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31757337 เธฃเธงเธกเธเนเธญเธชเธญเธ 1
31757337 เธฃเธงเธกเธเนเธญเธชเธญเธ 1
PQ 191 Rx CU 65 et al.
1.
2.
3.
4.
**
MCQ
( MCQ OSPE) **
MCQ 2549 case 2
10 case 2 20 case case 15 300 (
)
MCQ 2549 case 2
15 case 2 30 case case 10 300
()
4 A,B,C,D
()
1
(
)
case
: :
4:3:3 ( 2551)
(
)
..
-
- , , ,
(), (), (), , ,
New Light
(), (USA)
5
-
2549 (
1)
1
:
1.
a. ( tuberculosis)
b. (pneumonia)
c. (gonorrhoea)
d.
7.
4
1. zidovudine 100 mg 2.
ritonavir 3. azithromycin tab
150 mg 4. rifampicin
1. zidovudine
(candidosis)
e. ( HIV)
2.
3. GPOvir
3.azithromycin
a. Zidovudine +
Didanosine + Ritronavir
b. Stavudine + Lamivudine
+ Saquinavir
c. Stavudine +
Lamivudine
+Nevirapine
4. rifampicin
2.
ritonavir
8.
zidovudine
5. a. Inhibit protein synthesis
Inhibit HIV protease
c. Inhibit HIV reverse
transcriptase
lipodystrophy d. Inhibit thymidine kinase
c. Nevirapine
a.
d. Lamivudine
e. Diravirdine
b.
6.
....
peptide-like
a. Cotrimazole
...
b. Nystatin
d. basic functionality
c. Claritromycin
ionize
4.
e.
polar functionality
10. Rifampin
white sugar-coated
tablet
a. air
oxidation
b.
hydrolysis
hydrozone
c.
d.
e.
2
24
11.
a. Bacterial vaginosis
b. Candidiasis
c. Gonorrhea
d. Herpes genitalis
e. Trichomoniasis
12.
a. Tinidazole
single dose
b. Metronidazole
single
dose
c. Clotrimazole
7
d. Ciprofloxacin
e. Cotrimoxazole
13.
a. Tetracyclin
250 mg
b.
3
c.
d.
e.
14.
a.
b.
c. 8
15 c
d.
e.
2g
15.
a.
b.
c.
d.
e.
16.
a. Clotrimazole
b. Cotrimoxazole
c. Itraconazole
d. Metronidazole
17.
18.
a.
b.
c.
d.
e.
19.
a. Case control
b. Randomized control
study
c. Case
d. Analysis of secular trend
20.
Vanotab
a
2x2pc 20
70%
1
1 OD 1
?
90%
Vanota
a. 90
b. 98
c. 100
d. 103
e. 110
3
32
Partial
seizure secondarily to
generalized tonic-clonic seizure
Phenytoin
sodium (100mg) 3 capsule hs
1
Phenytoin
28
mg/L (
Phenytoin
10-20 mg/L)
21.
a.
b.
c.
d.
..
e.
2
22.
Phenytoin
Sodium
a. Ethosuximide
b. Diazepam
c. Vigabutrin
d. Carbamazepine
e. Gabapentin
23.
Phenytoin
a. Glugival hyperplasia
b. Hepatitis
c. Rash
d. Ataxia
e. Hyponatremia
24.
a. Phenytoin
b. Valproate
c. Phenobarbital
d. Carbamazepine
25.
phenytoin phenytoin
a. Erythromycin
b. Cimetidine
c. Conjugated estrogen
26. phenytoin
a.
b.
c.
d.
Lactose
Dextrose
Calcium sulfate
Pregelatinized starch
e. Microcrystalline cellulose
27.
phenytoin
a. Crospovidone
b. Croscarmellose
c. Sodium lauryl
sulphate
d. Sodium starch glycolate
e. Colloidal silicone dioxide
28.
29. phenytoin
a. infrared
spectroscopy (IR)
Benzene
b. infrared
spectroscopy (IR)
secondary amide
c. infrared
spectroscopy (IR)
carbonyl
d. ultraviolet
spectrometry (UV)
Benzene
e. ultraviolet
spectrometry (UV)
secondary amide
30.
......2540
Phenytoin
a.
b.
c.
d.
e.
4
50
Non-Small Cell Lung Cancer
(NSCLC) Satge IV
31. Cisplatin
a. 150
b. 175
c. 200
d. 225
e. 250
32.
Acute Emetic
a. Ondansetron
b. Dexamethasone
c. Metoclopramide
d. Ondansetron +
Dexamethasone
e. Metoclopramide +
Dexamethasone
33. Cisplatin
a.
b.
c.
d.
e.
a. Akylating agent
b. Topoisomerase II
inhibitor
c. Antimetabolite
d. Intercalating agent
e. Inhibitor of mitosis
34. Cisplatin
(Nephrotoxicity)
a.
b.
Magnesium
c. Osmotic
diuretic Mannitol
d. Cisplatin
Sodium chloride
35. etoposide
stability
: At temperature in D5W or NS
in polyvinyl
0.2 mg/ml
: 96
hours
0.4 - 0.21 mg/ml
:
48 hours
0.6 - 0.41 mg/ml
: 8
hours
1.0 - 0.61 mg/ml
: 2
hours
manufacturer does not
recommended administration at
conc. more than 0.4 mg/ml due
to highly unpredictable time to
precipitation
etoposide
(100 mg/m2) D5W 500
ml
96 .
48 .
8 .
2 .
36.
a.
b.
.....
c.
d.
e. ()
37.
Cisplatin
a. Doxorubicin
b. Cytarabine
c. Melphalan
d. Carboplatin
e. Metrotrexate
38.
+
+
+ + + +
+ +
+- +- ++- +
+- -+
+ +
a. Diffusion controlled
b. Dissolution controlled
c. Erosion controlled
d. Osmotic controlled
e. Ion exchange
controlled
FBS (<126)
HbA1c (<7)
39.
