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PY TEST SERIES-III
Duration: 2.00 hours Max Marks: 100

1. 2. 3. 4. 5. 6. 7.

This question paper contains 40 objective type questions. Q. 1 to 40 carry 2 marks each. Q. 41and 50 are common data based question, each carry two marks. In case of wrong answer 0.5 marks will be deducted. Using HP pencil, darken the appropriate double under each digit of your registration number and the letters corresponding to your paper code. Calculator is allowed in the examination hall. charts, graph sheets or tables are NOT allowed in the examination hall Rough work can be done on the question paper itself. Additionally blank pages are given at the end of the question paper for work.

CENTRE - LIC BUILDING, 3rd FLOOR, CIVIL LINES, SAGAR (M.P.) Sunil mokati

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PY TEST SERIES-III
1. 2. 3. 4. 5. 6. 7. Atropine is main alkaloid of belladona which is (a) Primary amine (b) Secondary amine (c) Tertiary amine a (d) Quaternary amine All -blockers are available in the form of Racemic mixture EXCEPT (a) Levobunolol (b) Timolol (c) Penbutolol (d) All $ The treatment of morphine solution with potassium ferricyanide and ferric chloride solution gives (a) Orange red color (b) Lemon yellow color (c) Bluish green color a (d) Deep reddish purple color The far ultra-violet region (below 200 m) is not much studied because of (a) Absorption by oxygen (b) Absorption by nitrogen (c) It require vaccume instruments (d) All a Solanum nigrum is adultrants of atropa belladona which contains (a) Needle shaped crystals (b) Anomocytic stomata (c) Denser lamina (d) All a A non-selective -adrenergic blocking agent which also have 5-HT2 blocking activity is (a) Ketenserine $ (b) Ketamine (c) Chlorpromazine (d) Prazosine When a beam of monochromatic radiation passes through a homogenous absorbing medium, the rate of decrease in intensity of radiation with thickness of absorbing medium is proportional to the intensity of the incident radiation. This is given by (a) Lamberts law a (b) Beers law (c) Both (d) None Which of the following statement is corerect about alkaloid SCOPOLETIN (a) It is d-methyl aesculetin (b) It is fluorescent in nature a (c) It is present in Peruvian bark (d) It is present as recemic form A non-selective -blocking agent with intrinsic sympathomimetic activity is (a) Propranolol (b) Pindolol $ (c) Sotalol (d) Acebutolol Hydrogen bonding shifts the ultra-violet absorptions to (a) Shorter wavelength a (b) Longerwavelength (c) It may be shorter or longer (d) No effect at all Which of the following drug are come in the category of quinoline alkaloid (a) Cancer tree a (b) Henbane (c) Catharathus (d) South American arrow poison Selective -1 activity of Quinazoline is mainly due to (a) 6,7-OCH3 group on quinazoline ring (b) Acyl moiety with piperazine ring (c) 4-NH2 group on quinazoline ring $ (d) Quinazoline and piperazine ring Which of the following statement is INCORRECT (a) The n* transition for carbonyl (b) Blue shift may be caused by the removal compounds experiences bathochromic of conjugation and also by changing the shift when the polarity of the solvent is polarity of the solvent decreased (c) The introduction of an auxochrome (d) The introduction of group which distorts usually increases intensity of absorption the geometry of the molecule causes hypsochromic shift a 2

8. 9. 10. 11. 12. 13.

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14. 15. 16. 17.

18.

19 20. 21. 22.

23. 24. 25.

26. 27.

The ergot alkaloid which is used as specific analgesic in treatment of migraine is (a) Ergometrine maleate (b) Ergotamine tartarate a (c) Egotoxine methanesulphonates (d) LSD Calculate the absorption maximum in the ultra violet spectrum of 2,4 hexadiene (a) 217 m (b) 222m (c) 227m a (d) 232m Which solution of Pilocarpine is used in the treatment of open angle glaucoma (a) 5 % (b) 1 % - 5 % (c) 0.5 % - 4 % a (d) 10 % Which of the following statement is fully different from the other statements (a) Indole dihydroindole alkaloids posses oncolytic activity (b) Vindoline is dihydroindoline alkaloid part (c) Cruciferous stomata are present more frequently on lower epidermis (d) Psychotrine is come in the category of phenolic alkaloidal group a Rate limiting step in the synthesis of catcholamines is (a) Neuronal uptake of tyrosine a (b) Conversion of DOPA to Dopamine (c) Inhibition of tyrosine to DOPA by alpha-met tyrosine (d) Granular uptake of Dopamine Strychnine with sulphuric acid and potassium dichromate gives (a) Violet colour a (b) Green colour (c) Brown colour (d) Purple colour Antioxidant property of Carvedilol is mainly due to (a) Pyrrole ring $ (b) Indole ring (c) Thiadiazole ring (d) Tricyclic ring structure The solvent as well as the solution of the sample may be contained in cells which is made of a) Glass (b) Silica cells (c) Quartz (d) Both b and c a Which of the following statement is INCORRECT (a) Codeine is a strong monoacidic base (b) Papaverine is inactive optically (c) The salts of narcotine are dextrorotatory (d) Diacetyl derivative of codeine is heroin a Indirect acting cholinomimetic drug is (a) Donaprazil a (b) Arecholine (c) Bathenechol (d) Pilocarpine A sympathomimetic drug which is used as nasal decongestant and pressor agent is (a) Naphazoline (b) Methoxamine (c) Xylometazoline (d) Phenylepherine a The following statement is correct about camtothecin alkaloid EXCEPT (a) It does not respond respond dragendroffs (b) It inhibit the replication of polio virus reagent a (c) It is used in the treatment of of liver (d) It is prototype DNA topoisomerase I cancer inhibitor Parasympatholytic drug having tertiary amine structure and antisecretory-antispasmodic action is (a) Clinidium (b) Procyclidine (c) Flevoxate $ (d) Isopropamide A Blue colour compound is formed upon metabolism of physostigmine. The blue compound is (a) Esseroline (b) Eserine a 3

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28. 29. 30.

