unnamed protein product [synthetic construct]

GenBank: CAL40517.1 FASTA Graphics Go to:

LOCUS 2006 DEFINITION ACCESSION VERSION DBSOURCE KEYWORDS SOURCE ORGANISM CAL40517 660 aa linear PAT 08-SEPunnamed protein product [synthetic construct]. CAL40517 CAL40517.1 GI:114211527 embl accession CS405716.1 . synthetic construct synthetic construct other sequences; artificial sequences. REFERENCE 1 AUTHORS Chambon,P. and Metzger,D. TITLE No title supplied JOURNAL Patent: EP 1692936-A1 23-AUG-2006; GIE-CERBM, Centre Europeen de Recherche en Biologie et en Medecine (FR) FEATURES Location/Qualifiers source 1..660 /organism="synthetic construct" /db_xref="taxon:32630" Protein 1..660 /name="unnamed protein product" CDS 1..660 /coded_by="CS405716.1:1..1983" /note="Chimeric sequence Homosapiens-Bacteriophage P1" /transl_table=11 ORIGIN 1 msnlltvhqn lpalpvdats devrknlmdm frdrqafseh twkmllsvcr swaawcklnn 61 rkwfpaeped vrdyllylqa rglavktiqq hlgqlnmlhr rsglprpsds navslvmrri 121 rkenvdager akqalafert dfdqvrslme nsdrcqdirn laflgiaynt llriaeiari 181 rvkdisrtdg grmlihigrt ktlvstagve kalslgvtkl verwisvsgv addpnnylfc 241 rvrkngvaap satsqlstra legifeathr liygakddsg qrylawsghs arvgaardma 301 ragvsipeim qaggwtnvni vmnyirnlds etgamvrlle dgdlepsagd mraanlwpsp 361 lmikrskkns lalsltadqm vsalldaepp ilyseydptr pfseasmmgl ltnladrelv 421 hminwakrvp gfvdltlhdq vhllecawle ilmiglvwrs mehpgkllfa pnllldrnqg 481 kcvegmveif dmllatssrf rmmnlqgeef vclksiilln sgvytflsst lksleekdhi 541 hrvldkitdt lihlmakagl tlqqqhqrla qlllilshir hmsnkgmehl ysmkcknvvp 601 lydllleaad ahrlhaptsr ggasveetdq shlatagsts shslqkyyit geaegfpata

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heat shock protein [Cryptosporidium meleagridis]

GenBank: BAI81975.1
LOCUS 2010 DEFINITION ACCESSION VERSION DBSOURCE KEYWORDS SOURCE ORGANISM BAI81975 623 aa linear INV 10-MAR-

heat shock protein, partial [Cryptosporidium meleagridis]. BAI81975 BAI81975.1 GI:290784596 accession AB539713.1 . Cryptosporidium meleagridis Cryptosporidium meleagridis Eukaryota; Alveolata; Apicomplexa; Coccidia; Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium. REFERENCE 1 AUTHORS Abe,N. TITLE Genotype Analysis of Cryptosporidium meleagridis Isolates from Humans in Japan JOURNAL Jpn. J. Infect. Dis. 63 (3), 214-215 (2010) PUBMED 20495279 REFERENCE 2 (residues 1 to 623) AUTHORS Abe,N. TITLE Direct Submission JOURNAL Submitted (25-DEC-2009) Contact:Niichiro Abe Osaka City Institute of Public Health and Environmental Sciences; 8-34 Tojo-cho, Tennoji-ku, Osaka, Osaka 543-0026, Japan FEATURES Location/Qualifiers source 1..623 /organism="Cryptosporidium meleagridis" /isolate="CP-127" /isolation_source="fecal sample from a patient" /host="Homosapiens" /db_xref="taxon:93969" /country="Japan:Osaka" Protein <1..>623 /product="heat shock protein" Region 1..588 /region_name="PTZ00009" /note="heat shock 70 kDa protein; Provisional" /db_xref="CDD:185395" CDS 1..623 /gene="HSP" /coded_by="AB539713.1:<1..>1872" /codon_start=3 ORIGIN 1 vpndqgnrtt psyvaftete rligdaaknq varnpentvf dakrligrkf ddqavqsdmt 61 hwpfkvvrgp kdkpiisvsy lgekkefhae eisamvlqkm keiseaylgr piknavvtvp 121 ayfndsqrqa tkdagaiagl nvmriinept aaaiaygldk kgtgernvli fdlgggtfdv 181 slltiedgif evkatagdth lggedfdnrl vefcvqdfkr knrgmdlttn aralrrlrtq 241 cerakrtlss stqatields lyegidysva vsrarfeelc adyfratlap vekvlkdagm 301 dkrsvhdvvl vggstripkv qaliqeffng kepckainpd eavaygaavq aailngeqss 361 avqdlllldv aplslgleta ggvmtklier nttipakktq vfttyadnqs gvliqvyege 421 ramtkdnhll gkfhldgipp aprgvpqiev tfdidangil nvsavdkstg ksskititnd

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481 kgrlskddie rmvndaekyk gedeqnrlki eaknslenyl ynmrntiqep kvkeklsqse 541 ideaekkikd aldwlehnqt aekdefehqq keieahmnpl mmkiysaegg mpggmpggmp 601 ggmpggmpgg mpggmpggmp ggm

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LPSg_P22 LPS stimulated Chicken PBL Macrophage Gallus gallus cDNA clone LPSg_P22 5- similar to GP|13241761|gb|AAK16442.1 transmembraneprotein induced by tumor necrosis factor alpha {Homosapiens}, partial (97%), mRNA sequence

GenBank: CK614695.1 GenBank FASTA

IDENTIFIERS dbEST Id: EST name: GenBank Acc: GenBank gi: CLONE INFO Clone Id: DNA type: PRIMERS PCR forward: PCR backward: PolyA Tail: SEQUENCE 21460334 LPSg_P22 CK614695 41335753 LPSg_P22 (5') cDNA T3 T7 Unknown AACCCTCACTNAGGGATTTCCGCACGAGGCTACAGACCACCCTTGTGCCTTGCAGGCTGG GGATAGTGGAACCTGGCAGGTTTGGTGCGAGGGCACAGTGTGGGGCAGTGATCTGCTCTC ATCCCTCTCCTACTGTTGGACCCTCTCTAGGGCTGACTCCTGTGCCCTGTGCTGTCACTA AATGACCACGGGCTGCTGCTTGAGGAAAAGGCAGAGCCTGCACCCGGCCAGGACCTGCAG GCACCCCCCTTTCCCCTGCAGCCCTCCTGTGCTCCAGCACTCAACAGGGCTGGGGGCAGC TCCTCTCCCCTCCCCACAAACCCGGTCTGGGGTCACAGCTGCAGGGTCCTGCTGGCTCCT TTGGGCCCTGCAACCAACAGCTCCCCTGTTCCCAACCCCTCTGCCACGCTGTGTACACTC TTTTTTAAAGAATACTGTTTTTGTTTCAATATCTTTGTGATTTTAATCATGGAAGA

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d1e02fs.r1 Fusarium sporotrichioides Tri 10 overexpressed cDNA library Fusarium sporotrichioides cDNA clone d1e02fs 5-, mRNA sequence
GenBank: BI188571.1 GenBank FASTA
IDENTIFIERS dbEST Id: EST name: GenBank Acc: GenBank gi: CLONE INFO Clone Id: Source: 8983186 d1e02fs.r1 BI188571 14662250

d1e02fs (5') Marian N. Beremand, Texas A&M University, m-beremand@tamu.edu Other ESTs on clone:d1e02fs.f1 DNA type: cDNA PRIMERS Sequencing: PolyA Tail: SEQUENCE T3 Unknown TTTCTCCTCTCACTCACTCTTATAATCCCCTGAGAACAGCTTTCTCTCGCTTTCGTCTCC TTCGTCTGTCTTTCGTTACCGGTATTGCGCCCGTTTCAACTCAGCTCATCTCGTCAACGA ATATTGGTACCTTCGCCGCCACCAGCCTATCTGTATAACCCCAGTCGAGCAATCCCGAGT ACTCGCTCGATCCGTGGTCAAGACCCCATTAAACAAACGATTCTCTACAGCAATTAGACT ATCTGTCCACCATCCCCAGGTTTTCATCTTATTGCACTCGGCTTGGCTGCACCAGTTCCA CAAACAACCGAAATACAGGGCAGACAGGGCATTTCGAGATAACGACTTTCATTGATCCCG GCCTTCGAAAGGAACCTTCAACTCCATTCCATCGTTTCTTAGTGACTCGTCAACACGCGA GACCCCACCACGAGCTTCATACCCCTGTGCGTCAAAGCCAGCGCGGTTGAGTCTGAGTCT GAGCAG High quality sequence stops at base: 388 Jul 10 2001 Jul 10 2001 Contact Dr. Marian Beremand regarding clone availability Included is the best homolog from a blastx search of Genbank nr 04-09-01 74 2.1 gi|9966797|ref|NP_06 phospholipid scramblase 3 [Homosapiens]gb| LIBRARY

Quality: Entry Created: Last Updated: COMMENTS

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Lib Name: Organism: Strain: Vector: R. Site 1: R. Site 2: Description: SUBMITTER Name: Lab: Institution: Address: Tel: Fax: E-mail: CITATIONS Title: Authors: Year: Status:

LIBEST_005598 Fusarium sporotrichioides Tri 10 overexpressed cDNA library Fusarium sporotrichioides Tri 10 pBlueScript SKEcoRI XhoI 5' end of cDNA cloned into EcoRI site of pBluescript; 3' end of cDNA cloned into XhoI site of pBluescript Bruce A. Roe, University of Oklahoma, broe@ou.edu Department of Chemistry and Biochemistry Advanced Center for Genome Technology, University of Oklahoma 620 Parrington Oval, Norman, OK 73019, USA 405 325 4912 405 325 7762 broe@ou.edu Analysis of a Fusarium sporotrichioides EST database Ren,Q., Tag,A., Peplow,A., Lai,H., Kupfer,C., Peterson,A., Beremand,M., Roe,B. 2001 Unpublished

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Homo sapiens mitogen-activated protein kinase kinase 2, mRNA (cDNA clone MGC:8600 IMAGE:2961198), complete cds
GenBank: BC000471.2 FASTA Graphics Go to:
LOCUS 2006 DEFINITION BC000471 1759 bp mRNA linear PRI 15-JULHomo sapiens mitogen-activated protein kinase kinase 2, mRNA (cDNA clone MGC:8600 IMAGE:2961198), complete cds. ACCESSION BC000471 VERSION BC000471.2 GI:33875487 KEYWORDS MGC. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1759) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CONSRTM Mammalian Gene Collection Program Team TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 1759) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (15-NOV-2000) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT On Aug 19, 2003 this sequence version replaced gi:12653402.

