LYPOSOMAL VITAMIN C AND CANCER

Liposomal Encapsulated Vitamin C

Cancer-Killing Effect Of High Oral-Dose Vitamin C

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From: http://www.naturalhealthstrategies.com/vitamin-c.html This is a 4-part video series of Dr. Thomas Levy at the 35th Annual Tree of Life Cancer Convention, on the breakthrough effectiveness of Liposomal Encapsulated Vitamin C You can download the 4 (10-minute) videos into Realplayer (A free program) if you have it, I did.. Please go and listen to them- According to this Dr., it's better made and orally ingested the ultrasound way than by IV, he tells you why on the videos. = == = In an overlooked study first published in 2008, for the first time, using a special liposomal form of oral-dose vitamin C, researchers in Britain demonstrated it is possible to achieve cancer-killing blood concentrations of this vitamin without undesirable side effects. Heretofore, National Institutes of Health Researchers claimed the maximal concentration of vitamin C that can be achieved following oral intake is not sufficient to produce a cancer-killing effect. Now British researchers demonstrate they were able to achieve blood concentrations of vitamin C that were twice what was incorrectly reported to be maximal, and in the range of what is known to be selectively toxic to tumor cells, yet not harmful to healthy cells. Studies with various forms of cancer show a 30-to-50 percent cancer cell-killing effect at the same blood concentration of vitamin C achieved in this study. For comparison, anti-cancer drugs are approved by the FDA if they achieve 50 percent tumor shrinkage. Researchers Stephen Hickey and Hilary J. Roberts, long-time advocates of vitamin C therapy and authors of the book Ascorbate: The Science of Vitamin C, writing in the Journal of Nutritional & Environmental Medicine, believe even higher concentration of vitamin C can be achieved, up to three times what was once mistakenly believed to be maximal, with measured, repeated oral doses. It was Linus Pauling, the two-time Nobel Prize winner, who first employed intravenous vitamin C to prolong the lives of terminal cancer patients. This was reported in 1978. A year later Mayo Clinic researchers then followed with a study of their own, which utilized oral-dose vitamin C, and errantly dispelled the notion of using vitamin C to treat cancer. However, oral doses cannot achieve the same high blood concentration that intravenous vitamin C can produce. Only recently has it come to light that the dismissal of vitamin C for cancer therapy was based upon oral-dose vitamin C, and subsequent studies found intravenous vitamin C has the potential to be used in cancer therapy. Some small pilot studies appear to be encouraging with the use of intravenous vitamin C therapy. Cancer

researchers have recently called for a reconsideration of intravenous vitamin C therapy. According to researchers Hickey and Roberts, repeated doses, and use of a special liposomal form of vitamin C that is absorbed in the gut and then into the liver before it is released into the blood stream, are key to making oral vitamin C therapy effective. Another important factor is to limit the consumption of carbohydrates (refined sugar) which impairs oral absorption of this vitamin. Dr. John Ely, emeritus professor at the University of Washington, has also shown that sugar depletes vitamin C from white blood cells and makes them sluggish. White blood cells are the very cells that attack tumor cells and destroy them. The liposomal form of vitamin C employed in this study consists of 1-gram (1000 milligram) dose sachets of vitamin C powder encapsulated in lecithin (phosphatidylcholine), as supplied by Livon Laboratories of Henderson, Nevada. A British laboratory (Biolab, London) that has conducted thousands of vitamin C assays over a 10-year period, confirms that 20-gram and 36-gram doses of oral vitamin C, as utilized by researchers Hickey and Roberts, achieved far higher blood concentration than had ever been measured previously. Repeated dosing rather than massive single-dose vitamin C averts side effects such as diarrhea. The cancer cell-killing effect of vitamin C is realized by the transient production of hydrogen peroxide (H2O2) within connective tissues (not in blood), which then destroys tumor cells, and subsequently turns to harmless water (H2O), ensuring non-toxic therapy. Reluctance by modern medical practitioners to offer vitamin C therapy to their cancer patients suggests the public will have to practice vitamin C therapy at home. This need not be a totally unguided experience, as there are instructive books available. Why this landmark study has been completely overlooked by the cancer community goes unexplained. The study was published in a journal catalogued by the National Library of Medicine (NLM), but articles from that journal cannot be accessed at the NLM website. When this report was submitted for publication, the publisher of the journal suddenly changed editors and the new editor attempted to scratch the report from its publication schedule altogether. Finally the report did get published, but suddenly the journal itself was discontinued and its articles no longer indexed by NLM. It appears an intentional effort was made to bury this study. An online abstract is provided at the Journal of Nutritional and Environmental Medicine website. Dr. Cinque's comments: I have said before that I would not want to undergo high-dose Vitamin C therapy all the time. However, my mind is entirely open to the possibility that it could be useful in treatment and management of cancer. Keep in mind that we are not talking about a nutritional effect here. It is most definitely a matter of poisoning. However, compared to chemotherapy, it is extremely safe and pretty close to harmless. And even in terminal cancer cases, it might bide the individvual much precious time. Liposomal Encapsulation Technology has been around since the 1970s, but it is just now finding practical application. The idea is to provide nutrients in a form that resists degradation in the gut, for instance by wrapping it in a phospholipid such as lecithin, which leading to more efficient absorption and utilization. For instance, VRP has begun offering Liposomal Glutathione as a way to get around the digestive cleavage of the peptide bonds in the gut. This is major breakthrough, and it makes all other forms of glutathione obsolete................. http://www.1to1vitamins.com/news/2010/artl7947.html

