Name of the Drug Mannitol

Dosage and Administration 100cc q4

Indication Adjunct for treatment of tuberculosis with primary and secondary antitubercular drugs when these are not successful

Adverse Effects Common: myalgia, nausea, vomiting, arthralgia, anorexia. Serious: thrombocytopenia, hepatotoxicity, nephritis, porphyria, gout, hypersensitivity reactions.

Contraindication Hypersensitivity to pyrazinamide, severe liver disease, acute gout.

Nursing Implication To minimize possible photosensitivity reaction, apply adequate sunscreen and use proper covering when exposed to strong sunlight. Notify treating physician if symptoms do not improve after several weeks on drug. Do not stop taking medication without consulting treating physician.

Clarithromycin

125 mg/ml syrup 3.5ml BID

Pharyngitis/tonsillitis Acute maxillary sinusitis Acute exacerbation of chronic bronchitis (Streptococcus pneumoniae, Moraxella catarrhalis), pneumonia (S. pneumoniae, Mycoplasma pneumoniae) Acute exacerbation of chronic bronchitis (H. influenzae)

Common: diarrhea, nausea, abdominal pain. Severe: pseudomembranous colitis, ventricular arrhythmias, nephritis, cholestatic jaundice, angioedema. .

Hypersensitivity to macrolide antibiotics, concomitant administration of pimozide.

Use with caution in patients with liver or kidney dysfunction. Parameters to monitor Signs and symptoms of superinfection, in particular pseudomembranous colitis. Signs and symptoms of renal toxicity. Signs and symptoms of hearing impairment. Patients with Kidney or liver disease is at highest risk.

Uncomplicated skin and skin structure infections

Rifampicin

200mg/ml syrup 3.75 OD before breakfast

Pulmonary tuberculosis: used in conjunction with other agents (combination therapy) Meningococcal prophylaxis Prophylaxis of Hemophilius influenzae type B infections

Common: diarrhea, red discoloration of urine and other body fluids. Serious: acute renal failure, confusion, bone marrow depression, hepatic injury.

Hypersensitivity to rifampin or rifamycins.

Avoid driving or other activities requiring alertness until full response to rifampin or ripampicin is evaluated. Avoid alcohol. Rifampin may stain soft contact lenses permanently. Accordingly, soft contact lenses should not be worn during treatment with this drug. Do not discontinue taking rifampin without approval of treating physician.

Isoniazid

200 mg/ml 2.5 ml p.c 20 min. before breakfast

Primary treatment for active tuberculosis; firstline drug for combination therapy Prophylaxis against TB bacillus, prophylaxis following exposure: Drug of choice

Common: anorexia, nausea, abdominal pain, weakness. Serious: peripheral neuropathy, hepatitis, bone marrow suppression, seizures, depression, optic neuritis, blindness.

Acute liver disease, prior liver toxicity associated with INH therapy, severe hypersensitivity reaction to isoniazid(drug fever, arthritis).

Avoid alcohol. Drink 23 L of fluids/d. Report symptoms of drug side effects such as fatigue, anorexia, weakness (symptoms of hepatitis) to treating physician and stop drug. Continue therapy uninterrupted

to prevent relapse and spread Of infection . Food: Ideally, should be taken on an empty stomach; may administer with food if gastric irritation occurs. There may be a severe reaction if isoniazid is taken along with foods that contain large amounts of tyramine (eg, aged cheese, Chianti wine,pickled herring).