31.

32. 33.

34.

35

36.

37. 38. 39. 40.

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(c) Carbamic acid (d) Rubeserine Which opium is called as soft opium (a) Indian opium (b) Turkish opium a (c) Persian opium (d). Chineese opium M3 selective antagonist used in treatment of smooth muscle/glandular over activity disorder is (a) Hexahydrosiladifenidol (b) Tripitamine (c) Tolterodine (d) Darifenacin $ R band transition is most characteristic for a carbonyl group of aldehyde or ketone then which of the following statement is correct (a) Aldehyde usually appears at lower (b) Aldehyde usually appears at higher wavelength as compared to ketones wavelength as compared to ketones a (c) Aldehyde usually appears at higher value (d) Aldehyde and ketone both appear at of max as compared to ketones equal wavelength Hyoscymus should contain not less than % of alkaloids of hyocymus, calculated as lhyoscyamine. (a) 0.05 a (b) 0.5 (c) 1.0 (d) 2.0 Sympathomimetic drugs generally exihibit following response EXCEPT (a) Increase heart rate (b) Increase respiration rate (c) Increase body temperature (b) Increase gastric secreation a Cocaine are hydrolysed by boiling with dilute hydrochloric acid then the different bases liberate in which of the following ways (a) Ecgonine + methyl alcohol + cinnamic (b) Ecgonine + methyl alcohol + benzoic acid acid a (c) Ecgonine + methyl alcohol + atropic acid (d) Ecgonine + methyl alcohol + truxillic acid Which of the following statement is correct about Atropine. (a) It is alkaloidal ester of tropic acid (b) It has anti-motion sickness property (c) It has CNS- stimulant property (d) All the above statement $ Ergot is the dried sclerotium of a fungus claviceps purpurea. Substitution of this ergot include all EXCEPT (a) Ergot of wheat (b) Ergot of diss (c) Ergot of oat (d) Ergot of rye a Specific absorption coefficient can be defined as (a) Absorbance per unit path length (b) Absorbance per unit path length and unit concentration a -1 (b) Absorption coefficient for mol L and (d) All path length of 1 cm Which of the following drug exhibit antispasmodic activity by inhibiting PDE 4 (a) Sildenafil (b) Meleone (c) Drotaverine $ (d) Oxybutyline Cinchona bark also contains a glycoside called (a) Cuprine (b) Quinovin a (c) Truxilline (d) Tigloidine Mulling agent is used in (a) visible spectroscopy (b) U.V. spectroscopy (c) I.R. spectroscopy a (d) All Colterol is an active metabolite of 4

(a) (c)

41. 42.

43. 44.

45. 46.

47.

48.

(b) Formeterol (d) Lebalbuterol DATA FOR 41-42 The drug whose epidermal cells of both sides show cruciferous stomata. The cell are covered with glandular and non glandular simple trichome and about 6-8 layers of spongy parenchymatous cells are also present. The palisade ratio is 3.5 to 6.5. The drug is (a) Atropa belladona (b) Datura metel a (c) Datura stamonium (d) Hyoscyamus niger The above drug is used in treatment of (a) Chloral hydrate poisoning (b) Spasm of urinary tract (c) Cough and cold a (d) Parkinsonian LINKED QUESTION A non-selective muscarinic receptor agonist which is used in the treatment of Glaucoma is (a) Levobunalol (b) Dipiverine (c) Pilocarpine a (d) Dorzolamide The moiety present in the structure of above drug is (a) Furane (b) Imidazole (c) Pyrimidine (d) a & b a DATA FOR 45-46 An organic compound X has an absorption maxima at 217 nm. Its max is 16000,the absorbance is 0.64when the cell length is 1 cm The molar concentration of X is (a) 5 X 10-5 (b) 4 X 10-4 (c) 4 X 10-5 a (d) 5 X 10-2 If the molecular weight is 56.06,its concentration in mg/ml will be (a) 2.5 X 10-3 (b) 0.25 X 10-3 -5 (c) 5 X 10 (d) 2.24 X 10-3 a LINKED QUESTION Which pressor agent acts directly as well as indirectly and produces both vasoconstriction and cardiac stimulation (a) Phenyl epherine (b) Methoxamine (c) Noradrenaline (d) Mephentermine a The above drug are come in the category of (a) Pressor agent a (b) Cardiac stimulant (c) Bronchodilators (d) Nasal decongestants DATA FOR 49-50 Phytostigmine is an alkaloid obtained from the dried ripe seeds. It occurs as a white, odourless microcrystalline powder. Its solution is most stable at pH 6 and its conjugated acid has a pK a 8. It is used in the treatment of glaucoma and atropine poisoning. Phytostigmine is an alkaloid obtained from the dried ripe seed (a) P. nodesum (b) P. venenosome a (c) Both (d) None In solution it is hydrolyzed to methyl carbamic acid and eseroline. Eseroline is oxidized into X and then further decomposed into Y compound (a) X= Rubreserine, Y= Eserolinine (b) X= Rubreserinine, Y= Eserelinine [Blue & Red] [Blue & red] (c) X= Rubreserine, Y= Eserenine [blue & (d) X= Rubreserine Y= Eserine [blue & Brown] brown] a 5

Bitolterol Isoetherine

49. 50.

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