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Contact: MGC help desk Email: cgapbs-r@mail.nih.gov Tissue Procurement: ATCC cDNA Library Preparation: Rubin Laboratory cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL) DNA Sequencing by: National Institutes of Health Intramural Sequencing Center (NISC), Gaithersburg, Maryland; Web site: http://www.nisc.nih.gov/ Contact: nisc_mgc@nhgri.nih.gov Akhter,N., Ayele,K., Beckstrom-Sternberg,S.M., Benjamin,B., Blakesley,R.W., Bouffard,G.G., Breen,K., Brinkley,C., Brooks,S., Dietrich,N.L., Granite,S., Guan,X., Gupta,J., Haghighi,P., Hansen,N., Ho,S.-L., Karlins,E., Kwong,P., Laric,P., Legaspi,R., Maduro,Q.L., Masiello,C., Maskeri,B., Mastrian,S.D.,McCloskey,J.C., McDowell,J., Pearson,R., Stantripop,S., Thomas,P.J., Touchman,J.W., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D., Wiggins,L., Young,A., Zhang,L.-H. and Green,E.D. Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAL Plate: 1 Row: l Column: 15 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi:

33469146.

Differences found between this sequence and the human reference genome (build 36) are described in misc_difference features below and these differences were also compared to chimpanzee genome (build 2). FEATURES Location/Qualifiers source 1..1759 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="MGC:8600 IMAGE:2961198" /tissue_type="Muscle, rhabdomyosarcoma" /clone_lib="NIH_MGC_17" /lab_host="DH10B-R" /note="Vector: pOTB7" gene 1..1759 /gene="MAP2K2" /gene_synonym="MAPKK2" /gene_synonym="MEK2" /gene_synonym="MKK2" /db_xref="GeneID:5605" /db_xref="HGNC:6842" /db_xref="MIM:601263" CDS 255..1457 /gene="MAP2K2" /gene_synonym="MAPKK2" /gene_synonym="MEK2" /gene_synonym="MKK2" /codon_start=1 /product="mitogen-activated protein kinase kinase 2" /protein_id="AAH00471.1" /db_xref="GI:12653403" /db_xref="GeneID:5605"

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EL KL LK GQ LE LP QP

/db_xref="HGNC:6842" /db_xref="MIM:601263" /translation="MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLE ELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMAR IHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV EAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVS LIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKE AIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPK NGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLN

GTPTRTAV" genomic sequence and not the cDNA." misc_difference 1735..1759 /gene="MAP2K2" /gene_synonym="MAPKK2" /gene_synonym="MEK2" /gene_synonym="MKK2" /note="polyA tail: 25 bases do not align to genome." ORIGIN 1 cccctgcctc tcggactcgg gctgcggcgt cagccttctt cgggcctcgg 61 ggctcgctcg cctcagcccc agcgcccctc ggctaccctc ggcccaggcc 121 cccgccctcg gccgccccga cgccggcctg ggccgcggcc gcagccccgg 181 gcgccgaccg ctcccggccc gccccctatg ggccccggct agaggcgccg 241 cccgcggagc cccgatgctg gcccggagga agccggtgct gccggcgctc 301 ctaccatcgc cgagggccca tcccctacca gcgagggcgc ctccgaggca 361 acctgcagaa gaagctggag gagctggaac ttgacgagca gcagaagaag 421 cctttctcac ccagaaagcc aaggtcggcg aactcaaaga cgatgacttc 481 cagagctggg cgcgggcaac ggcggggtgg tcaccaaagt ccagcacaga 541 tcatcatggc caggaagctg atccaccttg agatcaagcc ggccatccgg 601 tccgcgagct gcaggtcctg cacgaatgca actcgccgta catcgtgggc 661 ccttctacag tgacggggag atcagcattt gcatggaaca catggacggc 721 accaggtgct gaaagaggcc aagaggattc ccgaggagat cctggggaaa 781 cggttctccg gggcttggcg tacctccgag agaagcacca gatcatgcac 841 agccctccaa catcctcgtg aactctagag gggagatcaa gctgtgtgac 901 gcggccagct catagactcc atggccaact ccttcgtggg cacgcgctcc 961 cggagcggtt gcagggcaca cattactcgg tgcagtcgga catctggagc 1021 ccctggtgga gctggccgtc ggaaggtacc ccatcccccc gcccgacgcc 1081 aggccatctt tggccggccc gtggtcgacg gggaagaagg agagcctcac 1141 ctcggccgag gccccccggg cgccccgtca gcggtcacgg gatggatagc 1201 tggccatctt tgaactcctg gactatattg tgaacgagcc acctcctaag 1261 gtgtgttcac ccccgacttc caggagtttg tcaataaatg cctcatcaag 1321 agcgggcgga cctgaagatg ctcacaaacc acaccttcat caagcggtcc 1381 aagtggattt tgccggctgg ttgtgtaaaa ccctgcggct gaaccagccc 1441 cgcgcaccgc cgtgtgacag tggccgggct ccctgcgtcc cgctggtgac 1501 tccctgtcca tgccccgccc ttccagctga ggacaggctg gcgcctccac 1561 gcctcacccc tgcggagagc accgtggcgg ggcgacagcg catgcaggaa 1621 ctctcctgcc cgtcctggcc ggggtgcctc tggggacggg cgacgctgct 1681 tcagaggctc tgcttcctta ggttacaaaa caaaacaggg agagaaaaag 1741 aaaaaaaaaa aaaaaaaaa

the human cagcggtagc cgcagcgccg gctcgcgtag ccgccgccgg accatcaacc aacctggtgg cggctggaag gaaaggatct ccctcgggcc aaccagatca ttctacgggg ggctccctgg gtcagcatcg cgagatgtga ttcggggtga tacatggctc atgggcctgt aaagagctgg agcatctcgc cggcctgcca ctgcccaacg aacccagcgg gaggtggaag ggcacaccca ctgcccaccg ccaccctcct cgggggtctc gtgtgtggtc caaaaaaaaa

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Homo sapiens mitogen-activated protein kinase kinase 2 pseudogene, mRNA (cDNA clone IMAGE:5296643)
GenBank: BC067760.1 FASTA Graphics Go to:
LOCUS 2008 DEFINITION BC067760 1696 bp mRNA linear PRI 18-DECHomo sapiens mitogen-activated protein kinase kinase 2 pseudogene, mRNA (cDNA clone IMAGE:5296643). ACCESSION BC067760 VERSION BC067760.1 GI:45709597 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1696) AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A. CONSRTM Mammalian Gene Collection Program Team TITLE Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) PUBMED 12477932 REFERENCE 2 (bases 1 to 1696) CONSRTM NIH MGC Project TITLE Direct Submission JOURNAL Submitted (19-MAR-2004) National Institutes of Health, Mammalian Gene Collection (MGC), Bethesda, MD 20892-2590, USA REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov COMMENT Contact: MGC help desk Clone distribution: MGC clone distribution information can be found through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov Series: IRAK Plate: 168 Row: d Column: 10 This clone was selected for full length sequencing because it passed the following selection criteria: matched mRNA gi: 21614527. Differences found between this sequence and the human reference genome (build 36) are described in misc_difference features below and these differences were also compared to chimpanzee genome (build 2). FEATURES Location/Qualifiers source 1..1696

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/organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /clone="IMAGE:5296643" /tissue_type="Testis" /clone_lib="NIH_MGC_97" /lab_host="DH10B" /note="Vector: pBluescriptR" misc_difference 3 /note="'T' in cDNA is 'C' in the human genome. The chimpanzee genome agrees with the human genomic sequence and not the cDNA." misc_difference 882 /note="'A' in cDNA is 'G' in the human genome; amino acid difference: 'M' in cDNA, 'V' in the human genome. The chimpanzee genome agrees with the human genomic sequence and not the cDNA." misc_difference 1694..1696 /note="3 bases at the 3' end do not align to the human genome." ORIGIN 1 agtggcggcg gctcgctcgc ctcagcccca gcgcccctcg gctaccctcg gaccaggccc 61 gcagcgccgc ccgccctcgg ccgccccgac gccggcctgg gccgcggtcg cagccccggg 121 ctcgcgtagg cgccgaacgc tcccggcccg cccactacgg gcccaggcta gaggcgccgc 181 cgccaccggc ccgcggagcc cggatgctgg cccggaggaa gccgatgctg ccggcgctca 241 ccatcaaccc taccatcgcc gagggcccgt ccccaaccag cgagggcgcc tccgaggcaa 301 acctggtgga cctgcagaag aagctggagg agctggaact tgacgagcag cagaagcggc 361 tggaagcctt tctcacccag aaagccaagg tcggcgaact caaagacgat gacttcgaaa 421 ggacctcaga gctggacgcg ggcaacggcg gggtggtcac caaagtccag cacagaccct 481 cgggcctcat catggccagg aagctgatcc accttgagat caagccggcc atccggaacc 541 agatcatccg cgagcaccag gtcctgcacg agtgcaactc accgtacatc gtgggcttct 601 acggggcctt ctactgtgac agggagatca gcatctgcat ggagcacatg gatggcggct 661 ccctggacca ggggctgaaa gaggccaaga ggattcccga ggacatcctg gggaaagtca 721 gcattgcggt tctccggggc ttggcgtacc tccgagagaa gcaccagatc atgcaccgaa 781 atgtgaagcc ctccaacatc ctcgtgaact ctagagggga gatcaagctg tgtgacttcg 841 gggtgagcgg ccagctcatc gactccatgg ccaactcctt catgggcacg cgctcctaca 901 tggctccgga gcggttgcag ggcacacatt actcggtgca gtcggtcatc tggagcatgg 961 acctgtccct ggtggagctg gccatcgaaa ggtaccccat ccccccgccc gacgccaagg 1021 agctggaggc catctttggc cagcccgtgg tcgacaggga agaaggagag cctcacagca 1081 tctcctcttg gccagggtcc cccgggcgcc ccaacagcgg ttacgggatg gacagcctgc 1141 ccgccatggc catcttcgaa ctgctggact atattgtgaa agagccgcct cctaagctgc 1201 ccaacggtgt gttcaccccc gacttccagg agtttgtcaa taaatgcctc atcaaaaacc 1261 caacggagcg ggcggaccta aagatgctca caaaccacgc cttcatcaag cggtccgagg 1321 tgaaagaagc ggattttgcc tgctagttgt gtaaaaccct ggggctgaac cagcccggca 1381 cacccacgcg caccgccgtg taacagtggc caggctcccc gcgtcccgct ggtgacctgc 1441 ccaccgtccc tgtccacgcc ccgcccttcc agctgaggac aggctggcgc ctccacccac 1501 cctcctgcct cacccctgcg gagagcaccg tggcggggcg acaactgcgc acgcaggaac 1561 gggggtctcc tctcctgctg gtccctgccg gcgtgcctct agggacgggc gacgctgctg 1621 tgtgtggtct cagagcctct gcttccttag gttacaaaac aaaacaggga gagaaaaacc 1681 aaaaaaaaaa aaaaaa

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Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), mRNA

NCBI Reference Sequence: NM_030662.2

This sequence has been updated. See current version.

