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Title: The role of vitamins A, beta-carotene, E and C in cancer cell biology.
Author: Lupulescu, A
Citation: Int-J-Vitam-Nutr-Res. 1994; 64(1): 3-14
Vitamins A (retinol, retinoids), beta-carotene (provitamin A), E (alpha-tocopherol), and C
(ascorbic acid) are used in experimental, clinical and epidemiological studies for cancer
chemoprevention and treatment. The cellular and metabolic effects are depending on the dose
used, duration of exposure, and cancer cell type. Despite recent advances, the anticarcinogenic
mechanisms remain as yet unknown. Studies regarding the role of vitamins A, beta-carotene, E
and C in cancer cell biology and metabolism are of critical importance for their use in cancer
treatment. Autoradiographic, ultrastructural and cell surface studies demonstrated that
Abstract:
vitamins A, E and C are strong regulator factors of cancer cell differentiation, cell regression,
membrane biogenesis, DNA, RNA, protein, and collagen synthesis, as well as transformation of
precancer cells into cancer cells. These vitamins exert cytotoxic and cytostatic effects, and may
reverse the cancer cell to the normal phenotype. Interrelation of vitamins A, E and C with
oncogenes and growth factors play an important role in cancer cell biology. The data presented
in this review can provide new insights for the understanding of anticarcinogenic mechanisms,
and a rationale for the use of vitamins A, E and C in cancer chemo-prevention and treatment.
Review
78 refs.
References:
Copyright Hogrefe : & : Huber Publishers. Abstracts are reprinted by the permission of the
Notes: publisher of the journal for volume, pages, and dates cited. Hypertext links to electronic journal
sites, if available, can be found in the the Peer Reviewed Journal List on the IBIDS home page.
Language: English
Publication
Journal-Article; Review; Review,-Tutorial
Type:
Anticarcinogenic Agents pharmacology : Ascorbic Acid pharmacology : Carotene pharmacology :
Keywords: Cell Transformation, Neoplastic drug effects : Neoplasms prevention and control : Vitamin A
pharmacology : Vitamin E pharmacology
URL: http://verlag.hanshuber.com/Zeitschriften/IJVNR/index.html

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