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  • Table 1 - Features of Cytokines Cytokin e Cell Source Cell Target Primary Effects

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    99manu99
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    Table 1 summarizes the features of various cytokines, including their cell sources, cell targets, and primary effects. It shows that cytokines such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 family, IL-10, IL-12, IFN-gamma, TGF-beta, and GM-CSF are secreted by cells like T cells, B cells, macrophages, and endothelial cells. Their targets include T cells, B cells, macrophages, fibroblasts, epithelial cells, neutrophils, eosinophils, and liver cells. Their primary effects involve actions like activation, growth, differentiation, inhibition of activation, and stimulation of acute phase reactants

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    Cytokines

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    Cytokine Table

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    Table 1 summarizes the features of various cytokines, including their cell sources, cell targets, and primary effects. It shows that cytokines such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 family, IL-10, IL-12, IFN-gamma, TGF-beta, and GM-CSF are secreted by cells like T cells, B cells, macrophages, and endothelial cells. Their targets include T cells, B cells, macrophages, fibroblasts, epithelial cells, neutrophils, eosinophils, and liver cells. Their primary effects involve actions like activation, growth, differentiation, inhibition of activation, and stimulation of acute phase reactants

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    101 views4 pages

    Table 1 - Features of Cytokines Cytokin e Cell Source Cell Target Primary Effects

    Uploaded by

    99manu99
    Table 1 summarizes the features of various cytokines, including their cell sources, cell targets, and primary effects. It shows that cytokines such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 family, IL-10, IL-12, IFN-gamma, TGF-beta, and GM-CSF are secreted by cells like T cells, B cells, macrophages, and endothelial cells. Their targets include T cells, B cells, macrophages, fibroblasts, epithelial cells, neutrophils, eosinophils, and liver cells. Their primary effects involve actions like activation, growth, differentiation, inhibition of activation, and stimulation of acute phase reactants

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    Table 1 - FEATURES OF CYTOKINES Cytokin Cell Source Cell Target e Monocytes Macrophage s Fibroblasts Epithelial cells Endothelial cells

    Astrocytes T cells; NK cells Primary Effects

    IL-1

    Costimulator T cells; B y molecule cells Activation Endothelial (inflammatio cells n) Hypothalamu Fever s Acute phase Liver reactants T cells B cells Monocytes Bone marrow progenitors Growth Growth Activation Growth and differentiatio n

    IL-2

    IL-3 IL-4

    T cells T cells

    Naive T cells Differentiatio T cells n into a TH 2

    B cells

    cell Growth Activation and growth; Isotype switching to IgE Growth and activation Costimulator y molecule Growth (in humans) Acute phase reactants Activation and chemotaxis

    IL-5

    T cells

    B cells Eosinophils

    IL-6

    T cells; B T cells; cells Macrophage Mature B s; cells Fibroblasts Liver Macrophage s; Epithelial Neutrophils cells; Platelets

    IL-8 family IL-10

    T cells (TH2) Macrophage Inhibits APC s activity

    T cells

    Inhibits cytokine production

    IL-12

    Differentiatio Macrophage Naive T cells n into a TH 1 s; NK cells cell Monocytes Endothelial cells Many tissue cells especially macrophage s Activation Activation Increased class I and II MHC

    IFNT cells; NK gamma cells

    TGFbeta

    Inhibits T cells; T cells activation Macrophage Macrophage and growth s s Inhibits activation

    GMCSF

    T cells; Macrophage Bone s; marrow Endothelial progenitors cells, Fibroblasts

    Growth and differentiatio n

    TNFalpha

    Macrophage Similar to IL- Similar to ILs; T cells 1 1

    IL = interleukin GM-CSF = granulocyte-macrophage colony stimulating factor IFN = interferon TNF = tumor necrosis factor TGF = transforming growth factor

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