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Lab Oral Epithelial Tumors (Lab 3)
Lab Oral Epithelial Tumors (Lab 3)
OSCC
CIS
Hecks disease
Koilocytes
Papillary finger-like epithelial proliferation supported by thin fibrovascular cores. Acanthosis and hyperkeratosis. Hyperplastic rete ridges around margins slope inwards towards center. Large vacuolated cells (koilocytes) with prominent keratohyalin granules.
Verruca vulgaris
Koilocytosis.
1. Broad-based, exophytic mass with rough, nodular, warty, hemorrhagic, or necrotic surface.
Considerable variation. Invasion and destruction of local tissues accounts for induration and fixation detected clinically. Cytologically malignant squamous epithelium with variable degrees of differentiation. Keratinization varies with
degree of differentiation. Invasive malignant epithelium
Keratin pearl
Well-differentiated tumors: Obvious squamous differentiation. Masses of prickle cells with limiting layer of basal cells around them. Recognizable intercellular bridges. Central keratin pearl formation. Nuclear and cellular pleomorphism is not prominnemt. Relatively few mitotic figures.
Keratin pearl
Moderately differentiated tumors: Less keratinization. More pleomorphism of cells and nuclei. Abundant and atypical mitotic figures. Still readily identified as squamous type.
Pathology
Very well differentiated, heavily keratinized SCC with little or no cytological atypia. Mitoses are rare.
Although it is an exophytic tumor, it also has a slowly advancing, pushing, cohesive invasive front causing local destruction.
A term used to describe severe epithelial dysplasia in which the whole, or almost the whole thickness of epithelium is involved, but basement membrane is intact and there is no invasion of lamina propria.
Usually presents clinically as leukoplakia or erythroplakia. In some patients it may progress to invasive carcinoma, but in others it may remain static or even regress.
1. Precancerous lesions: a) Leukoplakia- homogeneous, non-homogeneous, nodular, and speckled types, including chronic hyperplastic candidosis and proliferative verrucous leukoplakia. b) erythroplakia c) carcinoma in situ.
Histologically consists of malignant basaloid cells arranged in various patterns , invading adjacent tissues.
Melanocytes
Junctional Nevus
Compound nevus
2. 3. 4.
ABCD Clinical Features: Asymmetry (uncontrolled growth pattern) Border irregularity Color variation Diameter greater than 6 mm
Highly pleomorphic neoplasms. Variable melanin production, may be absent (amelanotic melanoma). Immunohistochemical studies using specific markers for malignant melanocytes (S-100 and HMB-45) are useful. Ultrastructural examination to identify immature melanosomes can be used.