2
A
c
135 mg%
7.0%
Myocardial infarction
53
44
Glibencarmide 10 mg
BID
41. LDL- C
B
a. A hydrophobic
medium
b. B hydrophilic
medium
c. C hydrophobic
medium
d. B
e. C
40.
a. 130 mg/dl
b. 140 mg/dl
c. 150 mg/dl
d. 160 mg/dl
e. 170 mg/dl
42. major risk factor
Coronary heart
disease
Myocardial
infarction 53
Myocardial
infarction 44
2
HDL-C 33 mg/dl
53
43.
Hyperlipidemia
a. Total cholesterol
b. Triglyceride
c. HDL-C
d. LDL-C
e. Non-HDL-C
44.
LDL C
atherosclerosis
a. < 100 mg/dl
b. < 130 mg/dl
c. < 160 mg/dl
d. < 190 mg/dl
a. Statin
b. bile acid
segvegtrants
c. nicotinic acid
d. fibric acid
e. plant sterols
sitosterol campesterol
46. Statin
LDL-C
a. LDL-C
receptor
b. cholesterol
LDL-C
receptor
c. enterohepatic
recycling cholesterol
d. VLDL
e. HDL
a. Pravastatin
prodrug
b. Simvastatin
Pravastatin prodrug
c. Pravastatin
2
lactone ring
carboxylic acid
d. Simvastatin
lactone ring
e. Simvastatin
Pravastatin
prodrug
Simvastatin
Pravastatin
47.
a. Cholestyramine
Simvastatin
Simvastatin lactone
ring
b. Cholestyramine
Pravastatin
Pravastatin
carboxylic acid
c. Simvastatin
Cholestyramine
d. Cholestyramine
Simvastatin
Provastatin
e. Cholestyramine
Simvastatin
Provastatin
48.
49.
Drug use
statin
a.
b.
c.
d. ...
e.
50.
statin
....
d. Meta-analysis,
Randomized
controlled study
e. Cross-sectional study,
Randomized controlled
study
6 25
10
a.
b.
c.
d.
e.
Salbutamol MDI
51.
a.
b.
c.
d.
e.
52.
53.
Salbutamol MDI
a. long-
d. attack 2-4
puffs
3
e.
bioavailability
54. 2
a. Inhaled fenoterol
(100mcg/puff) 3
puffs
b.Zileuton (600mg/tablet)
1 4
c. Sustained-released
theophylline (200mg)
1 2
d.Inhaled budesonide (200
mcg/puff) 2 puffs
2
e. Ketotifen (1mg/tablet)
1 2
55.
a. Sore throat
b. Pharyngitis
c. Metallic taste
d. Gingivitis
e. Oral thrush
57.
Theophylline
a. Ciprofloxacin
b. Fluvexamine
c. Cimetidine
d. Amoxicillin
e. Rifampicin
58.
inhaler device
a. spacer
oral thrash
b.
Nebulizer
c. Dry powder
Inhaler (DPI) ...
10
d. breath
activated device
e. Turbuhaler
59.
a. Turbutaline (2.5mg/tab)
b. Prednisolone
(5mg/tab)
c. propellant nonCFC
d.
e.
7 33
61.
a. Prednisolone
b. Hydrocortisone,
cimetidine
c. Hyossacine HCl, Zinc
oxide
62.
a. Senna
b. Castor oil
c. Bisacodyl
d. Mineral oil
e. Phylium seed
63.
a.
6
b.
c.
d. 1
e.
64.
a.
b.
c.
d.
e.
65.
a. Senna
b. Castor oil
c. Bisacodyl
d. Lactulose
e. Phylium seed
66.
a.
b.
c.
d.
e.
15
67.
2g
0.3g Displacement
valve = 1.5
base
a. 155 g
b. 175 g
c. 180 g
d. 197 g
e. 200 g
68.
15
a. Calcium carbonate
b. Potassium chloride
c. Sodium bicarbonate
d. Potassium lichromate
e. Potassium
permanganate
69.
.....
15 3
a.
b.
c.
d.
e.
70.
a.
b.
c.
d.
e.
8
60 48 kg 170
cm
creatinine
clearance 18 ml/min
71.
Creatinine clearance
a.
b.
c.
d.
e.
72.
hyperkalemia
a. Potassium chloride
b. Sodium chloride
c. Sodium polystyrene
sulfonate
d. Calcium chloride
e. Calcium phosphate
73.
a.
b.
c.
d.
e.
Hydrochlorothiazide
Spironolactone
Furosemide
Amiloride
Indapamide
74.
a.
b. renal shut down
c.
d. -
e.
acidosis
sodium bicarbonate
bicarbonate 2.8 mmol/l
sterile water for injection 100 ml
75.
sodium bicarbonate
sodium
bicarbonate
5 ml 2 mg/ml
(Mw Na=23, H=1, C=12,
O=16)
a. 2 Amp
b. 3 Amp
c. 4 Amp
d. 5 Amp
e. 6 Amp
76.
a.
b.
c.
d.
Sterility
Osmolarity
Microbial limit test
Particulate matter
e. Preservative
78.
a.
b.
50,000
c.
d.
50,000
e.
79. A
diuretic
.......
HCTZ
A
a. Case control
b. Cohort
c. Meta-analysis of case
control studies
d. Deseriptive
e. Randomized control
trial
80.
a.
b.
c.
d.
e.
9
generalized
anxiety disorder
6
81.
a. Lithium carvonate
b. Clozapine
c. Chlorpromazine
d. Haloperidol
e. Diazepam
82.
fluoxetine
a.
b.
c.
d.
....
e.
83.
major depressive disorder
a. Venlafaxine
b.
c.
d.
e.
Paroxetine
Amitriptyline
Bupropion
Sertraline
84.
a. Imipramine
b. Elomipramine
c. Amitriptyline
d. Doxepin
e. Sertraline
85.
antidepressant
a.
b.
2-3
c.
d.
e.
86.
benzodiazepine
a.
b. Triazolam
25%
c. Olanzapine
75%
d.
25%
e.
