L V Prasad Eye Institute Kallam Anji Reddy Campus L V Prasad Marg, Banjara Hills Hyderabad 500 034, India

Tel: 91 40 3061 2345 Fax: 91 40 2354 8271 e-mail: education@lvpei.org

L V Prasad Eye Institute Patia, Bhubaneswar 751 024 Orissa, India Tel: 91 0674 3989 2020 Fax: 91 0674 3987 130 e-mail: Bikash@bei-lvpei.org

December 2008

L V Prasad Eye Institute G M R Varalakshmi Campus Door No: 11-113/1, Hanumanthawaka Junction Visakhapatnam 530 040, Andhra Pradesh, India Tel: 91 0891 3989 2020 Fax: 0891-398 4444 e-mail: joji@vizag-lvpei.org

Collaborating Centre for Prevention of Blindness

Our International Linkages

Our National Linkages

International
Alcon, USA Allergan, USA Bartimeus, The Netherlands Bausch & Lomb, USA Bristol Eye Bank, Bristol Eye Hospital, Bristol, UK Cambridge University, UK Carl Zeiss, Germany Centre for Eye Research Australia, Melbourne, Australia Centre for Eye Research & Technology, Australia Centre of Excellence in Molecular Biology, Lahore, Pakistan Champalimaud Foundation, Portugal Childrens Hospital of Philadelphia, University of Pennsylvania, USA Childrens Hospital of Florida, USA Christoffel Blindenmission, Germany Cornea & Contact Lens Research Unit, Australia Combat Blindness Foundation, USA Duke University, Durham, USA Eye Sight International, Vancouver, Canada Fred Hollows Foundation, Australia Fund Incorporated, Australian Federation of University Women (AFUW) and Queensland branch, Australia Harvard University, Cambridge, MA, USA Institute of Eye Research, Sydney, Australia International Federation of Eye & Tissue Banks, Baltimore, USA International Center for Eye Care Education, Australia International Association for Contact Lens Education, Australia Islamia Eye Hospital, Dhaka, Bangladesh i2 Foundation, Texas, USA Johns Hopkins University, Baltimore, USA Jules Stein Eye Institute, University of California, Los Angeles, USA Lighthouse International, New York, USA Lions International, USA London School of Tropical Hygiene & Medicine, UK Massachusetts Eye and Ear Infirmary, Boston, USA Moorfields Eye Hospital, London, UK National Institutes of Health, Bethesda, MD, USA National Institute of Sensory Organs, Tokyo, Japan Northwest Lions Eye Bank, Seattle, USA Northwestern University, Evanston, IL, USA Ohio State University, Columbus, USA Operation Eye Sight Universal, Canada ORBIS International, New York, USA Pharmacia & Upjohn, Sweden Queensland University of Technology, Brisbane, Australia Rotary International, USA SUNY School of Optometry, New York, USA Santen Inc., USA Service de Biologie Cinique Institut Salah Azaiz, Tunisie Sight Savers International, UK State University of Rochester, USA Tel Aviv University, Israel The Hadley School for the Blind, Illinois, USA The Tun Hussein On National Eye Hospital and the Malaysian Association for the Blind, Kuala Lumpur, Malaysia Tubero, Sendai University, Japan Tufts University of Medicine, Boston, MA, USA The Cooperative Research Center for Eye Research & Technology, Australia University of Aberdeen, Scotland, UK University of Florida, Gainesville, Fl, USA University of Heidelberg, Germany University of London, UK University of Melbourne, Melbourne, Australia University of Nottingham, Nottingham, UK University of New South Wales, Australia University of Ottawa, Canada University of Rochester, School of Medicine and Dentistry, Rochester, USA University of South Carolina, USA University of Tennessee, Memphis, Tennessee, USA University of Rochester Eye Institute, University of Rochester, New York, USA University of Waterloo, Canada Vanderbilt University, USA Vision CRC, Australia Wills Eye Hospital, USA World Health Organization, Switzerland William Beaumont Hospital, Michigan, USA Yayasan Penyatun Wyata Guna, Indonesia

National
Action on Disability and Development India, Bangalore Ali Yavar Jung National Institute for the Hearing Handicapped, Secunderabad Anthropological Survey of India, Hyderabad Aravind Eye Hospital System, Madurai Benares Hindu University, Varanasi Bhabha Atomic Research Centre, Mumbai Bio-Medix Optotechnik & Devices Pvt. Limited, Bangalore Birla Institute of Technology and Science, Pilani Blind Peoples Association, Ahmedabad Calcutta University, Kolkata CBR Forum, Bangalore Centre for Cellular and Molecular Biology, Hyderabad Centre for DNA Fingerprinting and Diagnostics, Hyderabad Centre for Human Genetics, Bangalore Consolidated Products Corporation Pvt. Limited, New Delhi Council for Advancement of Peoples Action, New Delhi Council of Scientific & Industrial Research, Government of India, New Delhi Department of Biotechnology, Government of India, New Delhi Department of Science & Technology, Government of India, New Delhi Eye Bank Association of India, Hyderabad Guru Nanak Dev University, Amritsar Holy Cross College, Tiruchirappalli Indian Council for Medical Research, New Delhi Indian Institute of Chemical Biology, Kolkata Indian Statistical Institute, Kolkata International Human Resource Development Centre, Coimbatore Indian Institute of Information Technology, Hyderabad Indian Institute of Science, Bangalore Indian Institute of Technology, Chennai Indian Orthocane Surgicals, Chennai Jammu University, Jammu Milmet Laboratories Pvt. Limited, Ahmedabad Micro Vision, Ahmedabad National Association for the Blind, Mumbai National Brain Research Centre, Gurgaon National Institute for Mentally Handicapped, Secunderabad National Institute for the Visually Handicapped, Dehradun National Institute of Mental Health, Hyderabad National Institute of Mental Health and Neuro Sciences, Bangalore National Institute of Nutrition, Hyderabad Sankara Nethralaya, Chennai Sir Ratan Tata Trust, Mumbai Thakur Hari Prasad Institute for Research and Rehabilitation of Mentally Handicapped, Hyderabad The Helen Keller Institute for Deaf and Deafblind, Mumbai University of Hyderabad, Hyderabad VIMTA Laboratories, Hyderabad Vision Research Foundation, Chennai

Relevance and Rigour

Research at L V Prasad Eye Institute

Collaborating Centre for Prevention of Blindness

L V Prasad Eye Institute

Kallam Anji Reddy Campus L V Prasad Marg, Banjara Hills, Hyderabad - 500 034, India Phone: 91 40 3061 2345 Fax: 91 40 2354 8271 Email: communications@lvpei.org Web site: www.lvpei.org

Vision
To create excellent and equitable eye care systems that reach all those in need.

Mission
The mission of L V Prasad Eye Institute is to be a centre of excellence in eye care services, basic and clinical research into eye diseases and vision-threatening conditions, training, product development, and rehabilitation for those with incurable visual disability; with a focus on extending equitable and efficient eye care services to underserved populations in the developing world.

Contents
L V Prasad Eye Institute: An Overview The Eye Health Pyramid Research at LVPEI Hyderabad Eye Research Foundation Highlights of Research Projects LVPEI Faculty
Hyderabad Bhubaneswar Visakhapatnam

1 2 5 9 17 25

Honors and Awards 2002 2007 Publications 2002 2007

55 61

December 2007

ORGANOGRAM
L V PRASAD EYE INSTITUTE

HYDERABAD EYE INSTITUTE

HYDERABAD EYE RESEARCH FOUNDATION

Eye Care / Clinical Services Vision Rehabilitation Services Clinical Research and Trials with HERF facilities

Basic Research in genetics of eye diseases Infection & Microbiology Cell Biology Public Health Postgraduate education and Ph.D. programmes

Translational Research (HEI + HERF) Bench to Bedside to Community

L V Prasad Eye Institute

Excellence and equity in eye care
L V Prasad Eye Institute (LVPEI) is a Centre of Excellence in eye care services, basic and clinical research into eye diseases and vision-threatening conditions, training, product development, and rehabilitation for those with incurable visual disability, with a focus on extending equitable and efficient eye care to disadvantaged populations in the developing world. The Institute is run by two not-for-profit, non-government, officially registered organizations, the Hyderabad Eye Research Foundation (HERF) and the Hyderabad Eye Institute (HEI). HERF conducts all research activities basic, clinical, translational and public-health related, while HEI provides comprehensive eye care delivery to all who need it. Clinicians at HEI use the facilities and support offered by the laboratories of HERF and collaborate with the scientists at HERF to do research. Established in 1987, the Institute has grown in strength over the last twenty years to become one of the premier eye health institutes in the world. LVPEI today extends beyond its Hyderabad campus into a network spanning two additional tertiary centers in Bhubaneswar and Visakhapatnam, 16 secondary care Service Centres and 50 primary care Vision Centres across Andhra Pradesh and the neighbouring states of India. In order to reach out, work with and provide service to the community, the Institute has embarked on a public health initiative, the International Centre for Advancement of Rural Eye care (ICARE). Through this initiative, L V Prasad Eye Institute is a World Health Organization Collaborating Centre in the area of blindness prevention. It has been the global headquarters of the International Agency for the Prevention of Blindness (IAPB) and is the nodal center for VISION 2020: The Right to Sight, the global initiative against avoidable blindness. LVPEI has been designated by the Andhra Pradesh State Government as a resource center for the state level VISION 2020: The Right to Sight program. The Institute also houses the editorial offices of the Community Eye Health Journal Indian Edition and the Indian Journal of Medical Microbiology.

The Eye Health Pyramid

L V Prasad Eye Institutes innovative eye care delivery model ensures excellent eye care for all, across villages and cities. This five-level inter-connected system has world-class permanent infrastructure and fully trained human resources at each level of care. Each level generates income and delivers quality eye care, with services offered free of cost to those who cannot pay.

The pyramidal advantage

Effective vision centres can entirely eliminate 25% of all blindness due to the need for spectacles, detect potentially blinding problems, address conditions like vitamin A deficiency, detect cataract, some glaucomas and diabetic retinopathy. Service centres can manage 75% of all avoidable blindness. Therefore, only 25% of all people with visual impairment actually need to travel to cities to access tertiary care.

An Eye Health System that reaches all those in need

The Services
The Centre of Excellence is at the apex of the pyramid, and functions as an advanced Tertiary Care Centre, engaging in Training Trainers and specialists, active research, and advocacy. Ten Tertiary Centres would link to 1 Centre of Excellence.

