LOCUS AFE2671 AFE2070 AFE2069 AFE2068 AFE1972 AFE0901 AFE0900 AFE0899 AFE0897 AFE0734 AFE0733 AFE0460 AFE0197 AFE0182

AFE3245 AFE3243 AFE3242 AFE3097 AFE2743 AFE2663 AFE2358 AFE2074 AFE2063 AFE2022 AFE1877 AFE1820 AFE1819 AFE1506 AFE1353 AFE0535 AFE0532 AFE0474 AFE0473 AFE0407 AFE0293 AFE0292 AFE0288 AFE3279 AFE3073 AFE2464 AFE1783 AFE0730 AFE0729 AFE0664 AFE0548 AFE0466 AFE0454 AFE0406

COMMON NAME phospho-2-dehydro-3-deoxyheptonate aldolase, putative N-(5phosphoribosyl)anthranilate isomerase tryptophan synthase, beta subunit tryptophan synthase, alpha subunit chorismate synthase 3-phosphoshikimate 1-carboxyvinyltransferase prephenate dehydrogenase phospho-2-dehydro-3-deoxyheptonate aldolase chorismate mutase/prephenate dehydratase shikimate kinase 3-dehydroquinate synthase trp repressor binding protein 3-dehydroquinate dehydratase, type II shikimate 5-dehydrogenase anthranilate synthase component I anthranilate phosphoribosyltransferase indole-3-glycerol phosphate synthase homoserine kinase diaminopimelate epimerase dihydrodipicolinate reductase dihydrodipicolinate synthase aspartate-semialdehyde dehydrogenase O-succinylhomoserine sulfhydrylase aspartate aminotransferase methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase succinyl-diaminopimelate desuccinylase homocitrate synthase asparagine synthase (glutamine-hydrolyzing) 5,10-methylenetetrahydrofolate reductase S-adenosylmethionine synthetase threonine synthase homoserine dehydrogenase aspartate kinase, monofunctional class homoserine O-acetyltransferase methionine biosynthesis protein MetW 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase diaminopimelate decarboxylase N-acetyl-gamma-glutamyl-phosphate reductase glutamate 5-kinase glutamate 5-kinase glutamate synthase, large subunit glutamate synthase, small subunit N-acetylglutamate synthase glutamate-ammonia-ligase adenylyltransferase glutamine synthetase, type I gamma-glutamyl phosphate reductase acetylornithine aminotransferase

AFE0405 AFE0404 AFE0281 AFE0262 AFE0256 AFE0226 AFE3277 AFE3047 AFE3046 AFE3045 AFE3044 AFE3043 AFE3042 AFE3041 AFE3040 AFE2582 AFE1888 AFE0898 AFE2596 AFE2075 AFE1989 AFE1673 AFE0747 AFE0746 AFE0745 AFE0722 AFE0662 AFE0626 AFE0624 AFE0547 AFE2832 AFE1505 AFE0896 AFE0895 AFE0671 AFE0368 AFE0295

ornithine carbamoyltransferase argininosuccinate synthase glutamate 5-kinase pyrroline-5-carboxylate reductase acetylglutamate kinase arginine biosynthesis bifunctional protein ArgJ argininosuccinate lyase phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase imidazoleglycerol phosphate synthase, cyclase subunit phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase imidazole glycerol phosphate synthase, glutamine amidotransferase subunit imidazoleglycerol-phosphate dehydratase histidinol-phosphate aminotransferase histidinol dehydrogenase ATP phosphoribosyltransferase histidinol-phosphate phosphatase domain protein ATP phosphoribosyltransferase regulatory subunit histidinol-phosphate aminotransferase 2-isopropylmalate synthase 3-isopropylmalate dehydrogenase 2-isopropylmalate synthase dihydroxy-acid dehydratase ketol-acid reductoisomerase acetolactate synthase, small subunit acetolactate synthase, large subunit, biosynthetic type threonine ammonia-lyase, biosynthetic dihydroxy-acid dehydratase 3-isopropylmalate dehydratase, small subunit 3-isopropylmalate dehydratase, large subunit branched-chain amino acid aminotransferase cysteine synthase B serine O-acetyltransferase D-3-phosphoglycerate dehydrogenase phosphoserine aminotransferase serine O-acetyltransferase phosphoserine phosphatase serine hydroxymethyltransferase