1
87.
a.
b.
c.
d.
e.
88. Risperidone
methanol
HCl 0.1 normal
a. Shellac
b. Cellulose acetate
phthalate
c. Hydroxypropyl
methylcellulose
d. Polyvinyl acetate
phthalate
e. Polyvinyl pyrroridone
89.
a.
matrix
b.
osmotic
c.
d.
matrix
90.
( bulking
agent)
( disintegrant )
a. Lactose
b. Magnesium sulfate
c. Microcrystalline cellulose
d. Corn starch
e. Sodium lauryl sulfate
10 28
91.
a. Goiter, constipation,
lethargy, dry skin
b. Goiter, depression, puffy
face, lethargy
c. Goiter, cold intolerance,
decreased sweating,
bradycardia
d. Goiter, loose bowels,
insomnia, irritability
e. Goiter, fatigue, weight
gain, decreased appetite
cuthyroidal
state
92. Propylthiouracil
2542
a.
b.
c.
d.
e.
93.
a.
Propylthiouracil
methimazole
b.
Propylthiouracil
c.
d.
iodine
e. propranolol
propylthiouracil
94.
thiouracil
a.
b.
c.
dealkylation
Propyl group
95.
Propylthiouracil
a.
thiourea
b.
thyroid hormone
c. hypothyroid
d. thyroid
peroxidase
e. T3
96. Propylthiouracil: White,
crystalline sub that has a
bit ?? water
... 50 mg
3
methimazole
carbimazole
propyl
thiouracil
methimazole, carbimazole
propylthiouracil
a. methimazole,
carbimazole
propylthiouracil
metabolized
desulfunation
b. propylthiouracil
metabolized
c. methimazole
metabolized
conjagation
carbimazole
d. amide
hydrolysis
carbimazole
e. ester
hydrolysis
carbimazole
97.
propanolol
propylthiouracil
a. Propanolol alphaadrenergic blocking
agent
b. Propanolol
tremor
tarchycardia
thyrotoxicosis
c. Propanolol
pharmacokinetic
propylthiouracil
propylthiouracil
d. Propanolol
propylthiouracil
e. Propanolol
propylthiouracil
T4
98. goiter
a. Ion
thiocyanate
goiter
b. Thiocyanate
metabolize ...
c. Lithium
secretion Thyroxine
thiiodothyroxine
hyperthyroidism
d. Goitrin
thyroid peroxidase
e. Percholate ion
uptake
iodide
iodide thyroid
99. toxic goiter
a. iodine
b. iodine
c.
d.
e.
thiocyanide
100.
Lugols solution
a. Iodine + KI
b. Manganese
c. Methimazole
d. Thiocyanate
e. Propylthiouracil
11 55
estradiol
a.
b.
c.
d.
e.
102.
(transdermal patch)
a.
first pass
metabolism
b.
c.
d.
e.
osteoperosis
103.
a. estradiol valerate 2 mg
+ norgestrel 0.5 mg
b. medroxyprogesterone
acetate 5 mg
c. ethimylestradiol 30 mcg
+ cypoterone acetate 2
mg
d. conjugated estrogen
0.625 mg
e. conjugated estrogen
0.625 mg +
medroxyprogesterone 5
mg
104.
103
a. Hyperlipidemia
b. Osteoperosis
c. Hyperbilirubinemia
d. Congestive heart failure
e. Thromboembolism
105.
Transdermal
a.
b.
c.
d.
partition coefficient
1
e.
therapeutic index
106.
a.
b.
c.
d.
e.
107.
spectrum
phytoestrogen
a. UV-visible
spectrophotometer
b. 1H-NMR spectrometer
c. 13C-NMR spectrometer
d. FT-IR spectro
e. Mass spectrometer
108.
a. B1-6-12 tablet
b. Doxycyclin capsule
c. Senna tablet
d. Antacid gel
e. Premarin 0.625 mg
109.
a.
b.
c.
d.
e.
Ibuprofen 400 mg
Dexamethasone 0.5 mg
Indomethazin 25 mg
Piroxicam 10 mg
Celebrex 200 mg
110.
a. Diazepam 10 mg
b.
c.
d.
e.
Diclofenac inj 75 mg
Methadone tab 10 mg
Pentazocine tab 25 mg
Voltaren SR tab 100 mg
12 22
Systemic Lupus
Erythematosus (SLE)
111.
SLE
a.
hydrazine
Lupus
b. sunscreen SPF
15
c.
d.
hydralazine
chorpropamide
anticonvulsant
lupus
e.
112.
topical steroid
topical steroid
a. Hydrocarbon base
b. Oleaginous base
c. Absorption base
d. O/W emulsion base
e. W/O emulsion base
Topical steroid
113.
a. Psuedoplastic flow
b. Psuedoplastic flow with
thixotropy
c. Dilantant flow with
thixotropy
d. Antithixotropy
e. Newtonium flow
SLE
hydroxychloroquin 200 mg
114.
a. Ocular examination
b. Chest x-ray
c. Liver function test
d. Urinalysis
e. EKG
aspirin
115.
aspirin tab
aspirin
Product A
Product B
Product C
Aspirin tab
a. Product A
b. Product B
c. Product C
d.
e.
116.
(rate constant, K)
aspirin tab
a. (slope)
b.
(slope)
c. Intercept
d. Intercept
e. Intercept
slope
117.
aspirin tab
a. (half life)
aspirin
b. (shelf life)
aspirin
c. .
aspirin
d. .
aspirin
e.
aspirin first order
rxn
118.
steroid
cytotoxic drug
TB
Isoniazid, Rifampin,
Pyrazinamide, Ethambutol
SLE
a.
b.
c.
d.
Isoniazid
Rifampin
Pyrazinamide
Ethambutol
e. Pyrazinamide
Ethambutol
Prednisolone
Dexamethasone
a. Dexamethasone
steroid short
acting steroid
b. Dexamethasone
steroid long
acting steroid
c. equivalent
dose
Potency
d.
