Family History (maternal side)

Bilateral Renal Artery Stenosis

Takayasu disease

cellular retention of sodium water retention, with increased ECF volume increased blood volume, cardiac output and events of early primary hypertension

disruption of sodium-potassium pump

net increase of intracellular sodium & calcium

Prolongs vasoconstriction Stimulates smooth muscle hypertrophy & hyperplasia Decreases arterial lumen size Inflammation

Release of histamine, leukotrienes, prostaglandins

Increase vascular permeability

Increase sodium, calcium, water, proteins, humoral substances

Increase vessel thickening

Calcium increases smooth muscle contraction

Increase vasoconstriction

Increase peripheral resistance

Blood pressure elevation