GENE SYMBOL EC NUMBER No Data No Data trpF 5.3.1.24 trpB 4.2.1.20 trpA 4.2.1.20 aroC 4.2.3.5 aroA 2.5.1.19 tyrA 1.3.1.12 No Data 4.1.2.15 pheA No Data aroK 2.7.1.71 aroB 4.2.3.4 wrbA No Data aroQ 4.2.1.10 aroE 1.1.1.25 trpE 4.1.3.27 trpD 2.4.2.18 trpC 4.1.1.48 thrB 2.7.1.39 dapF 5.1.1.7 dapB 1.3.1.26 dapA 4.2.1.52 asd 1.2.1.11 metZ 4.2.99.aspC 2.6.1.1 folD No Data dapD 2.3.1.117 dapE 3.5.1.18 nifV 2.3.3.14 No Data 6.3.5.4 metF 1.7.99.5 metK 2.5.1.6 thrC 4.2.3.1 metM 1.1.1.3 No Data 2.7.2.4 metX 2.3.1.31 metW No Data metE 2.1.1.14 lysA 4.1.1.20 argC 1.2.1.38 proB-1 2.7.2.11 proB-2 2.7.2.11 gltB 1.4.1.13 gltD 1.4.1.13 argA 2.3.1.1 glnE 2.7.7.42 glnA 6.3.1.2 proA 1.2.1.41 argD 2.6.1.11

ISOELECTRIC POINT 6.0211 8.6427 6.5584 5.7116 6.0999 No Data No Data No Data 6.0999 6.0999 6.0999 6.603 6.0999 No Data 6.0999 6.0999 6.0999 5.9915 6.897 7.2752 6.229 5.7319 6.6469 6.0999 7.3047 6.924 6.0999 6.0999 6.0999 5.8568 6.0999 6.0999 5.4359 5.1561 5.3971 6.0999 6.0999 6.0999 5.7446 9.8035 7.6692 6.0999 No Data 6.0999 6.0999 6.0999 6.0999 6.0999

SUBROLE Aromatic amino acid Aromatic amino acid Aromatic amino acid Aromatic amino acid Aromatic amino acid Aromatic amino acid Aromatic amino acid Aromatic amino acid Aromatic amino acid Aromatic amino acid Aromatic amino acid Aromatic amino acid Aromatic amino acid Aromatic amino acid Aromatic amino acid Aromatic amino acid Aromatic amino acid Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Aspartate family Glutamate family Glutamate family Glutamate family Glutamate family Glutamate family Glutamate family Glutamate family Glutamate family Glutamate family Glutamate family

family family family family family family family family family family family family family family family family family

MAINROLE Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid Amino acid

biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis

argF argG proB-3 proC argB argJ argH hisIE hisF hisA hisH hisB hisC-1 hisD hisG No Data hisZ hisC-2 leuA-1 leuB leuA-2 ilvD-1 ilvC ilvN ilvB ilvA ilvD-2 leuD leuC ilvE cysM cysE-1 serA serC cysE-2 serB glyA

2.1.3.3 6.3.4.5 2.7.2.11 1.5.1.2 2.7.2.8 No Data 4.3.2.1 No Data No Data 5.3.1.16 2.4.2.4.2.1.19 2.6.1.9 1.1.1.23 2.4.2.17 No Data No Data 2.6.1.9 2.3.3.13 1.1.1.85 4.1.3.12 4.2.1.9 1.1.1.86 4.1.3.18 2.2.1.6 4.3.1.19 4.2.1.9 4.2.1.33 4.2.1.33 2.6.1.42 2.5.1.47 2.3.1.30 1.1.1.95 2.6.1.52 2.3.1.30 3.1.3.3 2.1.2.1

6.0999 6.0999 6.0999 6.0999 6.0916 6.0999 6.0999 5.9387 5.6758 4.5293 6.0131 6.31 5.6409 4.9703 6.0335 6.776 6.0999 5.6624 5.8235 4.804 6.0999 6.0999 6.0999 6.3608 6.0999 6.516 6.0999 6.0999 6.0999 6.0999 7.6696 6.0999 6.0999 6.0999 6.0999 6.0999 7.2624