Prednisolone
glucocorticoid
dexamethasone
predni
solone
a.
Pregnane
b. Amcinonide
antiinflamatory activity
prednisolone
c. Amcinonide
lipophilicity
prednisolone
d. Amcinonide salt
water retention
prednisolone
e. Amcinonide
9-F 11-OH
amcinonide
glucocorticoid activity
prednisolone
119.
mineralocorticoid
e.
13
45
1
paracetamol
121.
a. Rheumatoid arthritis
b. Osteoarthritis
c. Osteoporosis
d. Acute gout
e. Osteomalacia
120.
amcinonide
prednisolone
122.
amcinonide
a.
b.
c.
d.
e.
Paracetamol
Probenacid
Colchicine
Tramadol
Allopurinol
123.
a.
b.
c.
d.
e.
124.
a.
b.
c.
d.
e.
Prednisolone
Indomethacin
Allopurinol
Paracetamol
Tramadol
125.
a. Corticosteroid
b. Xanthine oxidase
inhibitor
c. Uricosuric agent
d. NSAID
e. Para-aminophenol
derivatives
126.
Rx
Diclofenac 25 mg # 30
Sig: 2 tab p.o. tid pc
% labeled amount
60
. ..
2510
a.
b.
c.
d.
e.
127.
a. Uncoated tablet
b. Enteric coated tablet
c. Efervessant tablet
d. Filmed coated tablet
(enteric coated
tab)
a.
b.
c.
d.
e.
129.
a. Celecoxib
b. Tramadol
c. Meloxicam
d. Prednisolone
e. Indomethacine
130.
a.
b.
c.
d.
2
e.
3
14 19
131.
a. Staphylococcus
aureus
b. Staphylococcus
epidermidis
c. Streptococcus
pnuemoniae
d. Neisseria gonorrheae
e. Chlamydia tracamatis
132.
a. Dexamethazone eye
drop
b. Oxymethazoline eye
drop
c. Idoxuridine eye drop
133.
a. DNA
b.
c. RNA
d.
leucocytes
e. cell wall
134.
...
a. 25c 6-8
week
b. 25c 3-4
week
c. 2-8c 6-8
week
d. 2-8c 3-
4 week
e. 8-15c 3-
4 week
135.
C-3 hemisuccinoyl
ester
ester
a.
b.
c.
d.
e.
136.
2% A
180 ml isotonicity
(Freezing point
= -0.52 o c, freezing
point A 1% = -0.12 o c,
freezing point =
-0.58 o c)
a. 0.28%
b. 0.38%
c. 0.48%
d. 0.58%
e. 0.68%
137.
A
hydrolysis
A
a. complexing agent
b. pH pKa
c.
d. cosolvent
e.
lyophilized powder
A
138.
a. clay
b.
polysaccharide
c. cellulose
d. hydrated
silicate
e. colloidal
silicone dioxide
d. Topical steroid
e. Ketoconazole
shampoo
143.
topical steroids
topical
steroids
a. 0.1% betamethasone
valerate < 0.05%
betamethasone
dipropionate < 0.05%
clobetasone
propionate
b. 0.05% clobetasone
propionate < 0.1%
betamethasone valerate
< 0.05% betamethasone
dipropionate
c. 0.05% betamethasone
dipropionate < 0.05%
clobetasone propionate
< 0.1% betamethasone
valerate
d. 0.1% betamethasone
valerate < 0.1%
triamcinolone acetonide
< 0.05% clobetasone
propionate
e. 0.05% clobetasone
propionate < 0.1%
betamethasone valerate
< 0.1% triamcinolone
acetonide
139.
140.
8,500 units/ml
a.
b.
c.
d.
e.
15 25
(greasy scale)
nasolabial folds
10
psoriasis
141.
a. Contact dermatitis
b. Psoriasis
c. Saborrheic dermatitis
d. Dandruff
e. Tinea vesicolor
142.
a. Selenium sulfide
shampoo
b. Tar shampoo
c. Salicylic acid
144.
a. Ketoconazole shampoo
12
b. Dandruff
Topical
corticosteroid
c. Sulfur
keratolytic agent
d. coal tar
photosensitivity
e. Selenium sulfide
hyperproliferation
cell
145.
ointment each g
contains: Betamethasone 0.5
mg and salicylic acid 30 mg
in a paraben freez ointment
base of white petroleum and
mineral oil
ointment base
146.
salicylic acid
a.
b.
phospholipase
A2
c.
Keratolytic
agent
d.
antioxidant
e.
emulsifying agent
147.
Ketoconazole
a. Gas chromatography
b. UV/visible
spectrophotometer
c. IR spectroscopy
d. High performance
liquid
chromatography
e. High performance thin
layer chromatography
148.
Reg. no. 2C802/45
a.
..2545
b.
8 .. 2545
c.
8 ..
2545
d.
..2545
e.
8 .. 2545
149.
a. 1
b. 2
c. 3
d. 4
e. 5
150.
d. Hydroxyzine tablet 25
mg
e. Methotrexate tab 2.5
mg
2549
( 2)
1 44
penicillin
1.
. Norfloxacin
. Ciprofloxacin
. Erytromycin
. Chloramphenical
. Amoxycillin
2.
10
penicillin
( anaphylaxis )
. Erytromycin
. Levofloxacin
. Azithromycin
. Chloramphenical
. Amoxycillin
3.
. Tetracyclin
. Dicloxacillin
. Erytromycin
. Cotrimazole
. Amoxycillin
4.
griseofulvin
5.
( randomized cross)
( randomized parallel)
.
( cohort study design)
.
( single binded design )
6.
5
. .. 2510
.
.
.
.
.
7.
flocculation
8.
sedimentation ratio
0.60
. sedimentation ratio
. sedimentation ratio
. sedimentation
ratio
9. Cloxacillin
sodium for oral solution
sig. 1 tsp. qid ac & hs
.
( ready to use)
.
. 1
4
.
.
2
12
3
11.
Aspirin
. folic acid
. vitamin B 12
. ferrous gluconate
.