FASTA Graphics Go to:

LOCUS 2008 DEFINITION ACCESSION VERSION KEYWORDS SOURCE ORGANISM NM_030662 1759 bp mRNA linear PRI 16-MARHomo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2), mRNA. NM_030662 NM_030662.2 GI:21614527 . Homo sapiens (human) Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. 1 (bases 1 to 1759) Schulz,A.L., Albrecht,B., Arici,C., van der Burgt,I., Buske,A., Gillessen-Kaesbach,G., Heller,R., Horn,D., Hubner,C.A., Korenke,G.C., Konig,R., Kress,W., Kruger,G., Meinecke,P., Plecko,B., Rossier,E., Schinzel,A., Schulze,A., Seemanova,E., Seidel,H., Spranger,S., Tuysuz,B., Uhrig,S., Wieczorek,D., Kutsche,K. and Zenker,M. Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome Clin. Genet. 73 (1), 62-70 (2008) 18042262 GeneRIF: the results of HRAS, BRAF and MAP2K1/2 mutation screening in a large cohort of patients with CS and CFC 2 (bases 1 to 1759) Nava,C., Hanna,N., Michot,C., Pereira,S., Pouvreau,N., Niihori,T., Aoki,Y., Matsubara,Y., Arveiler,B., Lacombe,D., Pasmant,E., Parfait,B., Baumann,C., Heron,D., Sigaudy,S., Toutain,A., Rio,M., Goldenberg,A., Leheup,B., Verloes,A. and Cave,H. Cardio-facio-cutaneous and Noonan syndromes due to mutations in RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome J. Med. Genet. 44 (12), 763-771 (2007) 17704260 GeneRIF: 3 novel mutations for MEK2 (L46_E55del, K61T, A62P) were identified in 15 patients with cardio-facio-cutaneous syndrome. 3 (bases 1 to 1759) Razzaque,M.A., Nishizawa,T., Komoike,Y., Yagi,H., Furutani,M., Amo,R., Kamisago,M., Momma,K., Katayama,H., Nakagawa,M., Fujiwara,Y., Matsushima,M., Mizuno,K., Tokuyama,M., Hirota,H., Muneuchi,J., Higashinakagawa,T. and Matsuoka,R.

REFERENCE AUTHORS Mucke,J.,

TITLE JOURNAL PUBMED REMARK REFERENCE AUTHORS

TITLE the JOURNAL PUBMED REMARK REFERENCE AUTHORS

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TITLE Germline gain-of-function mutations in RAF1 cause Noonan syndrome JOURNAL Nat. Genet. 39 (8), 1013-1017 (2007) PUBMED 17603482 REFERENCE 4 (bases 1 to 1759) AUTHORS Scholl,F.A., Dumesic,P.A., Barragan,D.I., Harada,K., Bissonauth,V., Charron,J. and Khavari,P.A. TITLE Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia JOURNAL Dev. Cell 12 (4), 615-629 (2007) PUBMED 17419998 REMARK GeneRIF: Mek1/2 are functionally redundant in the epidermis, where they act as a linear relay in the MAPK pathway to mediate development and homeostasis. REFERENCE 5 (bases 1 to 1759) AUTHORS Leelawat,K., Leelawat,S., Narong,S. and Hongeng,S. TITLE Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion JOURNAL World J. Gastroenterol. 13 (10), 1561-1568 (2007) PUBMED 17461449 REMARK GeneRIF: These results indicated that the activation of CXCR4 and its signaling pathways (MEK1/2 and Akt) are essential for CXCL12-induced cholangiocarcinoma cell invasion. REFERENCE 6 (bases 1 to 1759) AUTHORS Derijard,B., Raingeaud,J., Barrett,T., Wu,I.H., Han,J., Ulevitch,R.J. and Davis,R.J. TITLE Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms JOURNAL Science 267 (5198), 682-685 (1995) PUBMED 7839144 REMARK Erratum:[Science 1995 Jul 7;269(5220):17] REFERENCE 7 (bases 1 to 1759) AUTHORS Alessi,D.R., Saito,Y., Campbell,D.G., Cohen,P., Sithanandam,G., Rapp,U., Ashworth,A., Marshall,C.J. and Cowley,S. TITLE Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1 JOURNAL EMBO J. 13 (7), 1610-1619 (1994) PUBMED 8157000 REFERENCE 8 (bases 1 to 1759) AUTHORS Zheng,C.F. and Guan,K.L. TITLE Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases JOURNAL J. Biol. Chem. 268 (32), 23933-23939 (1993) PUBMED 8226933 REFERENCE 9 (bases 1 to 1759) AUTHORS Charest,D.L., Mordret,G., Harder,K.W., Jirik,F. and Pelech,S.L. TITLE Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1 JOURNAL Mol. Cell. Biol. 13 (8), 4679-4690 (1993) PUBMED 7687743 REFERENCE 10 (bases 1 to 1759) AUTHORS Zheng,C.F. and Guan,K.L. TITLE Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2 JOURNAL J. Biol. Chem. 268 (15), 11435-11439 (1993) PUBMED 8388392 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000471.2. [WARNING] On May 1, 2008 this sequence was replaced by gi:187171274.

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On Jun 26, 2002 this sequence version replaced gi:13489053. Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. COMPLETENESS: complete on the 3' end. FEATURES Location/Qualifiers source 1..1759 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="19" /map="19p13.3" gene 1..1759 /gene="MAP2K2" /gene_synonym="MAPKK2; MEK2; MKK2; PRKMK2" /note="mitogen-activated protein kinase kinase 2" /db_xref="GeneID:5605" /db_xref="HGNC:6842" /db_xref="HPRD:03164" /db_xref="MIM:601263" exon 1..346 /gene="MAP2K2" /gene_synonym="MAPKK2; MEK2; MKK2; PRKMK2" /inference="alignment:Splign" /number=1 CDS 255..1457 /gene="MAP2K2" /gene_synonym="MAPKK2; MEK2; MKK2; PRKMK2" /EC_number="2.7.1.-" /note="mitogen-activated protein kinase kinase 2, p45; MAP kinase kinase 2; MAPK/ERK kinase 2; dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; CFC syndrome" /codon_start=1 /product="mitogen-activated protein kinase kinase 2" /protein_id="NP_109587.1" /db_xref="GI:13489054" /db_xref="CCDS:CCDS12120.1" /db_xref="GeneID:5605" /db_xref="HGNC:6842" /db_xref="HPRD:03164" /db_xref="MIM:601263" /translation="MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLE EL ELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMAR KL IHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQV LK EAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVS GQ

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LE LP QP exon

LIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKE AIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPK NGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLN GTPTRTAV" 347..557 /gene="MAP2K2" /gene_synonym="MAPKK2; MEK2; MKK2; PRKMK2" /inference="alignment:Splign" /number=2 558..704 /gene="MAP2K2" /gene_synonym="MAPKK2; MEK2; MKK2; PRKMK2" /inference="alignment:Splign" /number=3 705..782 /gene="MAP2K2" /gene_synonym="MAPKK2; MEK2; MKK2; PRKMK2" /inference="alignment:Splign" /number=4 783..834 /gene="MAP2K2" /gene_synonym="MAPKK2; MEK2; MKK2; PRKMK2" /inference="alignment:Splign" /number=5 835..959 /gene="MAP2K2" /gene_synonym="MAPKK2; MEK2; MKK2; PRKMK2" /inference="alignment:Splign" /number=6 960..1173 /gene="MAP2K2" /gene_synonym="MAPKK2; MEK2; MKK2; PRKMK2" /inference="alignment:Splign" /number=7 1174..1238 /gene="MAP2K2" /gene_synonym="MAPKK2; MEK2; MKK2; PRKMK2" /inference="alignment:Splign" /number=8 1239..1300 /gene="MAP2K2" /gene_synonym="MAPKK2; MEK2; MKK2; PRKMK2" /inference="alignment:Splign" /number=9 1301..1346 /gene="MAP2K2" /gene_synonym="MAPKK2; MEK2; MKK2; PRKMK2" /inference="alignment:Splign" /number=10 1347..1734 /gene="MAP2K2" /gene_synonym="MAPKK2; MEK2; MKK2; PRKMK2" /inference="alignment:Splign" /number=11 1734 /gene="MAP2K2" /gene_synonym="MAPKK2; MEK2; MKK2; PRKMK2" /experiment="experimental evidence, no additional details

exon

exon

exon

exon

exon

exon

exon

exon

exon

polyA_site

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ORIGIN 1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 cccctgcctc ggctcgctcg cccgccctcg gcgccgaccg cccgcggagc ctaccatcgc acctgcagaa cctttctcac cagagctggg tcatcatggc tccgcgagct ccttctacag accaggtgct cggttctccg agccctccaa gcggccagct cggagcggtt ccctggtgga aggccatctt ctcggccgag tggccatctt gtgtgttcac agcgggcgga aagtggattt cgcgcaccgc tccctgtcca gcctcacccc ctctcctgcc tcagaggctc aaaaaaaaaa

recorded" tcggactcgg cctcagcccc gccgccccga ctcccggccc cccgatgctg cgagggccca gaagctggag ccagaaagcc cgcgggcaac caggaagctg gcaggtcctg tgacggggag gaaagaggcc gggcttggcg catcctcgtg catagactcc gcagggcaca gctggccgtc tggccggccc gccccccggg tgaactcctg ccccgacttc cctgaagatg tgccggctgg cgtgtgacag tgccccgccc tgcggagagc cgtcctggcc tgcttcctta aaaaaaaaa gctgcggcgt agcgcccctc cgccggcctg gccccctatg gcccggagga tcccctacca gagctggaac aaggtcggcg ggcggggtgg atccaccttg cacgaatgca atcagcattt aagaggattc tacctccgag aactctagag atggccaact cattactcgg ggaaggtacc gtggtcgacg cgccccgtca gactatattg caggagtttg ctcacaaacc ttgtgtaaaa tggccgggct ttccagctga accgtggcgg ggggtgcctc ggttacaaaa cagccttctt ggctaccctc ggccgcggcc ggccccggct agccggtgct gcgagggcgc ttgacgagca aactcaaaga tcaccaaagt agatcaagcc actcgccgta gcatggaaca ccgaggagat agaagcacca gggagatcaa ccttcgtggg tgcagtcgga ccatcccccc gggaagaagg gcggtcacgg tgaacgagcc tcaataaatg acaccttcat ccctgcggct ccctgcgtcc ggacaggctg ggcgacagcg tggggacggg caaaacaggg cgggcctcgg ggcccaggcc gcagccccgg agaggcgccg gccggcgctc ctccgaggca gcagaagaag cgatgacttc ccagcacaga ggccatccgg catcgtgggc catggacggc cctggggaaa gatcatgcac gctgtgtgac cacgcgctcc catctggagc gcccgacgcc agagcctcac gatggatagc acctcctaag cctcatcaag caagcggtcc gaaccagccc cgctggtgac gcgcctccac catgcaggaa cgacgctgct agagaaaaag cagcggtagc cgcagcgccg gctcgcgtag ccgccgccgg accatcaacc aacctggtgg cggctggaag gaaaggatct ccctcgggcc aaccagatca ttctacgggg ggctccctgg gtcagcatcg cgagatgtga ttcggggtga tacatggctc atgggcctgt aaagagctgg agcatctcgc cggcctgcca ctgcccaacg aacccagcgg gaggtggaag ggcacaccca ctgcccaccg ccaccctcct cgggggtctc gtgtgtggtc caaaaaaaaa

