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Neurogenesis:
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What, how and why it is

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Neurodegenerat

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Parkins

Alzheimer
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Hunting ton

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Possible

Santiago Ramon Y
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Generating Functional Neurons from

Hippocampus
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Dentate Granule Cell

Bromodeoxyuridine (BrdU)

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Subgranular
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subventricular

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In a

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Where is?

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Neural Stem

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glial brillary acidic protein

NEURAL STEM CELL NICHE In the subventricular zone (SVZ) and a model of potential lineage relationship under basal (solid arrows) and injury 5/8/12 conditions (blue arrows).

NEURAL STEM CELL NICHE in the subgranular zone (SGZ) in the dentate gyrus and a model of potential lineage relationship

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Neurogenesis in

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Neurogenesis in

Development in one
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Regulatio ns?

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TGF2 Basic Fibroblast Growth Factor

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Notc h1

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Ciliary Neurotrophic Factor CNTF

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EGF Receptor

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Transforming Growth Factor- TGF-

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Sonic Hedgehog

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Astrocyt es

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Why SVZ and SGZ?

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A Disintegrin And Metalloproteases (ADDMs)

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Why SVZ and SGZ?

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P7C 3

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Tetrahydrocanna binol

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Functional Regulation

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Question s?

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Pleas e?