. ferrous sulfate
folic acid
12.
.
G6PD
. aplastic anemia
. hemolytic anemia
. pernicious anemia
. chronic renal failure
. iron deficiency failure
13.
. platelet
. folic acid
. vitamin B12
. ferrous sulfate
. packed red cell
14.
. aspirin
. Vit. c
. amoxy
. Amitryptyline
.
15 -18
19.
.
.
20.
.
.
.
.
21.
. Ginkgo , Tanakan
. chitosan
. hydroxyl citric acid
. medium chain triglyceride oil
. conjugated linoleic acid
22.
.
. dosage form
.
. 13
23.
145 .
61 . (BMI)
. 26
. 27
. 28
. 29
. 30
24.
Phentermine
.
.
.
.
.
25.
phentermine
2
.
2
26.
phentermine
1.
2.
3.
4.
thermogenesis
27.
phentermine
28.
tablet
37.5 mg
30.
. Tapioca starch
. Confectionness sugar
. Sodium starch glycolate
. magnesium stearate
. colloidal silicon dioxide
4
28
31.
.
. steroid
.
.
.
32.
.
systemic antibiotic
. antibiotic
33-38
39.
Isotretinoin
. Vitamin A
. Drug of choice
. serum
triglyceride
40. Isotretinoin 0.05%
.
.
.
.
5 57
stable angina 2
..
2542
6
TC
250 mg/dl
TG
245 mg/dl
41.
.
Simvastation 20 mg
flollow up
.
1
. Niacin
1gm BID follow up 6
.
Cholestyramine 4 gm BID
.
Gentibozil 600 mg BID
42.
(Rhabdo)
statin
. genfibrozil
.
propanolol
. Niacin
. enalapril
. cholertyramine
.
43.
. Atenolol
. Ramipril hypokalemia
. Cholestyramine
. Gentibrosil (blurred
vision)
. Isosorbide mononitrate
44.
Atenolol (
- block)
. heart rate
cardiac
output
. heart rate
cardiac output
. heart rate
cardiac
output
. rennin
. negative
feedback compensatory
outflow
45.
Sublingual isosorbide dinitrete
.
.
.
2
46.
isosorbide mononitrate 20 mg.
. 2
-
. 2 (3 )
. 2
-
. 2
. 2 (3 )
47.
. Atenolol
AMI
intrinsic
sympathomimetic activity
. Ramipril
heart
failure stroke
. Clopidogrel
Platelet glycoprotein I receptor
antagonist
. ASA
Clopidogrel
PT/ID
. ISDN Myocardial oxygen
demand HR BP
48.
Enalapril
. dissolution
.
. Active ingredient
. (limit)
Enalaprilat
. (limit)
piperazine diketone
49.
onset
duration
. Volatility
. route of administration
. metabolisum
. Structure (
oxide nitrogen
. alcohol
50. Angiotensin-converting
enzyme (ACE) inhibitor
pH
. Sinusitis
. Allergic rhinitis
. Cystitis
. Common cold
. Bronchitis
52.
4
Pseudoephredrine 60
.
2
.
.
53.
ephedrine
ephedrine
Pseudoephedrine
. 1,2
. 1,3
. 2,3
.
2,4
. 3,4
54.
ephedrine 0.5 1 drop bid
. 1
1
. 1
2
-
.
1 2
-
.
2 1
2 -
55.
.
hypertension
.
hyperglycemia
.
rebound congestion
.
insomnia
56.
. Preservative
. Coloring agent
. Buffering agent
. Antioxidant
. Toxicity adjusting agent
57.
ephedrine 0.5%
ephedrine 1.0%
.
.
.
.
.
60.
.
.
.
.
.
7
30
2
2-3
2-3
61.
.
.
Aluminium
hydroxide
.
Magnesium
. 1
.
.
62.
.
..............
.
10
. -
20
. Cimetidine 200 mg
10
. 100
.63.
64.
(rheology)
.
65.
(Sedimentation rate)
.
.
.
methylcellulose
.
(Surfactant)
Aluminum
hydroxide gel USP 26
Aluminum hydroxide
HCl
0.05 M disodium
ethylendiamine
(diNaEDTA)
5
Alcohol
dithis.. TS
0.05 M Zn SO4
66.
H2-blocker
.
8-12 wk.
.
duodenal ulcer gastric
ulcer
.
H. pytori
.
. prototype
69.
. Lupeol
. Curcumin
. Stignasterol
. andrographolide
. hydroxyanthracens
70.
.
.
.
.
.
8
29
1-2
3-4
71.
. T
. C
. Migraine
. T
. M
72.
. Methylergotamine
. Sunatriptane
. Amitriptyhline
. Naproxen
. Verapamil
ergotamine Caffeine
100 mg .
73.
. 1-2
.
30
.
. 6
74. Ergothamine
. Alkaloids
. Flavonoids
. Phenolics
. Tannins
. Terpenoids
75.
ergotamine
erythomycin
. Absorption
.
. Distribution
.
. Biotransformation
76.
ergotamine
. HPLC
. Ultra-Violet spectophotometry
. Potentiometry
. fluorometry
. Polamography
77.
. 2-3
/
.
. 12 .
55
.
78.
. Indomethacin
. Ergotamine
. Sumatriptan
. Propranolol
. Verapamil
79.
. 6
. 6
.
80.
. Amitriptyline
. Fluoxetine
. Propranolol
. Ketotifen
9
58 BMI = 28 kg/m2
DM
.
.
.
.
.
82.
. glibenclamide
30
. aspirin
.
metforin .
. alcohol
glibenclamine
83.
Metformin
glaucoma
Metformin
. glucoside
. rosiglitazone
. Chlorpropamide
84.
glibenclamide
. glucagon
. Insulin
. Insulin
. somatostatin
85.
Glibenstermine
. desensitization of sulfonylureas
receptor
. up-regulation of sulfonylureas
receptor
. down-regulation of
sulfonylureas receptor
. hyperinsulinemia
. increase insulin sensitivity
86.
