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of Colorado, Health Science Center described Anonymous. Blood Weekly. Atlanta: Oct 9, 2008. pg. 45 Abstract (Summary) Compared with the exchange transfusion models to study blood loss, less is known about HBOC oxygen delivery and vasoacitvity when it is infused in euvolemic subjects. We hypothesized that HBOC [polymerized bovine hemoglobin (PBvHb)] infusion creating hypervolemia would increase oxygen delivery to tissues during acute global hypoxia. Full Text (419 words) (c)Copyright 2008, Blood Weekly via NewsRx.com 2008 OCT 9 - (<http://www.newsrx.com> NewsRx.com) -- A report, 'Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat,' is newly published data in American Journal of Physiology - Heart and Circulatory Physiology (see also <http://www.newsrx.com/library/topics/BloodSubstitutes.html> Blood Substitutes). According to a study from the United States, "Hemoglobin-based oxygen carriers (HBOC) have been primarily studied for blood loss treatment. More recently infusions of HBOC in euvolemic subjects have been proposed for a wide variety of potential therapies in which increased tissue oxygenation would be beneficial." "However, compared with the exchange transfusion models to study blood loss, less is known about HBOC oxygen delivery and vasoacitvity when it is infused in euvolemic subjects. We hypothesized that HBOC [polymerized bovine hemoglobin (PBvHb)] infusion creating hypervolemia would increase oxygen delivery to tissues during acute global hypoxia. Vascular oxygen content and hemodynamics were determined after euvolemic rats were infused with 3 ml of either lactated Ringer or PBvHb solution (13 g/dl, 1.3 g/kg) during acute hypoxia (FIO2=10%, 4 h) or normoxia (FIO2=21%) exposure. Our data demonstrated that compared with Ringer-infused animals, in hypoxia and normoxia, PBvHb treatment improved oxygen content but raised mean arterial pressure, lowered stroke volume, heart rate, and cardiac index, which resulted in a net reduction in blood flow and oxygen delivery to the tissues. The PBvHb vasoactive effect was similar in magnitude and direction as to the Ringer-infused animals treated with a nitric oxide synthase inhibitor nitro-l-arginine, suggesting the PBvHb effect is mediated via nitric oxide scavenging," wrote D.C. Irwin and colleagues, University of Colorado, Health Science Center.

The researchers concluded: "We conclude that infusion of PBvHb is not likely to be useful in treating global hypoxia under these conditions.Irwin and colleagues published their study in American Journal of Physiology - Heart and Circulatory Physiology (Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat. American Journal of Physiology - Heart and Circulatory Physiology, 2008;295(3):H1090-H1099). For more information, contact D.C. Irwin, University of Colorado Health Science Center, Cardiovascular Pulmonary Research Group, School of Medicine, 4200 E 9Ave, Denver, CO 80262 USA..Publisher contact information for the American Journal of Physiology - Heart and Circulatory Physiology is: American Physiological Society, 9650 Rockville Pike, Bethesda, MD 20814, USA. Keywords: United States, Denver, Artificial Blood, Bioengineering, Biomedical Engineering, Biomedicine, Blood Substitutes, Blood Transfusion, Bovine Hemoglobin, Medical Device, Oxygen Carrier, Physiology, Therapy, Transfusion Medicine, Treatment. This article was prepared by Blood Weekly editors from staff and other reports. Copyright 2008, Blood Weekly via <http://www.newsrx.com> NewsRx.com. Indexing (document details) Author(s): Anonymous

Document types: Expanded Reporting Publication title: Blood Weekly. Atlanta: Oct 9, 2008. pg. 45 Source type: ISSN: ProQuest document ID: Document URL: Periodical 10656073 1564831741

Text Word Count 419 http://proquest.umi.com/pqdweb? did=1564831741&sid=4&Fmt=3&cl ientId=43005&RQT=309&VName=PQD