Gene

Familial Adenomatous Polyposis Autosomal Dominant APC

Gardner s syndrome Autosomal Dominant APC gene (phenotypic variant of FAP) Multiple adenomatous polyps

Turcots syndrome

In colon

Diagnosis Other cancer association

Numerous precancerous and cancerous polyps in colon and periampullary tumors More then 100 polyps in colon N\a

Herediatary nonpoliposos Cancer Autosomal Autosomal Recessive Dominant APC, MMR hMLH 1 and genes: MLH1 hMSH2 and PMS2 are (DNA involved in DNA mismatch mismatch repair repair gene) Colonic polyps Colorectal adenomas and cancer

Peutz-Jegers syndrome Autosomal Dominant STK11 (LKB1) [4] is a possible tumor suppressor gene Hamartomatous colon polyps

Association with other tumors Osteomas, Hepatoblastomas, Papillary thyroid carcinomas, periampullary adenomas Cutaneous findings of Gardner syndrome include epidermoid cysts, desmoid tumors, and other benign tumors N/a

Association with other tumors Tumor CNS: glioblastoma multiforme and medullablastoma

Clinical picture Stomach, breast and ovaries cancer

Other symptoms

N/a

N/a

Part of Lynch syndrome (1 and 2) Lynch 2 is associated with endometrium cancer,cancer ovary and pancreas

Mucocutaneous hyperpigmented lesion lips, genitals, oral mucosa, hands