The Structure
In a year, an average Centre of Excellence:

Provides outpatient services to 2,00,000 people Performs 25,000 surgeries Trains 250 professionals at all levels of eye care Publishes at least 50 research papers Provides eye banking services, collecting 2500 corneas Provides low vision services to 3000 people Contributes to eye health policy

Tertiary Care Centres offer a complete range of eye services, such as:

Comprehensive eye check-ups Advanced care for many complex problems Rehabilitation for the blind and low vision care

A Tertiary Eye Centre, servicing 50,00,000 people, offers the complete gamut of eye services including subspecialty care, low vision and rehabilitation, and conducts training and research. Within 5 years of establishment, every year, an average Tertiary Eye Centre:

Fully-equipped support pharmacy, opticals Training for all cadres of eye care professionals Clinical research

Provides 75,000 outpatient consultations Performs 10,000 surgeries Trains 100 professionals at all levels of eye care Publishes at least 10 research papers

Service Centres or Secondary Care Centres offer comprehensive eye care services, including surgery:

Comprehensive outpatient services World-class surgical services (secondary) Community based rehabilitation and low vision care Fully-equipped support pharmacy, opticals

The Service Centre serves a population of 5,00,000. Ten Vision Centres, within a radius of 50 km are linked to a service centre. In a year, an average Service Centre:

Provides outpatient services for 10-15 thousand people Performs 1500-2000 surgeries, refers 5-10% patients Performs 50 community-based screening activities. Acts as a referral administration source for 10 Vision
Centres. Each Vision Centre caters to around 50,000 people (2025 villages). Vision Technicians community members who have received a 1-year training; they screen the village population and link up with other community services. In a year, an average Vision Centre: Screens 2500 people (at the Centre) and 2500 children (in schools) Dispenses 400 pairs of spectacles and educates 300 people on spectacle usage Identifies and refers 500 people to the next level Vision Guardians service 5000 people (2-3 villages) and work closely with the nearest Vision Centre. for tertiary care

Vision Centres are Primary Care Centres, managed by Vision Technicians. At a Vision Centre, you will find:

Full eye screening Prescription and supply of low cost spectacles Referral to the next level for cataract surgeries and Link to other community services
other conditions

At this level are Vision Guardians volunteers who deliver Community Eye Care; they: Monitor the eye health of 5000 people, especially children and the elderly Refer people who need an eye check-up to the appropriate centre Monitor those who have had surgery Provide readymade near-vision glasses

Research at LVPEI
An Introduction

Hyderabad Eye Research Foundation

All research at L V Prasad Eye Institute is conducted through its constituent arm, the Hyderabad Eye Research Foundation (HERF), which is recognized by the Indian Governments Department of Scientific and Industrial Research (DSIR) as a Scientific and Industrial Research Organization (SIRO). HERF continues to compete for and receive grants from all over the world to conduct cutting edge research on the eye. The Prof Brien Holden Eye Research Centre (BHERC) investigates the causes and treatment strategies through its various components, namely the Champalimaud Translational Centre (C-TRACER), the Jhaveri Microbiology Centre, the Saroja A Rao Immunology Laboratory, the Kallam Anji Reddy Molecular Genetics Laboratory, the Ophthalmic Pathology Laboratory, the Sudhakar and Sreekanth Ravi Stem Cell Biology Laboratory, and the clinical research laboratories. Each of these components has been named after its donor, in recognition of their generous support.

Support and recognition

Research at HERF has concentrated on molecular genetics of inherited eye diseases, devising molecular diagnostics for early detection, microbiology of eye infections, biochemical features of cataract, and stem cell technology for reconstruction of the damaged ocular outer surface. Support for these projects have come from competitive grants received from the Department of Biotechnology (DBT), Department of Science and Technology (DST), Council of Scientific & Industrial Research (CSIR), and the Indian Council of Medical Research (ICMR) all from India, as well as the National Eye Institute (NEI, National Institutes of Health), USA. Thanks to the recently formalized US India eye research collaboration, several joint research projects have been initiated at HERF, in collaboration with researchers in the US. Likewise, HERF is one of the four pillars of the multinational research and development group called Vision CRC (operating from Sydney, Australia), and conducts research on its behalf on the genetics of myopia, as well as a series of clinical studies such as on antibacterial contact lenses and corneal onlays. The Institute is recognized as an external research centre by the University of Hyderabad, Hyderabad; Birla Institute of Technology & Science (BITS), Pilani; and the University of New South Wales, Sydney, Australia. This enables research scholars from LVPEI to register with, and obtain their Ph D degrees from these universities. Collaborative research has also been forged with national laboratories such as the Centre for Cellular & Molecular Biology (CCMB), Centre for DNA Fingerprinting & Diagnostics (CDFD), National Institute of Nutrition (NIN), and University of Hyderabad all in Hyderabad, and the Indian Institute of Science, Bangalore. The agreements allow researchers at LVPEI to access state-of-the-art equipment and sophisticated facilities at these centers.

Clinical Research
LVPEIs multidisciplinary clinical research is of international standards and is sponsored by Indian funding agencies and multinational companies from USA and France. The group conducts not only intramural clinical research, but also participates in multicentre clinical trials. Clinical research has also focused on the suitability of using extended wear contact lenses. This involves recruitment of volunteers and monitoring comfort levels and related factors upon the use of contact lenses over a period of time. Another area of study is the efficacy, pharmacodynamics and related features of ophthalmic drugs and antibiotics. Many of the studies are conducted in collaboration with leading pharmaceutical companies.

Hyderabad Eye Research Foundation Members of the Board

Chair Dr F C Kohli Chairman Emeritus Tata Consultancy Services Limited, Mumbai

Secretary/Treasurer Dr Gullapalli N Rao Distinguished Chair of Eye Health L V Prasad Eye Institute, Hyderabad Lt Gen D Raghunath Principal Executive Sir Dorabji Tata Centre for Research in Tropical Medicine, Bangalore Mr B Ramalinga Raju Chairman, Satyam Computer Services Limited, Secunderabad Dr Ch Mohan Rao Deputy Director Centre for Cellular and Molecular Biology, Hyderabad Dr Seyed E Hasnain Vice Chancellor, University of Hyderabad, Hyderabad Prof K Srinath Reddy President Public Health Foundation of India, New Delhi Dr Kiran Mazumdar-Shaw Chairperson & Managing Director The Biocon Group of Companies, Bangalore Prof D Balasubramanian (Ex-officio member) Director Research, L V Prasad Eye Institute, Hyderabad Dr G Chandra Sekhar (Ex-officio member) Director, L V Prasad Eye Institute, Hyderabad

Members Institutional Review Board

(Independent Ethics Committee)
Chair Justice T N C Rangarajan Retired Justice, Andhra Pradesh High Court, Hyderabad Member Secretary Dr Geeta K Vemuganti, MD, DNB Head, Ophthalmic Pathology Services Head, Sudhakar and Sreekanth Ravi Stem Cell Biology Laboratory L V Prasad Eye Institute, Hyderabad Dr Usha Raman, PhD Associate Director and Head, Communications L V Prasad Eye Institute, Hyderabad Dr Subhabrata Chakrabarti, Ph D Scientist, Kallam Anji Reddy Molecular Genetics Laboratory L V Prasad Eye Institute, Hyderabad Dr Evita Fernandez, MD, MRCOG Fernandez Hospital for Women and Newborn, Hyderabad Dr Madhukar Reddy, MS Dhrishti Eye Centre, Hyderabad Dr Roy Verghese, MD Elbit Medical Diagnostics Limited, Hyderabad Dr Ajit Babu, MD Ophthalmologist, L V Prasad Eye Institute, Hyderabad Dr Ramesh Murthy, MD Pediatric Ophthalmologist, L V Prasad Eye Institute, Hyderabad

Members Research Advisory Board

Chair Dr Avadhesha Surolia, PhD, FNA, FASc Director, National Institute of Immunology, New Delhi Dr Narinder K Mehra, PhD Professor & Head, Department of Transplant Immunology & Immunogenetics All India Institute of Medical Sciences, New Delhi Dr Jyotsna Dhawan, PhD Scientist, Centre for Cellular Molecular Biology, Hyderabad Dr Ch Mohan Rao, PhD Deputy Director, Centre for Cellular & Molecular Biology, Hyderabad Dr Seyed E Hasnain, PhD Vice Chancellor, University of Hyderabad, Hyderabad Lt Gen D Raghunath Principal Executive Sir Dorabji Tata Centre for Research in Tropical Medicine Indian Institute of Science Campus, Bangalore Prof D Balasubramanian Director Research, L V Prasad Eye Institute, Hyderabad

Hyderabad Eye Research Foundation

Prof. Brien Holden Eye Research Centre
Champalimaud Translational Centre Kallam Anji Reddy Molecular Genetics Laboratory Sudhakar & Sreekanth Ravi Stem Cell Biology Laboratory Jhaveri Microbiology Centre & Saroja A Rao Immunology Laboratory Biochemistry Laboratory Ophthalmic Pathology Laboratory Clinical Research

Dr Leonor Beleza, President, Champalimaud Foundation, at the inauguration of C-TRACER at LVPEI on January 30, 2008

Prof Balasubramanian, Director Research, LVPEI, shows the Centre to Smt. Purandareshwari, Minister of State for Human Resource Development, Govt of India, and Dr Leonor Beleza

Champalimaud Translational Centre of Eye Research

The Champalimaud Foundation, based in Lisbon, Portugal, was created on the bequest of the late Portuguese industrialist and entrepreneur, Antnio de Sommer Champalimaud. At the end of 2004 it was incorporated as the Anna de Sommer Champalimaud and Dr Carlos Montez Champalimaud Foundation, in honour of the benefactors parents. The Foundation has a long-term commitment to support medical research, in particular neurology, onclology and vision sciences. The Champalimaud Foundation and L V Prasad Eye Institute have agreed on the development of a vast program of translational research through the establishment of the Champalimaud Translational Centre of Eye Research or C-TRACER. This centre will lead to the beginning of the Foundations scientific activity in two years and allow Portuguese scientists to participate in research. LVPEI has been conducting translational research in relation to vision and has, notably, utilised stem cells for the treatment of eye diseases. Now this agreement has established a link between the scientific communities of Portugal, Africa and Asia, and will allow the creation of programs specific to the Lusophone countries of Africa. C-TRACER will focus on the following areas: Research and therapy through the utilisation of stem cells in vision-related illnesses; Translational research utilising existing and novel clinical methodologies with the objective of furthering the knowledge of vision in such a way that it can be readily applied to the patient; Exchange programs involving scientists chosen by LVPEI and the Champalimaud Foundation; and Introduction of capacity building programs aimed at developing Lusophone countries such as Mozambique, Angola, Timor and others. With the creation of C-TRACER the Champalimaud Foundation is making a significant contribution to the prevention and eradication of vision-related disease and illness in Portugal, in the countries of the Portuguese language, in India and in the world, apart from providing unique opportunities for training and experience for talented Portuguese scientists. The Department of Biotechnology, Government of India, has also granted a five-year program support to the Institute to aid the Centre in its activities.

10

Kallam Anji Reddy Molecular Genetics Laboratory

The Kallam Anji Reddy Molecular Genetics Laboratory, established with the generous support of Dr K Anji Reddy of Dr Reddys Laboratories, Hyderabad, conducts research leading to the understanding of underlying molecular mechanisms in various inherited eye disorders. This laboratory has facilities for advanced research in molecular genetics and molecular biology and is equipped with thermal cyclers, gel documentation units, spectrophotometer, electrophoresis equipment, dHPLC a Real Time PCR and two automated DNA sequencers. The primary focus lies in identifying and characterizing the genes involved in ocular disorders, understanding their mutation spectrum, screening SNPs that could be potential risk factors for the disease condition and generating haplotypes to understand the origin, evolution and differentiation of the mutations. Based on this an attempt is made towards establishing a genotype-phenotype correlation that may be useful to monitor prognosis. Identification of gene mutations and variants can further lead to devising molecular diagnostics for rapid screening and early intervention. In addition, functional studies are also being undertaken by cloning and expressing the disease-causing genes, and studying the resultant proteins so as to determine the molecular phenotype based on the function of the proteins and their interactions.

11

Sudhakar and Sreekanth Ravi Stem Cell Biology Laboratory

The stem cell laboratory, set up with the generous support of two brothers Sudhakar Ravi and Sreekanth Ravi of California, USA is engaged in frontline research designed to apply knowledge of stem cell biology to the treatment of eye diseases. Stem cells, or undifferentiated cells from a donor eye, are cultured in a special medium to generate corneal cells that can then be transplanted into the eye of a person with corneal blindness. In the area of ocular surface damage, the laboratory has been particularly successful in developing a technique of culturing limbal stem cells ex-vivo on an amniotic membrane substrate and transplanting the resultant corneal epithelium into the patients eye. The laboratory is also attempting to transdifferentiate stromal cells from the bone marrow into cells of neuronal lineage, which could then be taken further to grow retinal cells.

