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  • Buerger's Disease Pathophysiology

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    Bon Guevarra Sagun
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    This document discusses the pathophysiology of peripheral artery disease. It identifies several precipitating and predisposing factors including being male, between 20-60 years old, having a history of hyperlipidemia or hypertension, and having a Southeast Asian genetic background. Key risk factors include cigarette smoking, exposure to cold environments, and a sedentary lifestyle. Cigarette smoking can cause vasoconstriction, damage to blood vessels, reduced oxygen transport, and may trigger an autoimmune response leading to reduced blood flow and tissue ischemia. Over time this can progress to symptoms like pain, skin changes, numbness, ulcers, gangrene and potential limb amputation if not treated.

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    This document discusses the pathophysiology of peripheral artery disease. It identifies several precipitating and predisposing factors including being male, between 20-60 years old, having a history of hyperlipidemia or hypertension, and having a Southeast Asian genetic background. Key risk factors include cigarette smoking, exposure to cold environments, and a sedentary lifestyle. Cigarette smoking can cause vasoconstriction, damage to blood vessels, reduced oxygen transport, and may trigger an autoimmune response leading to reduced blood flow and tissue ischemia. Over time this can progress to symptoms like pain, skin changes, numbness, ulcers, gangrene and potential limb amputation if not treated.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
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    Download as docx, pdf, or txt
    2K views3 pages

    Buerger's Disease Pathophysiology

    Uploaded by

    Bon Guevarra Sagun
    This document discusses the pathophysiology of peripheral artery disease. It identifies several precipitating and predisposing factors including being male, between 20-60 years old, having a history of hyperlipidemia or hypertension, and having a Southeast Asian genetic background. Key risk factors include cigarette smoking, exposure to cold environments, and a sedentary lifestyle. Cigarette smoking can cause vasoconstriction, damage to blood vessels, reduced oxygen transport, and may trigger an autoimmune response leading to reduced blood flow and tissue ischemia. Over time this can progress to symptoms like pain, skin changes, numbness, ulcers, gangrene and potential limb amputation if not treated.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
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    Pathophysiology

    Precipitating Factor; Gender: Male Age: 20-60 y/o History (HPN, Hyperlipidemia Genetics Race: Southeast Asian

    Predisposing Factors; Lifestyle (Cigarette smoking, chewing of tobacco, sedentary lifestyle) Environment: exposure to cold, stressful environment

    CIGARETTE SMOKING

    Nicotine

    Carbon Monoxide

    Carbon Dioxide

    Vasoconstriction of arteries

    Destruction of the lining of blood vessel

    Decrease Oxygen Transport to tissue

    TRIGGERS AUTOIMMUNE RESPONSE (IDIOPATHIC)

    Tissue Ischemia

    Anaerobic Metabolism

    Lactic Acid Formation

    Intermittent Claudication

    cyanosis

    Tissue Hyoxia

    Rest Pain

    Trophic changes dryness, scaling of skin, loss of hair, thickened and ridge toenails

    Tissue Necrosis

    Numbness

    Pallor

    Coldness

    Tissue Ulceration

    Gangrene

    Amputation

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