Liposomal Encapsulation Technology (LET) is an exciting new process that may revolutionize many forms of oral pharmacological therapy and more importantly, may be in the realm of the common man to utilize. LET can offer a unique safe way to treat racehorses in a track situation without the use of banned syringes or needles. It is simply an encasing of nanoparticles of pharmaceutical compounds (herbs, too) by a phospholipid membrane (liposome) allowing safe passage through the gastrointestinal tract without degradation.

It would be the closest thing we have to giving a pill that mimics an intravenous injection! Plus, liposmes could more easily assault and penetrate many forms of infective biofilms resulting in a very effective delivery system against these pathological forms. As an example, it has been shown that 5 grams of Vitamin C which has been encased by liposomes is equal to 50 grams of Vitamin C that has been given intravenously! One can go out and purchase Liposomal Vit C and other compounds, but it can be made at home very cheaply. Certainly the home made Liposomal medications will not be quite as efficiently made as in the big med laboratories, but even if one can produce just 50% liposomal encapsulated material in the kitchen, that is more than good enough for our needs and can offer outstanding health benefits! My book, A Racehorse Herbal will study in detail new and exciting breakthroughs like LET which will more effectively treat the performance horse and will be within the capability of any horseman to process himself! Brooks Bradley has come up with a unique way to produce LET in your do-it-yourself Lab or kitchen for pennies. Most of his work has been done with Vitamin C. Vitamin C has very low absorbability in the gastrointestinal tract of humans (16%). By encapsulating Vitamin C nanoparticles with a phospholipid membrane, we could directly by-pass the destructive forces of the gut with Liposomal-C being directly absorbed into the blood stream. He has manipulated the natural tendency of phospholipids to form tiny encasing bubbles (liposomes) in a water-based pharmacological solution. The key is that these formed liposomes will automatically encase whatever is in the water solution with it. Thus, if you have an aqueous solution of Vitamin C, add soy lecithin (a common form of phospholipid easily purchased) and place the two solutions, together in even a cheap ultrasonic cleaning unityou will get an automatic encapsulation via the ultrasonic waves to form Lipsomal-C. This same process could be used for other compounds. The respected researcher, Brooks Bradley writes, "The implications are simply staggering. . .! Our vitamin C Liposomal encapsulation protocol is as follows: Using a small (2 cup) ultrasonic cleaner, like the ones sold at Harbor Freight for around $30.00, we performed the following: 1. Dissolved 3 level tablespoons of soy lecithin in 1 cup of distilled water. 2. Dissolved 1 level tablespoon of ascorbic acid powder (vitamin c) in half a cup of distilled water. 3. Poured both solutions together in the ultrasonic cleaner bowl and turned the unit on. Using a plastic straw (leaving the top of the cleaner open) gently, slowly, stirred the contents. Note: The cleaner will automatically self-stop every 2 minutes. Just push the ON button to continue. Repeat for a total of 3 series or 6 minutes total. By that time the entire solution should be blended into a cloudy, homogeneous, milk-like mixture. The LET solution is now formed. 4. This protocol furnishes about 12 grams (1200 mg) of vitamin C product at 70% encapsulation efficiency or 8400 mg of the LET type. This solution will keep at room temperature for 3-4 days. Refrigerated, it will keep much longer. The homogenizing effect is so powerful that after 3 days at room temperature, no precipitation of solution separation appears evident. This type of sequestered vitamin c has demonstrated to be at least 5 times more effective than any other form of orally ingested vitamin c that we tested. Additionally, it appears to be even more rapid in tissue-bed