12

Jhaveri Microbiology Centre and Saroja A Rao Immunology Laboratory

The Jhaveri Microbiology Centre, established with a generous donation from the Late Shri L D Jhaveri, a pearl merchant from Japan, and the Saroja A Rao Immunology Laboratory, which was set up with initial funding from Dr Narsing Rao of USA, are an integral part of the Prof Brien Holden Eye Research Centre. Research activities at both laboratories are supported through research grants received from national agencies and industries, including the Council of Scientific and Industrial Research (CSIR), Department of Biotechnology (DBT), New Millennium Indian Technology Leadership Initiative (NMITLI) under the CSIR, as well as international agencies such as The Thrasher Foundation. The Jhaveri Microbiology Centre is engaged in investigating a range of infectious diseases of the eye that are caused by bacteria, fungi, viruses, and parasites. The research has led to several conference presentations and publications in national and international journals. The centre has a team of three microbiologists and five technicians who work in the area of diagnostic microbiology.

13

Biochemistry Laboratory
The Biochemistry Laboratory is involved in research dealing with biochemical agents that play a crucial role in various eye diseases. One aspect of the work involves identifying substances for use in delaying the progression or onset of age-related eye diseases. Extracts of plants such as tea, Ginkgo biloba and Withania somnifera (Ashwagandha) have been analyzed and found to have a beneficial role. The effect is traced to the antioxidant and cytoprotective molecules present in these extracts. A second project involves the study of the molecular phenotypes in various eye disorders. The mutant gene identified as being associated with the disorder is cloned and expressed in heterologous systems, in order to produce the mutant protein, and the molecular properties of the latter are compared with those of the normal protein. Currently, the mutant crystallin genes in cataractous lenses, and the glaucoma-causing optineurin gene expressed in the trabecular meshwork cells, are being cloned and expressed to understand the molecular phenotypes. In addition, where necessary, the cDNAs of the target proteins are transfected into relevant cells and the differences in the behavior of the normal (wild type) and mutant molecules compared. This gives an idea of the functional alterations that occur in situ due to the mutation. The laboratory is equipped with all the advanced instruments required for biochemical and molecular biological work.

14

Ophthalmic Pathology Laboratory

The ophthalmic pathology laboratory supports the clinical services with routine tissue processing and histopathology reporting. In addition, the laboratory carries out tests in the areas of histochemistry and immuno-histochemistry, immuno-fluorescence studies, cytology of fluids, fine needle aspiration cytology, rapid intra-operative imprint, and squash cytology. In order to aid clinicians in difficult cases, the laboratory has introduced rapid intraoperative diagnosis by squash and imprint cytology. This enables the generation of a provisional report within 5-7 minutes of receiving a sample. Facilities for frozen section reporting are also available.

15

Clinical Research
LVPEI's large patient volume combined with its applied research focus has made it an ideal site for clinical research. The multidisciplinary clinical research that is undertaken here is of international standards, with several projects sponsored by national funding agencies as well as multinational drug and device manufacturing companies. In recent years, LVPEI has become a key participant in a variety of multi-site clinical trials, apart from conducting intramural clinical research. One of the primary areas of clinical research and one in which LVPEI has had a long history is contact lens studies. The suitability and safety of a variety of different contact lenses-antibacterial, extended wear, multi-focal, among others-is studied in target populations. This involves recruitment of volunteers and monitoring comfort levels and other factors related to use over time. These studies are done in collaboration with lens manufacturers as well as vision research groups across the globe. Another area where LVPEI research teams have worked in tandem with the industry and other research organisations is in studying the efficacy, pharmacodynamics and related features of ophthalmic drugs and devices, including drug delivery systems. All of LVPEI's clinical trials and other research involving human subjects are done with the approval and monitoring of an Institutional Review Board, which provides scientific and ethical oversight.

16

Highlights of Research Projects

Ocular surface reconstruction using oral cells

A method established by scientists at L V Prasad Eye Institute has given hope to patients who have lost their vision due to the loss of stem cells. These stem cells, called limbal stem cells, are essential for regenerating the corneal epithelium and maintaining proper integrity and vision. Limbal stem cells are usually lost due to chemical or thermal injury. This leads to the loss of the corneal epithelium, growth of neighboring conjunctival cells on the cornea, corneal opacity and, finally, blindness. To reconstruct the ocular surface in such patients, limbal cells are harvested from the healthy eye, cultured in the laboratory and then transplanted into the injured eye. This technique has been used successfully at L V Prasad Eye Institute to treat over 500 patients with limbal stem cell deficiency. But when both eyes are damaged, allogenous or non-self limbal stem cells from donors are used for transplantation, which have a higher chance of being rejected by the recipient. They also require life-long use of expensive immunosuppressants with undesirable side-effects. The research team at LVPEI has now demonstrated that cells from a patients oral cavity can be used to reconstruct the ocular surface, in cases where the patients own limbal stem cells are not available. The team has developed a technique to culture oral cells in the laboratory. Experiments show that although of oral origin, the cultured cells are similar in many ways to cultured limbal cells and, therefore capable of regenerating the ocular surface. In addition to eliminating the risks of allogenous transplants, this technique is also an improvement over a similar technique established earlier in Japan in that it does not require the use of feeder cells (animal cells that are cultured with stem cells to facilitate the growth of stem cells). This eliminates the risks inherent in introducing unknown animal products into the patient. The clinical trials for using oral epithelial cultures for ocular surface reconstruction were initiated in October 2007. Preliminary results have been encouraging; after the transplantation, patients have reported improvement in vision. Once established successfully, the treatment is likely to help treat around 30 such needy patients per year at the Institute.

Oral epithelial cells growing out from the oral biopsy

Histology of oral epithelial cells cultured on amniotic membrane

18

Origin and migration of disease-associated mutations in primary congenital glaucoma

Primary congenital glaucoma (PCG) is a severely blinding disorder in children with a prevalence of 1 in 3300 live births in Andhra Pradesh. It is an autosomal recessive disorder manifested by two copies of the mutant allele in the children; parents are usually asymptomatic carriers. The cytochrome P450 gene (CYP1B1) happens to be a major culprit as defects in this gene (mutations) account for a varied proportion of primary congenital glaucoma cases worldwide. The glaucoma research group at the Institute (Dr Subhabrata Chakrabarti, Ms Kiranpreet Kaur and Dr Inderjeet Kaur from the research wing and Drs Anil Mandal, Rajul Parikh and Ravi Thomas from the clinical services) has been working on the genetics of PCG for the last several years. They wanted to address a rather unusual question why are the mutation spectrums in CYP1B1 in PCG patients similar even across different countries? Dr Chakrabarti, in collaboration with Prof Partha P Majumder, a renowned geneticist at the Indian Statistical Institute, Kolkata, addressed this issue with the help of genetic signatures (haplotypes) in CYP1B1 in PCG patients and unaffected normal control patients. These were analyzed in conjunction with data available from other populations along with ancestral great apes like chimpanzees. The team observed that common mutations in CYP1B1 associated with PCG occurred on a uniform haplotype background among Indian patients that was completely distinct from the most frequent haplotype found among unaffected Indian control patients. Globally, there was a strong clustering of mutations by geographical and haplotype backgrounds. Together with the data of chimpanzees, and of normal controls from India and other global regions, it was possible to reconstruct the evolution of these mutations on different haplotype backgrounds. The presence of predominant CYP1B1 mutations on specific haplotypes, irrespective of geographical regions, is indicative of common founders and population movements. Some of these observations could be correlated with the ancient population movements from Saudi Arabia to India, immigration of the Roma gypsies from India to northern and central Asia and so forth. These results are useful for predictive testing of PCG and call for similar studies on PCG mutations that are not associated with CYP1B1. The detailed results of the study were published in the journal Investigative Ophthalmology and Visual Sciences (January 2006 issue) and also cited in the directory of the Online Mendelian Inheritance in Man (OMIM).

The migration of CYP1B1 mutation across different countries worldwide. The colour of the arrow indicates a common mutation that is found on the background of the same haplotype across different populations. The direction of the arrows indicate the hypothetical route of migration of these mutations in different countries.

19

Hyderabad Eye Research Foundation Status of Clinical Research Projects

Project
A prospective, single center, openlabel feasibility clinical evaluation of an accommodating intraocular lens Protein Kinase C inhibitor reduction in the occurrence of center-threatening diabetic macular edema B7A-MC-MBDL Posurdex study for DME Posurdex study for BRVO Posurdex study for uveitis An evaluation of the safety and efficacy of Moxifloxacin AF ophthalmic solution 0.5% for the treatment of bacterial conjunctivitis in India A natural history study and genetic study of macular telangiectasia the Mactel study Healthy eye study DME Macugen A study to evaluate the clinical and mirobial efficacy of 0.6% ISV-403 compared to VIGAMOX in the treatment of bacterial conjunctivitis MCS 650 device pilot study

Sponsor
Bausch & Lomb (S) Pvt Ltd, Singapore Eli Lilly & Company

Principal Investigator
Dr V S Sangwan

Duration
April 2005 to September 2007 September 2005 to 2009 January 2006 to February 2010 January 2006 to June 2008 January 2006 to 2008 March 2006 to December 2006

Dr Subhadra Jalali

Allergan India Pvt Ltd Allergan India Pvt Ltd Allergan India Pvt Ltd Alcon (Quintiles)

Dr Ajit B Majji Dr Annie Mathai Dr V S Sangwan Dr Prashant Garg

Mactel Foundation

Dr Raja Narayanan

October 2006 to 2011 November 2006 November 2006 to 2009 February 2007 to December 2007

Alcon (Quintiles) Pfizer Bausch & Lomb

Dr Prashant Garg Dr Subhadra Jalali Dr Prashant Garg

Scy Fix

Dr Subhadra Jalali Dr V S Sangwan

March 2007 to 2009 December 2007 to December 2009

Comparative, randomized, open trial on Ioltech SA (a company the anti-inflammatory efficacy of diclofenac of Carl Zeiss Meditec AG) released from an intra ocular lens versus administration of 0.1% diclofenac eye-drops in the prevention of post operative inflammatory manifestations after cataract surgery Ancillary study: 1 year follow-up of the safety Lux Biosciences LX211-01-UV LUX Biosciences Frankfurt, Germany LUX Biosciences Frankfurt, Germany LUX Biosciences Frankfurt, Germany Bharat Biotech, India Oculus Gen

Dr Somasheila Murthy

November 2007 to December 2008 November 2007 to December 2008 November 2007 to December 2008 December 2007 to December 2008 July 2007 to June 2008

Lux Biosciences LX211-02-UV Lux Biosciences LX211-03-UV Role of recombinant EGF in the healing of corneal epithelial defects Comparative study of the safety and effectiveness between trabeculectomy with trabeculectomy with OculusGen TM Collagen Matrix Implant Comparative study of the safety and effectiveness between OculusGen TM Collagen Matrix Implant and Mitomycin-C in glaucoma filtering surgery

Dr Somasheila Murthy Dr Somasheila Murthy Dr V S Sangwan Dr Anil K Mandal

Oculus Gen

Dr B L Harsha

July 2007 to June 2008

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Ongoing Basic Research Projects

Project
Proteome and genetic analysis of agerelated macular degeneration (AMD) patients Characterization of microsporidia causing ocluar infections Stem cell therapy for stroke in rat model

Supported by
DST India Japan (JSPS) Collaborative Scheme Department of Biotechnology Department of Biotechnology

