213
- - , 43
- -
- - - , 45
- -
- - - , 29
- -
- - - , 378
- -
- - - , 371
, 153
-
- -
- - -
- - - - , 153
, 298
-
- - -
- - -
- - - - , 298
, 499
-
- -
- - - , 499
, 184
- , 184
- , 184
- - , 184
, 104, 439
- , 104
-
- - , 439
, 139, 140, 141, 146, 148
- g, 141, 146
- - , 141
- -
- - -
- - - - , 146
- , 139, 140, 148
- - -2-
- - - , 148
- -
- - - , 139
214
- -
- - - -, 140
, 155, 158
-
- -
- - - , 155
-
- -
- - - , 158
, 343, 344, 345, 347, 348, 358, 405, 413, 422
-
- - , 422
-
- - , 413
-
- - , 405
-
- - , 343
- -
- - , 358
- , 344, 345, 347, 348
- - , 348
- - , 345
- - , 344
- - , 347
, 389
-
- -
- - - , 389
, 5, 16, 94, 207
-
- - , 5
- , 94
-
- - , 16
- - , 16
-
- - , 207
, 514
, 567, 569, 607
-
- -
215
- - - , 607
-
- - , 569
-
- - , 567
, 255, 260
-
- - , 255
- , 260
, 272, 522
-
- - , 522
-
- -
- - - , 272
, 233, 359
- , 233
-
- - , 359
, 13
-
- - /, 13
, 222
-
- - , 222
, 85, 90, 102, 105
- , 90, 102
- - , 90
- , 85, 105
- - , 105
- -
- - -
- - - - , 85
, 220
- , 220
, 225
- -
- - , 225
, 312, 336
216
- , 312, 336
- - , 336
- -
- - -
- - - - , 312
, 237
-
- - , 237
, 238
- , 238
- , 238
, 227
- , 227
, 154, 480
-
- -
- - -
- - - - , 154
-
- -
- - -
- - - - , 480
, 15
-
- - , 15
, 294
-
- - g, 294
, 257, 258, 265, 269, 273, 276, 279, 383
-
- - , 258
-
- -
- - - , 269
- -
- - , 273
-
- - , 265
- , 257, 383
- -
- - - , 257
217
- -
- - - , 383
-
- - , 276
-
- -
- - - , 279
, 262, 268
-
- - , 268
-
- - , 262
, 530
-
- -
- - - ,'
- - - - , 530
, 583
-
- - , 583
, 507
- , 507
, 421
-
- - , 421
, 68, 71, 77
-
- -
- - - , 71
- :
- - , 77
- - - , 77
- - , 68
- - -
- - - - , 68
, 69
-
- - , 69
, 539, 540
-
218
- -
- - - , 539
-
- -
- - - , 540
, 261
-
- - , 261
, 256
- , 256
, 404, 416, 425
-
- - 1979-2003 , 416
-
- -
- - - , 425
-
- - , 404
, 428, 441, 448
-
- - , 428
-
- - , 448
-
- - , 441
, 296
-
- - , 296
, 512
- , 512
, 152
- , 152
- , 152
- - , 152
, 288, 289, 290, 291, 292, 300, 306, 308
- , 290
- - , 290
- -, 290
-
- - , 289
219
- , 300
- -
- - , 308
- , 300, 306
- - , 300
- -
- - -
- - - - , 306
-
- -
- - - , 292
-
- - 12/23
- - -
- - - - , 288
-
- - , 291
- - , 291
, 497
- , 497
, 83
-
- -
- - - , 83
, 196
- , 196
, 168, 169, 170, 171, 172, 173, 175, 176, 177, 178, 179, 180, 181, 182, 185, 186, 187,
189, 194, 307, 518, 545, 563, 565, 582, 589, 597, 605
-
- - , 187
- - , 187
- - - , 187
-
- -
- - - , 180
- , 170, 171, 172, 173, 185, 186
- -
- - - , 171
- - , 186
- - , 172
- -
- - - , 173
- - , 170, 185
- - - , 170, 185
220
- - , 186
- - - , 186
- , 518, 605
- -
- - - , 518
- -
- - -
- - - - , 605
- , 582, 589
- -
- - -
- - - - , 582
- - 2-
- - - -
- - - - --, 589
- , 175, 176, 177, 178, 179, 194, 565
- - , 565
- - , 175
- - , 176, 177, 179
- - -
- - - - , 176
- - -
- - - - , 177
- - - , 179
- -
- - - , 194
- -
- - - , 178
-
- - -
- - - , 545
-
- -
- - - , 181
- , 168, 169, 189
- -
- - - , 189
- -
- - - , 168
- - -
- - - , 169
-
- - , 597
- , 563
-
- - , 307
-
- - 2
221
- - -
- - - - , 182
, 463
- , 463
, 211
-
- - , 211
, 329
, 552
- , 552
, 535, 603
-
- - , 603
-
- -
- - -
- - - -
- - - - - , 535
, 503
-
- - , 503
, 200
-
- -
- - - Nissen-, 200
, 232, 584
- , 232, 584
- - , 584
- - , 232
, 226, 230, 236, 242, 243, 251
-
- - , 230
- , 226, 236, 242, 243, 251
- - , 236
- -
- - - , 243
- -
- - -
- - - - , 251
222
- -
- - - -, 242
- -
- - - , 226
, 517
-
- - , 517
, 527
-
- -
- - - , 527
, 541
-
- - , 541
, 9
- , 9
, 543
-
- - , 543
, 28, 30, 34, 36, 41, 132, 352, 360, 370, 437, 442, 444, 446, 452, 594
-
- -
- - - , 370
-
- -
- - -
- - - - , 594
-
- - , 360
- , 28, 30, 34, 36, 41
- - ST-, 34, 41
- - - , 41
- - - , 34
- - , 30
- -
- - - , 36
- - , 28
-
- - -1, 442
- , 437, 444, 446, 452
- -
- - - , 437
223
- - in vitro, 452
- - , 444
- - , 446
- -
- - , 352
-
- - , 132
, 7, 116, 235
-
- -
- - - , 7
- -
- - , 116
-
- -
- - - , 235
- - - , 235
, 506, 509
-
- - , 506
- , 509
- , 509
, 231
-
- - , 231
, 490, 491
-
- -
- - - , 491
-
- - , 490
, 95, 553
-
- - , 553
- , 95
, 6
- , 6
- , 6
- - , 6
, 393
-
224
- - , 393
, 445
-
- - , 445
, 559
(1) , 558
-
- -
- - -
- - - - , 558
, 557
-
- - , 557
- - , 557
- - , 557
, 519, 546
-
- -
- - - , 546
-
- -
- - - , 519
, 392
-
- -
- - - , , , 392
, 391
-
- - , 391
, 320
- -
- - , 320
, 48, 162
-
- - , 48
-
- -
- - - , 162
- - - , 162
225
- - - -
- - - - -
- - - - - - , 162
, 250
, 2
-
- - , 2
, 119, 473
-
- - , 473
- - , 473
- , ,
119
, 585
- , 585
, 183
-
- - , 183
, 365
- 6-
- - , 365
, 122, 123
-
- - , 122
-
- - , 123
, 426, 449, 453, 454, 455, 456, 457
- , 426, 449, 453, 454, 455, 456, 457
- -
- - - , 426
- -
- - - , 449
- - - , 449
- - - - , 449
- -
- - - , 457
- - in vitro
- - - , 455, 456
- - , 454
- - , 453
226
, 234
- , 234
, 376
-
- -
- - - , 376
, 323
-
- - , 323
, 572, 574, 575, 576
- , 572, 574, 575, 576
- - , 576
- - , 574
- - , 575
- - , 572
- - , 572
- - - , 572
, 228
-
- - , 228
, 498
- -
- - , 498
, 229, 267, 270, 271, 274, 556
- , 229
-
- - , 271
-
- -
- - -
- - - - , 270
-
- - , 556
-
- - , 267
-
- - , 274
, 25
-
- - , 25
227
, 129
- , 129
, 534
- , 534
, 443
-
- - , 443
, 472
-
- -
- - - , 472
, 70, 74, 75, 76, 252, 264, 322, 333
-
- - , 74
-
- - , 322
- , 333
- , 70, 76
- -
- - -
- - - - , 76
- -
- - - , 70
-
- - , 264
-
- - , 75
- , 252
, 247
- , 247
, 525
-
- -
- - - , 525
, 10
-
- - , 10
, 415
-
228
- - , 415
, 561
-
- -
- - - , 561
, 266
-
- -
- - -
- - - - , 266
, 38
-
- -
- - - , 38
, 64, 80, 346
- , 64, 346
- - , 346
- -
- - - , 64
-
- - -
- - - , 80
, 432
-
- -
- - - , 432
, 564
- , 564
, 206
-
- - , 206
, 253, 390, 396, 528, 588, 590
- , 390, 396, 528
- -
- - - , 396
- -
- - - , 528
- -
- - -
- - - - , 390
229
- , 588, 590
- -
- - - , 588
- - 2--4
- - - , 590
-
- - , 253
, 31, 32, 44, 55, 56, 57, 78, 87, 88, 92, 99, 100, 103, 130, 138, 145, 149, 156, 159,
161, 167, 205, 215, 248, 458, 482, 598
-
- -
- - - , 130
-
- - D, 482
-
- -
- - -
- - - -
- - - - - , 149
-
- -
- - -
- - - - , 100
- , 87
- , 31, 32, 44
- - , 31, 32
- - - , 31
- -
- - - - , 44
- , 92, 103
- - -6
- - - , 103
- - , 92
-
- -
- - -
- - - - , 598
-
- -
- - - , 248
- , 145, 159, 161, 167
- -
- - -
- - - -
- - - - - , 161
- -
- - -
230
- - - -
- - - - - , 159
- - , 145, 167
- - -
- - - - , 145
- - -
- - - -
- - - - -
- - - - - - , 167
- , 458, 482
- - D, 482
- -
- - - , 458
- , 78, 88, 99, 205, 215
- - , 78, 88, 205, 215
- - - , 88
- - - , 78
- - - , 205, 215
- - - -
- - - - - , 215
- - - - , 205
- -
- - - y
- - - - , 99
- , 138, 156
- -
- - - , 138
- -
- - -
- - - - , 156
- , 55, 56, 57
- - , 55
- - , 56
- - , 57
Helicobacter spp., 319
, 212
-
- - , 212
, 82, 98
- , 82, 98
- -
- - -
- - - - , 82
- -
- - - , 98
231
, 460
-
- - , 460
, 311
-
- - , 311
, 209, 224, 315
-
- -
- - - , 224
- , 209, 315
- -
- - - , 315
- - , 209
, 54
-
- - , 54
, 593
-
- -
- - - , 593

: ..
: _______________
: _______________
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1 . (n = 185) . - , 2 .
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241

(=9,69), (=5,61), ,
(=8,26), , .

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(=3,12) (=5,30).
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, Occup. Hlth. Un., Publ. Hlth. Cent., Elche, Alicante.
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.
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78237 . 71666 .,
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21.

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. , Dept. Prevent.
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22.
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1994-1998 .
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243
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23.
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()
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- . , Epid. Branch, Nat.
Inst. Environ. Hlth. Sci., Nat. Inst. Hlth., res. Triangle Park.
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24. ,
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. ,
,
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: MCP-1, MIP, MMP-3. , :
. , Dept.
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26. .
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.,
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Cent. Expertise Hlth, Work Ab., Fin. Inst. Occup. Health, Helsinki. . 38.
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. , Dept. Prev. Med., Publ. Health, Sch. Med., Keio Univ.,
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28. ()
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, ()
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.
, . ,
,
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()
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420 . , 3 .: 1 .
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1, 2 3 . . 34,4; 51,7 59,1%;
(=2,21; 95%:1,25-3,92).
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(95%:1,62-4,20).
( 1, 2 3 . 11,71; 17,24
29,54%; =3,49).
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,
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(n=35705) 22-44 ., .
20 ., 2382 , 647
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( 60 ) .
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.
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UPDRS . ( 1,17, 95%:1,02 1,37)
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,
. , Jagiellonian University Medical College,
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, , ,
,
, , ,
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, 1040 ()

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5. ,
.
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() .

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1 . .