availability than intravenously applications. An astounding revelation to us!" More details in formulating liposomal Vitamin C: Sometimes a meniscus (layer) can form in the completed LET solution. This can occur if the ultrasonic process is not run long enough or too much lecithin has been added in relation to the available ascorbic acid fraction (if one is making Vit C LET). In such case, the meniscus will form on top in minutes after completing the ultrasonic cycle. More commonly, a meniscus will form on the bottom part of the LET solution overnight in some instances. One needs to continually experiment and adjust volumes to achieve the perfect homogenized LET solution that will withstand meniscus layering. Even if this happens, the solution is quite valuable and usable. You will just have a layer of lecithin within the LET solution and that in itself is of medicinal value and should not be discarded. Feed it all! Lecithin is slow in forming liposomes in aqueous solutions especially when one has not added correct amount ratios of lecithin to the pharmacological solution to be encapsulated. It is often natural to find a gelatinous mass of unencapsulated Lecithin floating on top of your LET solution. The encapsulation process is affected by amount ratios, temperatures of the solutions, and concentrations of the components. One can limit this unencapsulated lecithin layer by increasing the volume of the total water though this has a diluting effect in the combined solution and/or raising the temperature of the solution. Increasing the ultrasonic mixing cycle may also be of value. It should be noted that once the saturation point has been reached in the solution, no amount of adjusting will cause the lecithin to continue to encapsulate. The guiding line for the amateur LET processor is that it is far better to have a layer of unencapsulated lecithin than to produce a solution with too little, no matter how pretty the final solution may look. Brooks Bradley's simple test to gauge LET efficiency of a liposomal Vitamin C solution: 1) Pour 4 ounces of the finished LET Vitamin C into a 12oz container. 2) Add 1/4 teaspoon of sodium bicarbonate into 1 oz of distilled water, stirring well. 3) Pour the sodium bicarbonate solution into the LET Vitamin C mixture, stirring. Results: If the resulting foam reaction line from this mixture is .5" or less you will have approximately a 50% encapsulation rate of the raw ascorbic acid nanoparticles. If the foam is 3/8" or less you will have approximately 60% encapsulation. If the foam is 1/8" thick or less, you will have around 75% encapsulation. Foam occurs when the unencapsulated Vit C reacts with the sodium bicarbonate which is added to produce sodium ascorbate. The liposome encapsulated Vit C will not react. Thus, the less foam, the more Vit C is encapsulated and the more efficient went your process. By the way, this test solution should not be discarded as it is still valuable as a medicinal! The formed sodium ascorbate is a very useable form of Vitamin C. Further useful tips from DaddyBob and Steve N. of the CS list: For best encapsulation efficiency, blend both the lecithin and your encapsulation solution very well, with a blender, magnetic shaker, or by pure mechanical shaking, until you see no granules or other large debris in solutionthen place in the ultrasonic cleaner chamber. At least the use of a common kitchen blender is to be urged for pretreatment of solutions prior to ultrasonic process. Brooks Bradley writes on this above suggestion: "First, using some form of blender to enhance/accelerate the process is perfectly acceptable and effective. However, one must understand the limitations of using this modality. To wit: Because the entire encapsulation process is, essentially, a

refined homogenization process the researcher is bound within the limits of the chosen process, itself; Using a blender in the early stages of the ultrasonic type protocol, places a limit (especially particle size) on the resultant compounds. As a general rule, the smallest liposomes achievable are going to be larger than 150 nm in size----even after extensive agitating. Therefore, if smaller particles are desired--some procedure must be invoked to achieve this. Ultrasonic energy is an excellent way to achieve this. Ultrasonic energy applied to solutions having, previously been mixed using mechanical blenders (household type) will improve the encapsulation process greatly (sometimes as much as an order of magnitude) through the immediate size reduction of the encapsulated particle size. Additionally, both power levels and exposure time experienced from the ultrasonic energy have a pronounced effect on the end product: e.g. simply by extending the time exposed to the ultrasonic energy will yield a product with a majority of particles of a markedly reduced physical size (sometimes by more than one-half). Also, by increasing the power spectral density [energy delivered to the target], considerable size and complexity reduction may be achieved (sometimes from larger, multiple-layered liposomes, down to single-layered liposomes of much smaller size). This one characteristic, alone should justify the selection of the larger ultrasonic unit over the smaller one as the larger ultrasonic power level output is much higher. The way to capitalize on this advantage is to limit the depth of the parent solution in the larger ultrasonic unit to 3/4"- 1" deep. Because the distance from the ultrasonic energy source and the mass of the target material DOES, in fact, have a powerful effect on the delivered energy. Direct visual observation alone will confirm the powerful increase in cavitations (energy field) of the liquid medium. This type of innovation will yield effects that in some cases challenge the results of laboratory-grade, high pressure (over 3000 psi) impact plate systems costing $10,000 and up. What most commercial producers (and labs) do is they RECIRCULATE their candidate solutions in order to achieve smaller and more isolated end products. By extending your exposure time using shallow solutions, do-it-yourselfers can in many cases actually challenge the levels accomplished by these very high dollar commercial machines using their own do-it-yourself homemade systems. Someone asked the question: does pre-agitation via kitchen blending devices damage or compromise the candidate solutions. The short answer is NO. Almost any type of agitation, aids in the homogenization process."