Principal Investigator
Prof D Balasubramanian & Dr Inderjeet Kaur Dr Savitri Sharma & Prof D Balasubramanian Dr Prakash Babu (University of Hyderabad) & Dr Geeta K Vemuganti Prof D Balasubramanian Dr Geeta K Vemuganti Dr V S Sangwan Dr Geeta K Vemuganti Dr Geeta K Vemuganti & Dr Taraprasad Das Dr Geeta K Vemugati Dr Chitra Kannabiran & Dr Santosh G Honavar Dr Subhabrata Chakrabarti & Dr Chitra Kannabiran Dr Chitra Kannabiran Dr Subhabrata Chakrabarti & Dr Inderjeet Kaur Dr Yashoda Ghanekar

Duration
2005-2007 2004-2007 2006-2009

Phenotypic & genotypic characterization of limbal stem cell, cultivated limbal epithelial cells and the evaluation of these characteristics after clinical transplantation Centre for cell based therapy Transdifferentiation of bone marrow stem cell into neuronal cells Role of human papilloma virus, proliferative markers, and p53 in the genesis & prognosis of ocular surface squamous neoplasia Further molecular genetic studies of some eye diseases affecting the Indian population Molecular studies on hereditary congenital/ juvenile cataracts Genetics of myopia (strategic research) Characterization of cultivated oral mucosal epithelial cells and its application for reconstructing the ocular surface in patients with severe ocular surface disease Establishing a Risk assessment chip for the eye disease age-related macular degeneration (AMD) Genetic evaluation of factor B and complement component C2 in the susceptibility to age-related macular degeneration Programme support on translational research on eye diseases

Department of Biotechnology

2006-2009

Department of Biotechnology Department of Biotechnology Council of Scientific and Industrial Research Department of Biotechnology Council of Scientific and Industrial Research Vision CRC; Australia Department of Biotechnology

2005-2006 2004-2007 2005-2007

2005-2008

2007-2010

2005-2012 2007-2009

DST Indo Australian Collaborative Scheme DST India Japan (JSPS) Collaborative Scheme

Dr Subhabrata Chakrabarti & Dr Inderjeet Kaur Dr Inderjeet Kaur

2007-2010

2007-2010

Department of Biotechnology

Project A: 2007-2012 Dr Geeta K Vemuganti, Dr V S Sangwan, Dr Santosh Honavar & Dr Yashoda Ghanekar Project B: Dr Chitra Kannabiran & Dr Subhadra Jalali Project C: Dr Dr Subhabrata Chakrabarti, Dr Yashoda Ghanekar & Dr Anjli Hussain Project D: Dr Subhabrata Chakrabarti & Dr Rajul S Parikh Project E: Prof D Balasubramanian & Dr Anil Kumar Mandal

Inderjeet Kaur,

21

Projects for approval

Project
Genetic comparison of primary congenital glaucoma in India and Tunisia Gene therapy with channelopsin gene for patients with retinal dystrophy joint project

Supported by
Department of Science & Technology

Principal Investigator
Dr Subhabrata Chakrabarti

Duration
3 years 2 years

DST Japan Society for LVPEI: Dr T P Das Promotion of Science (JSPS) Dr Chitra Kannabiran Dr Subhadra Jalali Prof D Balasubramanian JSPS: Prof Makato Tamai Prof Hiroshi Tomita Prof Eriko Sugano Indo Australian Biotechnology Fund

Developing a global blueprint for zero PCG: Towards a complete understanding of the molecular basis of primary congenital glaucoma Micro RNA deregulation in cancer: Role as a biomarker in prognosis and in therapy

LVPEI: Dr Subhabrata Chakrabarti 3 years Indian Statistical Institute, Kolkata: Prof Partha P Majumder Western Australian Institute of Medical Sciences: Prof Luba Kalaydijeva Sankara Nethralaya: 3 years Dr S Krishna Kumar, Dr J Madhavan, Dr Vikas Khetan Dr Lingam Gopal LVPEI: Dr Geeta K Vemuganti Dr Chitra Kannabiran Dr Santosh G Honavar National Centre for Cell Sciences: Dr Gopal C Kundu Australia: Dr Jagat Rakesh Kanwar Dr Thomas Preiss LVPEI: Dr Yashoda Ghanekar Dr Virender S Sangwan Australia: Dr Mark Daniell Prof Rasik Vajyapee Dr David Steele, Dr Peter Murphy Dr Robert Short, Dr Erik Thompson 3 years

DBT Indo-Australian Biotechnology Fund

An advanced surface for the cell therapy of limbal epithemium for ocular surface disease: Proof of concept and clinical trials

DBT Indo-Australian Biotechnology Fund

Vision CRC: Vision Cooperative Research Centre, Australia DBT: Department of Biotechnology, Govt. of India CSIR: Council of Scientific and Industrial Research

JSPS: Japan Society for Promotion of Science DST: Department of Science & Technology, Govt. of India

Research scholars at the Prof Brien Holden Eye Research Centre

Kallam Anji Reddy Molecular Genetics Laboratory
Afia Sultana, S V V Kalyan Chakravarthi, K Rajeshwari Devi, Sreelatha Komatireddy, Kiran Preet Kaur, Hardeep Pal Singh, P Surya Prakash Goud, Saritha Katta, Vidya Parsam, K Nageswara Rao, B M Sankarathi, C Pulla Rao

Sudhakar & Sreekanth Ravi Stem Cell Biology Laboratory

Anees Fatima, K Purushotham Reddy, Naresh Polisetty, Soundarya Lakshmi Madhira, Murali Mohan Sagar Balla, G Subhash

Biochemistry Laboratory
Talla Venu, Madhavi Latha Chalasani

Jhaveri Microbiology Centre

Joveeta Joseph, Aparna Duggirala

Ophthalmic Pathology Laboratory

M Guru Prasad

22

Operations Research International Centre for Advancement of Rural Eye care (ICARE)
Project
Capacity building program for the management of diabetic retinopathy in the state of Andhra Pradesh Comprehensive Eye Health program in Prakasam district Diabetes prevention program through Child to Family Communication for change in lifestyle and health promotion in Prakasam district Providing Eyecare through Empowered People (PEEP) Child to Child and Child to Family communication as a strategy to improve awareness and uptake of eye care services Vision Centres for offering primary eye care services in rural Andhra Pradesh Impact Assessment Study after refraction error correction among schoolgoing children Sight for Kids Rapid assessment of cataract surgical services in Service Centre areas Pediatric Ophthalmology Learning and Training Centre (POLTC)

Principal Investigator
Dr Taraprasad Das Dr Annie Mathai ICARE team Ms S Sheeladevi

Funding Agency
Lions Club International Foundation Ravi Brothers, USA World Diabetes Foundation

Duration
August 2005 to July 2008 August 2005 to July 2010 August 2006 to March 2011

Mr Shubhrakanti Bhattacharya Mr D Kiran

ORBIS International, India Vision CRC, Australia

June 2004 to December 2007 April 2006 to December 2008

Mr Kovai Vilas

Lavelle Fund for the Blind, USA, and Latter-day Saint Charities Vision CRC, Australia

July 2003 to December 2008 September 2005 to December 2008 November 2005 to March 2007 At regular intervals

Mr Jachin D Williams

Mr Jachin D Williams Mr M Srinivas

Lions Club International Foundation LVPEI

Dr Ramesh Murthy

ORBIS International, India

October 2006 to March 2010

23

24

LVPEI Faculty

The LVPEI Research Team

An underlying theme in all research undertaken at LVPEI is relevance; relevance to clinical practice, to local conditions, to addressing eye problems of people most in need. Our team therefore represents a collaborative group of clinicians, and applied and basic scientists. Our core team is assisted by a number of doctoral research students and ophthalmology and optometry fellows, as well as support professionals such as social scientists, rehabilitation workers and bio-statisticians.

26

L V Prasad Eye Institute

Kallam Anji Reddy Campus, Hyderabad D Balasubramanian, PhD Director of Research, L V Prasad Eye Institute
Professor D Balasubramanian joined LVPEIs Prof Brien Holden Eye Research Centre after an illustrious scientific career, which included positions such as Director, Centre for Cellular and Molecular Biology, and Professor and Dean, University of Hyderabad. He was honoured by the Government of India with the Padma Shri in 2002, and has received several other awards from professional and institutional bodies. Notable among them are the Kalinga Prize for the popularization of science from UNESCO, the Third World Academy of Sciences Award for Basic Medical Science, and the Chevalier de lOrdre National du Merite from the President of France. Prof Balasubramanians research focuses on the biology of eye diseases. He has over 160 publications in national and international journals and has authored three books. He is a member of several editorial boards and serves on a range of national and international scientific committees. Currently, he is President of the Indian Academy of Sciences, and Secretary General of the Academy of Sciences for the Developing World (TWAS), Trieste, Italy. Email: dbala@lvpei.org Some recent representative publications
Chalasani ML, Radha V, Gupta V, Agarwal N, Balasubramanian D, Swarup G. A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants. Invest Ophthalmol Vis Sci 2007; 48: 1607-14 Talla V, Narayanan C, Srinivasan N, Balasubramanian D. Mutation causing self-aggregation in human gamma C-crystallin leading to congenital cataract. Invest Ophthalmol Vis Sci 2006; 47: 5212-7 Achary MS, Reddy AB, Chakrabarti S, Panicker SG, Mandal AK, Ahmed N, Balasubramanian D, Hasnain SE, Nagarajaram HA. Disease-causing mutations in proteins: structural analysis of the CYP1B1 mutations causing primary congenital glaucoma in humans. Biophys J 2006; 91: 4329-39 Krishnaiah S, Vilas K, Shamanna BR, Rao GN, Thomas R, Balasubramanian D. Smoking and its association with cataract: Results of the Andhra Pradesh Eye Disease Study from India. Invest Ophthalmol Vis Sci 2005; 46: 58-65 Balasubramanian D. Photodynamics of cataract: An update on endogenous chromophores and antioxidants. Photochem Photobiol 2005; 81: 498-501 Thiagarajan G, Lakshmanan J, Chalasani M, Balasubramanian D. Peroxynitrite reaction with eye lens proteins: Alpha-crystallin retains its activity despite modification. Invest Ophthalmol Vis Sci 2004; 45: 2115-21

Shubhrakanti Bhattacharya, MSc Assistant Public Health Specialist, International Centre for Advancement of Rural Eye care
Shubhrakanti Bhattacharya completed his Masters in Anthropology at the University of Kolkata and has since been working in the non-governmental space as a social researcher. His main role is to develop and test quantitative and qualitative research tools for data collection, assessment and evaluation of community eye health projects. He has served as an investigator on several operation research projects and has trained field workers in community eye health. Before joining LVPEI, he worked with CARE India as a field officer in the area of HIV/AIDS intervention. He has participated in several academic and professional meetings. His current interests include qualitative research in health, outcomes, impact and cost effectiveness of health interventions, and program management. Email: shubhra@lvpei.org