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. ,
. , 243
(14%) ABCD (10,0% 2. vs 20,3% ). 3
7 :
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250

. , Univer. f California. .12
(. )
-
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6. . ,
. Bernhardt J., Dewey H., Thrift A., et al. a very early rehabilitation trial for
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( )
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2
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(87%). 74,7 12,5 . 58% (n=41) >7
Nat. Inst. of Health Stroke Scale.
. (, 3 33; , 8 38; =0,20).
.
( , =0,003)
. , Univers. of Melbourne. .31.
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-
7. .
. Bruno A., Kent T.A., Coull B.M., et al. Treatment of hyperglycemia in
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.
/
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. 8,3 / ( 150 /).
2:1 /
(. 1) / (. 2).
1 . < 7,2 / (< 130/) < 11,1
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251
. 46 (31 1 15- 2 .). 1

. 11 (73%) 2- .
1 . (7,4 vs 10,5 / [133 vs 190 /], < 0,001).
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, 35%), 4 (13%) ,
1 (3%) .
. . , Indiana Univ. Sch. of Medicine. .30.
(. )
-
- -
- - -
- - - -
8. .
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.
- (). ,
.

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.

. 173
73 .
. ()
: 1,3; 1,3; 3,2; 20,4 ( < 0,001);
: 3,2; 8,1; 1,3; 1,5 (=0,004).

, .
, 8,7 12,9
, . ,

. , Univ. of Toronto. .39
(. )
-
- -
- - -
- - - -
9.
. Coca A., Messerly F.H., Benetos A., et al Predicting stroke risk in
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,
() . , ,

INVEST (INternational VErapamil SRtrandolapril STudy). (
) 22576 , ,
() .

( , -). ( 24
., > 70% < 140/90 ...) 61835 -
, 377 (6,1 /1000 ) 28% .
, , ,
, , /
, , .
< 140/90 ... . , Univ. of Barcelona.
.30.
(. )
-
- -
- - -
- - - -
10. - . Matsumoto M.,
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-
, - ()
.
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- 5243 12490 .
1992-1995. 9,7., ,
179 . 630 .
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253
. , Jichi
Med. Univ. .24.
(. )
-
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11.
. Staekenborg S.S., van der Flier W.M., van
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()
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), 2) (74%,
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4,5 (. 16).
(49%), (10%). 2
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- . , Vrije Universiteit
Med. Center. .52.
(. )
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12. .
ABCD. Sciolla R., Melis F. Rapid identification of highrisk transient ischemic attacks. Prospective validation of the ABCD score //Stroke.2008.-Vol.39, 2.-P.297-302.-.
6- ABCD, : , ,
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13
254
. 6- 7- ABCD ABCD (
). 274 10 (3,6%) 7 . 15
(5,5%) 30 . ABCD
, 7, 30 . ( = 2,55 7 . 2,62
30 ). (
= 2,68 7 . 2,89 30 ). ,
ABCD,
. , University of Turin. .15.
(. )
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- - - - ABCD
13.
. Lim J.Y., Koh J.H., Paik N.J. Intramuscular botulinum toxin-A
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, , ,
. , , -

() ()
. 29
( 24 .,
6/10) 2 . 1 . /
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Ashworth. 2,
6 12 . . 12 . 4,2 1 .
2,5 2- (=0,051), 82,9 51,8 .,
(=0,059). , .
Fugl-Meyer Ashworth. 3 .
. , Seoul Nat. Univer. College of Medicine. . 56.
(. )
-
- -
14.
. CARAT. Johnson S.C., Down C.F., Higashida R.T., et al.
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255

.
CARAT
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3 ,
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1001 4 . 19
, 3 . 58%
.
( : 1,1% , 2,9% 91-99% ,
5,9% 70%-90%, 17,6% < 70%; < 0,0001 -
).
(3,4% vs 1,3%; =0,092),
(=0,83). ,
,
. , Univ. of California, Los
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(. )
-
- -
- - -
- - -
15. ? Canhao P., Cortesao A.,
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().
()
624 . 6 .
3 : 1)
- (
); 2)
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2- . (26/146 vs 17/149, = 1,7; 95%
0,9-3,3); 2)
(26/146 vs 60/469, =1,5;
95% 0,9-2,4), ,
(8,45 vs 9/184, =4,2, 95% 1,6-11,6); 3)

. . ,
,
256
. . ,
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-
- -
- - -
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,
.
()
-.

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-
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() (. 1 2, .)
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27-2- 8 . . -
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< 8 ., 24 ., 2-5 . 4-6 .
(6 . ) F2-
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.
F2- ,
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- -
- -
17.
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, -, -
, ()
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257

. 1800. 1-
, 5 . , 2- 5-6 . 3, , 3 .
Rankin 3 . .
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- . 3 ., 33%
. (72/218) 32% . (71/221) 1-
, .
Rankin . . . 5 .
5,5% . 0,5% 1-
(=0,002).
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(. )
-
- -
- - -
18. -
. Yip H.-K., Chang L.-T., Chang W.-N.
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.- ()
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in situ. ,

(). 48 .
138 20 40 . .
,
(<0,05). ,
( Nat. inst. of Health stroke <12 ),
(<0,0001) 48 .
4 21 . (= 0,00004).
,
( 12 ) 48 .
( , 12 ) 90 . (<0,001).
. Chang Gung Univ. College of Medicine. Kaohsiung. . 28
(. )
-
- -
- - - -
- - - -
19. ,
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, 16 16 .
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1. 31 Rankin
Barthel.
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, , -
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1 , 2
. 1 .
.
, , . ,
,
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(. )
-
- -
- - -
20. . Ikram
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()
.
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, .
. 484
(, 60-90 .) Cockcroft-Gault.

(). .
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. . Erasmus Med. Center Rotterdam.
. 42
(. )
-
259
- -
- - -
- - - -
21. -
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- . 2
. ,
, .
1- , 2- , 1- .
2003 . 7700. . (. .)
1,8. . 10-14 ., .
20-24 . 0,54 100000
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(77,9%). -
, 10-.
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(0,34 1994 . 0,54 2003 . 100000). Tohoku Univ. Graduate School of
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(. )
-
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22.
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2566 ,
15 .

( Rankin)
,
. Rankin
- . . . (70 vs 67
.) . .
. .
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(=0,76)
(=2,57). . . (9 vs 8% ), .
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260
,
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(. )
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- - -
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. .
.

.
.

. 18 (7941
), 7 . .
, .
(=1,15; 95% : 1,03-1,29).
, (=1,25). ,
. (=1,47). , .
(=1,02).
, .
. -
, . .
Radeliffe Infirmary,Oxford. . 55.
(. )
-
- -
- - -
- - - -
24. 21 .
20 . Hallstrom B., Jonsson
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. -, , .

-.
1983-1985 . 1993-1995 .

( , , . ). .
261
46 .
,
. 2001-2002 . 456
. (
) 144 100000 .-. 2001-2002 ., 158
1993-1995 . 134 1983-1985 .
( 0,8; 95%:0,67-0,94) 2001-2002 .
1993-1995 . , 2050 .
59%.
, ,

. . Lund
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(. )
-
- -
- - -
- - - -
25. D
. Evatt M.L., Delong M.R., Khazai N., et al. Prevalence of
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. , , , .
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- ,
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. 2000-2006 .
MEDLINE EMBASE 114 .
(36%) (38%).
National Institute of Health Stroke Survey (NIHSS)
20,4. 85% . 22% .
81 18,5%,
27,3% 66 . 126 36%
Rankin (< = 2) 29% ;
24% 38% .
(=0,001)
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14,8
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482 (153 . 95
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- ()
, ,
, . - 1 . (n=220)
(100 /2 . ) ( 5
//.) (1000 /2 4 .). 3 . ( 6 ). - 2 . (n=222)
, 2-.
(400 /2 , 250 /2 1-.
). - 2 .
. ,
7,4 .
(1 .) 10,1 . (2 .). - 1 2 .
. 3,3 5,6 . ( 0,54; <0,001);
20 36%. ,
3/4 (, , )
. , Univ. Hosp. Dept. Med. Oncol., Edegem. 22
287
-
- -
- - -
14. , -
: . Ma
J., Li H., Giovannueci E. et al. Prediagnostic body-mass index, plasma C-peptide
concentration, and prostate cancer-specific mortality in men with prostate cancer: a longterm survival analysis //Lancet Oncol.-2008.-Vol.9. 11.-P.1039-1047.-.

() .,
(). 24-. 2546 - ,
3 . - 1, 2, 3 . . : 25,029,9; 30; <25 /2. 281 -. ,
- 1 2 . - 3 .,
( . 1,47 - 1 . 2,66
- 2 .).
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- - (.
2,38; 95%:1,31-4,30). - 3 .,
-, - 1 2 ., -, 4
.
. , Prostate Canc. Foundation, Santa Monica,CA.
(. : http://www.thelancet.com )
-
- -
- - -
15. 2
. Sasako M., Sano T., Yamamoto S., et
al. D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer
//N.Engl.J.Med.-2008.- Vol.359, 5.-P.453-462.-.
- ()
2 .

().
- 2, 3 4 24 .
- 1 . 2 , - 2 .
.
. ,
, - 1 2 . . 20,9 28,1 % (=0,07);
. 0,8%. 5-. - 1 2 .
69,2 70,3 .; 1,03 (95%:0,77-1,37; =0,85).
- . ; 1,08
(95%:0,83-1,42, =0,56). ,
288
-. ,
Dept. Surg., Hyogo Col. Med., Hyogo. 35
-
- - 2
- - -
- - - -
16. :
. Peto R., Emberson J., Landray M., et al. Analyses of cancer data from three
ezetimibe trials //N.Engl.J.Med.-2008.-Vol.359, 13.-P.1357-1366.-.
5-. - ,
, - . ,
, -
().

SEAS, - (),
. , - . ,
SEAS

(101 ., , vs 65
. .). .
(. 0,96; 95%:0,82-1,12; =0,61). ,
(97 vs 72 . .; =0,07),
(216 vs 254 . .; =0,08). , CTSU, Univ.
Oxford, Oxford. . 21.
-
- -
17. . Seters
M., Beurden M., Kate F.J.W.,et al. Treatment of vulvar intraepithelial neoplasia with
topical imiquimod //N.Engl.J.Med.-2008.-Vol.358, 14.-P.1465-1473.-.
5%

2/3 . 1 . -, 16 .
(2 /.), - 2 . .
20 . 81% - 1 .
25%, - 2 . (<0,001). - 1 .
- 2 . - 1
. .
. 20 . - 1 . . 9 ( 26)
20 .,
12 . . (
<1 ) 6% -.
.
, Dept. Obstet., Gynecol., Erassmus. . 31.
289
-
-
- -
18.
:
. Mitry E., Jields A., Bleiberg H. et al. Adjuvant chemotherapy after
potentially curative resection of metastasis from clorectal cancer: pooled analysis of two
randomized trials //J. Clin. Oncol.-2008.-Vol.26, 30.-.4911.-.
, ,
,
(),
-.
. - 1 .
6 ( 28-. )
/ 400 /2 + 200 /2 dl-
5 ., 370 /2 + 100 /2 l- 5 .; - 2
. . 278 -
. - 1 2 .
. 27,9 18,8 . ( 1,32; 95%:1,00-1,76; =0,058).
- 1 2 . . 62,2 47,3 . ( 1,32;
95%:0,95-1,82; =0,095).
(
). ,
, -
. , Hpit. Ambroise Par, Publ. Hpit. Paris, Paris.
-
- -
- - -
- - - -
19.
:
MABEL . Wilke H., Glynne-Jones R., Sharel J., et al. Cetuximab plus
irinotecan in heavily pretreated metastatic colorectral cancer progressing on irinotecan:
MABEL study //J.Clin.Oncol.-2008.-Vol.26, 33.-P.5335-5343.-.

- ()
. 400
/2, - 250 /2. 1 . ()
(125 /2), 2 . 2 . (
180 /2), 3 . 3 . ( 350 /2).
12 . ,
. 61%, 9,2 .
; 3/4
290
: (19%), (10%), (7%) (6%).

MABEL
-
. , Klinik. Essen-Mitte, Essen.
-
- -
- -
- - -
20. , ,
.
Ajani J.A., Winter K.A., Gunderson L.L., et al. Fluorouracil, Mitomycin and radiotherapy
vs Fluorouracil, Cisplatin and radiotherapy for carcinoma of the anal canal //JAMA.-2008.Vol.299, 16.-P.1914-1921.-.