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Acinetobacter baumannii plasmid pAB154 class 1 integron IntI1 (intI1), Arr2 (arr2), CmlA7 (cmlA7), Sul1 (sul1), ISCR1 (ISCR1), extended-spectrum beta-lactamase PER-7 (blaPER-7), and putative glutathione-Stransferase (gst) genes, complete cds, and transposon A...
GenBank: JQ639792.1 FASTA Graphics Go to:
LOCUS 2012 DEFINITION JQ639792 8652 bp DNA linear BCT 25-MARAcinetobacter baumannii plasmid pAB154 class 1 integron IntI1 (intI1), Arr2 (arr2), CmlA7 (cmlA7), Sul1 (sul1), ISCR1 (ISCR1), extended-spectrum beta-lactamase PER-7 (blaPER-7), and putative glutathione-S-transferase (gst) genes, complete cds, and

transposon ACCESSION VERSION KEYWORDS SOURCE ORGANISM

ACICU_01244, partial sequence. JQ639792 JQ639792.1 GI:380714700 . Acinetobacter baumannii Acinetobacter baumannii Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter; Acinetobacter calcoaceticus/baumannii complex. REFERENCE 1 (bases 1 to 8652) AUTHORS Opazo,A., Sonnevend,A., Lopes,B., Hamouda,A., Ghazawi,A., Pal,T. and Amyes,S.G. TITLE Plasmid-encoded PER-7 beta-lactamase responsible for ceftazidime resistance in Acinetobacter baumannii isolated in the United Arab Emirates JOURNAL J. Antimicrob. Chemother. (2012) In press PUBMED 22419799 REMARK Publication Status: Available-Online prior to print REFERENCE 2 (bases 1 to 8652) AUTHORS Opazo,A., Sonnevend,A., Lopes,B., Hamouda,A., Ghazawi,A., Pal,T. and Amyes,S.G.B. TITLE Direct Submission JOURNAL Submitted (08-FEB-2012) Molecular Chemotherapy, Centre for Infectious Diseases, The University of Edinburgh, 49 Little France Crescent, Edinburgh, Lothian EH16 4SB, United Kingdom FEATURES Location/Qualifiers

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source

mobile_element gene CDS

1..8652 /organism="Acinetobacter baumannii" /mol_type="genomic DNA" /strain="NM55" /isolation_source="sputum" /db_xref="taxon:470" /plasmid="pAB154" <1..>8652 /mobile_element_type="integron:class 1" 1..1014 /gene="intI1" 1..1014 /gene="intI1" /note="integrase" /codon_start=1 /transl_table=11 /product="IntI1" /protein_id="AFE02724.1" /db_xref="GI:380714702" /translation="MKTATAPLPPLRSVKVLDQLRERIRYLHYSLRTEQAYVHWVR IRFHGVRHPATLGSSEVEAFLSWLANERKVSVSTHRQALAALLFFYGKVLCTDLPW EIGRPRPSRRLPVVLTPDEVVRILGFLEGEHRLFAQLLYGTGMRISEGLQLRVKDL DHGTIIVREGKGSKDRALMLPESLAPSLREQLSRARAWWLKDQAEGRSGVALPDAL KYPRAGHSWPWFWVFAQHTHSTDPRSGVVRRHHMYDQTFQRAFKRAVEQAGITKPA HTLRHSFATALLRSGYDIRTVQDLLGHSDVSTTMIYTHVLKVGGAGVRSPLDALPP

AF LQ DF ER TP LT gene CDS

ED GN gene CDS

SER" 1050..1502 /gene="arr2" 1050..1502 /gene="arr2" /note="rifampin ADP-ribosylating transferase" /codon_start=1 /transl_table=11 /product="Arr2" /protein_id="AFE02723.1" /db_xref="GI:380714701" /translation="MVKDWIPISHDNYKQVQGPFYHGTKANLAIGDLLTTGFISHF GRILKHIYFSALMEPAVWGAELAMSLSGLEGRGYIYIVEPTGPFEDDPNLTNKKFP PTQSYRTCEPLRIVGVVEDWEGHPVELIRGMLDSLEDLKRRGLHVIED" 1709..3022 /gene="cmlA7" 1709..3022 /gene="cmlA7" /note="chloramphenicol efflux pump" /codon_start=1 /transl_table=11 /product="CmlA7" /protein_id="AFE02725.1" /db_xref="GI:380714703" /translation="MLLLYGSAAKSFVQGDGFVRSKNFSWRYSLAATVLLLSPFDL SLGMDMYLPAVPFMPNALGTTASTIQLTLTTYLVMIGAGQLLFGPLSDRLGRRPVL

LA LG

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YG AG TV WL PV misc_feature gene CDS

GGLAYVVASMGLALTSSAEVFLGLRILQACGASACLVSTFATVRDIYAGREESNVI ILGSMLAMVPAVGPLLGALVDMWLGWRAIFAFLGLGMIAASAAAWRFWPETRVQRV LQWSQLLLPVKCLNFWLYTLCYAAGMGSFFVFFSIAPGLMMGRQGVSQLGFSLLFA AIAMVFTARFMGRVIPKWGSPSVLRMGMGCLIAGAVLLAITEIWASQSVLGFIAPM VGIGVATAVSVSPNGALRGFDHVAGTVTAVYFCLGGVLLGSIGTLIISLLPRNTAW VVYCLTLATVVLGLSCVSRVKGSRGQGEHDVVALQSAESTSNPNR" 3179..3469 /note="similar to QacEdelta1" 3470..4396 /gene="sul1" 3470..4396 /gene="sul1" /note="sulfonamide resistance protein" /codon_start=1 /transl_table=11 /product="Sul1" /protein_id="AFE02726.1" /db_xref="GI:380714704" /translation="MGLCRYGAHNCCLFARPIPIVEVAAEADAMVTVFGILNLTED FDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDA DQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQ GIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETS VLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYV gene CDS HAPGDLRSAITFSETLAKFRSRDARDRGLDHA" 4802..6343 /gene="ISCR1" /note="transposase" 4802..6343 /gene="ISCR1" /note="insertion sequence" /codon_start=1 /transl_table=11 /product="ISCR1" /protein_id="AFE02727.1" /db_xref="GI:380714705" /translation="MSLARNATASQSPTQTNGYERHQPDQTLLYQLVEQHYPAFKA EAQGQHLPRYIQQEFNDLLQCGRLEYGFMRVRCEDCHHERLVAFSCKRRGFCPSCG RMAESAALLIDEVFPKEPIRQWVLSFPFQLRFLLARHPQLMGQVLSIVYRTLSTHL KAGYTKASAQTGSVTLIQRFGSALNLNVHYHMLFLDGVYAEDDYGKQRFHRVKAPT ELNTLAHTLSHRIARCMEKRGILERDAENTWLTLEEGEDDTLTQLHGASVTYRIAV QQGRKVFTLQTLPGREDKADSSSRVANHAGFSLHAGVMAEAHQRDKLERLCRYISR VSEKRLALTANGQVRYELKTPYRNGTTHVIFEPLDFIAKLAALVPKPRVNLTRFHG APNSKHRVQVTPAKRGKKPDKSEGLDTNWRDKSPAERHRAMTWMQRLKRVFNIDIE

SF LS RD LH RT

SL AR IK YD GP PA VF VC

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SQ gene CDS

EHCGGHVKVIASIEDPKVIEQILKHLKQKTAKANAAKQRELPPERAPPLTPSLFDP SRLFD" 6580..7506 /gene="blaPER-7" 6580..7506 /gene="blaPER-7" /codon_start=1 /transl_table=11 /product="extended-spectrum beta-lactamase PER-7" /protein_id="AFE02728.1" /db_xref="GI:380714706" /translation="MNVIIKAVVTASTLLMVSFSSFETSAQSPLLKEQIESIVIGK TVGVAVWGPDDLEPLLINPFEKFPMQSVFKLHLAMLVLHQVDQGKLDLNQTVIVNR VLQNTWAPIMKAYQGDQFSVPVQQLLQYSVSHSDNVACDLLFELVGGPAALHDYIQ GIKETAVVANEAQMHADDQVQYQNWTSMKGAAEILKKFEQKTQLSETSQALLWKWM TTTGPERLKGLLPAGTVVAHKTGTSGVRAGKTAATNDLGIILLPDGRPLLVAVFVK gene CDS AESSRTNEAIIAQVAQAAYQFELKKLSALSPN" complement(7582..8004) /gene="gst" complement(7582..8004) /gene="gst" /codon_start=1 /transl_table=11 /product="putative glutathione-S-transferase" /protein_id="AFE02729.1" /db_xref="GI:380714707" atgaaaaccg cgtgagcgca gttcgtgcct gtcgaggcat caggcattgg cttcaggaga gaagtggttc tatggaacgg gatcacggca cccgagagct aaggaccagg ccgcgcgccg gatccacgga ttcaaacgtg cactcgttcg ctcggccatt gccggagtgc gccaaatccc ataattacaa gtgacttgct tctacttttc ctggcctcga atccgaatct aacccttgag ggggaatgtt agttgggcgc aatcatgaga ccactgcgcc tacgctactt tcatccgttt ttctgtcctg cggccttgct tcggaagacc gcatcctcgg gcatgcggat cgatcatcgt tggcacccag ccgagggccg ggcattcctg gcggtgtcgt ccgtagaaca cgacggcctt ccgacgtctc gctcaccgct aacaattaag gcaggtgcaa aaccacaggg agccttgatg gggtcgcggc tacgaacaaa aattgttggc ggattcgtta acaataaggc tagtcagcag gttaccaccg gcattacagc ccacggtgtg gctggcgaac gttcttctac tcggccgtcg ttttctggaa cagtgagggt gcgggagggc cctgcgcgag cagcggcgtt gccgtggttc gcgtcgccat agcaggcatc gctccgcagc tacgacgatg tgatgcgctg ggtcttaaaa ggaccgttct ttcatctctc gagccagcag tacatataca aaatttcccg gttgttgaag gaggacttaa tcctcgcaga atgagcactt ctgcgttcgg ttacgaaccg cgtcacccgg gagcgcaagg ggcaaggtgc cggcgcttgc ggcgagcatc ttgcaactgc aagggctcca cagctgtcgc gcgcttcccg tgggtttttg cacatgtatg acgaagcccg ggttacgaca atttacacgc ccgcccctca tggtaaaaga atcatggaac atttcgagga tttggggagc tagttgagcc gtaatccaac actgggaggg agcgccgtgg gttgcttgaa ccaagaacgc tcaaggttct aacaggctta caaccttggg tttcggtctc tgtgcacgga cggtggtgct gtttgttcgc gggtcaagga aggatcgggc gtgcacgggc acgcccttga cgcagcacac accagacctt ccacaccgca ttcgaaccgt atgtgctgaa ctagtgagag ttggattccc caaagccaat cggtcgtatt tgaacttgct aacaggaccg acagtcctat gcatcctgtt tttacacgtc agttgttacg agacaagtaa ggaccagttg tgtccactgg cagcagcgaa cacgcatcgt tctgccctgg gaccccggat ccagcttctg tctggatttc cttgatgtta atggtggctg gcggaagtat gcattcgacc tcagcgcgcc caccctccgc gcaggatctg agttggcggt gtagtatgca atctctcatg ttggcgattg cttaagcaca atgtcactgt ttcgaagacg agaacctgcg gaattaataa attgaagact attcaaattc gccgcagcaa