Glutamate family Glutamate family Glutamate family Glutamate family Glutamate family Glutamate family Glutamate family Histidine family Histidine family Histidine family Histidine family Histidine family Histidine family Histidine family Histidine family Histidine family Histidine family Histidine family Pyruvate family Pyruvate family Pyruvate family Pyruvate family Pyruvate family Pyruvate family Pyruvate family Pyruvate family Pyruvate family Pyruvate family Pyruvate family Pyruvate family Serine family Serine family Serine family Serine family Serine family Serine family Serine family

Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino Amino

acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid

biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis

mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino

acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid

biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis

mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino mino

acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid acid

biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis biosynthesis

LOCUS AFE3011 AFE1924 AFE1675 AFE0453 AFE0259 AFE0246 AFE0245 AFE0244 AFE0243 AFE2635 AFE2066 AFE1911 AFE1773 AFE0576 AFE0295 AFE0126 AFE3244 AFE3064 AFE3063 AFE0785 AFE0366 AFE2761 AFE2346 AFE2263 AFE0728 AFE0635 AFE0570 AFE0179 AFE0134 AFE3303 AFE3300 AFE3299 AFE3298 AFE3143 AFE3126 AFE2570 AFE2899 AFE2389 AFE2388 AFE2383 AFE1975 AFE1825 AFE0647 AFE0593 AFE0592 AFE0305 AFE0289 AFE2561

AFE2559 AFE2078 AFE2077 AFE2076 AFE0976 AFE0975 AFE0652 AFE3217 AFE3067 AFE2764 AFE2544 AFE1974 AFE1933 AFE1861 AFE1537 AFE1531 AFE1529 AFE1517 AFE1516 AFE1509 AFE1507 AFE1450 AFE0678 AFE0675 AFE0674 AFE0673 AFE0672 AFE0371 AFE0370 AFE3258 AFE3089 AFE2755 AFE1771 AFE1770 AFE0357 AFE0187 AFE2948 AFE2206 AFE1392 AFE0451 AFE0428 AFE0057 AFE1974 AFE1403 AFE0628 AFE0165 AFE1994 AFE0557 AFE0300

AFE0299 AFE0298 AFE0297 AFE1974 AFE0948 AFE0928 AFE0643 AFE0642 AFE0523 AFE3305 AFE3304

COMMON NAME 8-amino-7-oxononanoate synthase, putative adenosylmethionine-8-amino-7-oxononanoate aminotransferase dethiobiotin synthetase birA bifunctional protein biotin synthase dethiobiotin synthetase biotin synthesis protein BioC bioH protein 8-amino-7-oxononanoate synthase dihydropteroate synthase folylpolyglutamate synthase/dihydrofolate synthase 4-amino-4-deoxychorismate lyase, putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, putative, degenerate para-aminobenzoate synthase, component I serine hydroxymethyltransferase dihydroneopterin aldolase para-aminobenzoate synthase glutamine amidotransferase component II glutamate--cysteine ligase glutathione synthetase gamma-glutamyltranspeptidase glutathione reductase glutamyl-tRNA reductase oxygen-independent coproporphyrinogen III oxidase, putative coproporphyrinogen III oxidase, aerobic uroporphyrinogen decarboxylase protoheme IX farnesyltransferase protoporphyrinogen oxidase ferrochelatase oxygen-independent coproporphyrinogen III oxidase glutamate-1-semialdehyde-2,1-aminomutase porphobilinogen deaminase uroporphyrinogen-III synthase delta-aminolevulinic acid dehydratase protoheme IX farnesyltransferase uroporphyrin-III C-methyltransferase lipoic acid synthetase octaprenyl-diphosphate synthase 2-octaprenyl-6-methoxyphenol hydroxylase 2-octaprenyl-6-methoxyphenol hydroxylase 3-octaprenyl-4-hydroxybenzoate carboxy-lyase geranyltranstransferase 3-demethylubiquinone-9 3-methyltransferase 3-octaprenyl-4-hydroxybenzoate carboxy-lyase, putative chorismate lyase family protein 4-hydroxybenzoate polyprenyl transferase 2-polyprenylphenol 6-hydroxylase ubiquinone/menaquinone biosynthesis methlytransferase UbiE molybdenum cofactor biosynthesis protein C