27

Sanghamitra Burman, MD, DNB, FRCS, MNAMS Consultant, Cornea and Anterior Segment Services
Sanghamitra Burman graduated from JIPMER, Pondicherry, and completed her residency training in ophthalmology from the All India Institute of Medical Sciences (AIIMS), New Delhi. In 2000, the National Board of Examinations, New Delhi, awarded her the G Venkataswamy Gold Medal in Ophthalmology for standing first in India in the DNB Ophthalmology Examination. Following a long-term cornea fellowship at Aravind Eye Hospital, Madurai, she received the Sir Ratan Tata Fellowship in phacoemulsification surgery from Sankara Nethralaya, Medical Research Foundation, Chennai. From 2003 to 2006, she underwent subspecialty training in Cornea, External Diseases, Cataract and Refractive Surgery at Moorfields Eye Hospital, London, UK. She has been involved in training and teaching corneal surgery. She has published widely in peer-reviewed national and international journals. Her areas of specialization include ocular surface reconstruction, infections, corneal transplantation, keratoprosthesis, scleral contact lenses and refractive surgery. Email: sanghamitra@lvpei.org Some recent representative publications
Burman S, Tejwani S, Vemuganti GK, Gopinathan U, Sangwan VS. Ophthalmic applications of preserved human amniotic membrane: A review of current indications. Cell Tissue Bank 2004; 5: 161-75 Sangwan VS, Burman S. Cataract surgery in Stevens-Johnson syndrome. J Cataract Refract Surg 2005; 31: 860-2 Sangwan VS, Surender P, Burman S. Cataract surgery in patients with Moorens ulcer. J Cataract Refract Surg 2005; 31: 359-62 Srinvasan M, Burman S, George C, Nirmalan PK. Non-contact lens related Acanthamoeba keratitis at a tertiary eye care center in south India: Implications for eye care programs in the region. Med Sci Monit 2003; 9: CR125-9 Sangwan VS, Burman S, Tejwani S, Mahesh SP, Murthy R. Amniotic membrane transplantation: A review of current indications in the management of ophthalmic disorders. Indian J Ophthalmol 2007; 55: 251-60

Subhabrata Chakrabarti, PhD

Scientist, Kallam Anji Reddy Molecular Genetics Laboratory Subhabrata Chakrabarti received his PhD from the Guru Nanak Dev University in Amritsar. He has received several prestigious awards, notable among them being the Clinician-Scientist Award (World Glaucoma Association, 2005), Associate (Indian Academy of Sciences, 2004), INSA Medal for Young Scientist (Indian National Science Academy, 2006) and the Young Scientist Platinum Jubilee Award (National Academy of Sciences India, 2007). He has published in international journals and obtained extramural research grants from national and international agencies. His current interest is in understanding the nature-nurture dialectic through genotypephenotype correlations in India and other countries through bilateral and multi-centre collaborations. He is on the Advisory Board of the World Glaucoma Association, and Editorial Board Member and reviewer for various international journals and funding agencies. He is an examiner for BITS, Pilani, University of Hyderabad, and University of Melbourne, Australia. Email: subho@lvpei.org Some recent representative publications
Chakrabarti S, Devi KR, Komatireddy S, Kaur K, Parikh RS, Mandal AK, Chandrasekhar G, Thomas R. Glaucoma-associated CYP1B1 mutations share similar haplotype backgrounds in POAG and PACG phenotypes. Invest Ophthalmol Vis Sci 2007; 48: 5439-44 Kaur I, Hussain A, Hussain N, Das T, Pathengay A, Mathai A, Hussain A, Nutheti R, Nirmalan PK, Chakrabarti S. Analysis of CFH, TLR4 and APOE polymorphisms in India suggests the Tyr402His variant of CFH to be a global marker for age-related macular degeneration. Invest Ophthalmol Vis Sci 2006; 47: 3729-35 Chakrabarti S, Kaur K, Kaur I, Mandal AK, Parikh R, Thomas R, Majumder PP. Globally, CYP1B1 mutations in primary congenital glaucoma are strongly structured by geographic and haplotype backgrounds. Invest Ophthalmol Vis Sci 2006; 47: 43-7 Kaur K, Reddy ABM, Mukhopadhyay A, Mandal AK, Hasnain SE, Ray K, Thomas R, Balasubramanian D, Chakrabarti S. Myocilin gene implicated in primary congenital glaucoma. Clin Genet 2005: 67: 335-40 Reddy ABM, Kaur K, Mandal AK, Panicker SG, Thomas R, Hasnain SE, Balasubramanian D, Chakrabarti S. Mutation spectrum of CYP1B1 gene in Indian primary congenital glaucoma patients. Mol Vis 2004: 10: 696-702

28

Beula Christy, MRSc, PGDGC

Associate Rehabilitation Specialist Dr PRK Prasad Centre for Rehabilitation of Blind & Visually Impaired Beula Christy holds a post-graduate degree in Rehabilitation Science from Holy Cross College in Tiruchirapalli, Tamil Nadu, and a post-graduate diploma in Guidance and Counseling from Annamalai University, Tamil Nadu. She also has a B.Ed. in special education and has attended several training programs in early intervention with a focus on visual impairment. Her professional interests lie in the area of early intervention, particularly in dealing with children with vision impairment and multiple disabilities. Email: beula@lvpei.org

Prashant Garg, MS Director, Education & Dr G Chandra Sekhar Distinguished Chair of Education Consultant, Cornea and Anterior Segment Services Medical Director, Ramayamma International Eye Bank
Prashant Garg completed his basic medical education in 1987 and specialization in ophthalmology from RNT Medical College Udaipur, Rajasthan, in 1992. He served as ophthalmologist in two private sector hospitals for three years before joining LVPEIs Cornea and Anterior Segment fellowship in 1996. He joined as faculty of the Institute in 1997 and since then has progressed steadily in his clinical and research career. He has over 60 scientific publications in peer-reviewed journals to his credit, and has presented in various forums across the world. He has been principal investigator for several clinical trials and is a reviewer for several ophthalmology journals, such as Cornea, Ophthalmology, Eye, Current Eye Research and British Journal of Ophthalmology. In 2004, he received the American Academy of Ophthalmologys Achievement Award. His specialization is infectious diseases of the cornea and anterior segment, and eye banking procedures. Email: prashant@lvpei.org Some recent representative publications
Garg P, Sharma S. Corneal Biopsy in the Management of Progressive Microbial Keratitis (Letter). AM J Ophthalmol 2002; 133:291-2 Garg P, Gopinathan U, Nutheti R, Rao GN. Clinical Experience with N-butyl cyanoacrylate Tissue Adhesive in fungal keratitis. Cornea 2003; 22:405-8 Garg P, Mahesh S, Bansal AK, Gopinathan U, Rao GN. Fungal Infections of Sutureless Self-Sealing Incision for Cataract Surgery. Ophthalmology 2003; 110:2173-7 Basti S, Garg P, Reddy MK. Comparison of Outcomes following Dehiscence of the Posterior Capsule During Phacoemulsfication. J Cataract Refract Surg 2003; 29:532-6 Garg P, Vemuganti GK, Chaterjee S, Gopinathan U, Rao GN. Pigmented plaque presentation of dematiaceous fungal keratitis: a clinicopathologic correlation. Cornea 2004; 23:571-6

29

Yashoda Ghanekar, PhD

Sudhakar and Sreekanth Ravi Stem Cell Biology Laboratory Yashoda Ghanekar joined L V Prasad Eye Institute in June 2006 and, since then, has been working on ocular surface reconstruction in patients with ocular surface disorders. She is also looking at the functional significance of some of the mutations observed in genetic disorders of the eye. Before joining L V Prasad Eye Institute, she did her doctoral work at the Indian Institute of Science, Bangalore in the area of signal transduction and then did post-doctoral research at the University of Manchester, UK, where she worked on the organization of the Golgi complex. Email: yashoda@lvpei.org Some recent representative publications
Ghanekar Y, Chandrashaker A, Visweswariah SS. Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C. Eur J Biochem 2003; 270: 3848-57 Ghanekar Y, Chandrashaker A, Tatu U, Visweswariah SS. Glycosylation of the receptor guanylyl cyclase C: Role in ligand binding and catalytic activity. Biochem J 2004; 379: 653-63 Ghanekar Y, Lowe M. Signaling for secretion. Nat Cell Biol 2005; 7: 851-3 Kaur I, Ghanekar Y, Hussain N. The future applications and indications of Anti-VEGF in ophthalmic practice. Indian J Ophthalmol 2007; 55: 445-50. Review

Usha Gopinathan, PhD

Associate Executive Director, L V Prasad Eye Institute Head, Jhaveri Microbiology Centre Technical & Scientific Director, Ramayamma International Eye Bank Usha Gopinathan received her PhD in medical microbiology from the University of New South Wales, Sydney, Australia. Before joining LVPEIs Prof Brien Holden Eye Research Centre in 1992, she worked at the Kidwai Memorial Institute of Oncology in Bangalore and at Christian Medical College, Vellore. Her current areas of interest are ocular infections, eye banking, hospital infection control and quality assurance. She has spearheaded the training program in eye banking at LVPEI in collaboration with ORBIS International. She has published widely in national and international journals, has served as principal investigator on a variety of funded research projects, and continues to be a key resource person for eye banking, nationally. Email: usha@lvpei.org Some recent representative publications
Gopinathan U, Ramakrishna T, Willcox M, Rao CM, Balasubramanian D, Kulkarni A, Vemganti GK, Rao GN. Enzymatic, clinical and histologic evaluation of corneal tissues in experimental fungal keratitis in rabbits. Exp Eye Res 2001; 72: 433-42 Gopinathan U, Garg P, Fernandes M, Sharma S, Athmanathan S, Rao GN. Epidemiological features and laboratory results of fungal keratitis. A ten-year review at a referral eye care center in south India. Cornea 2002; 21:555-9 Stretton S, Gopinathan U, Willcox MD. Corneal ulceration in pediatric patients: A brief review of progress in topical treatment. Paediatr Drugs 2002; 4: 95-110 Gaudio PA, Gopinathan U, Sangwan V, Hughes TE. Polymerase chain reaction based detection of fungi in infected corneas. Br J Ophthalmol 2002; 86:755-60

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Vijaya K Gothwal, MAppsc. (QUT)

Head, Meera and LB Deshpande Centre for Sight Enhancement Vijaya Kumari Gothwal completed her Bachelors degree in Optometry from the Elite School of Optometry [affiliated to the Birla Institute for Technology and Science (BITS), Pilani], Chennai. She did her Masters in Applied Science from the Queensland University of Technology (QUT), Brisbane, Australia, and has submitted her PhD thesis to QUT. She was awarded the prestigious Constance W Atwell award for Excellence in Low Vision Research in 2002 by the Low Vision Research Group Committee at Ford Lauderdale, Florida, USA. She specializes in clinical low vision rehabilitation and works with both adults and children with visual impairment. Her research interests lie in pediatric low vision and qualitative studies in low vision. E-mail: colonel@lvpei.org Some recent representative publications
Nirmalan PK, John RK, Gothwal VK, Baskaran S, Vijayalakshmi P, Rahmathullah L. The impact of visual impairment on functional vision of children in rural south India: The Kariapatti Pediatric Eye Evaluation Project. Invest Ophthalmol Vis Sci 2004; 45: 3442-5 Gothwal VK, Lovie-Kitchin JE, Rishita N. The development of the L V Prasad Functional Vision Questionnaire: A measure of functional vision performance of visually impaired children. Invest Ophthalmol Vis Sci 2003; 44: 4131-9 Gothwal VK, Herse P. Characteristics of paediatric low vision population. J Ophthalmic and Physiol Optics 2000; 20: 212-9 Hornby SJ, Adolph S, Gothwal VK, Gilbert CE, Dandona L, Foster A. Evaluation of children in 6 blind schools of Andhra Pradesh. Ind. Journal Ophthalmol 2000; 48:195-200 Hornby SJ, Adolph S, Gothwal VK, Gilbert CE, Dandona L, Foster A. Requirement for optical services in children with microphthalmos, coloboma and microcornea in southern India. Eye 2000; 14: 219-24