KA AK SM VE DS

ORIGIN 1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561

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1621 1681 1741 1801 1861 1921 1981 2041 2101 2161 2221 2281 2341 2401 2461 2521 2581 2641 2701 2761 2821 2881 2941 3001 3061 3121 3181 3241 3301 3361 3421 3481 3541 3601 3661 3721 3781 3841 3901 3961 4021 4081 4141 4201 4261 4321 4381 4441 4501 4561 4621 4681 4741 4801 4861 4921 4981 5041 5101 5161 5221

ccttcatttt caaatccttt ctttgttcaa cgccacggtg cttgccagca tacgctgaca ggaccgactg aatgggcctc ttgtggtgcc tcgcgaggaa ggtaggccca gtttctaggt ccgggtgcaa gaacttctgg ctccattgcg gctgttcgcc acccaagtgg agtattgctt aatgtggcta tcgaggattc actgctagga ggttgtcgtg agtgaagggc tacatcaaat gccgacccaa cacataattg cataataagc cgcaatagtt gcttgcccct ggttctgaaa cataattaca taggtatggg tgcggaggcc cttcgatgag gcgagtcgga tgtatcgccg gatgcaccgt cggcgtgggc tgctgaggcg ccgcaccggt gcgggtttcc gatgggattt aaagctgaag gggcgccacc tcacgcgatc cgcaatcacc gttagatcat ttaataaaac gaagatcgca acgcaaccgc ttgtgattgg ctgataacaa tggacgtctg catgtcgctg acgccaccaa caaagcctca cgacctcctc tcatcacgag tgcccgccgg cattcgccag ccagctgatg

tcggttgttg gttcaaggag ggagatggtt ttgttgttat gtgccgttta acgtacttgg gggcgccgcc gctcttacgt tcggcgtgcc agtaatgtca ttgctcggag ttgggcatga cgagttgcgg ttgtacacgt cccggactaa acagtggcaa ggcagcccaa gccatcaccg gtgggtattg gaccatgttg agcatcggaa tactgtttga tctcgcggcc cccaatcgtt aaccgctacg ctcacagcca cctacacaaa ggcgaagtaa tccgccgttg tccatccctg gccattgcct gctcataatt gacgccatgg agccggcggc tcagacgtcg gccgatgaga gtttcaatcg tacctgaacg gactgcaggc caccttcgac gccttgcgac ttcttgagcc tcggcgttgg gttggccttc ggcaatggcg ttctcggaaa gcctaggcat atccaataag ccgttaagct cgcaaacaga tggagcaata ctcgtgaggg aacgcaagcc gcaaggaacg cccgaccaga ctcgaagccc caatgtggcc cgtctggtcg atggccgaga tgggtgctca ggccaggtct

cggcgttctc atggtttcat tcgtgcgctc caccgttcga tgccaaacgc tcatgattgg ccgttctact catcggctga ttgtttccac tttacggcat cgctcgtcga tcgctgcatc gcttgcaatg tgtgttacgc tgatgggcag ttgccatggt gtgtcttgcg aaatatgggc gtgtcgccac ctggaacggt cgttgatcat cccttgcaac agggggagca gaagagaatg cggtttcggt aactatcagg ttgggagata tcgcaacatc tcataatcgg tcggtgttgc ggttgcttca gctgcctttt tgacggtgtt tagaccccgc tggatgtcgg tcagacgtat acagcttcca atatccaagg tggtggttat ccgaagacgc ggagcggggt ccgcaccgga ggcttccgct ctgtaaagga ctgactacgt ccctcgcgaa tcaccttccg ttgactgtgc cttatgtggg caagaaaaag gcaccctgaa ctattgcggg gctgatactg ccacggcgag cgctgctcta aaggtcaaca gtctggagta ccttcagctg gtgcggcgct gctttccttt tgagtatcgt

atgaatcctt ccttttgctc aaaaaacttt tttattggca gcttggtacg tgccggtcag gggaggtggc agtctttctg atttgcaaca actcggatcc catgtggctt tgcagcagcg gtcgcagctg cgctggaatg gcaaggtgtg gtttacggct aatgggaatg ttcgcagtcc agcggtatct cacggcagtc ttcgctgttg agtcgtgctc tgatgtggtc tggcaagcta cggctgagct tcaagtctgc tatcatgaaa cgcattaaaa ttatggcatc ttatgcagtc tgggcaaaag tgctcgcccg cggcattctg cggcgctgtc accggccgcc tgcgccgctc accggaaacc atttcctgac gcactcagcg gctcgacgag cgctgccgac aacatcgctg attggtctcg tctgggtcca ccgcacccac atttcgcagt gccgcccgct gtgaaaaaga atggtgcaga ccccaactga cccaaaacct ttaagcattt tacataacca tcaatcgccc ccagctggtt cctgcctcgc tggtttcatg taaacgacgc gctgatagac ccagctacgc ctatcgtaca

ttgctctacg tacgggagcg agttggcggt tcactcggca acagcgagca ctcttgtttg ctcgcctacg gggcttcgga gtacgtgaca atgctggcca gggtggcggg tggcgattct ctactccccg ggtagcttct tctcagcttg cgttttatgg ggatgcctga gtgttaggct gtgtcgccca tacttctgct ccgcgcaaca ggtctgtctt gcgctacaaa tcgcccaaca caggcgttag ttttattatt ggctggcttt tctagcgagg gcattttatt tggtcgggac cttgatgcgg atccccatcg aatctcaccg accgcggcga agccatccgg ttagacgccc cagcgctatg cctgcgctct cagcgggatg attgtgcggt cggctcatcc cacgtgctgt gtgtcgcgga gcgagccttg gcgcctggag cgcgacgcca aaatatctcc aagttttgtg gctcgacgac taacagttgg tctcgctcaa agcgatgtct cagtatcagc actcaaacaa gagcagcact tacatccaac cgggttcgct ggcttttgcc gaagtcttcc tttttgctgg ctctcaactc

ggagcgccgc ccgccaaatc actcccttgc tggacatgta caattcagct gaccgctatc ttgtggcgtc ttcttcaggc tttacgcagg tggtcccggc ctatctttgc ggcctgaaac ttaagtgcct tcgtcttttt gcttcagcct ggcgtgtgat tagctggagc ttattgctcc atggcgctct tgggcggtgt cggcttggcc gtgtttcccg gtgcggaaag aatcgctgca atgcactaag tttaagcgtg ttcttgttat gctttactaa ttctttctct tcggcgtcgt tggggctttg tggaagtcgc aggactcctt tcgaaatgct acgcgaggcc tgtccgatca cgctcaagcg atcccgatat gcatcgccac tcttcgaggc tcgatccggg cgaaccttca aatccttctt cggcggaact atctgcgaag gagaccgagg ttttgggttg tgatggcgtt taccgataaa ggcttcagta ccggtagtgg agggccagac ggaggatacc acggttacga acccagcctt aagaattcaa gcgaggattg ctagctgcgg ccaaggagcc ctcgccatcc atctgatcaa

`21

5281 5341 5401 5461 5521 5581 5641 5701 5761 5821 5881 5941 6001 6061 6121 6181 6241 6301 6361 6421 6481 6541 6601 6661 6721 6781 6841 6901 6961 7021 7081 7141 7201 7261 7321 7381 7441 7501 7561 7621 7681 7741 7801 7861 7921 7981 8041 8101 8161 8221 8281 8341 8401 8461 8521 8581 8641

aaaagccggt tggctccgcg cgaagatgac gaatacgctc tttggagcgt gactcaatta caaagtcttc agtagccaac ggataagctt ggcattaacc cacccatgtg gccgcgagtc tcaagtaaca ctggcgtgac gcgagtcttc tgccagcatc agccaaggcg tcccagcctg caaatccaac tctcgagcta ctggaccggc atacttcgga gtagttactg tccccactgt gttgcagtgt ccaatgcaaa ggaaagttgg tgggctccga ctgcaatact ggtggaccag gtcgcaaatg atgaaggggg tcgcaggctt ggtttgttac gggaaaactg ctggttgctg gcgcaggttg aattaaacag gtttgaaatt ctctagcgtc gtcaaaacct ggtcgtcaga ataacgataa tttgcgtgcc cgctacaaac agccactgaa tatttgatgg ccggtattaa agtcgcttgg tcccacgtga ttagctatat ttagttatat aactaactac tgtacactga ggttaatttt ttcaaaatca atctacccaa

tacaccaaag ctaaatctca tatggcaagc gctcacaccc gatgccgaga catggtgctt accctgcaaa catgctggtt gagcgcttgt gccaatgggc atcttcgagc aacctcacac cccgccaagc aagagtcctg aatattgata gaagatccga aatgccgcca ttcgatccat actgctcaac tcaggctaga agttaaaatt tgaggagcaa cctcgacgct taaaagagca gggggcctga gtgtatttaa atttaaatca taatgaaagc cggtctcgca ctgctttgca aagcgcagat ccgcagagat tgttatggaa cagctggtac cggccactaa tttttgtgaa ctcaggctgc actatcagca ggagtaggtt gcctgaattc gagcgcttac ccgttttcct attacgcctg ggattatgtt tgataaggtt cctaataact attgcgctca gtatgcaact ctcaacatat gtatgtagaa tcaaggtgta cgatgaaaca tggtgaagat cctaaatgtg atcatagtac aaaggtgaca tt

cctctgcaca atgtccacta aacgcttcca tcagccatcg atacgtggtt cggttacgta ccttgccagg tctcgctaca gtcgctacat aggtgcgtta cgctggactt gcttccacgg ggggcaagaa cagagcgcca ttgaagtctg aggtcattga agcagcgtga cacagagtcg actgccaact gattttaccg ggggcttgag aaaggtggtt actgatggta aattgaatcc cgatctggaa attgcattta gaccgttatc gtatcaggga cagcgataac tgactatatc gcacgccgat cctgaaaaag gtggatggtc tgtggtcgca tgatttaggt agactcagcc gtatcaattt ctatctaagc atcattgggt gctcatgctg aaagcagtaa gatcccagct aatcaaaaat gtaccaacac gccctgccag gcatccttct gttgcccgca gataagccaa attaagcttg gaattccaag cttgcgtctg ccactagctt gtcgttatta gtgcattggg attgcttcaa cataacctag

aactggctca ccacatgctg tcgtgtcaag catcgctcgc gacactggaa tcgcattgcc gcgtgaggat cgccggtgtg tagtcggcca cgagctcaaa catcgccaaa cgtctttgca gcccgacaaa ccgcgccatg cgaacactgc gcagattctc gctgccacca tctctttgac tttaaacggg ccaaatcgaa cggtaaacga tatacttcca tcttttagtt atagtcattg cctttactga gctatgttgg gtaaacaggg gaccagttta gtggcctgtg cagtctatgg gatcaggtgc tttgagcaaa gaaaccacca cataaaactg atcattctgt gagtcaagcc gaattgaaaa cgctgactct taggtcgtta aagattaaaa ttcaaccaag caatggtttg aacctgctct tgaacggcct tactaaacgt cggaaacccc tcggtgaaac gtaatgccaa gtcagtttat gctgtttaga agtttgaagg ctgcctcaat aagtacaaaa tcgggaaaac aatcaaaagg tgcactatgt

gtgactctta tttctcgatg gcacccactt tgcatggaaa gagggcgaag gtcggccccc aaagccgact atggccgaag gcggtttcag actccgtacc ctcgctgcgt ccgaacagca tcggaaggtc acctggatgc ggcggtcacg aagcatctga gaacgagcgc tgatctttga gcggtggggc ccttattaga gtgagggaat tgaatgtcat cattcgaaac gaaaaaaagc ttaatccttt tactgcatca ctaaggtttt gtgttccagt atttgttatt gtataaagga agtatcaaaa aaacacagct caggaccaga gtacttcggg tgcctgatgg gaaccaatga agctttctgc ggttgtacac aggtcatacg aacaatttat gagtctgtgc aatttcagtt ccatccacta tcagactcaa aaacgacgaa actgatgaaa cgcagtagtt actcatgcgt cgcgagtacc ccagacccca gcgtgattta tgctcaggtt accgggtgtt cccatttttc tttttatcat acacgctctt

tccaacgctt gtgtctatgc acgatgagct agcgtgggat acgatacgct agcaagggcg caagcagtcg cgcatcagcg aaaaacgtct gcaatggcac tggtacctaa aacaccgagt tcgatactaa aacgcctcaa tcaaagtgat aacagaaaac cgccactgac ctgacgaccc agtttgtatc gcggtttagg ttcaggtaag tataaaagct ctcagcgcaa cactgtaggc tgaaaaattc ggttgatcag acagaatacc gcagcaactg tgaactggtt gaccgctgtg ctggacctcg gtctgaaacc gcggttaaaa tgtcagagcc acggcccttg agctatcatt cctaagccca taaagctatg tatgaagtgc cttcagtcac aggcattgat tcgaagccaa acacaggcac aaatattaag caaaagggga aaaaatattt gcggctaaag gagacttttg ccatcgctat actttacctt agccagattt catgcggcta gaaaccattt gttgctaacg agtacattgc tattgaacca