molybdenum cofactor biosynthesis protein A molybdopterin biosynthesis MoeA protein molybdopterin-guanine dinucleotide biosynthesis protein B molybdopterin-guanine dinucleotide biosynthesis protein A molybdopterin converting factor, subunit 2 molybdopterin converting factor, subunit 1 molybdopterin biosynthesis MoeB protein molybdenum cofactor biosynthesis protein B iron-sulfur cluster assembly accessory protein 4-diphosphocytidyl-2C-methyl-D-erythritol kinase geranylgeranyl reductase family protein 1-deoxy-D-xylulose-5-phosphate synthase 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase pterin-4-alpha-carbinolamine dehydratase cysteine desulfurase iron-sulfur cluster assembly accessory protein nitrogenase cofactor biosynthesis protein NifB nitrogenase MoFe cofactor biosynthesis protein NifE nitrogenase molybdenum-iron cofactor biosynthesis protein NifN iron-sulfur cluster assembly accessory protein cysteine desulfurase 1-deoxy-D-xylulose 5-phosphate reductoisomerase ferredoxin, 2Fe-2S iron-sulfur cluster assembly protein IscA FeS cluster assembly scaffold protein IscU cysteine desulfurase IscS iron-sulfur cluster assembly transcription factor IscR 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase aspartate 1-decarboxylase pantetheine-phosphate adenylyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase pantoate--beta-alanine ligase phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase dephospho-CoA kinase nicotinate (nicotinamide) nucleotide adenylyltransferase nicotinate-nucleotide pyrophosphorylase L-aspartate oxidase ATP-NAD kinase glutamine-dependent NAD+ synthetase quinolinate synthetase complex, subunit A 1-deoxy-D-xylulose-5-phosphate synthase pyridoxal phosphate biosynthetic protein PdxJ pyridoxamine 5-phosphate oxidase 4-hydroxythreonine-4-phosphate dehydrogenase 3,4-dihydroxy-2-butanone 4-phosphate synthase riboflavin biosynthesis protein RibF 6,7-dimethyl-8-ribityllumazine synthase

3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II riboflavin synthase, alpha subunit riboflavin biosynthesis protein RibD 1-deoxy-D-xylulose-5-phosphate synthase thiamine biosynthesis protein ThiC thiamine-monophosphate kinase thiamin biosynthesis protein ThiG thiamine biosynthesis protein ThiS 4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme phosphomethylpyrimidine kinase, putative thiamine-phosphate pyrophosphorylase

GENE SYMBOL EC NUMBER No Data No Data bioA 2.6.1.62 bioD-1 6.3.3.3 birA 6.3.4.15 bioB 2.8.1.6 bioD-2 6.3.3.3 bioC No Data bioH No Data bioF 2.3.1.47 folP 2.5.1.15 folC No Data No Data No Data No Data No Data pabB 4.1.3.glyA 2.1.2.1 folB 4.1.2.25 pabA 4.1.3.27 gshA 6.3.2.2 gshB 6.3.2.3 ggt 2.3.2.2 gor 1.8.1.7 hemA 1.2.1.No Data No Data hemF 1.3.3.3 hemE 4.1.1.37 cyoE-1 2.5.1.hemG 1.3.3.4 hemH 4.99.1.1 hemN No Data hemL 5.4.3.8 hemC 4.3.1.8 hemD 4.2.1.75 hemB 4.2.1.24 cyoE-2 2.5.1.cobA 2.1.1.107 lipA No Data ispB 2.5.1.ubiH-1 1.14.13.ubiH-2 1.14.13.ubiD 4.1.1.ispA 2.5.1.10 ubiG 2.1.1.64 No Data No Data No Data No Data ubiA 2.5.1.ubiB 1.14.13.ubiE No Data moaC No Data