2 - ().
1 . (45-59 ) (1000
/2 1-4 29-32 .) (10 / 2 1 29 . ); 2 . -
(1000 /2 1 4, 29 32, 57 60, 85 88 .),
(75 /2 1, 29, 57 85 .) (45-59 ;
. 57 . ). 5-.
,
644 - 55 . (69% .); 27% -
>5 ; 26%
. 5-. - 1 2 . 75 70% (95% ); 5. - 1 2 . . 60 54% (95%; =0,17). 5. 25 15% - 1
. 33 19% - 2 . - 1 2 . 10
19%; =0,02. ,
- ; ,
.
, -
. , Univ.Texas M.D. Anderson Canc. Cent., Houston.
-
- -
- -
- - -
21. ,
. Miguel J.F., Schlag R., Khuageva N.K., et al. Bortezomib plus
Melphalan and Prednisone for initial treatment of multiple myeloma //N.Engl.J.Med.2008.- Vol.359, 9.-P.906-917.-.

/ -
291
(), . 1 . - 9 6. (9 /2 ), (60 /2) 1

4 . ; 2 .
(1,3 /2) 1, 4, 8, 11, 22, 25, 29 32 . 1-4 1, 8, 22 29
. 5-9 .
- 1 2 . . 16,6 24,0 . ( 2 . 0,48; <0,001).
35 71% - 1 2 .
., 4 30% - ( <0,008).
13,1 19,9 . 1 2 . .
2 . 0,61 (=0,008). 3/4
44 53% 1 2 . ,

- , . , Hosp.
Univ. Salamanca, Salamanca. .35
-
- -
- - -
22.
. Trock B.J., Han M., Freedland
S.J., et al. Prostate cancer-specific survival following salvage radiotherapy vs observation
in men with biochemical recurrence after radical prostatectomy //JAMA.-2008.-Vol.299,
23.-P.2760-2769.-.
635 -
()
. , -
. - (). 1 . -
. , 2 . , 3 . .
6 ., 9
. 116 (18%) - , 89 (22%), 18 (11%) 9 (12%) 1, 2
3 . . -
3 -, (
0,32; 95%; <0,001).
. , - . -
<6 .,
2 . -,
. -
. ,
Brady Urol. Inst., John Hopkins Sch. Med., Baltimore. . 25.
-
- -
- - -
292
23. . Llolet
J.M., Ricci S., Mazzaferro V., et al. Sorafenib in advanced hepatocellular carcinoma
//N.Engl. J.Med.-2008.-Vol.359, 4.-P.378-390.-.
- -
602 -
()
,
RAF-. 1 . - 400 /2
. ., 2 . .
321 , .
- 1 2 . 10,7 7, 9 . . (. 1
. 0,69; 95%).
- . (4,1 vs 4,9 .).
-
- 1 2 . . 5,5 2,8 . (<0,001). - 1 .
, , , .
, -
-
3 . , Barcelona Clin. Liver Canc. Group., Liver Unit,
Hosp.Clin., Barcelona. . 35.
-
- -
- - -
24. ,
> 3 . Cheng B.-Q., Jia
Ch./-T., et al. Chemoembolization combined with radiofrequency ablation for patients with
hepatocellular carcinoma larger than 3 cm //JAMA.-2008.-Vol.299, 14.-P.1669-1677..

(), ()
(PRA) 1., 2 ., PRA
3 . . - (n=291) >3 .
28,5 . - 1, 2 3 . .
37 (4,4 ), 24 (3,4 ) 22 (3,6 ). + PRA
( 1,87)
PRA ( 1,88).
- 1 . - 3 .,
( 2,50; 95%; =0,001); -
1 . - 2 ., ( 1,99; 95%;
<0,001). , 6 ., 54,
35 36% - 1 2 3 . . , + PRA
- >3 .
. , Dept. Gastroenter., Radiol., Surg., Oncol., Shandong Univ., Jinan.
293
-
- -
- - -
- - - -
25. - ,
.
Regine W.F., Winter K.A., Abrams R.A., et al. Flourouracil vs gemcitabine chemotherapy
before and after flourouracil-based chemoradiation following resection of pancreatic
adenocarcinoma //JAMA.-2008.-Vol.299, 9.-P.1019-1026.-.
, -

, - ,
.
. - 164 . 1 . -
( 250 /2 .; 230 -), 2 .
(930 . 1000 /2 .; 221 -) 3 .
+ 12 . +. (
250 /2 .) (50,4 )
. 2 . 20,5 ., 3-.
31% -; 1 . 16,9 ., 3-.
22% - (. 0,82).
(. 0,80%).
4 - 1 2 . 1 14% . (<0,001).
,
. -, . , Dept.
Radiat. Oncol., Univ. Maryland Med.Cent., Baltimore. . 35.
-
- -
26.
. Nalluri Sh.R., Chu D., Keresztes R., et al. Risk of
venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer
patients //JAMA.-2008.-Vol.300, 19.-P.2277-2285.-.
-
(). ,
,
,
- - .

1966 2008 ., - (n=7956) .
, ,
. 11,9 6,3% (95%). . -
(-1,33) . .
(2,5 /
.), (5 / .). ,
294
-,
. , Div. Med. Oncol., Dept. Med., St. Brook Univ., New York.
-
- -
- - -
- - - -
27.
. Chen Zh., Arendell
L., Aickin M., et al. Hip bone density predicts breast cancer risk independently of Gail
score //Cancer.-2008.-Vol.118, 5.- .907-915.-.
()
. ,
() ,
. .
(n=9941) 63,0 7,4 .,
. . , 8,43 .,
327 .
1,35 (95%)
(>1,67%). ,
.
,
. ,
Divis. Epidem., Biostat., Mel. Enid Zuckerman Col. Publ. Hlth., Univ. Arizona. . 18.
(. : http://www.ncbi.nlm.nih.gov/pubmed)
-
- -
- - -
: ..
: _______________
: _______________
1. vs : 136 . Kim Y.M., Kim
H.S., Park J.Y., et al. External vs endoscopic approach for inverted papilloma of the sinonasal cavities: a retrospective study of 136 cases //Acta Otolaryngol.-2008.-Vol.128, 8..909-914.-.

.
,
. 20-. (19862006) .
. () . ().
295
. ,
4,3% 9,5% . .
72,93+/-18,51 ., 112,02+/-56,52 .;
4,66+/-1,75 . 9,54+/-4,79 . ,
3,2% 33,3% . , .
, .
, Chungham Nat. Univ. College of Medicine.
- -
- -
2.
. Gosepath J., Pogodsky T., Mann W.J. Characteristics of
recurrent chronic rhinosinusitis after previous surgical therapy //Acta Otolaryngol.-2008.Vol.128, 7.-.778-784.-.
()
, .
()
, , ,
-,
. 143
,
. ,
. 66/143 55/143
. , . ,

. 34
79%. , 17,6%
, . ,

. , Univ. of Manz.
-
- -
- - -
3. :
, , . Lee J.Y. Unilateral
paranasal sinus diseases: analysis of the clinical characteristics, diagnosis, pathology, and
computed tomography findings //Acta Otolaryngol.-2008.-Vol.128, 6.-.621-626.-.

(), .
, ,
. ,
. 524 121 (23,1%).
, . .
296
. .
, .

,
.
, - .
94,3%
. , Soonchunhyang Univ. College of Medicine.

-
4. . Windfuhr J.P., Schloendorff
G., Baburi D., Kremer B. Lethal outcome of post-tonsillectomy hemorrhage //Eur.Arch.
Otorhinolaryngol.-2008.-Vol.265, 12.-.1527-1534.-.
,
() .

. 29 , 18
. (64%). , (>24 .),
1-28 . . 13
. , 21 .
11 . 11 18
. , .
.
. ,
,
.
.
. , K.
-
- -
5.
. Psillas G., Pavlidis P., Karvelis I., et al.
Potential efficacy of early treatment of acute acoustic trauma with steroids and piracetam
after gunshot noise //Eur.Arch. Otorhinolaryngol.-2008.-Vol.265, 12.-.1465-1469..

() . 52 ,
( G3).
3 .: (20 ) . ; (17
) 1-16 . ; (15 ) 24 . . 1
. 36 (69%) .
( ) .
. (65%) .
297
(23,5%) (13,3%). , .
(<0,001), . .
. .,
. , Aristotle Univ. of Thessaloniki.
-
6.
. -
. Tesche S., Metternich F., Sonnemann U., et al. The value of herbal
medicines in the treatment of acute non-purulent rhinosinusitis. Results of a double-blind,
randomized, controlled trial //Eur.Arch. Otorhinolaryngol.-2008.-Vol.265, 11.-.13551359.-.

() () 5
(5). 150
( 75 ). .
(),
. ,
,
, , ,
, 7 . . 4
7 . . 6,7 (+/-3,4) 11,0 (+/-3,3) ., . . 3,6 (+/-2,8) 8,0 (+/3,0) . .
(<0,00001). ,
. 5 . ,
Univ. Hosp. Hamburg-Eppendorf.
-
- -
7. . Voelter
Ch., Kleinsasser N., Joa P., et al. Detection of hormone receptors in the human vocal
fold //Eur.Arch. Otorhinolaryngol.-2008.-Vol.265, 10.-.1239-1244.-.

(). 140
104 , : 25 , 19
, 19 , 10
, 4 in situ, 20 7
. 58 .
, . ,
, .
.
,
298
lamina propria. -
,
. , Univ. of Wuerzburg.
-
- -
8. . Cingi C., Conk-Dalay M., Cakli H., Bal C.
The effects of spirulina on allergic rhinitis //Eur.Arch. Otorhinolaryngol.-2008.-Vol.265,
10.-.1219-1223.-.

. .

. . ,
. -
. ,
, (<0,001),
, , .
. , Eskisehir
Osmangari Univ.
-
- -
9. :

. Hornigold R., Gillett D., Kiverniti E., Harries M. The
management of otitis externa: a randomized controlled trial of a glycerol and icthammol
ribbon gauze versus topical antibiotic and steroid drops //Eur.Arch. Otorhinolaryngol.2008.-Vol.265, 10.-.1199-1203.-.
()
()
. 43 48
47 . (18-80 .). .
5 . 10-
. ,
.
.
. (<0,001).
,
. 27,8%
. .
,
299
.
,
( ). , Brighton and Sussen Univ. Hosp.
-
10. : .
Page C., Charlet L., Strunski V. Cartilage tympanoplasty: postoperative functional
results //Eur.Arch. Otorhinolaryngol.-2008.-Vol.265, 10.-.1195-1198.-.

. 230
10-. (1990-2000 .) -
. 49% ,
16% 11%.

.
. , Amiens-Hpital Nord.
-
11.
: .
Kaprana A.E., Karatzanis A.D., Prokopakis E.P., et al. Studying the effects of mobile phone
use on the auditory system and the central nervous system: a review of the literature and
future directions //Eur.Arch. Otorhinolaryngol.-2008.-Vol.265, 9.-.1011-1019.-.

() .
().
, ,
., .
,
, .
, ,
.
,
, ,
. ,
.
,
. , Univ. of Crete.
-
- -
- - -
- - -
300
12. :
. Dudvarski Z., Pendjer I., Djukic V., et al. The analysis of clinical
characteristics of the chronic rhinosinusitis: complicated and uncomplicated
form //Eur.Arch. Otorhinolaryngol.-2008.-Vol.265, 8.-.923-927.-.

() . .

(), Lanza Kennedy
Lund-Mackay. 90
, 47 . (52%) 43 . (48%), 45 . 1 .
( ) 30 , 2 . (
) 60. ,
, 2 . (<0,01).
35,55 2 . 23,13 1 . (<0,01).
. 2 1 9,03 2,43 16,05 4,37 .
,
, , ,
. , Clinical Center of Serbia.
-
- -
13.
. Broekema F.I., Dikkers F.G. Side-effects of cidofovir in the treatment of
recurrent respiratory papillomatosis //Eur.Arch. Otorhinolaryngol.-2008.-Vol.265, 8..871-879.-.
() ,
. 1998 .
.
,
. 31
. 188
. 5
, 2,7%.
(2-3%).
,
.
. , Univ. of Groningen.
-
- -
14. . Finsterer J. Management of
peripheral facial nerve palsy //Eur.Arch. Otorhinolaryngol.-2008.-Vol.265, 7.-.743-752..
301
. () ( )
( ).
.
, , , , , ,
. ,
,
, .
,
.
.