`22

Dengue virus 2 env gene for envelope protein, partial cds, isolate: R05-624_10
GenBank: AB587985.1 FASTA Graphics Go to:
LOCUS 2011 DEFINITION isolate: ACCESSION VERSION KEYWORDS SOURCE ORGANISM AB587985 1485 bp RNA linear VRL 01-NOVDengue virus 2 env gene for envelope protein, partial cds,

R05-624_10. AB587985 AB587985.1 GI:354952618 . Dengue virus 2 Dengue virus 2 Viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; Flavivirus; Dengue virus group. REFERENCE 1 AUTHORS Kurosu,T., Chaichana,P., Phanthanawiboon,P., Khamlert,C., Ikuta,K. and Anantapreecha,S. TITLE Dengue Virus Type 2 from Patients with Primary Infection is Highly Heterogeneous JOURNAL Unpublished REFERENCE 2 (bases 1 to 1485) AUTHORS Kurosu,T., Chaichana,P., Phanthanawiboon,P., Khamlert,C., Ikuta,K. and Anantapreecha,S. TITLE Direct Submission JOURNAL Submitted (15-SEP-2010) Contact:Takeshi Kurosu Research Institute for Microbial Diseases, Osaka University, Virology; Yamadaoka, 31, Suita, Osaka 565-0871, Japan FEATURES Location/Qualifiers source 1..1485 /organism="Dengue virus 2" /mol_type="genomic RNA" /isolate="R05-624_10" /isolation_source="dengue patients" /db_xref="taxon:11060" /note="synonym: Dengue virus type 2" gene 1..>1485 /gene="env" CDS 1..>1485 /gene="env" /codon_start=1 /product="envelope protein" /protein_id="BAL05300.1" /db_xref="GI:354952619" /translation="MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLD FE

`23

WG GK PL GN CK WF SG ORIGIN 1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 atgcgttgca gttgacatag ttggatttcg atagaagcaa agcctgaaag tggggaaatg tgcaaaaaga gtaacacctc gaaatcaaag gtcacgatgg atggaaaata ctgcccggag aaaaatcccc catacagcac ggacatctca atgtgcacag gttatcagag gatttggaaa aaagataacc ggagtagagc atgtttgaga gacttcggat ggagcaatct gtcattatca ctggtgggaa

LIKTEAKQPATLRKYCIEAKLTNTTTESRCPTQGEPSLKEEQDKRFVCKHSMVDRG NGCGLFGKGGIVTCAMFTCKKNMEGKIVQPENLEYTIVVTPHSGEEHAVGNDTGKH EIKVTPQSSITEAELIGYGTVTMECSPRTGLDFNEMVLLQMENKAWLVHRQWFLDL PWLPGADKQESNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSS LLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSP IPFEIMDLEKRYVLGRLITVNPIVTEKDNPVNIEAEPPFGDSYIIIGVEPGQLKLN KKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAF VSWTMKILIGVIITWIGMNSRSTSLSVSLVLVGIVTLYLGVMVQA" taggaatatc tcttagaaca aactgataaa aactaaccaa aagagcagga gatgtggatt acatggaagg actcagggga taacaccaca agtgctcccc aagcttggct cggataaaca atgcgaagaa tcacaggagc agtgcaggct gaaagtttaa tgcaatatga aaagatatgt cagtcaacat cgggacaact caacgatgag ccctgggagg atggagctgc catggatagg ttgtgacact aaatagagac tggaagctgt aacggaagcc cacaacaaca taagaggttc atttggaaag gaaaatcgtg agagcatgcg gagttccatc gagaacaggc ggtgcatagg agagtcaaat acaggatgtt cacagaaatc gagaatggac agttgtgaag aggggacggc cttaggccgc agaagcagaa gaagctcaac aggggcgaag agtgtttaca cttcagtggg aatgaactca gtatttggga tttgtagaag gtgacgacga aaacagcctg gaatcccgtt gtctgcaaac ggaggcattg caaccagaaa gtcggaaatg acagaagcag ctcgacttca caatggtttc tggatacaga gttgttttag caaatgtcgt aagctacagc gaaatagcag tctccatgca ctgatcacag cctccattcg tggttcaaga agaatggcca tctataggaa gtttcatgga cgcagcacct gtcatggtgc gggtttcagg tggcaaaaaa ccaccctaag gcccaacaca actccatggt tgacctgtgc acttggaata acacaggaaa aattgatagg atgagatggt tagacctgcc aagaaacatt gatcccaaga caggaaactt tcaaaggaat aaacacaaca aaatcccttt tcaacccaat gagacagtta aaggaagttc ttttgggtga aagctctcca ccatgaaaat cactgtctgt aggcc aggaagttgg caaaccaaca gaagtactgc aggggaaccc agacagagga tatgttcaca caccattgtg acacggcaag ttatggcacc gttgctgcag attaccatgg ggtcactttc aggggctatg gctcttcact gtcatactct tggaacgata cgagataatg tgtaacagaa catcatcata tatcggccaa cacagcctgg ccaagtcttt cctcatagga gtcactagta

`24

Foot-and-mouth disease virus capsid protein VP1 RNA, and 2A protein, 5' end
GenBank: M58601.1 FASTA Graphics Go to:
LOCUS 1993 DEFINITION ACCESSION VERSION KEYWORDS SOURCE ORGANISM REFERENCE AUTHORS TITLE to JOURNAL PUBMED COMMENT genomic FEATURES source APHVP12A 666 bp ss-RNA linear VRL 02-DECFoot-and-mouth disease virus capsid protein VP1 RNA, and 2A protein, 5' end. M58601 M58601.1 GI:210511 antigen; capsid protein. Foot-and-mouth disease virus Foot-and-mouth disease virus Viruses; ssRNA positive-strand viruses, no DNA stage; Picornavirales; Picornaviridae; Aphthovirus. 1 (bases 1 to 666) Krebs,O., Berger,H.G., Niedbalski,W. and Marquardt,O. Foot-and-mouth disease virus O1Lombardy is biochemically related O2 isolates Virus Genes 5 (3), 255-265 (1991) 1663294 Original source text: Foot-and-mouth disease virus, cDNA to RNA. Location/Qualifiers 1..666 /organism="Foot-and-mouth disease virus" /mol_type="unassigned RNA" /db_xref="taxon:12110" gtgaatcagc agaggcgcca aagaccaaac tcctgcgtgc atctcacctg cagcttacca tgttggcaac gaggtgacct acggtgccat cgtactgtcc ttgtggcacc agatcccgtg acacacggac caatgttttg atccacgtac ggtcccaaat caaagctnca agtgtacaac ccaggtgcta cagggcaact caggcccctg cgtaaagcaa gctgccaccg gtctngttca gacctcatgc tacttctctg ggggctcctg ctcacccgac ggtgggtcta acccaaaagg cgggtcactg ctggccattc accttgaact ttgagaacta tcatggacag agattccatc acttagagat aatctgcgct tcgccctgcc ggtacagcag cggcgcgaac agcttctcta acccaactga ttgacctcct cggtggagag atttgtgaaa ctacacactg agcagtaaag ggagaacacc ttacacggca aaacactgtg gctgcctacc ccggatgaag agccagacac aaagttggct

ORIGIN

1 61 121 181 241 301 361 421 481 541 601 661

acctccgcgg acacaggtcc gttacaccaa gtgggagcac cacgagggat accaacccaa ccacaccgtg cccaatgtga tctttcaact agggctgaga aaacagaaaa ggagac

`25

Babesia bigemina DNA sequence

GenBank: M85187.1
1993 DEFINITION ACCESSION VERSION KEYWORDS SOURCE JOURNAL PUBMED COMMENT Babesia bigemina DNA sequence. M85187 M85187.1 GI:155880 . Babesia bigemina

Mol. Biochem. Parasitol. 53 (1-2), 149-158 (1992) 1501634 Original source text: Babesia bigemina (strain Mexico) merozoite DNA. FEATURES Location/Qualifiers source 1..1962 /organism="Babesia bigemina" /mol_type="genomic DNA" /strain="Mexico" /db_xref="taxon:5866" /dev_stage="merozoite" ORIGIN 1 tatggcacat tggcgcataa gcactcccaa taagtgattg tgaacgcgga attaggtcgg 61 ccgtgccgtt tttccgttag aataatattt caagcagatt cgtctaatcg ttctgctgtc 121 actatcgtaa tacacatagc gttgtctgct aacgttttgt gagcaacatt cccatttgcg 181 taacaatgag gagcttcttg ggtgtgtgtt ttggagctct cttgctcgta gcaaggagcg 241 gttctgctat tcgctatact caccgttcgg gtgttatgtc agcagaggtg gttggagatg 301 tgtccaagac cttgctggca gccaacgagg ttgtcaatgc tgaaatggaa gcagctcaga 361 ttaacgaaga tatgaagatt cagttggcga acgtcaagga gaccatcgtt gatgaggtct 421 gcagaaaaga tgctggaagc cctacgtgcc gcaagagcgt aattgcctat gttgaccgtt 481 gtgatgaggg cgattgtctg acgcttgaca gcatgaagta caagccgttg agtctgccaa 541 atccttacca gttggacgct gccttcatgc ttttcaggga aagtgattct aaccctgcga 601 agaatgaggt gaagcgcttc tggatgcgtt cgaggagcag ccacggcgac taccatcact 661 ttgttgttag cttgttgaag aagaatgttg tacgcgaccc tgaatccaat gatgttgaga 721 acttcgcatc gcagtacttc tacatgacta cgttgtacta caagacttac ctgaccgttg 781 actttacggc ggctaagttc ttcaacaagc ttgctttcac aactcgcctg ttcggtttcg 841 gtatccagaa ggcgttgaag cgtttggtta ggagcaacct tcccgttgac cttggaaccc 901 accctgaggc caccatccgc gaaatagcta gcggctacgg cgagtacatg atgacccagg 961 tgcctgcgat gacctcgttc gctgggcgtt tctccaagat ggctactaag actctgttgg 1021 ttaccgtcag cgactacgtc catttgcccg cgtacaagag gtggtacagg aagttcaagg 1081 aattcattgt gaacttcttt actgaccctg ccaagttgat tatgaagcac gtctctcagc 1141 ctgtaaagac tgcctacaca aagctggtcc ccgaagagca caggcaggct atcaggaatg 1201 tcgtcggtca aagcaccaag catattgcca acggtgtacg tgatttgtca aggatgatta 1261 aggagcctag ccaacaaata attcgtgaga agctgcctca ctacctttct aaggcaaagg 1321 gagccgttga gcacgttgtt aagaaggtta aatccgttgt gccgataaag caaaagggcg 1381 accaaccatc cgaagcagct gtagaggaaa ccgttccgtc tggcgattcc gcggaaactg 1441 aatttgaggt ccctgaagaa caatacgtcg atgctgttac tactcaggag gttaacagcg 1501 agaaggttga tgccgacgat gcgggtaatg ccgaaaccca gcagcttcca gatgcagaaa 1561 atgaagtgcg cgctgatgac cccaaaaatg aggattcttc aagttcttca gatgattcag 1621 atgcgtaaca gcaatttagc tgtacatttc gatagtgttg ctgtcaaata atcgccatat 1681 aacaatttcg aatgcctaat ctccatcgtt ttttactttt atgttggtca ggtgttcata 1741 tttgccaagg caccgtgctg agatcgctgc gtcatttttg cgtgtaatat gtcgtataat 1801 atgcgtccca tggctgcgct gctattcgct acatgcgctg ccaacatggc cgtagatagc 1861 gtgtctgcag gcaacgctgc aataataaaa agtgtcgtga ctgagttacg cacgcgccat 1921 aacgttatac aatcagtatt agaagagtac agcgtcgact gc