ISOELECTRIC POINT 7.3039 6.0999 6.6153 5.9824 6.0999 7.0078 6.0999 6.0999 6.8444 5.1668 6.5108 6.0999 6.0999 7.1903 7.2624 6.0999 6.0999 5.6643 5.9259 6.8736 6.0999 6.2301 5.9723 6.2425 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999 7.0822 6.0999 5.3978 6.0999 6.7971 7.4069 4.7066 9.2654 No Data 6.3346 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999 6.7669

SUBROLE Biotin Biotin Biotin Biotin Biotin Biotin Biotin Biotin Biotin Folic acid Folic acid Folic acid Folic acid Folic acid Folic acid Folic acid Folic acid Glutathione and analogs Glutathione and analogs Glutathione and analogs Glutathione and analogs Heme, porphyrin, and cobalamin Heme, porphyrin, and cobalamin Heme, porphyrin, and cobalamin Heme, porphyrin, and cobalamin Heme, porphyrin, and cobalamin Heme, porphyrin, and cobalamin Heme, porphyrin, and cobalamin Heme, porphyrin, and cobalamin Heme, porphyrin, and cobalamin Heme, porphyrin, and cobalamin Heme, porphyrin, and cobalamin Heme, porphyrin, and cobalamin Heme, porphyrin, and cobalamin Heme, porphyrin, and cobalamin Lipoate Menaquinone and ubiquinone Menaquinone and ubiquinone Menaquinone and ubiquinone Menaquinone and ubiquinone Menaquinone and ubiquinone Menaquinone and ubiquinone Menaquinone and ubiquinone Menaquinone and ubiquinone Menaquinone and ubiquinone Menaquinone and ubiquinone Menaquinone and ubiquinone Molybdopterin

moaA moeA mobB mobA moaE moaD moeB moaB No Data ispE No Data dxs ispG phhB iscS-1 No Data nifB nifE nifN No Data iscS-2 dxr fdx iscA iscU iscS-3 iscR ispF ispD ispH panD coaD panB panC coaBC coaE nadD nadC nadB ppnK nadE nadA dxs pdxJ pdxH pdxA ribB ribF ribE

No Data No Data No Data No Data No Data No Data No Data No Data No Data 2.7.1.148 No Data 2.2.1.7 No Data 4.2.1.96 4.4.1.No Data No Data No Data No Data No Data 4.4.1.1.1.1.267 No Data No Data No Data 4.4.1.No Data 4.6.1.12 2.7.7.60 1.17.1.2 4.1.1.11 2.7.7.3 2.1.2.11 6.3.2.1 No Data 2.7.1.24 2.7.7.18 2.4.2.19 1.4.3.16 2.7.1.23 6.3.5.1 No Data 2.2.1.7 No Data 1.4.3.5 1.1.1.262 No Data No Data 6.3.3.-

8.6004 6.2333 8.4879 7.9948 6.0999 6.0999 6.0999 4.9901 3.6097 6.6029 6.5153 6.8741 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999 6.2352 6.9196 6.855 6.0999 6.0999 6.6759 6.5151 6.0999 6.8809 6.9976 8.9151 6.5621 6.5088 6.0999 5.118 6.0999 6.0999 6.8741 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999

Molybdopterin Molybdopterin Molybdopterin Molybdopterin Molybdopterin Molybdopterin Molybdopterin Molybdopterin Other Other Other Other Other Other Other Other Other Other Other Other Other Other Other Other Other Other Other Other Other Other Pantothenate and coenzyme Pantothenate and coenzyme Pantothenate and coenzyme Pantothenate and coenzyme Pantothenate and coenzyme Pantothenate and coenzyme Pyridine nucleotides Pyridine nucleotides Pyridine nucleotides Pyridine nucleotides Pyridine nucleotides Pyridine nucleotides Pyridoxine Pyridoxine Pyridoxine Pyridoxine Riboflavin, FMN, and FAD Riboflavin, FMN, and FAD Riboflavin, FMN, and FAD

A A A A A A

ribBA ribE ribD dxs thiC thiL thiG thiS thiJ No Data thiE

No Data 2.5.1.9 3.5.4.26 1.1.1.193 2.2.1.7 No Data 2.7.4.16 No Data No Data No Data No Data No Data 2.5.1.3