.
aspirin
.
metformin
.
isosorbide mononitrate
.
glibenclamide
.
87. 10
uniformity
125
mg. S (Sample standard
deviation) RSD (relative
standard deviation)
. 2%
. 3%
. 4%
. 5%
. 6%
88. aspirin
. faking
. paling
. picking
. mottling
. capping
89.
. .
.
.
.
.
90.
glibenclamide
. polarized
.
HPLC-UV detection
.
10
Ethinyl estradiol 30 g
+ Levonorgestrel 0.15 mg
5
18.00 .
91.
. Lynestrenol
. Levonorgestrel
. Ethinyl estradiol +
Levonorgestrel
. Ethinyl estradiol + Desogestrol
. Ethinyl estradiol + Gestodene
92.
3
2
30 + 2
.
.
.
Levonorgestrel 0.75 mg
20
HPLC Levonorgestrel
0.15 mcg/ml
1
2
3
ava s
rag d
e
stan 125 124 124 124 5
dar 000 000 500 500
d
sam 128 128 127 128 5
ple 000 500 500 00
94. Labeled amount
Levonorgestrel
. 98.8
. 99.8
. 100.8
. 101.8
. 102.8
95.
Levonorgestrel
. Identification
IR spectorphotometry
. Specific rotation
. Related substance
. UV analysis
. Loss on drying
96.
dose
. wet granulation
. dry granulation
. direct compression
. wet dry
granulation
. wet granulation
direct compression
97. Ethinyl estradiol
.
rifampin
.
corticosteroid
.
barbiturate
. phenyltoin
. aspirin
98. Ethinyl
estradiol + Levonorgestrel
. Ethinyl estradiol
estrogen
. Levonorgestrel
progestins
. Ethinyl estradiol
0.03 mg + Levonorgestrel 0.15
mg
biphasic combination 2
. Levonorgestrel
Ethinyl
estradiol
. Levonorgestrel isomer
Norgestrel
99.
2
- Lynestrenol
Norethindrone
. Lynestrenol
estrogen
. Norethindrone
progestins
. Norethindrone
androgenic effect
Testosterone
. Lynestrenol androgenic
effect Norethindrone
. C=CH
2
oxidation OH
ketone
100. ... .. 2510
1.
1.
2.
3.
over the
counter
4.
11
27
2-3
paracetamol Ibuprofen 1.
20
2.
Paracet 1-2
4-6
Ibuprofen 1
3
101.
Primary dysmenorrhea
1.
27
2.
3.
.
4. 2-3
5.
paracet Ibuprofen
102.
. Ibuprofen
.
Ibuprofen
.
Ibuprofen
103. Ibuprofen
1.Serotonin
2.
Prostaglandin
3.Cycloxygenase
4.Leukotriene
5.thromboxane
104.
Ibuprofen 1 .
mefenamic acid
hyoscine-n-butylbomide
3. estradiol+ levonorgertrel
4. orphenadine
5. tolperisone
105.
1. aspirine
2. colcicine
3. naproxen
4. celecoxib
5. mefenamic acid
106. major
metabolite paracetamol
1.
2.
3.
4.
5.
107.
108.
Ibuprofen
1.
2
2.
3.
4.
109.
Paracet
1. punch
(deep concave punch )
2. die
3.
4. hygroscopic
5.
110. Ibuprofen
1.
2.
3.
4.
5.
12
8 ..
1
para syrup amoxicillin
dry powder 3
..
..
111.
1.
2.
3.
1.
2.
3.
4.
5.
4.
5.
..
..
112. ..
/
113.
..
1.
2.
..
..
.. 9
..
9
DTP MMR
1 ..
114.
1.
2.
3.
..
4.
5.
115. DTP MMR Vaccine
1. DTP vaccine
MMR vaccine
2. DTP vaccine
MMR vaccine
/
3. DTP vaccine inactivated
vaccine MMR liveattenuated vaccine
4. DTP vaccine toxoid
MMR vaccine
subunit vaccine
5. DTP vaccine subunit
vaccine MMR vaccine
toxoid
1.
2.
3.
4.
5.
1.
2.
3.
4.
5.
1.
2.
3.
4.
5.
116.
117.
live-attenuated vaccine
118.
1.
2.
3.
4.
5.
119. .. 4
.. 1.
.. 2.
3.
Chlorphenimine maleate tablet 4.
Hydroxyzine HCI tablet
5.
Neomycin/bacitracin ointment
Calamine lotion
Prednisolone cream
1.
120. 2.
Cost Minimization Analysis
Cost Effectiveness Analysis
Cost benefit Analysis
Cost Utility Analysis
Cost outcome Description
13
22 75 kg. 155
cm
Diclofenac gel
121.
glucosamine sulfate
hydroxychloroquine
aruanofin
Prednisolone
methotrexate
122.
3.
4.
5. codeine para
123.
diclofinac emulsion gel
1. carbopol
2.
preservative
3.
1.
2.
3.
4.
5.
freeze- cycle
4. emulsion gel
cream
5. emulfying
agent
124.
diclofinac emulsion
gel
125.
126.
1.
opioid analgesic
NSAIDs
2. opioid analgesic
3. NSAIDs
4.
opioid analgesic
5. cox-2
cox-1
127.
cox-2 selective
inhibitor
cox-2 selective inhibitor
1.
Cox-2 inhibitor Carboxyl
group
enzyme cox-2
2. cox-2 inhibitor
cox-2
3. cox-2 inhibitor
cox-2/cox-1 Selective
ratio
4. cox-2 inhibitor
sulfonamide
5. cox-2 inhibitor
Cox-2
cox-1
128. Diclofenac pKa = 4.5
(pH=1) .
1000/1
100/1
1/1
1/1000
1/100
129.
Diclofenac injection 75 mg/3 ml
Dexanethasone injection
Methadone tablet 10 mg
Prednisolone tab 5 mg
Rofecoxib tab 25 mg
130.
