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11/13/12

Tuberculosis (TB) Overview

Tuberculosis(TB)
Overview
Indevelopedcountries,suchastheUnitedStates,manypeoplethinkTBisa diseaseofthepast.TB,however,isstillaleadingkillerofyoungadultsworldwide. Some2billionpeopleonethirdoftheworld'spopulationarethoughttobeinfected withTBbacteria,Mycobacteriumtuberculosis(Mtb).

VolunteerforNIAIDfunded TBisachronicbacterialinfection.Itisspreadthroughtheairandusuallyinfectsthe clinicalstudiesrelatedto tuberculosison lungs,althoughotherorgansandpartsofthebodycanbeinvolvedaswell.Most peoplewhoareinfectedwithMtbharborthebacteriumwithoutsymptoms(havelatent ClinicalTrials.gov. TB),butsomewilldevelopactiveTBdisease.In2010,anestimated8.8million peoplefellillwithTB,including1.1millioncasesamongpeoplewithHIV,according Additional totheWorldHealthOrganization. InformationFrom Onein10peoplewhoareinfectedwithMtbmaydevelopactiveTBatsometimein theirlives.Theriskofdevelopingactivediseaseisgreatestinthefirstyearafter infection,butactivediseaseoftendoesnotoccuruntilmanyyearslater.

NIAID
GlobalResearch,Africa RapidlyandEffectively DiagnosingTuberculosis EmergingandReemerging InfectiousDiseases

TBintheUnitedStates
AccordingtotheCentersforDiseaseControlandPrevention(CDC),11,182TB cases(arateof3.6casesper100,000persons)werereportedintheUnitedStatesin 2010.BoththenumberofTBcasesreportedandthecaseratedecreased, representinga3.1%and3.8%declinecomparedto2009.

TBcaseratesvarybywellknownfactorssuchasage,raceandethnicity,andcountryoforigin.Minoritiesare affecteddisproportionatelybyTB,whichoccursamongforeignbornindividualsmorefrequentlythanamongpeople bornintheUnitedStates.ThisispartiallybecausetheywereoftenexposedtoMtbintheircountryoforiginbefore movingtotheUnitedStates.Theproportionoftotalcasesoccurringinforeignbornpersonshasbeenincreasing since1993.In2010,60%ofTBcasesoccurredinforeignbornpersons.Foreignbornpersonshaveaccountedfor themajorityofTBcasesintheUnitedStateseveryyearsince2001.Moreover,thecaserateamongforeignborn personsin2010wasapproximately11timeshigherthanamongU.S.bornpersons,accordingtotheCDC.

RelatedLinks

CentersforDiseaseControlandPrevention WorldHealthOrganization
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LastUpdatedAugust13,2010

www.niaid.nih.gov/topics/tuberculosis/understanding/pages/overview.aspx

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