Santosh Honavar, MD, FACS Associate Director, L V Prasad Eye Institute Head, Ophthalmic Plastic Surgery, Orbit and Ocular Oncology Services
Santosh Honavar completed his basic medical education at Bangalore Medical College, Bangalore, and his post-graduate training at the All India Institute for Medical Sciences, New Delhi. He completed a second fellowship, in ocular oncology, at Wills Eye Hospital in Philadelphia. His clinical interests include ocular and adnexal tumours, ophthalmic plastic surgery and orbital diseases, particularly in pediatric patients. His research interests lie in tumours of the ocular surface, eyelid and orbit, retinoblastoma, ptosis and pediatric lacrimal disorders. Santosh Honavar has been recognised by the American Academy of Ophthalmology, and by several other professional organisations, for excellence in research and clinical practice. He has published and presented widely. Email: oculoplasty@lvpei.org, oncology@lvpei.org Some recent representative publications
Honavar SG, Shields CL, Shields JA, Demirci H, Naduvilath TJ. Intraocular surgery after treatment of retinoblastoma. Arch Ophthalmol 2001; 119:1613-21 Honavar SG, Shields CL, Demirci H, Shields JA. Sclerochoroidal calcification: clinical manifestations and systemic associations. Arch Ophthalmol 2001; 119:833-40 Honavar SG, Singh AD, Shields CL, Meadows AT, Demirci H, Cater J, Shields JA. Postenucleation adjuvant therapy in high-risk retinoblastoma. Arch Ophthalmol 2002; 120:923-31 Shields CL, Honavar SG, Meadows AT, Shields JA, Demirci H, Naduvilath TJ. Chemoreduction for unilateral retinoblastoma. Arch Ophthalmol 2002; 120:1653-8 Honavar SG, Singh AD. Management of advanced retinoblastoma. Ophthalmol Clin North Am 2005; 18(1):65-73

31

Subhadra Jalali, MS Head, Smt. Kanuri Santhamma Retina Vitreous Centre

Subhadra Jalali completed her basic medical education at Jammu University and received her postgraduate training in ophthalmology at the Post-Graduate Institute for Medical -Education and Research (PGIMER), Chandigarh. She joined LVPEIs retina services in 1994 after completing a three-year fellowship at the Institute. She also underwent fellowship training under Dr Kaiser Kupfer at the National Eye Institute, Bethesda, Maryland, USA, and later with Dr Michael Trese at the William Beaumont Hospital in Michigan. She has been closely involved in the retinopathy of prematurity program and networks with neonatal centres in the city for screening newborns and initiating early intervention efforts. She pioneered a hands-on one-month fellowship ROP training program to train manpower in this critical field and helped set up ROP screening and treatment centres in cities across India and Asia. Her fields of interest include advanced vitreoretinal surgery, especially in pediatric cases, ocular trauma, visual electrophysiology and endophthalmitis. She has over 65 publications and 250 presentations, in both national and international fora. E-mail: subhadra@lvpei.org Some recent representative publications
Jalali S, Anand R, Kumar H, Dogra MR, Azad RV, Gopal L. Program planning and screening strategy in Retinopathy of Prematurity. Ind J Ophthalmol 2003; 51: 89-99 Jalali S, Parra SL, Majji AB, Hussain N, Shah V. Ultrasonographic and treatment outcomes of surgery for vitreous haemorrhage in Idiopathic polypoidal choroidal vasculopathy. Am J Ophthalmol 2006; 142: 608-19 Jalali S, Hussain A, Matalia J, Anand R. Modification of screening criteria for India and other middle-income group countries. Am J Ophthalmol 2006; 141: 966-8 Jalali S, Madavi C, Reddy GP, Nutheti R. Pilot study on in-vivo evaluation of retinal vascular maturity in newborns in the context of Retinopathy of Prematurity. Am J Ophthalmol 2006; 142: 181-3 Singh H P, Jalali S, Hejtmancik JF, Kannabiran C. Homozygous null mutations in the ABCA4 gene in two families with autosomal recessive retinal dystrophy. Am J Ophthalmol 2006; 141: 906-13

Prof Coen de Jong, PhD

Principal, Bausch & Lomb School of Optometry Director, Kismatpur Campus Director, Education Development After spending many years in The Netherlands and in international bodies successfully planning and implementing rehabilitation programs for those with visual and other disabilities, in 2002 Prof Coen de Jong accepted Dr Gullapalli N Raos invitation to use his experience to contribute to the growth of LVPEI into new areas of education and to strengthen existing programs. E-mail: coendejong@lvpei.org

Korani Jyothi, MSW Project Coordinator, International Centre for Advancement of Rural Eye care
Korani Jyothi completed her Masters in Social Work from Osmania University, Hyderabad. Before joining LVPEI, she had worked in the Andhra Pradesh Rural Livelihood Program as a Social Investigator, as State Resource Person in Catholic Health Association of India's (CHAI) HIV/AIDS Education Program and as translator in the Technical Resource Unit organization for evaluating the NGOs of Andhra Pradesh. She was field investigator for the collaborative study conducted in Andhra Pradesh by LVPEI and Sight Savers International 'Impact of cataract surgery on quality of life'. Currently, she is Project Coordinator for the 'Impact of refractive error correction on activity based performance and other vision based functions of children aged 10 to 15 years' research study, being conducted in collaboration with Vision CRC, Australia. She is also involved in the 'Sight for Kids' project for training schoolteachers and grassroot level workers. Her research interests include qualitative research projects and human resource development. Email: jyothi@lvpei.org

32

Chitra Kannabiran, PhD Scientist, Kallam Anji Reddy Molecular Genetics Laboratory
Chitra Kannabiran leads the molecular genetics research at LVPEI, which looks into the genetic basis of eye disease. She received her PhD from the Indian Institute of Science in Bangalore, and served as a post-doctoral fellow at Cold Spring Harbor Laboratory, New York, and at the University of Medicine and Dentistry in New Jersey, USA. After joining LVPEI, she was a visiting fellow at the National Eye Institute, National Institutes of Health, USA. Her current area of interest is ophthalmic molecular genetics, focusing on identification of genes responsible for eye diseases. Specific areas of research include molecular genetic aspects of retinoblastoma, corneal dystrophies, congenital cataracts and retinitis pigmentosa. Her work is funded by several national and international competitive grants, including the Indian Council of Medical Research and the National Institutes of Health, USA. She has published widely in national and international journals. Email: chitra@lvpei.org Some recent representative publications
Ponnam SPG, Ramesh K, Tejwani S, Ramamurthy B, Kannabiran C. Mutation of the gap junction protein alpha 8 (GJA8) gene causes autosomal recessive cataract. J Med Genet 2007; 44: e85 Friedman JS, Chang B, Kannabiran C, Chakarova C, Singh HP, Jalali S, et al. Premature truncation of a novel protein, RD3, exhibiting sub-nuclear localization is associated with retinal degeneration. Am J Hum Genet 2006; 79: 1059-70 Jiao X, Sultana A, Garg P, Ramamurthy B, Vemuganti GK, Gangopadhyay N, Hejtmancik JF, Kannabiran C. Autosomal recessive corneal endothelial dystrophy (CHED2) is associated with mutations in SLC4A11. J Med Genet 2007; 44: 64-8 Kalyan Chakravarthi SV, Kannabiran C, Sridhar MS, Vemuganti GK. TGFBI Gene mutations causing lattice and granular corneal dystrophies in Indian patients. Invest Ophthalmol Vis Sci 2005; 4: 121-5 Kiran VS, Kannabiran C, Kalyan Chakravarthi SV, Vemuganti GK, Honavar SG. Mutational screening of the RB1 gene in Indian patients with retinoblastoma reveals 8 novel and several recurrent mutations. Human Mutat 2003; 22: 339

Inderjeet Kaur, PhD

Scientist, Kallam Anji Reddy Molecular Genetics Laboratory Inderjeet Kaur obtained her Masters in forensic science from Punjabi University, before doing her doctoral studies in molecular human genetics at Guru Nanak Dev University (GNDU) in Amritsar. She served as a lecturer at GNDU before joining LVPEI to continue research on molecular genetics, with a focus on the genetics of eye disease. Her main thrust is on understanding the molecular mechanisms in complex eye diseases, age-related macular degeneration (AMD), myopia and glaucoma. Her work has been published in peer-reviewed international journals and she has generated funds through extramural research grants from government funding agencies, such as the Department of Biotechnology and Department of Science and Technology. Her research on AMD and myopia has been hailed widely as pioneering work in the field from India. She received the Young Investigator (Merit) Award (Basic Sciences) from the Association on Research in Vision and Ophthalmology (ARVO) at the SERI-ARVO 2007 meeting, Singapore, and the Amjad Rahi Prize (Indian Eye Research Group, Hyderabad, 2005). Email: inderjeet@lvpei.org Some recent representative publications
Hussain N, Ghanekar Y, Kaur I. The future implications and indications of antiVEGF therapy in ophthalmic practice. Indian J Ophthalmol 2007; 55:445-50. Review Kaur I, Hussain A, Hussain N, Das TP, Pathengay A, Mathai A, Hussain A, Nutheti R, Nirmalan PK, Chakrabarti S. Analysis of CFH, TLR4 and APOE polymorphisms in India suggests the Tyr402His variant of CFH to be a global marker for age-related macular degeneration. Invest Ophthalmol Vis Sci 2006; 47: 3729-35 Chakrabarti S, Kaur K, Kaur I, Mandal AK, Parikh R, Thomas R, Majumder PP. Globally, CYP1B1 mutations in primary congenital glaucoma are strongly structured by geographic and haplotype backgrounds. Invest Ophthalmol Vis Sci 2006; 47: 43-7 Kaur I, Roy S, Chakrabarti S, Sarhadi VK, Majumder PP, Bhanwer AJS, Singh JR. Genomic diversities and affinities among four endogamous groups of Punjab (India) using insertion/deletion and mitochondrial DNA polymorphisms. Hum Biol 2002; 74: 819-36

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Ramesh Kekunnaya, FRCS

Consultant, Jasti V Ramanamma Childrens Eye Care Centre Ramesh Kekunnaya received his basic medical training from Karnataka Medical College, Hubli, Karnataka, and specialized in ophthalmology from Government Medical College, Mysore. He completed a fellowship in comprehensive ophthalmology at L V Prasad Eye Institute, before joining as consultant in the Childrens Eye Care Centre. He has presented at various international and national meetings. He is actively involved in teaching and research activities in the pediatric ophthalmology services. His clinical interests include strabismus, pediatric ophthalmology, and neuro-ophthalmological disorders. Email: rameshak@lvpei.org Some recent representative publications
Ponnam SPG, Ramesh K, Tejwani S, Ramamurthy B, Kannabiran C. Mutation of the gap junction protein alpha 8 (GJA8) gene causes autosomal recessive cataract. J Med Genet 2007; 44: e85 Rao BV, Ramesha K. Ocular motor nerve problems in diabetes. In Das T and Rani A (eds.) Diabetic Eye Diseases; JayPee Brothers Medical Publishers (P) Ltd, New Delhi, India; 2006: 31-41

Rohit Khanna, MBBS, DOMS, MSc (CEH)

Consultant, International Centre for Advancement of Rural Eye care Rohit Khanna received his basic medical education in Nagpur, after which he completed a fellowship in comprehensive ophthalmology at LVPEI. He went on to do his masters in community eye health from the London School of Hygiene and Tropical Medicine. He is responsible for the clinical and outreach aspects of LVPEIs community eye health program, and training for manual small-incision cataract surgery. His clinical interest lies in glaucoma, with a focus on community ophthalmology. Email: rohit@lvpei.org Some recent representative publications
Khanna R, Raman U, Rao GN. Blindness and poverty in India: the way forward. Clin Exp Optom 2007; 90: 6: 406-14 Hussain N, Khanna R, Mathur A, Hussain A. Measurement of greatest linear diameter for choroidal neovascular membrane using optical coherence tomography. Am J Ophthalmol 2007; 143: 1038-40 Murthy SI, Moreker MR, Sangwan VS, Khanna RC, Tejwani S. The spectrum of Vogt-Koyanagi-Harada disease in South India. Int Ophthalmol 2007; 27: 131-6 Hussain N, Das T, Khanna R, Sumasri K, Mohan Ram LS. Verteporfin therapy for neovascular age-related macular degeneration in Indian eyes. Jpn J Ophthalmol 2006; 50: 524-8 Hussain N, Das T, Rawal H, Kallukuri SB, Mohan Ram LS, Khanna R. Combination therapy of intravitreal triamcinolone and photodynamic therapy with verteporfin for subfoveal choroidal neovascularization. Indian J Ophthalmol 2006; 54: 247-50 Hussain N, Khanna R, Hussain A, Das T. Transpupillary thermotherapy for chronic central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 2006; 244: 1045-51

