Name of Drug Cefuroxime 750 mg TIV q 8

Generic Name Cefuroxime

Mechanism of Action Bactericidal/Antibacterial Bactericidal: inhibits synthesis Indication: of bacterial cell wall, causing cell For dermatologic infections, caused by S. death. aureus, S. pyogenes Fights bacteria in the body. Is used to treat many different types of bacterial infections.

Specific Action

Complications An allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, face, or tongue; hives; or a rash). Rash, redness or itching. Severe nausea, vomiting, or diarrhea

Adverse Reactions CNS: Headache, dizziness, lethargy, paresthesias GI: Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous colitis, liver toxicity Hematologic: Bone marrow depression: decreased WBC, decreased platelets, decreased Hct GU: Nephrotoxicity Hypersensitivity: Ranging from rash to fever to anaphylaxis, serum sickness reaction Other: Superinfections, disulfiram-like reaction with alcohol

Nursing Responsibilities 1. Cefuroxime axetil for PO use is available in tablet and suspension forms. Swallow tablets whole and not crush, crushed tablet has a strong, bitter, persistent taste. The tablets may be taken without regard for food. Protect tablets from excessive moisture. 2. Tablet are not bio-equivalent and not substitutable on a mg-per-mg basis. 3. Prior to reconstitution, protect drug from light. The power and reconstituted drug may darken without affecting potency. 4. Continue therapy for at least 10 days in infections due to Streptococcus pyogenes.

5. Do not take cefuroxime if patient have ever had an allergic reaction to another cephalosporin or to a penicillin unless the doctor is aware of the allergy and monitors their therapy.