. ,
.
, , , , ,
. 80%
, 15% . 5%
. , Krankenanstalt Rudolfstiftung.
-
-
15. : . Page C., Biet A., Zaatar
R., Strunski V. Parapharyngeal abscess: diagnosis and treatment //Eur.Arch.
Otorhinolaryngol.-2008.-Vol.265, 6.-.681-686.-.
, 7-. ,
, , 16
(). 5-7 . /
.

. 5 (2 , 3
1 ). 2
. , , .
, .
2 .
.
.
(/ - )
. , Univ. Hosp. of Amiens.
-
-
16. :
. Hirano S., Kishimoto Y., Suehiro A., et al.
Regeneration of aged vocal fold: first human case treated with fibroblast growth
factor //Laryngoscope.-2008.-Vol.118, 12.-.2254-2259.-.
302
() ()
, , .
() .
. 63-. .
10 .
1-3 . ,
. 1 .
.
. 3 .

. , Kyoto Univ.
-
- -
17. :
. Kari E., DelGaudio J.M. Treatment of sinus headache as migraine: the
diagnostic utility of triptans //Laryngoscope.-2008.-Vol.118, 12.-.2235-2239.-.
-
() .
, ,
, ,
. , ,
.
. - : 1)
( >50%); 2) ( 25-50%) 3) -.
41 . (23-70 .). 54 31 (82%)
1 ., 35 (92%)
. ,
- . , Emerg.
Univ. Sch. of Medicine.
-
- -
18.
. Das S., Maeso P.A., Becker A.M., et al. Proteomics blood testing to
distinguish chronic rhinosinusitis subtypes //Laryngoscope.-2008.-Vol.118, 12.-.22312234.-.
()

- - (-).
,
. 42 15
, 10 17
.
303
0 100 .
84 90%, 88 88% ., 2 .
3
76 82% 80 90% . ,
- . - ,
.
, The Ohio State Univ.
-
- -
- - - -
19. .
Litvack J.R., Fong K., Mace J., et al. Predictors of olfactory dysfunction in patients with
chronic rhinosinusitis //Laryngoscope.-2008.-Vol.118, 12.-.2225-2230.-.

().
,
, , 367
- . ,
64% 18-64 . 95% 65 .
(<0,001) .
, ( 2,4; 95%:1,3-4,2; =0,003)
>65 . ( 10,0; 95%:2,3-43,7; =0,002) .
( 13,2; 95%:5,7-30,7; <0,001), ( 4,2;
95%:1,8-9,8; =0,001), 65 . ( 15,6; 95%:2,3-104,9; =0,005) ,
( 7,6; 95%:1,8-31,6; =0,05), .

.
. , Oregon Sinus
Center, Portland.
-
- -
- - -
20. -432 ()
. Kim M.G., Kim S.G., Lee J.H., et al. The therapeutic effect of OK-432
(picibanil) sclerotherapy for benign neck cysts //Laryngoscope.-2008.-Vol.118, 12..2177-2181.-.
, .
-432 75 (42 ., 33 .).
.
-432. ,
, , .
75 31 (41,3%) , 7 (9,3%)
304
(>90% ), 5 (6,6%) (>70% ) 17 (22,7%)

(<70% ). 15 (20%) .
, 8 (10,7%) .
, ,
. , -432

. , Sungkyunkwan Univ.
-
- -
21. ,
- . Roberts D.S., Mahoney E.J.,
Hutchinson C.T., et al. Analysis of recurrent angiotensin converting enzyme inhibitorinduced angioedema //Laryngoscope.-2008.-Vol.118, 12.-.2115-2120.-.
, (), (),
, , .
. ,
, ,
.
, .
, 6,2%.
, .
, ,
,
. , Boston Medical Center.
-
22. , . Nunes F.P., Bishop T., Prasad
M.L., et al. Laryngeal candidiasis mimicking malignancy //Laryngoscope.-2008.-Vol.118,
11.-.1957-1959.-.
()
, 40 . ,
, 1015% , .
, ,

.
. , Univ. of
Massachusetts.
305
23.
: . Olusanya B.O., Somefun A.O., Swanepoel de W. The need
for standardization of methods for worldwide infant hearing screening: a systematic
review //Laryngoscope.-2008.-Vol.118, 10.-.1830-1836.-.

, .

,
, .
.
Functioning, Disability and Health (ICF)
() . (ICF-CY).
, ICF-CY,
. ,
Univ. College London.
-
24.
:
. Salt A.N., Gill R.M., Plontke S.K. Dependence of
hearing changes on the dose of intratympanically applied gentamicin: a meta-analysis using
mathematical simulations of clinical drug delivery protocols //Laryngoscope.-2008.Vol.118, 10.-.1793-1800.-.

.

.
568 19 .
, - ,
. ,

-, . .
, .
, ,

. , Washington Univ. Sch. of Medicine.
-
- -
- - -
25. : -. Stenner M., Vent
J., Httenbrink K.B., et al. Topical therapy in anosmia: relevance of steroidresponsiveness //Laryngoscope.-2008.-Vol.118, 9.-.1681-1686.-.
306
( , )
.
,
- () .
299 , 89
.
,
. ,
(). 15,5 18,7
(<0,001). , (<0,001).
-,
. - . (<0,001).
,
. , -
.
. 2,1 , .
1,0. , Univ. Hosp. of Cologne.
-
- -
26. . Cope D., Bova R. Steroids in otolaryngology //Laryngoscope.-2008.-Vol.118, 9.-.1556-1560.-.

. -
, .
. ,

, , ,
. ,
L,
. , St. Vincents Hosp.
27. . Houser S.M.,

Keen K.J. The role of allergy and smoking in chronic rhinosinusitis and
polyposis //Laryngoscope.-2008.-Vol.118, 9.-.1521-1527.-.
()
(),
.
,
, 6-. .
,
.
(56,4%) ,
(=0,0073 =0,0114 .).
307
.
. , Case Western
Res. Univ. College of Medicine.
-
- -
- - -
- - - -
28. :
. Roberts D.S., Dowdall J.R., Winter L., et al. Cervical tuberculosis: a decision
tree for protecting healthcare workers //Laryngoscope.-2008.-Vol.118, 8.-.1345-1349..
()
.
.

.
,
. , ,
, - -
.
. . ,
, .
.

. .
,

. , Boston Univ. Sch. of Medicine and Boston
Med. Center.
-
29. . Pade J., Hummel T. Olfactory function
following nasal surgery //Laryngoscope.-2008.-Vol.118, 7.-.1260-1264.-.

. 775 (482 ., 293 .)
41 . (10-81 .).
, .
Sniffin Sticks. 356
4 . . 206
, 150 .
.
23%, 68% 9%,
13, 81 7% . ,
308
, , .
,
. ,
. , St. Johannes Hosp.
-
- -
30.
: 1000 . Helmstaedter V., Wittekindt C.,
Huttenbrink K.B., Guntinas-Lichius O. Safety and efficacy of botulinum toxin therapy in
otorhinolaryngology: experience from 1,000 treatments //Laryngoscope.-2008.-Vol.118,
5.-.790-796.-.
()
1000 261 .
, , ,
. ,
16 ,
, .
1,3%
,
. . 3 (1,2%)

. 2,8%
4 . .
, -
, .
,
, . , Univ. of Cologne.
-
- -
- - -
: ..
: _______________
: _______________
1.
. Morris B.H., Oh W., Tyson J.E., et
al. Aggressive vs. conservative phototherapy for infants with extremely low birth
weight //N.Engl.J.Med.-2008.-Vol.359, N18.-P.1885-1896.-.
, () ()
()
(1000 ). 1974 12
309
36 ., , () .
, ()
(), 91% ,
.
(7,0 vs 9,8 /, 120 vs 168 /, <0,01),
(52 vs 55%; 0,94; 95%:0,87-1,02; =0,15).
(26 vs 30% ; 0,86; 95%:0,74-0,99). .
. 24 23% ( 1,05; 95%:0,90-1,22).
, 13% 14%
751 1000 , 501 750 . 39 34% ( 1,13;
95%:0,96-1,34). ,
. ,
501 750 . , Univ. Texas
Medic. Sch., Houston. . 41.
(. )
-
- -
2. .
Moster D., Lie R.T., Markestad T. Long-term medical and social consequences of preterm
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, . , .
.
.,
() 1967-1983 ., 2003 .;
.
903402 ., ; 1822 .
23 27 ., 2805 28 30 ., 7424 31
33 ., 32945 34 36 . 858406 37 .
, , . 17,8,
57,3, 85,7, 94,6 96,5%. , ,
0,1% , , vs 9,1%
23 27 .; 23-27 . 78,9; 95%:56,5110,0. . 0,4 vs 4,4% ( 10,3;
95%:6,2-17,2). , , .
1,7 vs 10,6% ( 7,5; 95%:5,5-10,0). , ,
, ,
, ,
. ,
, 1967-1983 .,

. , Univ. Bergen, Bergen. . 39.
(. )
-
- -
310
3.
, . Tyson J.E., Parikh N.A., Langer J., et al. Intensive
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,
() (). ,
. .
4446 , 22 25 . (
)
. .

,
18 22 .
3702 (83%)
. 4192 (94%),
18 22 ., 49% , 61% , ,
73% , . ,
, ,
, , :
, . , ( 100 ). , 1-.
.
, , .
, ,
. ,

: ,
,
. , Cent. Clin. Res. a. Evidence-Based, Medic., Univ. Texas Medic.
Sch. at Houston, Houston. . 40.
(. )
-
- -
4. . Beden A.B., Brecelj J.,
Bratani N., et al. Guidelines for management of children with cystic
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()
. ,
,
, ,
, , . vas
deferens.
,
. ,
311
.

.
. . , Univ. Klin. Cent. Ljubljana,
Ljubljana. . 111.
(. )
-
- -
5. .
Beardsall K., Vanhaesebrouck S., Ogilvy-Stuart A.L., et al. Early insulin therapy in verylow-birth-weight infants //N.Engl.J.Med.-2008.-Vol.359, N18.-P.1873-1884.-.
., ,
, () ()
.
().
,

. 195
0,05 / /. 20%- (1 .); 2, ., . 194
. 1-7 .
.
.
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. . 1 . (6,21,4 vs
6,72,2 /, 11225 vs 12140 /, =0,007). 1 . .
>10% . (21 vs 33%, =0,008). 1
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//., <0,001) . (
-0,550,52 vs -0,700,47;
=0,006). 1 . (
<2,6 / [47 /] >1 .), 29% 1 . vs 17% .
., =0,005. >1
. (intention-to-treat)
. . ; 28
. 1 ., 2 (=0,04). ,
. ,
. , Univ. Cambridge, Cambridge. .
31.
(. )
-
- -
6.
. Morley C.J., Davis P.G., Doyle L.W. Nasal CPAP or
312
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() .
,
()

. . 610
, () 25 28 . 1 .
, 2 . 5 . .
28- . , 36-. . 36-.
33,9% 307 1 . 38,9%
303 2 . ( 1 . 0,80; 95%:0,58-1,12, =0,19). 28- . 1
. , 2 . ( 0,63;
95%:0,46-0,88, =0,006). . 46% . 1
. 5 .,
. 1 . 9%, 2 . 3% (<0,001); .
. 1 . .
. ,
. .
. , . .
28- . . . , Royal
Womens Hosp., Melbourne. . 43.
(. )
-
- -
7.
. Skoner D.P., Maspero J., Banerji D. Assessment of the long-term safety
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() . .
- -
. . 6-.
661 . ( 5 8,5 .) 3 .; 1 2
. 1 . 1 /. . 40 160
(ex-actuator); 3, ., . .
2 . . 4-
. ()
( 10 . 24 .).
.
., : 1 . 6,59 /., 2 . 6,20 /., 3 . 6,49 /.
. (5,75 /.)
- 1 . -0,02 /., 2 . -0,15 /.
.
.,
10-. ( ) 24-.
313
. ,
., , , ,
. , Allegheny General Hosp.,
Pittsburgh.
(. http:/ www.ncbi.nlm.nih.gov/pubmed)
-
- -
8. . Asilsoy S., Bayram E., Agin H., et al. Evaluation
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() () . ,
. ,
, .
() 2006 .
108 . 6 14 . , 4 . -
2-4- . .
25% - () - , 23,4%
, 20,3% ()
4,6% .
- , .
, 2006 . .
. ,
Dr Behcet Uz Child Dis. a. Surg. Education a. Res. Hosp., Izmir.
-
- -
9.
- ,
. Willemsen R.H., de Kort S.W.K., van der Kaay D.C.M., Hokken-Koelega
A.C.S. Independent effects of prematurity on metabolic and cardiovascular risk factors in
short small-for-gestational age children //J.Clin.Endocrinol.Metab.-2008.-Vol.93, N2.P.452-458.-.
(), .
- ()
2 . , ,
., .
,
. .
479 . ( 6,8 .),
(<36 .) (36 .).
, -., .,

. .
, . (<0,001),
. .
314
, %
, .
, ,
. . ,

. . , %
,
. , Erasmus MC Sophia, Rotterdam.
- -
10. -
(PWS): . Hagg A.M., Grambow S.C., Muehlbauer M., et al.
Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes
during development //Clin.Endocrinol. (Oxf).-2008.-Vol.69, N6.-P.911-920.-.
- (PWS)
.
.
() . ,
. PWS.
33 PWS 28 . . -
- PWS ,
- . . , z-
(z-score) . , . PWS - . 11
33 - PWS >95- . . (>2871
/): 6 - PWS z-scores <0. -
( PWS, .) .
PWS ,
, .
: PWS, , ,
, , .; , 33% -
, z-score <0.
PWS. , Duke Univ. Medic. Cent., Durham.
- -
- -
11. , ,
6- :
,
LISA. Zutavern A., Brockow I., Schaaf B., et al. Timing of
solid food introduction in relation to eczema, asthma, allergic rhinitis, and food and
inhalant sensitization at the age of 6 years: results from the prospective birth cohort study
LISA //Pediatrics.-2008.-Vol.121, N1.-P.e44-e52.-.

