Scribd Logo
Upload

Welcome to Scribd!

  • 6MP - Allopurinol

    Uploaded by

    Raghava Reddy
    20 views3 pages
    1) The study examined the effect of allopurinol on the pharmacokinetics of 6-mercaptopurine in rabbits when administered alone and in combination at two dosage levels. 2) When given together, allopurinol caused a two-fold increase in the half-life and area under the curve of 6-mercaptopurine, a two-fold decrease in total body clearance, and an approximate three-fold decrease in elimination rate constant. 3) Allopurinol had a negligible influence on the pharmacokinetic parameters of 6-thiouric acid, the major metabolite of 6-mercaptopurine.

    Original Description:

    Original Title

    6MP -Allopurinol

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    DOC, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    1) The study examined the effect of allopurinol on the pharmacokinetics of 6-mercaptopurine in rabbits when administered alone and in combination at two dosage levels. 2) When given together, allopurinol caused a two-fold increase in the half-life and area under the curve of 6-mercaptopurine, a two-fold decrease in total body clearance, and an approximate three-fold decrease in elimination rate constant. 3) Allopurinol had a negligible influence on the pharmacokinetic parameters of 6-thiouric acid, the major metabolite of 6-mercaptopurine.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as doc, pdf, or txt
    20 views3 pages

    6MP - Allopurinol

    Uploaded by

    Raghava Reddy
    1) The study examined the effect of allopurinol on the pharmacokinetics of 6-mercaptopurine in rabbits when administered alone and in combination at two dosage levels. 2) When given together, allopurinol caused a two-fold increase in the half-life and area under the curve of 6-mercaptopurine, a two-fold decrease in total body clearance, and an approximate three-fold decrease in elimination rate constant. 3) Allopurinol had a negligible influence on the pharmacokinetic parameters of 6-thiouric acid, the major metabolite of 6-mercaptopurine.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as doc, pdf, or txt
    of 3

    Effect of Allopurinol on the Pharmacokinetics of 6Mercaptopurine in Rabbits1

    1. 2. 3. 4. Lambros Tterlikkis2, James L. Day, Donald A. Brown, and Edward C. Schroeder3

    + Author Affiliations 1. School of Pharmacy, Florida A & M University, Tallahassee, Florida 32307 + Author Notes

    3 Present address: School of Veterinary Medicine, University of Tennessee, Knoxville, Tenn.

    Abstract

    The effect of allopurinol on the pharmacokinetics of 6mercaptopurine (6MP) was studied in rabbits. 6MP alone and in combination with allopurinol was administered i.v. at two dosage levels (2.5 and 20 mg/kg). The plasma concentrations of 6MP and its major metabolite,

    6-thiouric acid, were assayed by high-performance liquid chromatography. Plasma levels of 6MP decay biexponentially. The influence of allopurinol on the pharmacokinetic parameters of 6MP was as follows: (a) a 2-fold increase in the halflife and area under the concentration-time curve; (b) a 2-fold decrease in the total body clearance; and (c) an approximate 3-fold decrease in elimination rate constant. The influence of allopurinol on the pharmacokinetic

    parameters of 6-thiouric acid was negligible. The results suggest that allopurinol serves to increase the plasma level of 6MP by inhibiting its catabolism and thus contributing to a greater availability of 6MP to the tissues.

    You might also like