4.7263 6.0999 7.1535 6.8741 6.0999 4.7715 6.0999 6.0999 6.0999 6.0999

Riboflavin, FMN, and FAD Riboflavin, FMN, and FAD Riboflavin, FMN, and FAD Thiamine Thiamine Thiamine Thiamine Thiamine Thiamine Thiamine Thiamine

MAINROLE Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis

of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of

cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors,

prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic

groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups,

and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and

carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers

Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis

of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of of

cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors,

prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic

groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups,

and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and

carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers

Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis Biosynthesis

of of of of of of of of of of of

cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors, cofactors,

prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic prosthetic

groups, groups, groups, groups, groups, groups, groups, groups, groups, groups, groups,

and and and and and and and and and and and

carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers carriers

LOCUS AFE3060 AFE3059 AFE3058 AFE2766 AFE2720 AFE2718 AFE2660 AFE2639 AFE2638 AFE2356 AFE2355 AFE2354 AFE2264 AFE2261 AFE2260 AFE2174 AFE2173 AFE2123 AFE2064 AFE2023 AFE1929 AFE1913 AFE1897 AFE1896 AFE1889 AFE1778 AFE1777 AFE1772 AFE1672 AFE1463 AFE1446 AFE1144 AFE1127 AFE0908 AFE0907 AFE0902 AFE0847 AFE0780 AFE0777 AFE0776 AFE0775 AFE0773 AFE0772 AFE0732 AFE0731 AFE0640 AFE0639 AFE0563

AFE0540 AFE0365 AFE0364 AFE0356 AFE0348 AFE0295 AFE0273 AFE0272

COMMON NAME PyrR bifunctional protein aspartate carbamoyltransferase dihydroorotase, multifunctional complex type ribose-phosphate pyrophosphokinase anaerobic ribonucleoside-triphosphate reductase, beta subunit anaerobic ribonucleoside-triphosphate reductase, alpha subunit deoxycytidine triphosphate deaminase ribonucleoside-diphosphate reductase, beta subunit ribonucleotide-diphosphate reductase, alpha subunit adenylosuccinate lyase phosphoribosylaminoimidazole-succinocarboxamide synthase phosphoribosylformylglycinamidine synthase dihydroorotate dehydrogenase phosphoribosylamine--glycine ligase phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase NUDIX hydrolase NUDIX hydrolase MTA/SAH nucleosidase, putative amidophosphoribosyltransferase phosphoribosylglycinamide formyltransferase 2 nucleoside diphosphate kinase thymidylate kinase phosphoribosylformylglycinamidine cyclo-ligase phosphoribosylglycinamide formyltransferase adenylosuccinate synthetase GMP synthase inosine-5-monophosphate dehydrogenase deoxyguanosine kinase/deoxyadenosine kinase, putative dihydroorotase, homodimeric type dihydroorotase, multifunctional complex type uridylate kinase dihydroorotate dehydrogenase domain protein, putative nucleoside 2-deoxyribosyltransferase family protein orotate phosphoribosyltransferase orotidine 5`-phosphate decarboxylase cytidylate kinase CTP synthase xanthine dehydrogenase accessory factor, putative xanthine dehydrogenase, FAD-binding protein, putative xanthine dehydrogenase, iron-sulfur binding subunit, putative xanthine dehydrogenase, molybdenum-binding subunit, putative adenosine deaminase guanine deaminase, putative thymidylate synthase, flavin-dependent deoxyguanosinetriphosphate triphosphohydrolase, putative carbamoyl-phosphate synthase, small subunit carbamoyl-phosphate synthase, large subunit guanylate kinase

GENE SYMBOL pyrR pyrB pyrC-1 prsA nrdG nrdD dcd nrdB nrdA purB purC purL pyrD purD purH No Data No Data No Data purF purT ndk tmk purM purN purA guaA guaB No Data No Data pyrC-2 pyrH No Data No Data pyrE pyrF cmk pyrG No Data No Data No Data No Data add No Data thyX No Data carA carB gmk

adenine phosphoribosyltransferase, putative methylthioadenosine phosphorylase hypoxanthine-guanine phosphoribosyltransferase, putative deoxyuridine 5`-triphosphate nucleotidohydrolase adenylate kinase serine hydroxymethyltransferase phosphoribosylaminoimidazole carboxylase, ATPase subunit phosphoribosylaminoimidazole carboxylase, catalytic subunit