() .
315
, ( 4 6 .)
(), (), () ()
() 6 . 2073 .;
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6 . .
, ( 4 6 .)
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,
4 .
,
6-. . ,
.
.
. , Inst.
Epidemiol., Neuherberg.
-
- -
- - -
12. : ? Kumanov P., Robeva R.N., Tomova A.
Adolescent varicocele: who is at risk? //Pediatrics.-2008.-Vol.121, N1.-P.e53-e57.-.
()
. , .

.
.
6200 5 0 19 . .
, , , .
4,1% , . 10
19 . 7,9%.
, , : ,
, .
, ,
. .
,
.
. , Clin. Cent.
Endocrinol., Medic. Univ.-Sofia, Sofia.
-
- -
316
13. , .
Shankar A.G. The role of recombinant erythropoietin in childhood cancer //The
Oncologist.-2008.-Vol.13, N2.-P.157-166.-.
() ., - (), ,
-, .
,
, ..
(, , ), ,
,
.
- b,
.

, , .,
.

,
, ; ., -
,
. , Univ. Coll. London Hosp. NHS
Foundation Trust, London.

-
- - ,
14. -
. Van Tijn D.A., de Vijlder
J.J.M., Vulsma T. Role of the thyrotropin-releasing hormone stimulation test in diagnosis
of congenital central hypothyroidism in infants //J.Clin.Endocrinol.Metab.-2008.-Vol.93,
N2.-P.410-419.-.
.
,
. ()
() -
().
,
/
(GH). ,
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- (TRH), TRH- .
,
;
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. . 15 (10 5 ) ,
317
; 6 -
, .
TRH-,
- . -
(TSH) 3 TRH , (67%)
- 2 TSH. ,
TRH- TSH
. TRH-, - 3 ,
- ,
- . , Emma Childrens Hosp., Acad.
Medic. Cent., Univ. Amsterdam, Amsterdam.
-
- -
15.
. Kzyrski A.L., Mai X.-M., McGrath
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, () () ()
() .
,
.,
, .
() ,
. 7 .
1995 . 13907 . ,
. ,
,
.
. ,

. 7 . ( 1,25; 95%:1,01-1,55).
, . ,
. , ,
, ., , .
( 1,44; 95%:1,12-1,85). ,
., ,
. , Cent. Hlth. Policy a Univ. Manitoba,
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- -
16. -
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318
a short course of prednisolone in infants with oxygen-dependent bronchopulmonary

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, ()
36-.
.
385 , 131 (34%)
(1 .) , 254 (66%) (2 .).
. , , .
1 . ,
,
, . 1 . 63%.
, ,
, (pulmonary acuity score
PAS) 2. . PAS .
. PAS 0,5 20% 97,4%,
. 94,1 42,1%.
2 . ,
. - 2
<48,5 . . 50% 89,7% .
89,1 51,8%. ,

, PAS <0,5 2 <48,5 . . 1
, . ,
Connecticut Child. Medic. Cent., Hartford.
- -
- -
17.
: - -
. Bolt P., Barnett P., Babl F.E., Sharwood L.N. Topical
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randomized trial //Arch.Dis.Child.-2008.-Vol.93, N1.-P.40-44.-.
() .,
() .
2%- () ( )
. 3 17 . -
3 . - 2% (1 .),
( ) (2 .).
; Bieri
faces pain scale 10, 20 30 .
50%
; 25% 2
. 1 . 1 . .
. 1
. 31, 2 . 32 . 3 12 . .
319
,
4 . 1 . . ,
50% 10 . ( 2,06; 95%:1,03-4,11; =0,03)
30 . ( 1,44; 95%:1,07-1,93; =0,009), 20 . ( 1,35;
95%:0,88-2,06). 25% ;
20 30 .
. 30 .
,
. ;
. , Univ. Melbourne, Royal Childrens Hosp., Melbourne.
-
- -
18. ,
/ . Aksglaede L., Molgaard C.,
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() .
().
3
. 18 6 ,
. . 11,0 . (
4,3 18,6 .). .
, (), (), % (%),

. . - ( -0,3 (-2,4
+2,1) +1,1 (-1,6+2,1)),
( +0,5 (-10+2,3), =0,02, +1,6 (-0,2+2,4), =0,01) (
). : -0,4 (3,1+0,9) +1,0 (-1,4+3,0), ( +0,1 (1,8+3,3), +1,5 (-1,1+2,5)) .
% , ,
/.
. , ,
, ,
, , . ,
Univ. Copenhagen, Copenhagen.
-
- -
19. . Ciocca
M., Ramonet M., Cuerterolo M., et al. Prognostic factors in paediatric acute liver
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320
,
() (). 210
(107 103 ; 5,33 ., 1
17,4 .). - (1 .), (2 .)
() (3 .). - 1 . . .,
. : 128 (61%)
, 68 (32%) 14 (7%) .
, (59 .), (61) ,
(90 .). ,
/V ,
.
- , . 96 95%,
82 82%. :
. .
.

., ,
. , J.P. Garrahan Hosp., Buenos Aires.
-
- -
- - -
20. : ,
? Petrou S., McIntosh. Measuring the benefits of growth
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()
. ,
, , -, .
,
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? ,
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, ,
. , Hlth. Economics Res.
Cent., Univ. Oxford, Oxford.

-
321
21. -: .
Guillem P., Cans C., Robert-Gnansia E., et al. Rare diseases in disabled children: an
epidemiological survey //Arch.Dis.Child.-2008.-Vol.93, N2.-P.115-118.-.
()
, 7-. .
. .
, , ( )
(MSN-1) . . .,
1980-1994 . 7-. .
, <1/2 .
. 26% . MSN-1 ; 36% . MSN-1
. , ,
: 3,3% ; 16,0%
; 37,2% ; 41,2% ,
81,1% .
2,1/1 . (459/218283),
(=0,003).
, . .
, 26%
MSN-1. ,
, .. MSN-1 ,
. , Grenoble Univ. Hosp., Grenoble.
-
- -
22. ,
. Poomthavorn P., Maixner W., Zacharin M. Pituitary function in
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(), (),
. ., ,
,
.
. .
., . 1020 .,
() 10 ., 117
, . 54 (31 .
) ,
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; 21,
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9,7 .). 0,9 8,5 . ( (4,5
.). 54 - 9 , 4
. , ., ,
322
; , - . ,
Royal Childrens Hosp., Melbourne.
-
- -
23. 6- : 4-11 .
Lammers A.E., Hislop A.A., Flynn Y., Haworth S.G. The 6-minute walk test: normal values
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6-. (6-. )
.
. ,
. 12 .
. 4 11 . 328
. 4 11 . (54% ). : ,
6 ., 6-. 3-.
. 6-.
97-99%. 10219 /. 13612
/. , , 6 ., 47059 ;
(r=0,64, <0,0001), (r=0,51, <0,0001) (r=0,65,
<0,0001), .
. 4 7 . ( 4 . 38341 , 5 . 42039 ,
6 . 48340 , 7 . 48835 , <0,05). 7 .
.
6-. . .
., - .
- . , Great Ormond
Street Hosp. Children, London.
- 6-
- -
24.
. Eskedal L.T., Hagemo P.S., Seem E., et al.
Impaired weight gain predicts risk of late death after surgery for congenital heart
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(
) ., (),
( 30 . ),
., .
- 80 ., 1990-2002
., Rikshospitalet, .
74 ., 31 , 31 ,
, .
74 ., , , Z-,
323
, .
0,12, -1,31 -2,09. 31 ., , Z- .
0,07, -1,21 -2,01, Z- . . . 0,05, -1,10 -0,99.
Z- >0,67 , 13,5
(95%:3,6-51,0). 5,7 .
, .
>0,67 Z-
. , Srlandet Regional Hosp., Kristiansand.
-
- -
- - -
- - - -
25. D 1 :
. Zipitis C.S., Akobeng A.K. Vitamin D
supplementation in early childhood and risk of type 1 diabetes: a systematic review and
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, D
1 (-1) .
MEDLINE, EMBASE, Cinahl, Cochrane
Central Register of Controlled Trials .
-1. ,
D -1.
5 (4 -
1 ).
. ,
-, , -1 ,
D , ( 0,71,
95%:0,60-0,84).
. - (
D -1).
,
-1. , D
-1.
,
D, ,
. , Stockport NHS Foundation Trust, Stockport.
D
-
- - 1
26.
(
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324
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(),
() . 176 . 5
10 . 3 . 1 .
400 2 /. 1 .; 200 2 /.
2-6- ., 100 2 /. 718- .; 2 .
1 . 1-6- ., ,
, 7-18- ., 3 . - (DSCG)
() 10 3 /. 1-18- . 400
2 /. 2 . ,
. ,
,
, . , 18 .
- . 7-18- .
- 1 . ( 0,97), 2 . (1,69)
3 . (1,58).
. ,
, ,
. ,
. .
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- -
27. - . Rodriguez-Morn M.,
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,
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488 . 10 13 .
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. 109 . (22,3%) hsCRP 101 (20,7%)
; 87,1% , . .,
hsCRP (2,45 [10,6] /) (1,3 [0,3] /),
(96,0 [13,9] /), (13,6 [7,5]
/) (131,5 [43,5] /),
(46,4 [9,0] /).

hsCRP ( 4,1; 95%:1,3-10,8). ,
hsCRP; ,
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Medic. Res. Unit Clin. Epidemiol. Mexican Soc. Security Inst., Durango.
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325
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() .
. 2001
. 2004 . .
15 . 1150 . 169 92
. . 2001 . 2004 .
. 92 . 53,3% ;
35,7% (<37 . ) 64,6%
(<2,5 ). (94,4%)
78,3% 1 .
3,3 . ( 11,9 .); 6,5%
63% 5 . 92 56% , 53,2%
, 85,9% , 24%
, 5,4% 4,3% .
65% . , 51% ,
40,2% . ,
.
,
,
-. , Univ. Sydney, Childrens Hosp.
Westmead, Westmead.
-
- -
- - -
29. .
Senzaki H., Kamiyama M., Masutani S., et al. Efficacy and safety of torasemide in children
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() .
(). 102 . ,
. 62 (1 .)
. 40 . (2 .) >3 .
(), .
( ), - ()
3-4 . .
. 1 .
-
( : 52 (51) vs 43 (49) /). 25 . 1 .,
, ,
. 2 . -
: 50 (104)
326
45 (71) /, (=0,07).
- ( 1 . - ; 2 .
4,2 (0,5) 4,3 (0,5) mEq/l), -
. - Na -
, ,
. ,
.
. , Saitama Medic. Univ., Saitama.
-
- -
- - -
30. . Cass H., Gringras P.,
March J., et al. Absence of urinary opioid peptides in children with
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. , . ()
() . ,
,
-
,
. . . . 65 , 2- 3 ,
; . . 158
. .
7,4 . ( 5 11 .), . . . 7,8 . ( 4,2
11 .).
(L) (MALDI-TOF-MS) .
L . . .
L , ; MALDITOF-MS , . :
- . ,

