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Teta Patho Edit ARROW
Teta Patho Edit ARROW
Presence of puncture
Presence of anaerobic condition (oxidation-reduction potential, such as those with dead or devitalized tissue)
Tetanolysin
Tetanospasmin
It is synthesized as a 150-kd protein consisting of a 100-kd heavy chain and a 50kd light chain joined by a disulfide bond
It mediates binding of tetanospasmin to the presynaptic motor neuron and also creates a pore for the entry of the light chain into the cytosol
Headache
After the light chain enters the motor neuron, it travels by retrograde axonal transport from the contaminated site to the spinal cord in 2-14 days
develops when only the nerves supplying the affected muscle are involved
Develops when the toxin released at the wound spreads through the lymphatics and blood to multiple nerve terminals. The blood-brain barrier prevents direct entry of toxin to the CNS.
dysfunction in the interneurons that inhibit the alpha motor neurons of the affected muscles
The brain receives blood with toxins from the internal carotid arteries, which arise at the point in the neck where the common arteries bifurcate.
If treated:
If Not treated:
-tetanus immune globulin IV or IM -metronidazole IV for 10 days -diazepam -tetanus vaccination -tetanus shots -tetanus digestion
Toxin reaches the spinal cord, it enters central inhibitory neurons. The light chain cleaves the protein synaptobrevin,
Synaptobrevin, which is integral to the binding of neurotransmitter containing vesicles to the cell membrane.
Good Prognosis
Autonomic hyperactivity as well as uncontrolled muscle contractions (spasms) in response to normal stimuli.
If treated:
If not treated:
Severity muscle spasms -Require admission to intensive care -maintenance of an airway and proper nutrition are required -An intake of 3500-4000 calories, and at least 150 g of protein per day, is often given in liquid form through a tube directly into the stomach -This high-caloric diet maintenance is required because of the increased metabolic strain brought on by the increased muscle activity -Full recovery takes 4 to 6 weeks because the body must regenerate destroyed nerve axon terminals. Painful Contraction Uncontrolled /involuntary muscular contraction of the vocal cords Interferes breathing Breathin g foreign materials
Laryngospas m Paralysis
Pneumon ia
Bad Prognosis ?Medications: -human tetanus immunoglobulin injected intrathecally -tracheostomy and mechanical ventilation for 3 to 4 weeks,
Good Prognosis
Blockage of the main artery of the lung or one of its branches by a blood clot that has travelled from elsewhere in the body through the bloodstream
flow of blood to the heart becomes restricted, causing the muscles of the heart to become damaged.
muscle tissues are broken down, causing a protein called myoglobin to leak into the
Pulmonary embolism
Cardiac Arrest
DEATH