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  • Channels (Short List) N1 & N2 Excitatory Nachr Ampa & Kainite Excitatory Glutamate R 5-Ht

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    This document summarizes various receptor classes, including both ionotropic and metabotropic receptors. It separates receptors by their neurotransmitter and lists whether they are excitatory or inhibitory. The major receptor classes covered are acetylcholine, dopamine, adrenaline, serotonin, glutamate, GABA, glycine, histamine, adenosine, ATP, and other purinergic receptors. For each class, it notes the specific receptor subtypes and whether they are ligand-gated ion channels or G protein-coupled receptors that increase or decrease intracellular signaling molecules like cAMP, DAG, and IP3.

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    review of R

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    This document summarizes various receptor classes, including both ionotropic and metabotropic receptors. It separates receptors by their neurotransmitter and lists whether they are excitatory or inhibitory. The major receptor classes covered are acetylcholine, dopamine, adrenaline, serotonin, glutamate, GABA, glycine, histamine, adenosine, ATP, and other purinergic receptors. For each class, it notes the specific receptor subtypes and whether they are ligand-gated ion channels or G protein-coupled receptors that increase or decrease intracellular signaling molecules like cAMP, DAG, and IP3.

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    13 views8 pages

    Channels (Short List) N1 & N2 Excitatory Nachr Ampa & Kainite Excitatory Glutamate R 5-Ht

    Uploaded by

    painmd87
    This document summarizes various receptor classes, including both ionotropic and metabotropic receptors. It separates receptors by their neurotransmitter and lists whether they are excitatory or inhibitory. The major receptor classes covered are acetylcholine, dopamine, adrenaline, serotonin, glutamate, GABA, glycine, histamine, adenosine, ATP, and other purinergic receptors. For each class, it notes the specific receptor subtypes and whether they are ligand-gated ion channels or G protein-coupled receptors that increase or decrease intracellular signaling molecules like cAMP, DAG, and IP3.

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    of 8

    review of R organized by R class + excitatory ligand gated Na -channels (short list) classical excitatory ionotropic N1 & N2 = excitatory nAChR

    AChR AMPA & kainite = excitatory glutamate r 5-HT3 = excitatory serotonin R NMDA requires glutamate or aspartate & co-binding of glycine requires partial depolarization of membrane commonly on the same membranes as AMPA (required for partial depolarization) 2+ + has a very high Ca flux along w/ the Na inhibitory ligand-gated Cl channels (short list) GABAA = inhibitory GABA R glycine = inhibitory glycine R inhibitory metabotropic triggered outward K channels (short list) GABAB = inhibitory GABA R excitatory (metabotropic) DAG, IP3, & PKC (short list) M1, M2, M3 excitatory mAChR 1 = excitatory adrenergic R (AR) (NE & epi) 5-HT2 = excitatory serotonin R mGluR1,5 = excitatory glutamate R H1 = excitatory histamine R P2x , P2y excitatory ATP R excitatory (metabotropic) cAMP & PKA (short list) D1, D5 excitatory dopa R = excitatory AR (NE & epi) 5-HT4, 6, 7 = excitatory serotonin R H2 = excitatory histamine R inhibitory (metabotropic) cAMP M2, M4 = inhibitory AChR D2, D3, D4 inhibitory dopa R 2 = inhibitory AR (NE & epi) 5-HT1,5 = inhibitory serotonin R mGluR2 & 3 = inhibitory glutamate R R classes (organized by NT) AChR + nAChR = excitatory ligand-gated Na channels N1 found primarily at the NMJ N2 found primarily in the brain m1, m3, m5 (mAChR) = excitatory mAChR DAG + IP3 m2, m4 (mAChR) = inhibitory mAChR cAMP commonly found in the PNS dopa R: D1, D5 = excitatory (metabotropic) cAMP D2, D3, D4 = inhibitory (metabotropic) cAMP AR (NE &epi) 1 = excitatory (metabotropic) DAG & IP3 2 = inhibitory (metabotropic) cAMP 1, 2, 3 = excitatory (metabotropic) cAMP
    +

    serotonin R: 5-HT1, 5-HT5 = inhibitory (metabotropic) cAMP 5-HT2 = excitatory (metabotropic) DAG & IP3 + 5-HT3 = excitatory ligand gated Na channels 5-HT4, 6, 7 = excitatory (metabotropic) cAMP glutamate R: + AMPA = excitatory ligand gated Na channel + kainate = excitatory ligand gated Na channel + 2+ NMDA = excitatory ligand gated Na & Ca channels NMDA responds to either glutamate or aspartate requires co-binding of glycine & partial depolarization of membrane commonly on the same membrane as AMPA (required for the partial depolarization) 2+ + has a very high Ca flux along w/ the Na mGluR1,5 = excitatory (metabotropic) DAG & IP3 mGluR2, 3, 4, 6, 7, 8 = inhibitory (metabotropic ) cAMP grp II = 2,3 grp III = 4,6,7,8 GABA R GABAA = inhibitory ligand gated Cl channels similar to glycineR, but found in the brain + GABAB = inhibitory (metabotropic) triggered outward K channels similar to inhibitory mGluRs GABAC = inhibitory ligand gated Cl channels similar to A, but highly expressed in the retina glycine R inhibitory ligand gated Cl channels similar to GABAA, but found in the spinal cord histamine R: H1=excitatory (metabotropic) DAG & IP3 H2= excitatory (metabotropic) cAMP H3, 4 = inhibitory (metabotropic) cAMP adenosine R: A1,3 = inhibitory (metabotropic) cAMP A2= excitatory (metabotropic) cAMP ATP type of purigenic R: + 2+ P2x = excitatory ligand gated Na & Ca channels P2y (subtype 2 & 11) = excitatory (metabotropic) DAG & IP3 other purigenic R: P2y (other subtypes) = some are excitatory, others are inhibitory this grp is very complex & responds to ADP, UDP, UTP, & others

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