`26

Rabbit T-cell receptor gamma mRNA, partial cds

GenBank: L22290.1 FASTA Graphics Go to:
LOCUS 1993 DEFINITION ACCESSION VERSION KEYWORDS SOURCE ORGANISM RABTCRGAM 147 bp mRNA linear MAM 22-SEPRabbit T-cell receptor gamma mRNA, partial cds. L22290 L22290.1 GI:402731 T-cell receptor; T-cell receptor gamma chain. Oryctolagus cuniculus (rabbit) Oryctolagus cuniculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus. REFERENCE 1 (bases 1 to 147) AUTHORS Sawasdikosol,S., Hague,B.F., Zhao,T.M., Bowers,F.S., Simpson,R.M., Robinson,M. and Kindt,T.J. TITLE Selection of rabbit CD4- CD8- T cell receptor-gamma/delta cells by in vitro transformation with human T lymphotropic virus-I JOURNAL J. Exp. Med. 178 (4), 1337-1345 (1993) PUBMED 8376938 COMMENT Original source text: Oryctolagus cuniculus (strain New Zealand White) cDNA to mRNA. FEATURES Location/Qualifiers source 1..147 /organism="Oryctolagus cuniculus" /mol_type="mRNA" /strain="New Zealand White" /db_xref="taxon:9986" ORIGIN 1 cattgctgaa acaaaactgc ataaggctgg gacatatctt tgtctgcttg agaaattctt 61 ccctgatgtc atcaaggtgt actggaaaga gaagaatggt gatacgattc tggaatccca 121 ggaaggaaac accatgaaga ttaacgg

`27

Poliovirus type 1 (strain 6288) VP1/2A junction region, bases 3296-3445

GenBank: M19628.1 FASTA Graphics Go to:
LOCUS 1993 DEFINITION POLHONDR 150 bp ss-RNA linear VRL 02-AUGPoliovirus type 1 (strain 6288) VP1/2A junction region, bases 3296-3445. ACCESSION M19628 VERSION M19628.1 GI:332936 KEYWORDS . SOURCE Human poliovirus 1 ORGANISM Human poliovirus 1 Viruses; ssRNA positive-strand viruses, no DNA stage; Picornavirales; Picornaviridae; Enterovirus; Human enterovirus C. REFERENCE 1 (bases 1 to 150) AUTHORS Rico-Hesse,R., Pallansch,M.A., Nottay,B.K. and Kew,O.M. TITLE Geographic distribution of wild poliovirus type 1 genotypes JOURNAL Virology 160 (2), 311-322 (1987) PUBMED 2821678 COMMENT Original source text: Poliovirus type 1 (strain 6288) RNA, from Honduras 1984. Draft entry and computer-readable sequence for [1] kindly provided by R.Rico-Hesse, 03-DEC-1987. FEATURES Location/Qualifiers source 1..150 /organism="Human poliovirus 1" /mol_type="genomic RNA" /db_xref="taxon:12080" ORIGIN 1 cgccccagag cggtagcgta ttacggtcct ggggtggact ataaggatgg taccctcaca 61 cccctttcca ccaaggattt gactacttac gggtttggac accagaacaa ggcagtgtat 121 accgctggct ataagatctg caactaccac

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Homo sapiens protein kinase D2 (PRKD2), transcript variant 1, mRNA

NCBI Reference Sequence: NM_016457.4 FASTA Graphics Go to:
LOCUS 2012 DEFINITION mRNA. ACCESSION VERSION KEYWORDS SOURCE ORGANISM NM_016457 3617 bp mRNA linear PRI 25-MARHomo sapiens protein kinase D2 (PRKD2), transcript variant 1, NM_016457 NM_016457.4 GI:120659783 . Homo sapiens (human) Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. 1 (bases 1 to 3617) Zheng,H., Qian,J., Baker,D.P. and Fuchs,S.Y. Tyrosine phosphorylation of protein kinase D2 mediates ligand-inducible elimination of the Type 1 interferon receptor J. Biol. Chem. 286 (41), 35733-35741 (2011) 21865166 GeneRIF: Tyrosine phosphorylation of PKD2 is required for IFNalpha-stimulated activation of this kinase as well as for efficient serine phosphorylation and degradation of IFNAR1 and ensuing restriction of the extent of cellular responses to IFNalpha. 2 (bases 1 to 3617) Bhavanasi,D., Kim,S., Goldfinger,L.E. and Kunapuli,S.P. Protein kinase Cdelta mediates the activation of protein kinase D2 in platelets Biochem. Pharmacol. 82 (7), 720-727 (2011) 21736870 GeneRIF: PKD2 is a common signaling target downstream of various agonist receptors in platelets and G(q)-mediated signals along calcium and novel PKC isoforms, in particular, PKCdelta activate PKD2 in platelets. 3 (bases 1 to 3617) Zheng,H., Qian,J., Varghese,B., Baker,D.P. and Fuchs,S. Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2 Mol. Cell. Biol. 31 (4), 710-720 (2011) 21173164 GeneRIF: Expression and kinase activity of PKD2 are required for the ligand-inducible stimulation of IFNAR1 ubiquitination and endocytosis and for accelerated proteolytic turnover of IFNAR1. 4 (bases 1 to 3617) Crowther-Swanepoel,D., Corre,T., Lloyd,A., Gaidano,G., Olver,B.,

REFERENCE AUTHORS TITLE JOURNAL PUBMED REMARK

REFERENCE AUTHORS TITLE JOURNAL PUBMED REMARK with REFERENCE AUTHORS TITLE JOURNAL PUBMED REMARK REFERENCE AUTHORS

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Ghia,P.,

Bennett,F.L., Doughty,C., Toniolo,D., Caligaris-Cappio,F.,

Rossi,D., Rawstron,A.C., Catovsky,D. and Houlston,R.S. TITLE Inherited genetic susceptibility to monoclonal B-cell lymphocytosis JOURNAL Blood 116 (26), 5957-5960 (2010) PUBMED 20855867 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) Erratum:[Blood. 2011 Mar 24;117(12):3477. Calligaris-Cappio, Federico [corrected to Caligaris-Cappio, Federico]] REFERENCE 5 (bases 1 to 3617) AUTHORS Azoitei,N., Pusapati,G.V., Kleger,A., Moller,P., Kufer,R., Genze,F., Wagner,M., van Lint,J., Carmeliet,P., Adler,G. and Seufferlein,T. TITLE Protein kinase D2 is a crucial regulator of tumour cellendothelial cell communication in gastrointestinal tumours JOURNAL Gut 59 (10), 1316-1330 (2010) PUBMED 20732914 REMARK GeneRIF: PKD2 regulates hypoxia-induced VEGF-A expression/secretion by tumour cells and VEGF-A stimulated blood vessel formation and a essential mediator of tumour cell-endothelial cell communication and a target to inhibit angiogenesis in gastrointestinal cancers REFERENCE 6 (bases 1 to 3617) AUTHORS Mihailovic,T., Marx,M., Auer,A., Van Lint,J., Schmid,M., Weber,C. and Seufferlein,T. TITLE Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells JOURNAL Cancer Res. 64 (24), 8939-8944 (2004) PUBMED 15604256 REMARK GeneRIF: Data show that Bcr-Abl-induced activation of the nuclear factor kappaB cascade in myeloid leukemia cells is largely mediated by tyrosine-phosphorylated PKD2. REFERENCE 7 (bases 1 to 3617) AUTHORS Yeaman,C., Ayala,M.I., Wright,J.R., Bard,F., Bossard,C., Ang,A., Maeda,Y., Seufferlein,T., Mellman,I., Nelson,W.J. and Malhotra,V. TITLE Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network JOURNAL Nat. Cell Biol. 6 (2), 106-112 (2004) PUBMED 14743217 REMARK GeneRIF: specificity of different PKD isoforms in regulating protein trafficking from the trans-Golgi network REFERENCE 8 (bases 1 to 3617) AUTHORS Rey,O., Yuan,J. and Rozengurt,E. TITLE Intracellular redistribution of protein kinase D2 in response to G-protein-coupled receptor agonists JOURNAL Biochem. Biophys. Res. Commun. 302 (4), 817-824 (2003) PUBMED 12646243 REFERENCE 9 (bases 1 to 3617) AUTHORS Sturany,S., Van Lint,J., Gilchrist,A., Vandenheede,J.R., Adler,G. and Seufferlein,T. TITLE Mechanism of activation of protein kinase D2(PKD2) by the CCK(B)/gastrin receptor JOURNAL J. Biol. Chem. 277 (33), 29431-29436 (2002) PUBMED 12058027 REMARK GeneRIF: mechanism of activation by CCK(B)/gastrin receptor REFERENCE 10 (bases 1 to 3617) AUTHORS Sturany,S., Van Lint,J., Muller,F., Wilda,M., Hameister,H.,

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and TITLE JOURNAL PUBMED COMMENT

Hocker,M., Brey,A., Gern,U., Vandenheede,J., Gress,T., Adler,G. Seufferlein,T. Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases J. Biol. Chem. 276 (5), 3310-3318 (2001) 11062248 REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC008635.6, AF309082.1 and AL050147.1. On Jan 4, 2007 this sequence version replaced gi:48255892. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. Summary: The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin

via

the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same isoform (A). COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-718 AC008635.6 20397-21114 719-2460 AF309082.1 1-1742 2461-3617 AL050147.1 698-1854 FEATURES Location/Qualifiers source 1..3617 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="19" /map="19q13.3" gene 1..3617 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /note="protein kinase D2" /db_xref="GeneID:25865" /db_xref="HGNC:17293" /db_xref="HPRD:09523" /db_xref="MIM:607074" exon 1..997 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /inference="alignment:Splign" /number=1c misc_feature 560..562 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /note="upstream in-frame stop codon" CDS 758..3394 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2"

