Scribd Logo
Upload

Welcome to Scribd!

  • 262 views

    Yersinia

    Uploaded by

    drparachuru
    Yersinia is a genus of Gram-negative coccobacilli bacteria. There are two main pathogenic species: Y. enterocolitica causes gastroenteritis and grows at cold temperatures, while Y. pestis causes plague and is transmitted via flea bites or respiratory droplets. Both species produce virulence factors like invasin, type III secretion systems, and F1 capsular antigen to evade the immune system and invade host cells. Y. enterocolitica infection presents as abdominal cramps and dysentery in children or pseudoappendicitis in adults. Y. pestis causes bubonic, pneumonic, or septicemic plague. Treatment involves antibiotics like cephalosporins, amin

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content

    You might also like

    Yersinia

    Uploaded by

    drparachuru
    262 views15 pages
    Yersinia is a genus of Gram-negative coccobacilli bacteria. There are two main pathogenic species: Y. enterocolitica causes gastroenteritis and grows at cold temperatures, while Y. pestis causes plague and is transmitted via flea bites or respiratory droplets. Both species produce virulence factors like invasin, type III secretion systems, and F1 capsular antigen to evade the immune system and invade host cells. Y. enterocolitica infection presents as abdominal cramps and dysentery in children or pseudoappendicitis in adults. Y. pestis causes bubonic, pneumonic, or septicemic plague. Treatment involves antibiotics like cephalosporins, amin

    Original Description:

    Yersinia enteriocolitica Yersinia pestis www.easymicrobiology.com

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Yersinia is a genus of Gram-negative coccobacilli bacteria. There are two main pathogenic species: Y. enterocolitica causes gastroenteritis and grows at cold temperatures, while Y. pestis causes plague and is transmitted via flea bites or respiratory droplets. Both species produce virulence factors like invasin, type III secretion systems, and F1 capsular antigen to evade the immune system and invade host cells. Y. enterocolitica infection presents as abdominal cramps and dysentery in children or pseudoappendicitis in adults. Y. pestis causes bubonic, pneumonic, or septicemic plague. Treatment involves antibiotics like cephalosporins, amin

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    262 views15 pages

    Yersinia

    Uploaded by

    drparachuru
    Yersinia is a genus of Gram-negative coccobacilli bacteria. There are two main pathogenic species: Y. enterocolitica causes gastroenteritis and grows at cold temperatures, while Y. pestis causes plague and is transmitted via flea bites or respiratory droplets. Both species produce virulence factors like invasin, type III secretion systems, and F1 capsular antigen to evade the immune system and invade host cells. Y. enterocolitica infection presents as abdominal cramps and dysentery in children or pseudoappendicitis in adults. Y. pestis causes bubonic, pneumonic, or septicemic plague. Treatment involves antibiotics like cephalosporins, amin

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    of 15

    Kingdom:Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacteriales Family: Enterobacteriaceae Genus: Yersinia

    Yersinia
    Dr.Aravind

    Safety Pin Yersinia

    Dr.Aravind

    Gram Negative Coccobacillus, Bipolar Staining (Safety Pin) Lactose Negative, Non Motile, H2S Negative, Facultative Anaerobe Oxidase Negative, Catalase Positive, Urease Positive (Except Y,pestis) Best Growth At 25-30O C 2 Imp Pathogenic Species: 1. Yersinia Enterocolitica: Motile At 25o C And Non Motile At 37o C, Grows At Cold Temp Gastroenteritis 2. Yersinia Pestis: Plague
    Dr.Aravind

    Virulent Factors
    Endo toxin Invasin: binds to integrins on the surface (Y.enterocolitica) of host cells Type III secretary system: a. Secrets YOP proteins in host cells: Phagocytosis, cytotoxicity by disrupting actin filaments, Initiates apoptosis b. inflammation F1 capsular antigen : phagocytosis

    Plasminogen Activator (Pla): C3b, C5a anti phagocytosis

    Dr.Aravind

    Fibrinolysis And Phospholipase : Helps In Invasion Yersinia Plasmid And Chromosomes Have Virulent Genes Virulent Factors Produced Depends On Temperature And Calcium Concentration

    Dr.Aravind

    Epidemiology
    Y.enterocolitica:
    Contaminated food products Pork intestines Common in daycare Grows at cold temperature, More in Michigan and scandanavia

    Dr.Aravind

    Y. pestis
    Zoonotic Infection
    Natural Reservoirs Include Rats, Squirrels, Rabbits, And Domestic

    Animals
    Spread By Flea Bites Or Direct Contact Respiratory droplet from A Patient With Pulmonary Disease

    Dr.Aravind

    Courtesy by CDC
    Dr.Aravind

    Dr.Aravind

    Pathogenesis of Y.Enterocolitica
    Entry by oral fecal route

    Attach to enterocytes: invasin & YOPs Replicates in macrophages Inflame payers patches Distructs Enterocytes

    Dysentery

    Taken by macrophages
    Dr.Aravind

    Pathogenesis of Y. Pestis
    Entry : flea bite, contact with rodents or respiratory droplet

    Invasion: Pla, F1 Secretary YOPs

    Lymph Nodes (Inguinal) Bubonic Plague

    Disseminates Septicemia & Pneumonic plague Dr.Aravind

    Clinical features
    Y.Entirocolitica:
    Young Children: Abdominal Cramps, Nausea , Dysentery Higher Aged Children: Dysentery, Fever, Enlarged Mesenteric Lymphnodes, Pseudo Appendicitis, Rash. Adults: Dysentery, Rash And Arthritis

    Dr.Aravind

    Y.Pestis: Plague 3 Types


    Bubonic Plague

    Pneumonic Plague
    Septicemia Plague

    Dr.Aravind

    Diagnosis
    Bipolar Stain Florescent Antibody Test Hazard To Lab Personal Y.Enterocolitica Cold Cultures Y.Pestis Growth More Than 24 Hrs

    Dr.Aravind

    Treatment & Prevention


    Y. enterocolitica:
    Cephalosporins, Aminoglycosides, Chloramphenicol, Tetracyclines, And Trimethoprim Sulfamethoxazole Proper Food Handling

    Plague:
    Streptomycin, Tetracycline, Chloramphenicol, Or Trimethoprim Sulfamethoxazole Vaccine And Reducing Rodent Population
    Dr.Aravind

    You might also like