- .
, Great Ormond Street Hosp. Children, London.
-
- -
- - -
: ..
: _______________
: _______________
327
1. 4-
. Tashkin D.P., Celli B., Senn S., et al. A 4-year trial of tiotropium in
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, , ()
- (),
.
- 5993 - 40 . (
65 8 .) , 4 . (1 ., 2987 -) (2
. ., 3006 -). -
, . -
/1 (FEV1) 70% ()
FEV1 (FV) 70%.
FEV1 ,
30- . FV, St.
Georges Respiratory Questionnaire (SGRQ), .
FEV1 1 . 2 .
( 87 103 47 65
, <0,001). 30- . .
FEV1 .
SGRQ () 1 . 2 .
4-. ( 2,3 3,3 .,
<0,001). 30 ., 4 .
, ,
. , David Geffen Sch. Medic., Univ. California., Los Angeles. .26
(. )
-
- -
2.
. Sethi S., Murphy T.F. Infection in the pathogenesis and course of chronic
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. 50-60- . ., . ,
()
().
, (),
,
() . , , ,
,
.
. , ,
- ,
, ,
. () ;
, -
-. . ,
, , 15 20% . ,
328
, , 50% .
.
( 1/3 2/3 ),
, , ,
. , Univ. Buffalo, State Univ. New York, Buffalo. . 67.
(. )
-
- -
3.
, .
Rusinaru D., Saaidi I., Godard S., et al. Impact of chronic obstructive pulmonary disease
on long-term outcome of patients hospitalized for heart failure //Am.J.Cardial.-2008.Vol.101, 3.-.353-358.-.
()
- ().
-, .
799 -,
2000 . 156 (19,5%).

. . , . .,
, .
- (6 vs 27%, <0,001). 5 .
. (31 vs 42%, =0,03).
. , 5-. -
(31 vs 71%). ,
( 1,53; 95%:1,21-1,94, <0,001).

, .
, -
-
. - . , INSERM, ERI 12 and Univ. Hosp. Amiens., Amiens. . 23.
(. )
-
- -
4. AngioJet . Margheri M., Vittori
G., Vechio S., et al. Early and long-term clinical results of AngioJet rheolytic
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2.-.252-258.-.

() () (), ,
. ,
.
329
,
.
25 -
() 6 Fr Xpeedior AngioJet. 3
. -: 8 (., ), 12
5 . ,
, , Miller- .
-, ,
Miller . (
<0,001). 8
-, , 17 -
(<0,05). 4 , -, ,
,
( 61 .). ,

. , Florence. . 12.
(. )
-
- -
5.
. Mazhdrakov G.B., Velchev V.D., Rifai N.I., et al. Our
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1 2006 . 1 2007 . 12 -

. -
, <100 ... /
, .
. - >20 Miller.
- 7 . 5 ., 64,3 .
111 /. 91 /.,
90 94%,
64 50 ..., 91 105 ...
, , 30 ., 6 .
5,4 . , Cardiol.Clinic,
St.Anne Univ.Hosp., Sofia. .12.
(. )
-
- -
6. . Gray
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330
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(=2,63) . (=1,87). ,
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359
. (5,9 10000 2,4 10000 0,4 10000).

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9. ,
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(2,5) , . Apheis,
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10 /3 26 >40 . ,
2,5 15 /3
30 . 4 , 2,5 25
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2,5 10 /3 7 (3,0
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- -
- - -
13. :
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.
, , 8,4% (95%:7,7-9,1%),
9,3% (95%:8,6-10,1%).
1,2 /100 -. (95%:1,1-1,3).
5,6 /1000 -. (95%:4,9-6,3%). 66,3%
, 69,9% .
42,8% , .
>65 .
(12,4 5,4%; <0,001; 2,5).
(37,4%), - (25,3%)
, (25,0%). 31,4%
.
, , ,
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() (50 .).
. . (n=9359) . () 1953 . ,
12 . . 1,0 2,4%
. . 1 .
(),
() 18 . .

(=2,49; 95%:1,03-6,02),
( . 0,77 [95%:0,59-1,01] 0,81
[95%:0,64-1,02]). , ,
. 1953 . . ,
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15.
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4
. ,
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, , .
- WOMAC.
- ,
.
WOMAC (=0,021) (=0,039). ,
.
, 4 ,
, .
. , ,
. .
, Divis. Orthopaed., Dept. Surg., St. Mich. Hosp., Univ. Toronto, Toronto. . 25.
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- -
16. ,
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,
.
2 . . (n=322) 52 .
() =31 /2. 1 .
, 2 .
, 3 .
.

. 3 .
, , .
1, 2 3 . 2,9; 4,4 4,7 . 272 ,
, 3,3; 4,6 5,5 1, 2, 3 .
.
3 .,
1 . (20 12%). ,

. , S. Daniel Abraham Int. Cent.
Hlth. Nutrition, Dept. Epidemiol., Beer-Sheva. . 33.
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- -
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363
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, 90- .,
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. 1986-1989 1998-2001 .
, 80%. ,
.,
, . ,
(95%) (
, )
(, ) 1,02 ,
1,14 (=0,02). .
(
).
( ) ;
. .
, Dept. Soc., Hum. Develop., Hlth., Harv. Sch. Publ. Hlth., Boston.
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18. .
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. 4218 .
5007 . 65-85 ., . ,
. . ,
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)
( = 2,14 . 1,75 .).
. .,
, . .
. , Univ.
Pompen Fabra, Barcelona. . 50.
-
- -
- - -
364

19.
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5 .: , (1 .);
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.); 3-4 (4 .); >5 (5 .).

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, ,

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, .
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20.
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.

, ,
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.

.
, , ,
,
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16 . (pebia) ()
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- -
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( 300 /.) .
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( 13,30 /; 95%:5,09-21,44 /, =0,02),
( 6,74 . .) ( 6,74 . .)
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366
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- -
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23.
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() 34-.
() . 1462 . 38
60 ., . () 1968-1969 . 2002 . 164 .
. .
1974-1975, 1980-1981 1992-1993 . ,
(=0,6; 95%:0,4-0,8).
. (=0,3; 95%:0,1-0,8);
., , .
( ) (=1,5;
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- -
.
: ..
: _______________
: _______________
1.
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.
.

. Staphylococcus aureus 72
Wistar. . .
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. 2 4 6 . , ,
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. , Ankara Numene Res. and
Train.Hosp.
-
- -
2. -
. Matewski D., Szymkowiak E., Bilinski P. Analysis of management of patients
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.
.
- ().
. ,
(53%, .)
16-45 . 80,6%.
49,4%, 33,2% 14,1%; 75%
. 92,9%,
368
31,5% 21,3%.
14%. Injury Severity Score (ISS) New ISS (NISS)

. NISS,

. , Collegium Medicum in Bydgoszcz.
-
3.
:
. Clifton R., Haleem S., McKee A., Parker M.J. Closed
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.
.
6 , 664 .
,

. .
.
.
, Peterborough District Hospital.
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- -
- - -
4.
. Lau T.W., Leung F., Chan C.F., Chow
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(),
. , .
48 ,
. ,
, 9,4 .
18,7 . 48 7
. 15%.
. 25 (52%)
.
. ,
, . , The Univ. of Hong Kong.
369
-
- -
5. : ? Ulrich S.D.,
Seyler T.M., Bennett D., et al. Total hip arthroplasties: what are the reasons for revision
//Int.Orthop.-2008.-Vol.32, 5.-.597-604.-.
, 10 .
()
95%. , ,
,
.
.
.
2 6 . 225 ,
237 . 83 . (-360 .).
123 (51,9%),
40 (16,9%) 37 (5,5%) . 2
. ( 5 . 5 . ) , 118 237 (50%)
., 33% 24%
. ,

, . , Sinai Hospital of Baltimore.
-
- -
- - -
6. Cierny-Mader T :
, ,
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Cierny-Mader T () ,
,
.
.
26 (19 . 7 .; 34,7 .),
, , .
(16 ), (n=10). ,
5
. 3 , 3
.
3,6 . ,
. ,
Ankara Univ. Sch. of Medicine.
370
-
7.
. Emara K.M., Khames A. Functional outcome after
lengthening with and without deformity correction in polio patients //Int.Orthop.-2008.Vol.32, 3.-.403-407.-.
.

.
.
32 ,

.
.
2 . 9 .
,
5 ( ) 50 500 . ,
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- -
8.
. Sebestyn A., Boncz I., Sndor J., Nyrdy J. Effect of surgical delay on
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30 . 60 .
.
. 30 .
4 . , 1)
12 ., 2) 12-24 ., 3) 24-48 . 4) 48 .
.
3777 . 4 . 7,7, 10,5, 10,5 9,4%, .

. 2 . 1.
. 2-4
, . ,
, ,
,
. , County Baranya Hlth. Insurance fund Administration.
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- -
371
9.
: . Ibrahim T., Tleyjeh I.M.,
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. 1960 . 2005 .
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Oswestry Disability Index (ODI)

. 58 3 1
634 .
ODI . ( ODI: 4,13, 95%:-0,82
9,08, =0,10, (2)=44,4%). 16%
(95%:12-20, (2)=0%). ODI
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. , Leicester General Hospital.
10.
. Oguz E., Sehirlioglu A., Altinmakas M., et al. A new classification and
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,
,
.
( ),
. .
76 (55 . 25 .). 5
, ., , 3 (,
) . 76
.
(. 8 ) ,
. .

. , Gulhan Military
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11.
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6.-.1421-1424.-.
, , ,
. ,
, ()
, .

22-. . 34 47 .
4 . : 1
0-24%; 2 25-49%; 3 50-74%; 4 75-100%.
62 . ,
<25%; 37,5% (6
16) <25% 9,7% (3 31) >25%,
0,045. , <25%
,
. , Univ. of Texas M.D.
Anderson Cancer. Houston.
-
- -
12.

: . Osborn T.M., Bell R.B., Qaisi
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,
()
(). 5-. ,
.
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t
. 65
(. 1-24 . 2-41). . 1
(n=6) . 2 (n=27). 6 .
,
. 27 . 2 14
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, 48% , 0% . 1.
, ,
, . , Legacy Emanuel Hosp. and Health Center.
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- -
373
- - -
- - - -
13.
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() ,
()
. ,
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, 2000 . 2006 .
,
() Glasgow. ,
(+) . 87 317
, ( , )
73%, 89%. . ,
. . ,
.
,
+ . (36 vs 6%). ,
.
. 16%. , Henry Ford Hlth.
System Detroit.
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- -
14. :
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11 1027
()
6, 13, 26 . 1 .
Constant i Neer. -
. ,
. 1,1%,
8% 10%
33 100%. ,
6 . .
6 . .
.
,
.
, , 6
., ,
. , Royal Infirmary of Edinburg.
374
-
- -
15.
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31% ()
, , ,
. ,
, .

. 2000-2005 . 31
().
26 (6-46) . . 3 .: 1)
(n=9), 2) (n=15) 3)
(n=7). .
. 7
1 5 .
.
. . Constant i
Murley .
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- -
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16.
,
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.
,
/ ,
. 52
1) (n=26) 2) (n=26).
100
.
375
() ;
26
6. 2 26 1 . .
. ;
. ,
. , Med. Univ. of
Vienna.
-
- -
- - -
- - - -
17.
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.
() .
, ,
, .
2867 18-84 . , ,
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. 1 .
.
, ,
. ,
( 0,99; 95%).
50-365 . (1,28; 55%),
50 . ( 0,95; 95%). ,
. ,
,
- ,
. , Univ. of Washington, Seattle.
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18.
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() 13-18 . ,
684 , 18 .
.
376
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13-18 . , ,
2422, 3628 316 , .
13 18 . 0,05; 0,11 0,005
, , .
, ,
. ,
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19. -
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(). -
.
1418 . 787
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.
-
(136 / 45 / )
. .
96 / ( 92%, 93%).
, -
. ( -
96 / 4 .)
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20. TLICS : ,
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. (STSG)
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377
.
.
. , The Rothman Inst., Philadelphia.
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21.
:
98 . Larsen K., Hansen T.B., Sballe K. Hip arthroplasty patients benefit from
accelerated perioperative care and rehabilitation: a quasi-experimental study of 98
patients //Acta Orthop.-2008.-Vol.79, N5.-P.624-630.-.
2005 . 6500 .
.
, ,
, (),
, .
- ,
? 98

(n=48 n=50, .).
, EQ-5D, 5
(, , , /
/) 3 . .
0,8
. ,
10% . ,
Holstebro Regional Hosp.
-
- -
22. :
450 -. Busse J.W., Morton E., Lacchetti C., et al.
Current management of tibial shaft fractures: a survey of 450 Canadian orthopedic trauma
surgeons //Acta Orthop.-2008.-Vol.79, N5.-P.689-694.-.