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D Kiran, MA, PGDPM Research Investigator, International Centre for Advancement of Rural Eye care
D Kiran holds a postgraduate degree in Public and Personnel Management from Osmania University and a postgraduate Diploma in Planning and Project Management from the University of Hyderabad. He did an Eye Care Program Management Course at LVPEI. He is Principal Investigator for the study CHILD to child and CHILD to Family Communication as a strategy to improve awareness and uptake of eye care services and was co-investigator for the study Impact of cataract surgery on quality of life in Andhra Pradesh, India. He was involved in developing the Indian Visual Function Assessment Questionnaire, supported by the National Eye Institute, USA. He has wide experience in conducting qualitative research and operational research projects, along with planning, monitoring and implementing community based health projects. Email: kiran@lvpei.org

Pravin V Krishna, MS Consultant, Cornea & Anterior Segment Services Consultant, Contact Lens and Refractive Surgery Services Consultant, Jasti V Ramanamma Childrens Eye Care Centre
Pravin V Krishna completed his basic medical education at Bangalore Medical College, and his internship at Victoria Hospitals, Bowring & Lady Curzon Hospital, Bangalore. After an MS in ophthalmology from Guntur Medical College in Andhra Pradesh, he came to LVPEI in 2003 for a fellowship and, subsequently joined the Institute. He received the Young Investigator Award for outstanding research in clinical ophthalmology for 2005 at the second Singapore Eye Research Institute Association for Research in Vision Ophthalmology (SERI ARVO) meeting in Singapore. He received the Best Paper in Cornea award at the All India Ophthalmological Society annual meeting in 2006. He is reviewer for Investigative Ophthalmology & Vision Research, Archives of Ophthalmology, Ophthalmology, Canadian Journal of Ophthalmology, and the Indian Journal of Ophthalmology. He has devised innovative modifications in deep lamellar and penetrating keratoplasty and is involved in research projects in contact lens and refractive surgery. His areas of interest include corneal surgery, cataract and refractive surgery, contact lenses, pediatric cornea and corneal diagnostics. He serves as faculty for training programs and has published papers and presented posters at international and national forums. Email: pravin@lvpei.org Some recent representative publications
Joseph J, Sharma S, Murthy SI, Krishna PV, Garg P, Nutheti R, Kenneth J, Balasubramanian D. Microsporidial keratitis in India: 16S rRNA gene-based PCR assay for diagnosis and species identification of microsporidia in clinical samples. Invest Ophthalmol Vis Sci 2006; 47: 4468-73 Vaddavalli PK, Garg P, Sharma S, Thomas R, Rao GN. Confocal microscopy for Nocardia keratitis. Ophthalmology 2006; 113: 1645-50 Sridhar MS, Majji AB, Vaddavalli PK. Severe inflammation following iris fixated anterior chamber phakic intraocular lens for myopia. Eye 2006; 20: 1094-5 Ritesh K, Joveeta J, P K Vaddavalli, S Sharma. Microsporidial keratoconjunctivitis in a corneal graft. Eye 2006; 20: 1314-5 Garg P, Vaddavalli PK, Stratis AK, Gopinathan U. The value of corneal transplantation in reducing corneal blindness, Review. Eye 2005; 19: 1106-14

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S Krishnaiah, MSc, MPS

Ophthalmic epidemiologist, International Centre for Advancement of Rural Eye care S Krishnaiah received his masters degree in statistics from Nagarjuna University in Guntur, Andhra Pradesh, followed by a second masters program in population studies from the International Institute for Population Sciences (IIPS), Mumbai, for which he received a Government of India Fellowship. Before joining LVPEI, he worked as Research Officer at IIPS on an international project on reproductive and child health, which was jointly funded by the World Health Organization and Ministry of Health & Family Welfare, Government of India. His interests are in teaching and research in blindness prevention. He has authored more than 12 papers in peer-reviewed international journals and books. Email: krishnaiah@lvpei.org Some recent representative publications
Krishnaiah S, Das TP, Nirmalan PK, Shamanna BR, Nutheti R, Rao GN, Thomas R. Risk factors for diabetic retinopathy: Findings from the Andhra Pradesh Eye Disease Study. Clinical Ophthalmology 2007; 1: 1-8 Krishnaiah S, Nirmalan PK, Shamanna BR, Srinivas M, Rao GN, Thomas R. Ocular trauma in a rural population of southern India: the Andhra Pradesh Eye Disease Study. Ophthalmology 2006; 113: 1159-64 Krishnaiah S, Vilas K, Shamanna BR, Rao GN, Thomas R, Balasubramanian D. Smoking and its association with cataract: Results of the Andhra Pradesh Eye Disease Study from India. Invest Ophthalmol Vis Sci 2005; 46: 58-65 Thomas R, Nirmalan PK, Krishnaiah S. Pseudoexfoliation in southern India: the Andhra Pradesh Eye Disease Study. Invest Ophthalmol Vis Sci 2005; 46: 1170-6 Nirmalan PK, Krishnaiah S, Shamanna BR, Rao GN, Thomas R. A population-based assessment of presbyopia in the state of Andhra Pradesh, South India: The Andhra Pradesh Eye Disease Study. Invest Ophthalmol Vis Sci 2006; 47: 2324-8

Ajit B Majji, MD, DNB

Consultant, Smt. Kanuri Santhamma Retina Vitreous Centre Ajit Babu Majji received his postgraduate training from the All India Institute of Medical Sciences, New Delhi, after completing his basic medical education at Andhra Medical College, Visakhapatnam. He followed it up with a fellowship in retina at the Johns Hopkins School of Medicine, Baltimore, USA. His special areas of interest include retinal vasculopathies, agerelated macular degeneration, and retinal prostheses. He has published more than 30 research papers in peer-reviewed journals, and has made presentations at more than 150 national and international conferences. E-mail: ajit@lvpei.org Some recent representative publications
Majji AB, Vemuganti GK, Shah VA, Singh S, Das T, Jalali S. A comparative study of epiretinal membranes associated with Eales disease: A clinicopathologic evaluation. Eye 2006; 142: 608-19 Raju B, Majji AB, Jalali S. von Hippel angioma in South Indian subjects a clinical study. Retina 2003; 23: 670-4 Majji AB, Cao J, Chang KY, Hayashi A, Aggarwal S, Grebe RR, de Juan E Jr. Age-related retinal pigment epithelium and Bruchs membrane degeneration in senescence accelerated mouse. Invest Ophthal Vis Sci 2000; 41: 3936-42 Majji AB, de Juan E Jr. Retinal pigment epithelial autotransplantation: Morphological changes in retina and choroid. Graefes Arch Clin Exp Ophthalmol 2000; 238: 779-91 Majji AB, Humayun MS, Weiland JD, Suzuki S, DAnna S, deJuan E Jr. Long-term histological and electrophysiological results of an inactive epiretinal electrode array implantation in dogs. Invest Ophthal Vis Sci 1999; 40: 2073-81

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Anil Kumar Mandal, MD Head, Jasti V Ramanamma Childrens Eye Care Centre Consultant, VST Centre for Glaucoma Care
Anil Kumar Mandal is a glaucoma specialist with particular interest and expertise in developmental glaucoma. Dr Mandal was trained at the University of Calcutta and the All India Institute of Medical Sciences (AIIMS), New Delhi, and completed fellowships in glaucoma and emergency ophthalmology at AIIMS. He was a visiting research fellow at the Kellogg Eye Care Center and the Doheny Eye Institute in the United States. He has won several national and international awards and has published widely in premier medical journals worldwide. His current research focuses on the clinical and genetic aspects of glaucoma in adults and children, which earned him the Shanti Swarup Bhatnagar Award for excellence in science from the Government of India in 2003; he was the first ophthalmologist to receive this award. Email: mandal@lvpei.org Some recent representative publications
Mandal AK, Naduvilath TJ, Jayagandan A. Surgical results of combined trabeculotomy-trabeculectomy for developmental glaucoma. Ophthalmology 1998; 105: 974-82 Mandal AK, Gothwal VK, Bagga H, Nutheti R, Mansoori T. Outcome of surgery on infants younger than one month of age with congenital glaucoma. Ophthalmology 2003; 110: 1909-15 Mandal AK, Bhatia PG, Bhaskar A, Nutheti R. Long-term surgical and visual outcomes in children with developmental glaucoma operated within 6 months of birth. Ophthalmology 2004; 111: 283-90 Panicker SG, Mandal AK, Reddy ABM, Gothwal VK, Hasnain SE. Correlations of genotype with phenotype in Indian patients with primary congenital glaucoma. Invest Ophthalmol & Visual Sci 2004; 45: 1149-56 Mandal AK, Gothwal VK, Nutheti R. Surgical outcome of primary developmental glaucoma: a single surgeons long-term experience from a tertiary eye care centre in India. Eye 2007; 21: 764-74

Annie Mathai, MS, Dip NB, FRCS

Consultant, Smt Kanuri Santhamma Retina Vitreous Centre Annie Mathai received her undergraduate and postgraduate medical training at Christian Medical College (CMC), Vellore, and completed a fellowship in medical and surgical retina at the Sydney Eye Hospital in Australia. She spent several years on the retina faculty at CMC, Vellore, before joining the Retina Vitreous Services at LVPEI. Her areas of interest are vitreoretinal diseases, diabetic retinopathy and uveitis. She has co-authored 13 papers published in national and international journals. Email: anniemathai@lvpei.org Some recent representative publications
Mathai A, Lall A, Jain R, Pathengay A. Systemic non-Hodgkins lymphoma masquerading as Vogt-Koyanagi-Harada disease in an HIVpositive patient. Clin Experiment Ophthalmol 2006; 34: 280-2 Mathai A, Sangwan VS, Pathengay A. Acute postoperative multidrug-resistant Pseudomonas aeruginosa endophthalmitis treated with intravitreal Piperacillin/Tazobactam. Asian J Ophthalmol 2007; 9 Thomas R, Paul P, Rao GN, Muliyil JP, Mathai A. Present status of eye care in India. Survey Ophthalmol 2005; 50: 85-101

