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UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K
CURRENT REPORT
PURSUANT TO SECTION 13 OR 15(d)
OF THE SECURITIES EXCHANGE ACT OF 1934

Date of Report (Date of Earliest Event Reported): February 20, 2009

Neose Technologies, Inc.

(Exact Name of Issuer as Specified in Charter)

Delaware 0-27718 13-3549286

(State or Other Jurisdiction of (Commission File Number) (I.R.S. Employer Identification
Incorporation or Organization) Number)

102 Rock Road, Horsham, Pennsylvania 19044

(Address of Principal Executive Offices) (Zip Code)

(215) 315-9000
(Registrant’s Telephone Number, Including Area Code)

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K is intended to simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

o Written communications pursuant to Rule 425 under the Securities Act

o Soliciting material pursuant to Rule 14a-12 under the Exchange Act

o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act

o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act

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Item 3.01 Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing.

On February 20, 2009, Neose Technologies, Inc. (the “Company”) notified the NASDAQ Stock Market (“NASDAQ”) of its intent to delist its
common stock (the “Stock”) from the NASDAQ Global Market. The Company currently anticipates that on March 3, 2009 it will file with the
Securities and Exchange Commission (the “SEC”) and NASDAQ a Form 25 relating to the delisting of the Stock. The Company expects that
trading in the Stock will be suspended by NASDAQ effective at the open of business on March 3, 2009, with official delisting of the Stock
effective ten days thereafter, on March 13, 2009.

A copy of the press release issued by the Company with respect to this matter is attached hereto as Exhibit 99.1.

“Safe Harbor” Statement under the Private Securities Litigation Reform Act of 1995. Statements in this press release regarding our
business that are not historical facts are “forward-looking statements” that involve risks and uncertainties. Among those risks and
uncertainties are: the risk that the Company will not file a Form 25 with the SEC on March 3, 2009 or at any time thereafter, as well as
more specific risks and uncertainties set forth in the sections of the Company’s Annual Report on Form 10-K for the year ended
December 31, 2007, as amended, entitled “Risk Factors” and “Special Note Regarding Forward-Looking Statements,” and discussions of
risk factors in the Company’s subsequent SEC filings. Any of these risks and uncertainties could cause the Company’s actual results to
differ from those contained in the forward-looking statements.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits: The Exhibit Index annexed hereto is incorporated herein by reference.

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Signatures

Pursuant to the requirements of the Securities and Exchange Act of 1934, the Company has duly caused this Current Report on
Form 8-K to be signed on its behalf by the undersigned, hereunto duly authorized.

NEOSE TECHNOLOGIES, INC.

Date: February 20, 2009 By: /s/ A. Brian Davis

A. Brian Davis
Senior Vice President and Chief Financial Officer

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Exhibit Index

Exh ibit No. De scription

99.1 Press Release dated February 20, 2009

EXHIBIT 99.1

Neose Technologies’ Announces Voluntary Delisting

from Nasdaq and Closing of its Stock Transfer Books

HORSHAM, PA, February 20, 2009 — Neose Technologies, Inc. (NasdaqGM: NTEC) today announced that it has notified the NASDAQ Stock
Market (“NASDAQ”) of its intent to delist its common stock (the “Stock”) from the NASDAQ Global Market. The Company currently
anticipates that on March 3, 2009 it will file with the Securities and Exchange Commission (the “SEC”) and NASDAQ a Form 25 relating to the
delisting of the Stock. The Company expects that trading in the Stock will be suspended by NASDAQ effective at the open of business on
March 3, 2009, with official delisting of the Stock becoming effective ten days thereafter, on March 13, 2009.

As previously disclosed, on December 17, 2008, the Company filed a definitive proxy statement for a special meeting of its stockholders, which
was held on January 26, 2009 (the “Special Meeting”). At the Special Meeting, the Company’s stockholders approved two separate asset
purchase agreements for the sale of substantially all of the Company’s assets (the “Asset Sales”) and the liquidation and dissolution of the
Company (the “Liquidation”). The Asset Sales closed on January 27, 2009 and the Company intends to file its certificate of dissolution with
the Secretary of State of the State of Delaware on March 2, 2009 and close its stock transfer books at the close of business on such date.

During 2008 and early 2009, the Company received a number of Staff Determinations from NASDAQ indicating deficiencies related to its failure
to satisfy certain NASDAQ listing standards. An appeal hearing regarding these deficiencies was held on December 18, 2008 before a
NASDAQ Hearings Panel (the “Panel”). On February 3, 2009, the Company received a decision from the Panel allowing the Stock to continue
to trade on the NASDAQ Global Market. The Panel determined, however, that if the Company does not file its certificate of dissolution by
March 3, 2009, NASDAQ would delist the Stock and suspend its trading on the NASDAQ Global Market effective at the open of business on
March 4, 2009. The Panel’s decision to delist the Stock was based upon determinations by the NASDAQ staff (the “Staff”) that: (i) the
Company announced the Asset Sales and the Liquidation, in violation of NASDAQ Marketplace Rules 4300, 4450(f) and IM-4300; (ii) the
Company’s shareholders’ equity had fallen below the required $10 million minimum for continued listing on NASDAQ, in violation of
NASDAQ Marketplace Rule 4450(a); and (iii) the Company failed to hold an annual meeting during its fiscal year ended December 31, 2008, in
violation of NASDAQ Marketplace Rules 4350(e), 4350(f) and IM-4350-8.
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CONTACTS:

Neose Technologies, Inc.

A. Brian Davis
Sr. Vice President and Chief Financial Officer
(215) 315-9000

“Safe Harbor” Statement under the Private Securities Litigation Reform Act of 1995. Statements in this press release regarding our
business that are not historical facts are “forward-looking statements” that involve risks and uncertainties. Among those risks and
uncertainties are: the risk that the Company will not file its certificate of dissolution on March 2, 2009, the risk that the Company will not
file a Form 25 with the SEC on March 3, 2009 or at any time thereafter, as well as more specific risks and uncertainties set forth in the
sections of the Company’s Annual Report on Form 10-K for the year ended December 31, 2007, as amended, entitled “Risk Factors” and
“Special Note Regarding Forward-Looking Statements,” and discussions of risk factors in the Company’s subsequent SEC filings. Any of
these risks and uncertainties could cause the Company’s actual results to differ from those contained in the forward-looking statements.