OLEG KHATSENKO, Ph.D.

San Diego, CA 92103 okhatsen@gmail.com 858-395 5032

SR. RESEARCH SCIENTIST / DIRECTOR

Well published scientist with more than 15 years of experience and expertise in pharmaceutical/biotech industry. Further expertise in drug discovery, preclinical and clinical development with specialization in areas of pharmacokinetics, drug metabolism (DMPK/ADME) and bioanalysis. Demonstrated success in design and execution of experiments, data analysis and contract negotiations. Proven ability in laboratory set-up, budgeting and capital equipment purchasing. Recognized for identifying critical issues and implementing effective solutions. Excellent communicator as evidenced by a successful history of technical writing. Core competencies include:
Project Management Understand Complex Scientific Information -Process Development Conduct Experiments Contract Negotiations Data Analysis Methods Development Consulting - Technical Reporting Equipment Purchasing/Management - Lab Set-Up

PROFESSIONAL ACHIEVEMENTS
Helped to move 7 drug candidates from discovery phase to the clinical stage. Served as DMPK representative on several drug discovery and development project teams. Results: 3 drugs are currently on the market and 4 compounds are at Phase I-II of the clinic. Made a significant contribution to the development of Setrobuvir (ANA598) at Anadys Pharmaceuticals. Coordinated and managed pre-IND and Phase I DMPK activities for the compound. Results: Anadys was acquired by Roche for $230 M due to this compound. Played key role in submission of section 8 of two INDs and 1 IMPD. Wrote, verified or edited content of DMPK data. Results: Company successfully filed IND in short time. Created DMPK laboratory infrastructure from scratch in two of start-ups. Started DMPK laboratory at Signal Pharmaceuticals (now Celgene) and Regulus Therapeutics. Results: Both companies gained access to DMPK data in a short time which enabled multiple drug discovery programs to move forward. Set-up and led, for 2 years, DMPK project team at Regulus Therapeutics. Conducted monthly meetings; prepared presentations and minutes with action plans. Results: Company managed to have DMPK support on several projects simultaneously without having a DMPK group. Assumed responsibility of single point person for DMPK/ADME issues at Anadys Pharmaceuticals. Handled all writing and editing of over 70 PK/BA reports for regulatory submission. Results: Company was able to submit its most important IND to FDA without hiring any additional personnel.

PROFESSIONAL EXPERIENCE
CONSULTANT Mello Biotech, Los Angeles, CA; Tanais Pharma, Russia; Ugichem CmbH, Austria 2011 Present

SENIOR SCIENTIST, PK / ADME Regulus Therapeutics, San Diego, CA SENIOR MANAGER, CLINICAL PHARMACOLOGY Anadys Pharmaceuticals, San Diego, CA SENIOR SCIENTIST, PHARMACOKINETICS Celgene, San Diego, CA POSTDOCTORAL SCIENTIST, PK ISIS Pharmaceuticals, Carlsbad, CA POSTDOCTORAL SCIENTIST University California, Irvine, Irvine CA

2009 2011 2007 2009 2000 2006 1997 2000 1995 1997

JUNIOR RESEARCH SCIENTIST Institute of Clinical & Experimental Medicine, Russian Academy of Sciences, Novosibirsk, Russia 1985 1990 EDUCATION Ph.D. in Pharmacology, Oxford Brookes University, United Kingdom in Association with William Harvey Research Institute, St. Bartholomew's Medical College, London B.S. in Biochemistry, Novosibirsk State University, Russia

Affiliated with: ACRP (Association of Clinical Research Professional); AAPS (American Association of Pharmaceutical Scientists); ISSX (International Society for Study of Xenobiotics); SOT (Society of Toxicology)
Speaks English and Russian See Full CV for Detailed Research, Development and Clinical Research, Awards, Patents, Publications and Training

Professional References Available Upon Establishment of Mutual Interest