Yang Xia 21135501 Tute: 11 1.

Centre for Genetics Education 2007, 'Hereditary Haemochromatosis', The Australasian Genetics Resource Book, 5th edn, Government of Australia, Available from: <http://www.genetics.edu.au/Information/Genetics-Fact-Sheets/HereditaryHaemochro matosisFS36>. [5 May 2012].

This is a detailed fact sheet concerning about many aspects of Hereditary Haemochromatosis (HH), along with some introductive genetic principle. It effectively explains the causes of HH in terms of gene mutations and describes the symptoms, thus it can be easily used to explain the second assignment question. (48)

2. Lobo, I. 2008 'Environmental Influences on Gene Expression', Nature Education, available from: <http://www.nature.com/scitable/topicpage/environmental-influences-on-gene-expres sion-536>. [5 May 2012].

In this article Lobo covers most environmental factors which influences gene expression, such as gender, chemicals and temperature. Though some examples used consisted of animals, it will be useful when explaining the differences in gene expression for different sexes and understanding the theory behind external treatment/environmental treatment of genetic diseases. (50)

Yang Xia 21135501 Tute: 11 3. Lobo, I. 2008 'Same Genetic Mutation, Different Genetic Disease Phenotype', Nature Education, available from: <http://www.nature.com/scitable/topicpage/same-genetic-mutation-different-genetic-d isease-phenotype-938>. [5 May 2012].

The concepts of variable expression and incomplete penetrance is explained by Lobo in this article. He uses Neurofibromatosis, Holoprosencephaly and Van der Woude Syndrome as examples and identifies the reasons for variable expression and incomplete penetrance. This will help understand what is meant by variable expression and incomplete penetrance. (49)

4. Lobo, I. 2008 'Pleiotropy: One Gene Can Affect Multiple Traits', Nature Education, available from: <http://www.nature.com/scitable/topicpage/pleiotropy-one-gene-can-affect-multiple-tr aits-569>. [5 May 2012].

Lobo, using examples in animals as well as humans, explained the concept of pleiotropy. The article explored instances this has been seen on humans, including PKU and antagonistic pleiotropy, and it will become a great information source when explaining pleiotropy as it is better understood when backed with examples. (49)