.
. 450
( ) -
. 268 (60%) .
(80%)
; 47%
, 40% . 59%
(16%)

378
(45%)
. ,
(21%
) 80% , 6 .
. , McMaster Univ.
Hamilton. Ontario.
-
- -
23. In vivo
: 19 .
Swieringa A.J., Goosen J.H., Jansman F.G, Tulp N.J. In vivo pharmacokinetics of a
gentamicin-loaded collagen sponge in acute periprosthetic infection: serum values in 19
patients //Acta Orthop.-2008.-Vol.79, N5.-P.637-642.-.
in vivo
, in
vivo . 19
. 2-5 (130 /).
- 3,2-7,2 /,
. - . /. -
2,5-36 . aeruginosa, S. aureus klebsiella spp. , 18-62 .
- 0,3 /. 24 .
2 /., .
24 . - , 2-5

. , Univ. of Groningen.
-
- -
24. : 628
461 20-. . Larsson J.,
Eneroth M., Apelqvist J., Stenstrm A. Sustained reduction in major amputations in diabetic
patients: 628 amputations in 461 patients in a defined population over a 20-year period
//Acta Orthop.-2008.-Vol.79, N5.-P.665-673.-.

. .
1982 .
1982-2001 .
199000 234000
1 1982 . 31
2001 . 0,57 16 6,8 100 .
4-. .
379
80 . .
(n=240) 0,23 4-. 0,31; 0,49; 0,47 0,49 ,
0,34 4-. 0,27; 0,21; 0,32; 0,21
. ,
. , Lund Univ. Hosp.

-
25. , 4
: 663
906
. Gjertsen J.E., Vinje T., Lie S.A. Patient satisfaction, pain,
and quality of life 4 months after displaced femoral neck fractures: a comparison of 663
fracture treated with internal fixation and 906 with bipolar hemiarthroplasty reported to the
Norwegian Hip Fracture Register //Acta Orthop.-2008.-Vol.79, N5.-P.594-601.-.
2
(). ,
,
. ,
, , 4 .
>70 . , (n=663)
(n=906).
VAS ( ) EQ5D. (VAS 27 vs 41),
(VAS 33 vs 48) EQ-5D (0,51 vs 0,42) 4 .
, .
,
. , Haukeland Univ. Hosp. Bergen.
-
- -
- - -
26. in vitro
:
. Dunne N., Buchanan F., Hill J., et al. In vitro testing of chitosan in
gentamicin-loaded bone cement: no antimicrobial effect and reduced mechanical
performance //Acta Orthop.-2008.-Vol.79, N6.-P.851-860.-.
,
, .

Staphylococcus spp.
.
.
- .
380
,
, . ,
ISO ASTM PMMA
. ,
.
, 29 . ,
. ISO
ASTM. , Schools of Mechanical and Aerospace Engineering. Belfast.
-
- -
27. . Patton
M.S., Lyon T.D., Ashcroft G.P. Levels of systemic metal ions in patients with
intramedullary nails //Acta Orthop.-2008.-Vol.79, N6.-P.820-825.-.
,
- , .
.
. 61 ,
, 3 . 21 Russell-Taylor
in situ 26 (21-32) . (316 LVm
), 20 Trigen in situ 43 (35-51) . (Ti6AL-4V ) 20 -
. -
, , , . . ,
. 1 . (0,1/)
- 2,5 , . 2 .
(6,5 /).
. ,

.
, ,
. , Univ. of Aberdin.
-
- -
- - -
28.
. Andersen L.O., Husted H., Otte K.S., et al. A compressin
bandage improves local infiltration analgesia in total knee arthroplasty //Acta Orthop.2008.-Vol.79, N6.-P.806-811.-.
,
,
. 48
(170 ) 0,2%
381
.
24 . 8
. ,
, ;
.
(2,8 3,3 .) . ,

. , Hvidovre Univ. Hosp. Copenhagen.
-
- -
- - -
29. :
? , -, . Andersen L.., Kristensen B.B., Husted H., et al. Local
anesthetics after total knee arthroplasty: intraarticular or extraarticular administration? A
randomized, double-blind, placebo-controlled study //Acta Orthop.-2008.-Vol.79, N6.P.800-805.-.

,
. 32

(170 ) 0,2% 20
(0,2%) () 30
() 20 0,2% 30
0,2 24 . .
4 . .
, .
,
. , Hvidovre Univ. Hosp.
-
- -
.
: ..
: _______________
: _______________
1. : 5 .
Barbey F., Lidove O., Schwarting A. Fabry nephropathy: 5 years of enzyme replacement
therapy a short review //Nephrol.Dial.Transplant.Plus.-2008.-Vol.1, N1.-P.11-19.-.

()
. , ,
382
,
/ .

.

(). 5-. ,
, ,
,
.
,
,
. . 53.
(. )
-
- -
- - -
2. -1
. Chen C.-H., Shu K.-H., Wen M.-C., et al. Impact of
plasminogen activator inhibitor-1 gene polymorphisms on primary membranous
nephropathy //Nephrol.Dial.Transplant.-2008.-Vol.23, N10.-P.3166-3173.-.
1 ()
.
()
104 , , 140 , . .
-

. .
4G/4G , 4G/5G
5G/5G (43,6; 55,8 73,3 /. .)
4G/5G (14/32%) 4G/4G (4/11%), 5G/5G
(1/5%).
4G/5G (18/41%) 4G/4G (6/16%), 5G/5G (3/14%).
4G/4G (20/53%) 4G/5G (25/57%)
5G/5G (5/23%). , 4G
- . .
4G/4G. ,
Inst. of Clinical Medicine. . 20.
(. )
-
- -
- - -
383
3. ,
. Hofstra J.M., Deegens J.K.J., Steenbergen E.J., Wetzels
J.F.M. Urinary excretion of fatty acid-binding proteins in idiopathic membranous
, - () -
. ()
, () .
40 (27 ., 13 .)
(). 4815 .,
- 8917 /, 8,95,0 /24 .
ELISA.
>25% . 39
. 3,29 / ( <0,38
/ ). 9 . 1,53 /
( <0,1 ). 2-,
1-, gG . 7532 . 16
(40%) .
81
83% .

. ,
. , Radboud Univ.
Nijmegen Med. Center. . 21.
(. )
-
- -
- - - -
4. - 1 (1) g . Harada K., Akai Y., Yamaguchi
Y., et al. Prediction of corticosteroid responsiveness based on fibroblast-specific protein 1
(FSP1) in patients with IgA nephropathy //Nephrol.Dial.Transplant.-2008.-Vol.23, N10.P.3152-3159.-.
, 1
g (g).
50 g, .
7,13,0 . 1 . -1
. 12
. 38
<1,0 /.
, , ,
/ ,
1+ . 1 ., 2.
2 ,
1 . - .
g >32,6 1 ./HPF,
. , Nara Med. Univ. . 28.
384
(. )
- g
- -
5.
. Achenbach J., Mengel M., Tossidou I., et al. Parietal
epithelia cells in the urine as a marker of disease activity in glomerular
diseases //Nephrol.Dial.Transplant.-2008.-Vol.23, N10.-P.3138-3145.-.

.

(D). D- .

(), () () .,
, . ,

D- ., , , .
. .
. -
D- ., 50% .
(8-18).
, 100% . D-,
, 45% 100%
. 8-18 .
8-18. , D-
.
. , .

. , Hannover Med. Sch. . 29.
(. )
-
- -
- - -
6.
-. Baekken M., Os I., Sandvik L., Oektedalen O.
Microalbuminuria associated with indicators of inflammatory activity in an HIV-positive
population //Nephrol.Dial.Transplant.-2008.-Vol.23, N10.-P.3130-3137.-.
(), ,
, - ()
. ,
- (n=495) .
(n=2091). 3
. - 8,7%, 3-5
, . -
385
, , , -2-
90 /. ,
, -2- -.
,
- .
, Ullevaal Univ. Hosp., Oslo. . 44.
(. )
- -
- - -2-
7. (): 7 Troms. Kronborg J., Solbu M., Njlstad I., et al.
Predictors of change in estimated GFR: a population-based 7-year follow-up from the
Troms study //Nephrol.Dial.Transplant.-2008.-Vol.23, N9.-P.2818-2826.-.
-
-
.
,
. 2249 . 2192 .
, 7 .
- .
(- 10 . .,
.=-0,14, .=-0,07) (-, .=-0,12, .=-0,11).
/./1,732/. .
. . .
/ . ,
-,
., . ,
Univ. Hosp. of North Norway, Troms. . 42.
(. )
-
- -
- - -
- - - -
8.
, . Chonchol M., Lippi G., Montagnana M., et al.
Association of inflammation with anaemia in patients with chronic kidney disease not
rquiring chronic dialysis //Nephrol.Dial.Transplant.-2008.-Vol.23, N9.-P.2879-2883..
()
. - ()
.
7389 .
() MDRD
386
(Modification of Diet in Renal Disease). ,

. 2221 (30,1%) 90 /./3; 4310
(58,3%) 60-89 /./3 858 (11,6%) <60 /./3.
- - () , , ,
(<0,0001). -
. .
,
. , Univ. Hosp. of Verona. . 26.
(. )
-
- -
- - -
9. g ,
. Lv J., Zhang H., Cui Z., et al. Delayed severe
pneumonia
in
mycophenolate
mofetil-treated
patients
with
IgA
()
() () - g
(g). 850
32 (1-1,5 .) 47 () (50-100 .).
.
,
. . ,
, . 3
. 6 32 : 3 , 2
, 1 . .
. ,
(4 ).
. 6 16
( [] <60 /./1,733)
>60 /./1,733 .
,

. , Pekin Univ. . 27.
(. )
- g
- -
- - -
- - - -
10. ,
:
/ . Zhu S., Liu Y., Wang L., Meng Q.H.
Transforming growth factor-, is associated with kidney damage in patients with essential
387
hypertension: renoprotective effect of ACE inhibitor and/or angiotensin II receptor

blocker //Nephrol.Dial.Transplant.-2008.-Vol.23, N9.-P.2841-2846.-.
()
(
) /
(). 156 ,
. . - (). 90
12 .
, .
.
12 . . , .
. .
, . . ,

. , Royal Univ.
Hosp. . 39.
(. )
-
- -
- - -
- - - -
11. -2-
, N---. Hofstra J.M.,
Deegens J.K.J., Willems H.L., Wetzels J.F.M. Beta-2-microglobulin is superior to N-acetylbeta-glucosaminidase
in
predicting
prognosis
in
idiopathic
membranous
()
,
.
-2- (2) N-- () . .
57 (38 ., 19 ., 4816.)
<135 /.
.
>50%
135 /. <2,0 /.
. 8036 . -
8920 /, 245,3 /
8,94,8 /24 . 28 (49%) .
2
. 81 90% ., 2
( 54 / .) 74 81% (
2,64 ./ .). 44%.
78% 2 14% . 2
388
.
, Radboud Univ. Med. Center. Nijmegen. . 20.
(. )
-
- - -2-
- - -
12. g :
. Haas M., Rahman .H., Cohn R.A., et al. IgA nephropathy in
children
and adults:
comparison of histologic features and clinical
outcomes //Nephrol.Dial.Transplant.-2008.-Vol.23, N8.-P.2537-2545.-.

g (g) ., . ,
g ,
.
,
.
, 99 . (17
.) g 125 g.
. (14 vs 24%)
(3 vs 17%). .
(). 2 .
. .

( vs ). , Johns Hopkins Med. Inst., Baltimore. . 28.
(. )
-
- -
- - -
- - - -
- - - - -
13. 2-
. Oda T., Tamura K., Yoshizawa
N., et al. Elevated urinary plasmin activity resistant to 2-antiplasmin in acute
poststreptococcal glomerulonephritis //Nephrol.Dial.Transplant.-2008.-Vol.23, N7.P.2254-2259.-.