... 2510
1. Diclofenac tab 25 mg
2
2. Piroxicam cap 10 mg
3. Tolperisone 50
mg Diclofenac 25 mg
1
4. Piroxicim 20mg
3
5. Rofecoxib 25 mg
1.
2.
14 3.
4.
45.
131.
1.
132.
2.
3.
4.
1.
2. 1.
steroid 2.
3. 3.
4.
4. 5.
Atropine
5.
(
)
133.
aqueos humer
1.
Timolol
. Pilocarpine
. Mannitol
. Thiazide
. Carbachol
134.
Solution
Suspension
Ointment
Cream
Ocular insert
137.
1.
170 C 2 .
2.
3.
1.
2.
3.
4.
5.
1.
2.
3.
4.
5.
sterile membrane
4. LAL test
5. E.coli
10 cfc/ml
138.
139.
24 .
5
7
1
3
140.
Diclofenac ED
Chloramphenicol eye ointment
Timolol ED
Dexamethazone ED
Tetracycline eye ointment\
15
triamcinolone 0. %
% by weight
Triamcinolone acetonide
0.1
Lanolin ( HLB for o/w)
1.0
Stearic acid ( HLB for o/w)
2.0
1.
Propylene glycol
2.
8.0
3.
Liquid paraffin ( HLB for o/w)
4.
5.0
5.
Tween 80 ( HLB for o/w)
2.5
141.
1.Breaking
2.Cracking
3.Caping
4.Phase inversion
5.
Phase seperation
142.
1.
2.
3.
4.
(emulsifier)
5.
1.9.5
2.10.75
3. 11.04
4.12.13
5.14.0
144.
o/w
Tween 80 : Span 80 = 8.43 : 2.87
Tween 80 : Span 80 = 2.87 : 8.43
Tween 80 : Span 80 = 15.0 : 3.7
Tween 80 : Span 80 = 3.7 : 15.0
Tween 80 : Span 80 = 1.5 : 2.5
145.
o/w
.
.
.
.
.
1.
( emulsifier
system) HLB
2.
( emulsifier
system) HLB
3.
( emulsifier
system) HLB
4.
( emulsifier
system) HLB
5.
( emulsifier
system) HLB
146. steroid
A. Hydrocortisone cream
2.5%
B. Clobatasol ointment
1.
0.05 %
2.
C. Triamcinolone 0.1%
D. Betametasone cream 3.
4.
B>D>C>A
5.
D>A>C>B
A>D>B>C
C>D>A>B
D>B>C>A
147.
glucocorticoids
.....
conjugated 3- ketone (b)11-OH
group (c)17 B ketol side
chain
acetonide 16
17
triamcinolone acetonide
1.
steroid
2. receptor
van der waal force
3.
lipophilicity
4.
hydrophiliciy
5. sodium retention
148.
triamcinolone acetonide
HPLC internal
standard fluoxymesterone
peak triamcinolone
peak fluoxymesterone
chromatogram
peak
flow rate
injection volume
column
guard column system
mobile
phase
149.
1.
triamcinolone lotion
2.
triamcinolone lotion
3.
triamcinolone
lotion
4.
1.
2.
3.
4.
5.
triamcinolone lotion
5.
150.
triamcinolone cream 0.1 %
15 g
49( 1)
1 Ishmic Hearth
Disease
HTN 5
HCTZ + Metoprolol
Lab BP 125/85
BUN Scr
1.
Metoprolol
-
heart attack
2. Metoprolol
5
3.
heart attack
- NTG
4. NTG
-
5.
NTG
1. ASSAY
2. Disolution
3. Dissintigration
4. Uniformity
6.
2 Asthma
Salbutamol MDI
PRN
1.
- GINA (
)
2.
1.
2.
3.
4.
5.
3. 2
- steroid
4.
- Oral thrush
6. Prednisolone
- special control
7.
- spacer
()
8.
MDI DPI (dry powder
inhaler)
- Turbuhaler
9. Evohaler
3 Glaucoma
Betaxolol
.
1.
5.
6.
7.
Compliance
8. .
9.
1.
2.
3.
4.
5.
4 Otitis Media
6
+
1.
- Strep pneumo.
2.
First choice
- Amoxycillin
3. Erythromycin
4.
Purified water
5. Preservative
- Paraben
6.
pseudoephedrine
7. Pseudoephedine
- P2
8.
- ..
9.
pseudoephedrine
10. 3
% LA
-
5 Anxiety /
Depression
1. -
2
1 .
2. Zolpidem
3.
Amitriptyline
4.
- Sertaline
5.
6. fluoxetine
-
7.
6 Parkisonism
?
levodopa/Carbidopa
Ibuprofen 400 mg
MTV
1.
Levodopa/Carbidopa
2.
On Off
3.
4.
Psychosis
MTV
5.
SAR
7 Oral
Contraceptives
1. Phyto
Estrogen
2. 3
3. EE
4. Progestogen
5.
-
6.
8 Primary
dysmennrhea +
+
5
1.
2.
3.
4.
Displcement Value = 2
1 20
5.
6.
9 Cysitis
1.
2.
3. Norfloxacin
4. 1 gr / 2 flz
-
5.
10 Gout
20 Lab
gout
1.
1.
2.
3.
4.
5.
2. gout attack
- Allopurinol
3.
5.
6.
Colchicine
-
7. Colchicine
8. K
Shelf-life
- 0.104/K
11 Diabetes
Miletus
2
Type II
2 Insulin
1.
- hypoglycemia
2. - Glucose
3. Shift electron
Chlopropamide
Tolbutamide
4. Insulin
-
5. Insulin
Glucagon
6. NPH
7. Insulin
8. Sulfonylurea
9.
Sulfonylurea
- Glipizide
Glipizide!?
10. Glipizide
1. Sulfonylurea----
2. Sulfone
11.
Scr
12.
13. Thiazolidinedione
Type I
-
14. Thiazolididione
- Hepatotoxicity
15.
12 Peptic Ulcer
3-5
1. Antacid
- 7
2.
3.
