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Chitosan supports the expression of extracellular matrix proteins in human osteoblasts and chondrocytes Ashkan Lahiji, Afshin Sohrabi, David S. Hungerford, Carmelita G. Prondoza Department of Orthopaedic Surgery, Good Samaritan Hospital, folms Hopkins University, Professional Office Building, 5601 Loch Reven Boulevard, Baltimore, Maryland 21239 Received 21 April 1999; revised 6 fanuary 2060; accepts 26 January 2000 Avtanee sch r bconpal ms tet Ave Te sc revue mith te diopters aren fe gis toon a mage pls on of toe ng cm fe pe a sng tn ce Clay septa pheoai an Heeger uy pa aes sa ln te ete rae i» bas were un ee oa ey STs Pe ann tl cedar te i roaring tamer et hl tS i nef epee at oan ome ts ur and ann pci dh sare, Gen i a ad Momsen ae ttc cite grat ec er 1 ces al Cw uae A ECO, feetodel Cally we at i seg ence oar pn Te poate INTRODUCTION The need for more effective metheds of repairing bone and cartilage defects has prompted investigation into the utility of tissue engineering approaches. One such approach is to generate histologically and func- tionally normal tissue by delivering healthy celis in 2 biocompatible scaffold, The cell-material complex can then be implanted to repair osseous and chondral de- fects, A number of natural and synthetic materials have been considered for their potential use as cell delivery vehicles However, the identilication of ma- terials that can support osteoblast and chondrocyte Coccespondence to: C. Frondora: email: cphrondoe nents ‘Conleact grant sponsor: The Joly Hopkins University Or thopadic Hheamatotogy Gilt Fund CConteact grant sponsur The Good Samactan Hospital 1a john Way Sons. tne cytochemistry. Osteoblasts and chondrocytes appeared spherical and refractile on chitosan-

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