(-
[]) , 2- ()
().

. 10 , 10 g
(g), 10 () 10 .
. - -
.
389
. , - ,
- (./ )
(2,990,63), g (1,020,2), (0,790,17) . (0,730,18).
.
-, -
. , Nat.
Defense Med. College, Saitama. . 20.
(. )
-
- -
- - - 2-
- - - -
14. . Cattran D.C., Reich H.N.,
Beanlands H.J., et al. The impact of sex in primary glomerulonephritis //Nephrol.Dial.Transplant.-2008.-Vol.23, N7.-P.2247-2253.-.
395
(), 370
() 542 g (g).
(), , ,
, 50%
( ). .
, 2 . , 2 g

. . . 50 30%
, g .
., . ( 0,63, 95%:0,40-1,00,
=0,05) ( 0,67, 95%:0,48-0,95, =0,02), g.
,
, .
,
.
. , , .
, .
. , Univ. Hlth. Network, Toronto. . 60.
(. )
-
- -
- - -
- - -
- - - -
- - - - -
- - - - - g
- - - - - -
- - - - - - -
390
15. /
:
. Antunes V.V.H., Veronese F.J.V., Morales J.V. Diagnostic
accuracy of the protein|creatinine ratio in urine samples to estimate 24-h proteinuria in
patients with primary glomerulopathies: a longitudinal study //Nephrol.Dial.Transplant.2008.-Vol.23, N7.-P.2242-2246.-.
. / ()
.
. 6-.
41
, .
() . .
6-. (<0,001
). 1 6 .
2,00; 1,88; 1,22; 1,07; 0,65; 0,34 0,57 .
,
.
. , Sch. of
Medicine, Porto Alegre. . 25.
(. )
-
-
- -
16. 5- ,
- . Schiffl H., Fisher R. Five-year outcomes of severe acute
kidney injury requiring renal replacement therapy //Nephrol.Dial.Transplant.-2008.-Vol.23,
N7.-P.2235-2241.-.

. ()
,
12 .
425 , - (), 226,
, 60 . .
.
5 . ; 57%
, 43% . 1 .
18% , 2 . 4%, 3-5 . 2% . 5 . 25%
. 26
., 8. 5 .
86%, 9% 5% .
, ,

. ,
- ,
391
. , Univ. of Munich,
Munich. . 21.
(. )
-
- -
- - -
- - - -
17.
. Covic A., Schiller A., Mardare N.-G., et al.
The impact of acute kidney injury on short-term survival in an Eastern European
population with stroke //Nephrol.Dial.Transplant.-2008.-Vol.23, N7.-P.2228-2234.-.
.
() ,
. : 1)
(); 2) 30-. ; 3) ,
. 1090
, . ,
, .
30 . . 66,111,5 .
(49,3% .), () 68,922,6 /./1,732; 30-.
17,2%. 932 , 158 .
14%, 36,3%. 158
(14,5%) . , ,
,
,
30-. (43,1 vs 12,8%).
,
, , . , Dr. C. I. Parhon Univ. Hosp.
Iasy. . 26.
(. )
-
- -
- - -
- - - -
18. . Paulsen L., Holm C.,
Bech J.N., et al. Effects of statins on renal sodium and water
handling //Nephrol.Dial.Transplant.-2008.-Vol.23, N5.-P.1556-1561.-.
-
, , ,
. 2 - () .
1 80 .
2 20 80 4
. (),
392
(), - (), (),

() () ().
1
; . . .
,
, , , ,
,
, .
, Holstebro Hosp., Holstebro. . 20.
(. )
-
- -
- - -
19. :
. Ortiz A., Oliveira J.P., Waldek S.,
et al. Nephropathy in males and females with Fabry disease: cross-sectional description of
patients before treatment with enzyme replacement therapy //Nephrol.Dial.Transplant.2008.-Vol.23, N5.-P.1600-1607.-.
, -
, .

(), 1262 (585 .
677 .) . 28% . ( 20-79) 13% . ( 20-82)
() <60 /./1,732. (>300
/24 .) 43 26% . . 1 .,
. 11% . 28% . <60 /./1,732
<300 /24 . 60 /./1,732
55% . 35% . >30 /24 .
130/80 . . 48 67% <60
/./1,732 . . .
. ,
, .
,
. , Fundacion Jimenes Diaz., Madrid. . 36.
(. )
-
- -
- - -
- - - -
20.
. Gupta K., Iskandar S.S., Daeihagh P., et al.
Distribution of pathologic findings in individuals with nephritic proteinuria according to
serum albumin //Nephrol.Dial.Transplant.-2008.-Vol.23, N5.-P.1595-1599.-.
393
()
, , .

.
>3 /24 .
<30 / (. 1),
30-35 / (. 2) 35 / (. 3). 1 . 57 , 2 . 20 3 . 35.
()
.: 26% (1), 45% (2) 74% (3). 35 3 . 34
. . 6 . 7 17 3
. , .
, .

,
. , Medical Center Boulevard, Winston Salem. . 21.
(. )
-
-
- -
- - -
- - - -
21. :
. Hoorn E.J., Betjes M.G.H., Weigel J., Zietse R. Hypernatraemia in critically
ill patients: too little water and too much salt //Nephrol.Dial.Transplant.-2008.-Vol.23, N5.P.1562-1568.-.
() - .
, 2005 . ()
, .
, - 150 /.
- 130 (1 .) 260 (2 .).
(9 vs 2%), (53 vs 34%), (53 vs 13%),
(91 vs 55%), (10 vs 1%)
(23 vs 0,4%) 1 . .
80 (-312 //.)
50 (723 //.).
(1482 vs 1333 /).
(405 /). 1 . (48 vs 10%),
( 4,3; 95%:2,5-7,2). ,
,

. /
. /
. , Erasmus Med. Center, Rotterdam. . 34.
(. )
394
-
- -
- - -
22.
: . De Biase V., Tobaldini O.,
Boaretti C., et al. Prolonged conservative treatment for frail elderly patients with end-stage
renal disease: the Verona experience //Nephrol.Dial.Transplant.-2007.-Vol.23, N4.-P.13131317.-.

(),
.
11 75 .
, ,

. ,
,
() .
. ,
,
. , Univ. Hosp. of Verona. . 18.
(. )
-
- -
- - -
- - - -
- - - - -
23. g . Kaartinen K., Syrjnen
J., Prsti I., et al. Inflammatory markers and the progression of IgA
glomerulonephritis //Nephrol.Dial.Transplant.-2007.-Vol.23, N4.-P.1285-1290.-.
g (g),
, 15-40% .
g ,
.
, -6
(-6) , g - ()
. 174 (70 .) 11 16 .
g .
5 . .
- 20%
, , .
-, , , , -6 . ().
2 19,5% . ,
g; -6 .
.
395

. , Univ. of
Tampere. . 18.
(. )
-
24. .
Schaeffner E.S., Kurth T., Bowman T.S., et al. Blood pressure measures and risk of chronic
kidney disease in men //Nephrol.Dial.Transplant.-2007.-Vol.23, N4.-P.1246-1251.-.
() ,
,
. (), (), ()
() .
(). 8093 .
, 24 .
14 . .
, <60 /./1,732.

. 14 . 1039 . (12,8%)
. 10 . . .
1,11 ; 1,11 , 1,14 1,05 . ,
, .
, . ,
Charite Campus Virchow, Berlin. . 28.
(. )
-
- -
- - -
- - - -
- - - - -
25.
:
. Kane G.C., Stanson A.W., Kalnicka D., et al. Comparison between
gadolinium and iodine contrast for percutaneos intervention in atherosclerotic renal artery
stenosis: clinical outcomes //Nephrol.Dial.Transplant.-2008.-Vol.23, N4.-P.1233-1240..
()
,
.
() ,
.
() 176 / (2 /) (n=57;
), (n=68; ) (n=38).
,
( 44 / [0,5 /] 7 .
396
- . ) . (3/57, 5,3%)
+ (4/38, 10,5%) (14/68, 20,6%)
30 . (<0,005).
4022 .
. .
, .
2 ,
. , Mayo Clinic
College of Medicine, Rochester. . 42.
(. )
-
- -
- - -
- - -
- - - -
- - - - -
- - - - - -
26. . Sonck J., Laureys G., Verbeelen D. The neurotoxicity and safety of
treatment with cefepime in patients with renal failure //Nephrol.Dial.Transplant.-2008.Vol.23, N3.-P.966-970.-.
()
. 8 ,
: ,
, , , , .
4,752,55 .;
1714,7 . , 3 . 5
, 3
.

.
,
.

. , Vrije Univ. Brussel.
. 26.
(. )
-
- -
- - -
27. . Bergesio F., Ciciani A.M.,
Manganaro M., et al. Renal involvement in systemic amyloidosis //Nephrol.Dial.Transplant.-2008.-Vol.23, N3.-P.941-951.-.
397
290 373 ,
1995-2000 .,
. 83
.
,
,
. 24 .
(L) , 30 . () 52 . (F). L , .
.
, ,
, .
L,
(
.) - . ,
L,
(),
. .
. , Azienda
Ospedaliero-Universitaria Careggi, Firenze. . 28.
(. )
-
- -
28.
:
. Oppert M., Engel Ch., Brunkhorst F.-M., et
al. Acute renal failure in patients with severe sepsis and septic shock a significant
independent risk factor for mortality: results from the German Prevalence
Study //Nephrol.Dial.Transplant.-2008.-Vol.23, N3.-P.904-909.-.
, ()
()
.
. 3877
415 . 14
(3,4%) - . 401
, , 166 (41,4%) ,
2
<0,5 / . APACHE
22 16 (<0,00001).
/ 55,2%,
67,3%, 42,8% (<0,0001).
( 2,11;
95%:1,27-3,52).
- , 86%. , Humboldt
Univ., Berlin. . 21.
398
(. )
-
- -
- - -
- - - -
29. g
. Lemley K.V., Lafayette R.A., Derby G., et al. Prediction of early progression
in recently diagnosed IgA nephropathy //Nephrol.Dial.Transplant.-2008.-Vol.23, N1.P.213-222.-.
g (g)
,
.
. 22 g
4-5 . .
. 30 (
, ) 22
.
41 /./. 8,6 /./.
5 : ,
, ,
.
3 ,
g
.
. ,
Stanford Univ., Stanford. . 35.
(. )
- g
- -
- - -
30. ,
. Day C., Hewins P., Hildebrand S., et al. The role of renal biopsy in women
with kidney disease identified in pregnancy //Nephrol.Dial.Transplant.-2008.-Vol.23, N1.P.201-206.-.

, .
- .
2 . .: 1) 20 ,
; 2) 75 ,
. 1 . 19/20
(95%) 9/20 (40%). 17/20 (85%) .
36 . , ,
103,3 . , 9/20 (45%) () <60
/./1,732 (6 []) 3/20 .
399
. 2 . (62/75; 82,6%) (40%

) , .
64%. , 14 . (29,7%)
, 20 (42,6%) <60 /./1,732, 6 (12,7%) .
, ,
. .
. , Univ. Hosp.
Birmingham. . 19.
(. )
-
- -
- - -
- - - -
- - - - -
: ..
: _______________
: _______________
29. . V. P //N.Engl.J.Med.-2008.-Vol.359, N8.-P.800-809.-.
. , I. . 35.
(. )
400

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later: a population based study of Swedish twins //J.Gerontology.-2008.-Vol.63, 1.P.62-66.-.

neurobehavioural effects due to electromagnetic field exposure emitted by GSM mobile

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vulvovaginal candidiasis (ReCiDiF trial) //Am.J.Obstet.Gynecol.-2008.-Vol.199, N6.P.613 e1-e9.-.

adolescent females using injectable or oral contraceptives: a 24-month prospective

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new risk for interstitial lung damage //Occup.Environ.Med.-2008.-Vol.65, N1.-P.51-55..

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mitochondria and reduces cerebral ischemia/hypoxia injury //Stroke.-2008.-Vol.39, 2.P.455-462.-.

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intubation at birth for very preterm infants //N.Engl.J.Med.-2008.-Vol.358, N7.-P.700708.-.

a short course of prednisolone in infants with oxygen-dependent bronchopulmonary

hospitalized patients with community-acquired pneumonia //Chest.-2008.-Vol.134, 5.P.955-962.-.

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