-
4. Antacid
5. GU, DU
6.
7. H2 Block
-
8. Triple therapy
- 3
9.
- curcumin
10.
13 Hypersensitivity
1. Type
2. Hydroxyzine 10 mg 1 x 3
3.
-
4.
5.
6.
7.
14 Vitamin A
Deficiency
5-6
1.
2.
-
3.
-
4.
- Cholestyramine
5. Cod liver oil
-
6. Preservative
7.
-
8. % RDA
RDA -
15 Vaccine and
Biologics
1.
-
Immunoglobulin
Immunoglobulin
tetanus
2.
3.
4.
5.
6.
7.
8.
9.
Imunoglobulin
-
Active HMI
5
2
-
5
6
Dry freeze
Pka
Pka
pH .
-
49( 2)
1 Heart Failure
HF
HCTZ
1.
2. HCTZ
- Gout
3. Cross allergy
Sulfa
HCTZ
4.
5. HCTZ
6.
HCTZ
7.
25 mg 1
1
- 30
2
Hyperlipidemia
Lab
LDL
+ Lab 7-8
1.
- atorvastatin
2.
Prodrug
3. Statin
- hepatotoxic
Lab
aminotransferrase
4. Gemfibrozil
5. Guideline
6.
7.
- CUA
3 DM
4 Renal
Diclofenac
1.
2.
-
3. Diclofenac
Lab
4. Diclofenac
5.
6.
7. -
8. -
-
5 HRT
1.
2.
vasomotor symptom
3.
EE
6 Osteoartritis
Glucosamine
40 40
1.
2.
OA
- ---,
,
3. /
OA
4. Glucosamine
5. Glucosamine
6. Calcium carbonate xx
mg / tab
calcium yyy mg
7.
Calcium
8. specific cox
2
7 Opportunistic
Infections
5.
6. CI 1
significant
8
.
1.
2. - ketoconazole
3. - 200 mg OD
4. Ketoconazole
-
5.
5
6. Ketoconazole
- CMA
7. pKa pH %
9
+ Lab +
+BSA
1. BSA
2. BSA
10 Pregnancy
1. Isotretinoin cat - X
2. teratogenic
3. Insulin
4.
5.
11 Allergy
1. Mediator
2.
3.
- CPM
4.
- 4
Low
5.
3
6.
7.
Cetyl acohol
12 Migraine
1.
Rofecoxib
2.
3. Ergotamine
4. Ergotamine
5.
13 Bacteria
Pharyngitis
Amoxy
1. -
2.
3. Rhinitis
medicament
4. 4
14 Bacteria
conjunctivitis
1.
2.
3.
meq/L
15 Diarrhea
2
1. Loperamide
2.
-
3. 5 anova
Article 1.
1. Thiethanolamine
2. Zeta Potential
3. Rx
X 0.5 ml E = 0.23, NaCl x ml
E = 0.1, q.s water 100 ml, Mft ad 30
ml X
4. NaCl 0.45 % 500 ml
meq
5.
6.
7. Theobroma oil
8.
9. 8
Assay .
1.
2. Science
Care
3.
4. Law
5. Econ 2 Epidermio
1 Research 1
6. medchem assay
50 ( 1)
Case 1 PU
1. cisapride
Case 2 vaccine
1. vac. .......
(BCG)
2. vac.
3. vac.
4. DTP
( 40
)
vac.
5. pt.
rabies vac.
choice
1. + betadine
2. + tetanus
3. + rabies
6.
vac.
Case 3 Migraine
1. (
case with or
without aura)
Case
pt.
metoclopramide + Ibuprofen
2. metoclopramide
3.
Case 4 Cystitis
Pt.
1.
2. pt.
Pt.
1
3.
4. pt.
5.
capsule
Case 5 Cancer
Pt. CHOP regimen
, . pt.
s/e
Case 6 renal
Pt. lab
(
urine)
1. (
prerenal, intrinsic
BUN/Scr >20:1
)
2. lab
hypokalemia , azotemia
3.
(poly / oligo /
normal/ anuria/.)
urine
Case 7 Bacterial conjunctivitis
1. isotonic
2. isotonic
hypo / hyper / isotonic
RBC
Case 8 Acne case
Case 9 Asthma
Case 10 Allergic rhinitis
Case 11 DM 2
50 ( 2)
Case 1
1.
choice
2.
KMnO4
3. pt.
( case)
4. DV
5.
Pt.
.
15 3
1. Pco
2.
3.
GI
4.
5. .
6.
2
Case 2 Hypothyroid
Lab
FT4 TSH
1.
2. /
(Myxo)
3. /
(Hashimoto.)
4. drug of choice
(levothyroxine)
5.
receptor
(I
,
D L
DL form)
6.
( T3
3 5
.......)
7. (
choice
therapy
TSH
4-6
)
Case 3 Glaucoma
Pt.
1. pt.
2.
pt. ,
3. /
( )
4.
pt.
5. sterile
6.
...........
7. , pKa
atropine, atropine sulfate
(
pH
/
pKa )
Case 4 Depression
(
3-4 )
fluoxetine /
amitrip.
pt.
1.
2. (
)
3. SSRIs
..............
4.
( fluoxetine
MCQ & OSPE )
Case 5 Toxicology
Pt.
para.
1.
2. Antidote
3. func. Group
antidote
4.
(
effervescent )
5. Dead mixture
Case 6 DM + hyperlipidemia
1. pt. 2
2. NPH
intermediate
3. pt.
(
)
Case 7 HIV + TB
Pt.
1. Opportunistic infection
2.
CD4/ CD8
????
3.
metabolic ( PIs)
abacarvir
NRTIs
Case 8
1. Calamine
lotion
........
2.
1.
2.
3. Emulsifier
4.
flocculating
5.
Case 9 /
Case 10 Traveler diarrhea
(,
)
Case 11 HRT
Case 12 HTN
Case 13 RA + OA
Case 14 Sinusitis
Case 15 URI
Ospe
2551
( )
3-4
( 49
3),
MCQ