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SG TS LF CT PT SE TT VE AL VY VF LL VI SV RD misc_feature

/EC_number="2.7.11.13" /note="isoform A is encoded by transcript variant 1; serine/threonine-protein kinase D2" /codon_start=1 /product="serine/threonine-protein kinase D2 isoform A" /protein_id="NP_057541.2" /db_xref="GI:19923468" /db_xref="CCDS:CCDS12689.1" /db_xref="GeneID:25865" /db_xref="HGNC:17293" /db_xref="HPRD:09523" /db_xref="MIM:607074" /translation="MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPG VSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDP ANLLQLVRSSGDIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEM GLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLP AEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTR VCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDF ADKSALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRH RKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILT SAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQ MPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGV GGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEK VVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENV ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVG MYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRY DKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTD LGGACPPQDHDMQGLAERISVL" 1322..1324 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1346..1348 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1349..1351 /gene="PRKD2"

Prot misc_feature

Prot misc_feature

`32

/gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/SwissProt misc_feature (Q9BZL6.2); phosphorylation site" 1352..1354 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (Q9BZL6.2); phosphorylation site" 1355..1357 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1364..1366 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1373..1375 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1397..1399 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1430..1432 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1436..1438 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (Q9BZL6.2); phosphorylation site" 1463..1465

misc_feature

Prot misc_feature

Prot misc_feature

Prot misc_feature

Prot misc_feature

Prot misc_feature

misc_feature

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Prot misc_feature

/gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1466..1468 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1469..1471 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1487..1489 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by CSNK1D and CSNK1E; propagated from UniProtKB/Swiss-Prot (Q9BZL6.2); phosphorylation site" 1769..1771 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1814..1816 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1820..1822 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1841..1843 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded"

Prot misc_feature

Prot misc_feature

misc_feature

Prot misc_feature

Prot misc_feature

Prot misc_feature

`34

Prot misc_feature

/note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1877..1879 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1880..1882 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 1943..1945 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 2069..2071 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphotyrosine, by ABL1; propagated from UniProtKB/Swiss-Prot (Q9BZL6.2); phosphorylation site" 2309..2311 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss(Q9BZL6.2); phosphorylation site" 2873..2875 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by PKC; propagated from UniProtKB/Swiss-Prot (Q9BZL6.2); phosphorylation site" 2906..2908 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded" /note="Phosphotyrosine; propagated from UniProtKB/Swiss-Prot (Q9BZL6.2); phosphorylation site" 3383..3385 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /experiment="experimental evidence, no additional details recorded"

Prot misc_feature

Prot misc_feature

Prot misc_feature

misc_feature

Prot misc_feature

misc_feature

misc_feature

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exon

exon

exon

exon

exon

exon

exon

exon

exon

exon

exon

exon

/note="Phosphoserine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q9BZL6.2); phosphorylation site" 998..1136 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /inference="alignment:Splign" /number=2b 1137..1268 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /inference="alignment:Splign" /number=3 1269..1423 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /inference="alignment:Splign" /number=4 1424..1646 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /inference="alignment:Splign" /number=5 1647..1724 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /inference="alignment:Splign" /number=6 1725..1878 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /inference="alignment:Splign" /number=7 1879..1996 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /inference="alignment:Splign" /number=8 1997..2074 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /inference="alignment:Splign" /number=9 2075..2333 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /inference="alignment:Splign" /number=10 2334..2386 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /inference="alignment:Splign" /number=11 2387..2459 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /inference="alignment:Splign" /number=12 2460..2566 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; PKD2" /inference="alignment:Splign"

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exon

exon

exon

exon

exon

STS

STS

STS

polyA_signal polyA_site polyA_site ORIGIN

/number=13 2567..2728 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; /inference="alignment:Splign" /number=14 2729..2827 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; /inference="alignment:Splign" /number=15 2828..3095 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; /inference="alignment:Splign" /number=16 3096..3181 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; /inference="alignment:Splign" /number=17 3182..3601 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; /inference="alignment:Splign" /number=18 3386..3535 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; /standard_name="D19S1076" /db_xref="UniSTS:40442" 3451..3577 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; /standard_name="A006X30" /db_xref="UniSTS:12019" 3453..3566 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; /standard_name="D19S1076" /db_xref="UniSTS:35374" 3558..3563 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; 3579 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; 3601 /gene="PRKD2" /gene_synonym="HSPC187; nPKC-D2; cggacacttc gagctactgg ccttcctcac ctacccactc acccctttat aaggtgaatt gggattccct ctctcctgat atcgctggga ccgggcctct ctcctgggcc cgcctggcga ggctcccgac cggccctcgg ctctggaatc cccccgggcc ctgccccctt ccctgtgacc cctccaaccc gacccactat gccgccgccg ccctccctgc cgaacttttc gacccctctg cactcggtcc gccttctgag ctcaatccct ccgacctact actacttttc agtgcctttc

PKD2"

PKD2"

PKD2"

PKD2"

PKD2"

PKD2"

PKD2"

PKD2"

PKD2" PKD2" PKD2" ccgccgactt cccccaccca tccaacttct cccatcccct ccgactcaga tgggatcctc cctctaggga agatttcctc tcctttctga tctccttccc aaactttgga accccgctcc gcgactcgtg ggccggtcgg gactcctgcc ttcttggagc aggggccttt tcaggcttct tcttctggga aggaccccgc

1 61 121 181 241 301 361 421 481 541

actgtcgctc gggggaaaaa ggcaacgccc agattccctt gtccctgcga ctccaccccc actggatcct gaatcgcggg tggaatctca gccctggatt

`37

601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 1501 1561 1621 1681 1741 1801 1861 1921 1981 2041 2101 2161 2221 2281 2341 2401 2461 2521 2581 2641 2701 2761 2821 2881 2941 3001 3061 3121 3181 3241 3301 3361 3421 3481 3541 3601

catcctcagg gctcacgaga gggtgggctc cgccgggctc gcagtcgccg catccagatc tgtgaagcag cctttacgac ggtgcgctcg ggccaccttc gcctgccttc gtgcgatggc tagtggggcc cctcggcacc actcctgcct ccgccccatt catccacagc cttccggcag ccgcgtccct ggccaccgat tgtcatccct gggaggcaag gcgacacacg caacaaggac cttccagaac ggtggagtcc gatcgtcact gccaagtggg gatgcccgtc ttctctgagc ctaccagatc aaaacaccgg taccaagcag cgggatcgtg gaagctgcat gcgcctcacc gaacattgtc tcctcaggtg ccgctcagtg caaccgctcg cttccctttc cccggccagc gcaggtgaag ggagtaccag cacgcatgag gtctgggctg gcaggggctg ccctccacag ctgcccaaac tccctgtttc aaaaaaaaaa

tcccctccgc tcccgcggat caggcggccg cctggctctc ccaccgctac gggctgaccc ctggcctgtt aagatcctgc tccggagaca gaggacttcc tgtgatcact tgcgggctga cgcaaacggc tccgagtccc cgccgtcccc gagctggaca tatacacggc ggcctgcaat aatgactgcc ttcagcgagg ggctcccact gcccagagct acgcggaaat acgctgagaa aacacgacca gcccagaact gccaatgcca cagggggctg atccttcagg atctctgtgt ttccctgacg aagacaggcc gagagccagc aacctggagt ggggacatgt aagttcctca cactgtgact aagctgtgtg gtgggcacgc ctggacatgt aacgaggatg ccctggagcc atgcgcaaac acgtggctgg agtgacgacg cccacggaca gcggagcgca cggttcttca tggatgggac cccagcaatt aaaaaaa

ctgccagatc ctagaaccca gtccccggcc ccgggccggg tgccccagat gcgagttcgt ccatcgtgga ttttcaaaca tccaggaggg agatccgccc gcggggagat actaccacaa gcctgtcatc tgccctgcac cgtcatcctc agatgctgct ccaccgtttg gcaaagactg tgggggaggc ctgacaagag cagagaatgc ccctggggta ccagcaccac agcggcacta acagatacta tcagccttgt cctacttcgt aggccgcccg acgcacccag ccaacagtca aagtgctggg gggacgtggc tccggaatga gcatgttcga tggagatgat tcacccagat tgaaaccaga actttggctt cggcctacct ggtcagtggg aggacatcaa acatctcagc gctacagcgt acctccgaga cgcgctggga gggatctcgg tcagtgttct caggatccca acgtggggag aaaacggact

ttttctcgga gggtcccccg tccccccatg gtctcctccg cccggccccg gctgttgccc ccagaagttc tgaccccacg cgacctggtg gcacgccctc gctcttcggc gcgctgtgcc cacgtctctg ggctgaagag ttcctcctct ctccaaggtc ccaggcttgc caagtttaac ccttatcaat cgccctcatg gctccacgcc catcccccta gctgcgggag ttggcgcctg taaggaaatt gccgccgggc gggcgagatg gggctgggag cgccccaggc gatccaagag ctcagggcag agttaaggtc agtggccatt gacgcctgag cctgtccagt cctggtggct aaacgtgttg tgctcgcatc ggcacccgag cgtgatcatg tgaccagatc tggagccatt ggacaaatct gctggagggg gcagtttgca tggggcctgt ctgaggtcct gcaatgaact tggggtgggg catctctggc

tccccgctct gggccccccg gccaccgccc ccccccggcg ggttccgggg gccgcctccg cctgagtgtg tcggccaacc gaggtggtgc acggtgcact ctagtgcgcc ttcagcatcc gccagtggcc ctgagccgta tctgcctcat aaggtgccgc aagaaactcc tgtcacaaac ggagatgtgc gatgagtcag agtgaggagg atgagggtgg ggttgggtgg gactgcaagt ccgctgtcag accaacccac cctggcggga acagccatcc cacgcgcccc aatgtggaca tttggagtgg attgacaaac ctgcagagcc aaagtgtttg gagaagggcc ttgagacacc ctggcatcag atcggcgaga gtgctgctca tacgtcagcc cagaacgccg gacctcatca ctcagccacc aagatgggag gcagagcatc ccaccacagg gtgccctcgt gttctaggga ggagctattt cccatggcct

cccaccacct gccgggtccc cctcttatcc gcctagagct tctcctttca agctggctca gcttctacgg tcctgcagct tgtcggcctc cctatcgggc agggcctcaa ccaacaactg actcggtgcg gcaccaccga cgtatacggg acaccttcct tcaagggcct gctgcgccac cgatggagga aggactccgg aggaaggcga tgcaatcggt ttcattacag gtatcacgct aaatcctcac actgctttga ctccgggtgg gccaggccct acagacaagc ttgccactgt tctatggagg tgcgcttccc tgcggcatcc tggtgatgga ggctgcctga ttcacttcaa cagacccatt agtcgttccg accagggcta tcagcggcac ccttcatgta acaacctgct cctggttaca agcgatacat cgctgcctgg accacgacat ccagctgctg aagtggcttc ccaaggcccc tgatctcagc

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