No Data mtaP No Data dut adk glyA purK purE

EC NUMBER 2.4.2.9 2.1.3.2 3.5.2.3 2.7.6.1 1.97.1.4 1.17.4.2 3.5.4.13 1.17.4.1 1.17.4.1 4.3.2.2 6.3.2.6 6.3.5.3 1.3.3.1 6.3.4.13 No Data 3.6.-.No Data No Data 2.4.2.14 2.1.2.2.7.4.6 2.7.4.9 6.3.3.1 2.1.2.2 6.3.4.4 6.3.5.2 1.1.1.205 No Data 3.5.2.3 3.5.2.3 2.7.4.No Data No Data 2.4.2.10 4.1.1.23 2.7.4.14 6.3.4.2 No Data No Data No Data No Data 3.5.4.4 No Data 2.1.1.148 No Data 6.3.5.5 6.3.5.5 2.7.4.8

ISOELECTRIC POINT 4.6927 7.5067 6.4474 5.4421 7.1875 6.4034 5.6673 5.2001 6.0731 6.0876 5.4567 5.7147 9.1915 6.5134 5.4994 5.2421 8.3144 6.6728 6.8665 6.0999 5.6006 6.0999 6.0999 6.5105 6.0999 6.0999 6.0999 6.5164 6.0999 6.0999 5.3883 6.0999 6.0999 6.0999 4.8336 6.0999 5.8106 6.0999 No Data 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999 6.0999

No Data 2.4.2.28 No Data 3.6.1.23 2.7.4.3 2.1.2.1 4.1.1.21 4.1.1.21

6.0999 6.0999 6.0999 6.0999 6.0999 7.2624 6.3505 6.0999

SUBROLE Pyrimidine ribonucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis Purine ribonucleotide biosynthesis 2'-Deoxyribonucleotide metabolism 2'-Deoxyribonucleotide metabolism 2'-Deoxyribonucleotide metabolism 2'-Deoxyribonucleotide metabolism 2'-Deoxyribonucleotide metabolism Purine ribonucleotide biosynthesis Purine ribonucleotide biosynthesis Purine ribonucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis Purine ribonucleotide biosynthesis Purine ribonucleotide biosynthesis Salvage of nucleosides and nucleotides Salvage of nucleosides and nucleotides Salvage of nucleosides and nucleotides Purine ribonucleotide biosynthesis Purine ribonucleotide biosynthesis Nucleotide and nucleoside interconversions Nucleotide and nucleoside interconversions Purine ribonucleotide biosynthesis Purine ribonucleotide biosynthesis Purine ribonucleotide biosynthesis Purine ribonucleotide biosynthesis Purine ribonucleotide biosynthesis Nucleotide and nucleoside interconversions Pyrimidine ribonucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis Nucleotide and nucleoside interconversions Pyrimidine ribonucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis Nucleotide and nucleoside interconversions Pyrimidine ribonucleotide biosynthesis Other Other Salvage of nucleosides and nucleotides Salvage of nucleosides and nucleotides Salvage of nucleosides and nucleotides Salvage of nucleosides and nucleotides 2'-Deoxyribonucleotide metabolism Nucleotide and nucleoside interconversions Pyrimidine ribonucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis Nucleotide and nucleoside interconversions

MAINROLE Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines, Purines, pyrimidines,

nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides,

and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and

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Salvage of nucleosides and nucleotides Salvage of nucleosides and nucleotides Salvage of nucleosides and nucleotides 2'-Deoxyribonucleotide metabolism Nucleotide and nucleoside interconversions Purine ribonucleotide biosynthesis Purine ribonucleotide biosynthesis Purine ribonucleotide biosynthesis

Purines, Purines, Purines, Purines, Purines, Purines, Purines, Purines,

pyrimidines, pyrimidines, pyrimidines, pyrimidines, pyrimidines, pyrimidines, pyrimidines, pyrimidines,

nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides, nucleosides,

and and and and and and and and

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des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des, des,

and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and and

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des, des, des, des, des, des, des, des,

and and and and and and and and

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