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Srinivas Marmamula, MA, MSc Scientist, International Centre for Advancement of Rural Eye care Faculty, Bausch & Lomb School of Optometry
Srinivas Marmamula completed his Master's in sociology, after a diploma in ophthalmic techniques and a post-diploma fellowship in optometry from L V Prasad Eye Institute. He completed his Master's in Community Eye Health from the London School of Hygiene and Tropical Medicine, University of London, with a joint sponsorship from the Department For International Development (DFID - UK), British Council for Prevention of Blindness (Boulter Award) and LVPEI. He was Chief Optometrist for the Andhra Pradesh Eye Disease Study (APEDS, 1996 - 2000) and for the National Eye Institute/World Health Organization supported Refractive Error Study in Children (2000). He has participated as faculty in many workshops in India and abroad. His areas of interest include refractive errors, prevention of visual impairment in children and training personnel for community eye care. Currently he is doing a PhD on development of 'Rapid Assessment Methodology for Detection of Refractive Errors (RARE)' from the School of Optometry & Vision Science, University of New South Wales, Sydney, Australia, with support from Vision CRC, Australia. Email: srioptom@lvpei.org Some recent representative publications
Dandona R, Dandona L, Srinivas M, Giridhar P, McCarty CA, Rao GN. Population-based assessment of refractive error in India: The Andhra Pradesh eye disease study. Clin Experiment Ophthalmol 2002; 30: 84-93 Dandona R, Dandona L, Srinivas M, Sahare P, Narsaiah S, Munoz SR, Pokharel GP, Ellwein LB. Refractive error in children in a rural population in India. Invest Ophthalmol Vis Sci 2002; 43: 615-22 Dandona L, Dandona R, Srinivas M, Giridhar P, Vilas K, Prasad MN, John RK, McCarty CA, Rao GN. Blindness in the Indian state of Andhra Pradesh. Invest Ophthalmol Vis Sci 2001; 42: 908-16 Srinivas M, Keeffe J, Khanna R, Rao GN: Rapid assessment methods in eye care and their use in assessing refractive errors. J Comm Eye Health; 20 (63): 95-97, Indian supplement

Ramesh Murthy, MD FRCS Consultant, Pediatric Ophthalmology and Strabismus Consultant, Ophthalmic Plastic Surgery, Orbit and Ocular Oncology Services
Ramesh Murthy completed his basic medical education from Armed Forces Medical College, Pune, and his postgraduation in ophthalmology from Aravind Eye Hospital and Post Graduate Institute in Madurai. He received the Major General P P Choudhary medal and trophy for standing first in college in Preventive and Social Medicine in 1996. He did a fellowship in oculoplasty, orbit and ocular oncology from LVPEI in 2003. Subsequently, he did fellowships at Moorfields Eye Hospital in London and specialized further in pediatric ophthalmology and strabismus. He has published widely in peer-reviewed international and national journals and written chapters in textbooks. He has presented at various national and international conferences and is actively involved in clinical research into pediatric orbital diseases and squint. His areas of specialization include pediatric eye diseases, squint and ophthalmic plastic surgery and ocular oncology. Email: rameshmurthy@lvpei.org Some recent representative publications
Murthy R, Vemuganti GK, Honavar SG, Burman SG, Naik MN, Parthasaradhi A. Ocular surface squamous neoplasia in Papillon Lefevre syndrome. Am J Ophthalmol 2005; 139: 207-9 Murthy R, Honavar SG, Vemuganti GK, Naik MN, Reddy VP. Systemic metastasis following hyphema drainage in an unsuspected retinoblastoma. J Pediatr Ophthalmol Strabismus 2007; 44: 120-3 Dawson ELM, Murthy R, Lee J. Does Botulinum toxin have a role in the treatment of Oscillopsia? Neuro-Ophthalmology 2007; 31: 73-8 Murthy R, Honavar SG, Burman S, Vemuganti GK, Naik M, Reddy VA. Neoadjuvant chemotherapy in the management of sebaceous gland carcinoma of the eyelid with regional lymph node metastasis. Ophthal Plast Reconstr Surg 2005; 21: 307-9 Murthy R, Honavar SG, Vemuganti GK, Naik M, Burman S. Polycystic echinococcosis of the orbit. Am J Ophthalmol 2005; 140: 561-3

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Somasheila Murthy, MS Consultant, Cornea and Anterior Segment Services

Somasheila Murthy completed her basic medical education at BYL Nair Charitable Hospital in Mumbai and specialized in ophthalmology at Lokmanya Tilak Municipal Medical College, Mumbai. She has done a fellowship in uveitis and ocular pathology from the Doheny Eye Institute at the University of Southern California, Los Angeles. She served as a fellow in the cornea services at LVPEI before joining as faculty. Her areas of interest are uveitis, ocular pathology and clinical research. Currently, she is an investigator in 13 research projects. She has made over 50 presentations at national and international fora and has authored and coauthored several peer-reviewed publications. Email: smurthy@lvpei.org Some recent representative publications
Ipsilateral rotational autokeratoplasty: An alternative to penetrating keratoplasty in non-progressive central corneal scars. Murthy SI, Bansal AK, Sridhar MS, Rao GN. Cornea 2001; 20: 455-7 Bilateral senile scleral plaques mimicking post-inflammatory scleral ectasia. Murthy SI, Sangwan VS. Indian J Opthalmol 2004; 52: 59-60 Outcome of cataract surgery in Fuchs heterochromic cyclitis. Tejwani S, Murthy SI, Sangwan VS. J Cataract Refract Surg 2006; 32: 1678-82 Corneal endothelial cell loss following chemical injury. Tejwani S, Murthy SI, Sangwan VS. Asian J Ophthalmol 2006; 8: 115-1173 Spectrum of Vogt-Koyanagi-Harada disease in southern India. Murthy SI, Morekar M, Sangwan VS, Khanna RC. Int Ophthalmol 2007; 27: 131-6

Milind N Naik, MD Consultant, Aesthetic and Facial Plastic Surgery

Milind Naik completed his post-graduate training at Christian Medical College, Vellore, followed by a clinical fellowship in Ophthalmic Plastic Surgery, Orbit and Ocular Oncology at LVPEI. He did a fellowship in ophthalmic and orbito-facial plastic surgery at the Jules Stein Eye Institute, University of California, Los Angeles, California, USA. His areas of interest include aesthetic and facial plastic surgery, thyroid eye disease, and minimally invasive ophthalmic plastic surgery. Email: milind@lvpei.org Some recent representative publications
Naik MN, Honavar SG, Bhaduri A, Linberg JV. Congenital horizontal tarsal kink: A single-center experience with 6 cases. Ophthalmology 2007; 114: 1564-8 Aggarwal E, Naik MN, Honavar SG. Effectiveness of the gold weight trial procedure in predicting the ideal weight for lid loading in facial palsy: a prospective study. Am J Ophthalmol 2007; 143: 1009-12 Naik MN, Gangopadhyay N, Fernandes M, Murthy R, Honavar SG. Anterior chemodenervation of levator palpebrae superioris with botulinum toxin type-A (Botox) to induce temporary ptosis for corneal protection. Eye 2007; [Epub ahead of print] Naik MN, Honavar SG, Murthy RK, Raizada K, Thomas R. Ethanolamine oleate sclerotherapy versus simple cyst aspiration in the management of orbitopalpebral cyst associated with congenital microphthalmos. Ophthal Plast Reconstr Surg 2007; 23: 307-11 Naik MN, Soparkar CN, Murthy R, Honavar SG. Botulinum toxin in ophthalmic plastic surgery. Indian J Ophthalmol 2005; 53: 279-88

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Raja Narayanan, MS Consultant, Smt Kanuri Santhamma Retina Vitreous Centre

Raja Narayanan completed his basic medical education from Delhi University, followed by a Master of Surgery in ophthalmology from Guru Nanak Eye Center, New Delhi. He underwent a preceptorship in uveitis, ocular immunology and uveitis service at the Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA. He was a Fellow in Medical Retina, and Clinical and Research Fellow in Vitreo-Retinal Diseases, at the Department of Ophthalmology, University of California, California, USA. He has received the Sir Ratan Tata Fellowship in cataract surgery from Sankara Nethralaya, Medical Research Foundation, Chennai. He was also Visiting Faculty at the University of California and Visiting Scholar at the Massachusetts Eye and Ear Infirmary, Boston. He received the International Ophthalmologist Education Award at the 2007 American Academy of Ophthalmology meeting at New Orleans. He has published widely in peer-reviewed journals, written book chapters and is a reviewer for journals such as Investigative Ophthalmology & Visual Science, Retina, Journal of Cataract and Refractive Surgery, Archives of Ophthalmology, European Journal of Ophthalmology and Current Eye Research. Email: narayanan@lvpei.org Some recent representative publications
Narayanan R, Butani V, Boyer DS, Atilano SR, Resende GP, Kim DS, Chakrabarti S, Kuppermann BD, Khatibi N, Chwa M, Nesburn AB, Kenney MC. Complement factor H polymorphism in age-related macular degeneration. Ophthalmology 2007; 114: 1327-31 Narayanan R, Kuppermann BD, Jones C, Kirkpatrick P. Ranibizumab. Nat Rev Drug Discov. 2006; 5: 815-6 Narayanan R, Kuppermann BD. It is not compassionate to use a drug before the risks and benefits are known from phase III clinical trials. Arch Ophthalmol 2006; 124: 1032-4 PJ Kappel, A Charonis, GN Holland, R Narayanan, AD Kulkarni, F Yu, DS Boyer, RE Engstrom, BD Kuppermann; Southern California HIV/eye consortium. Long-term outcomes associated with Ganciclovir implants in patients with AIDS-related Cytomegalovirus retinitis. Ophthalmology 2006; 113: 683.e1-8 R Narayanan, MC Kenney, JK Mungcal, GM Seigel, BD Kuppermann. Toxicity of Triamcinolone Acetonide on retinal neurosensory (R28) and pigment epithelial cells (ARPE-19). Invest Ophthalmol Vis Sic 2006; 47: 722-8

Giridhar Pyda, PhD Scientist, International Centre for Advancement of Rural Eye care
Giridhar Pyda received his M Phil and doctoral degrees in Sociology from the University of Jabalpur. He worked with two research organizations, the Centre for Public Policy Studies and the Centre for Social Science Research on Leprosy, and has been associated with L V Prasad Eye Institute since 1996, with projects like the Andhra Pradesh Eye Disease Study (1996-2000) and Refractive Error Study in Children. He independently handled a major project Community Assisted and Financed Eye care over four years. Actively involved in community eye care activities he is currently coordinating the Pediatric Ophthalmology Learning & Training Centre (POLTC) project. His main interest is in qualitative research including planning, monitoring and implementing community-based eye health projects on prevention of avoidable blindness. Email: dr.giridhar@lvpei.org Some recent representative publications
Giridhar P, Dandona R, Prasad MN, Vilas K, Dandona L. Fear of blindness and perception about blind people: The Andhra Pradesh Eye Disease Study. Ind J Ophthalmol 2002; 50: 239-46 Dandona R, Dandona L, Srinivas M, Giridhar P, Prasad MN, Vilas K, McCarty CA, Rao GN. Moderate visual impairment in India: The Andhra Pradesh Eye Disease Study. BJO 2002; 86: 373-7 Dandona R, Dandona L, Srinivas M, Giridhar P, McCarty CA, Rao GN. Population-based assessment of refractive error in India. Clin Experiment Ophthalmol 2002; 30: 84-93 Dandona R, Dandona L, Srinivas M, Giridhar P, Nutheti R, Rao GN. Planning low vision services in India: A population-based perspective. Ophthalmology 2002; 109: 1871-8 Dandona R, Dandona L, Vilas K, Giridhar P, Prasad MN, Srinivas M. Population-based study of spectacles use in southern India. Ind J Ophthalmol 2002; 50: 145-55

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Deepa Raizada, DOT Ocularist, Ocularistry Services

Deepa Raizada completed her basic optometry education and fellowship in Clinical Optometry at L V Prasad Eye Institute, Hyderabad. She underwent advanced training in ocularistry at Moorfield's Eye Hospital, London. Her clinical interests include fabrication and fitting of ocular prosthesis, particularly in pediatric patients. Her research interests lie in finding practical solutions to problems in the field of ocularistry. She received the Best Paper award at the 7th Indian Optometric Association, 2005. Email: deepa@lvpei.org Some recent representative publications
Raizada K, Honavar SG, Murthy R, Naik MN, Raizada D. Enucleation and orbital implants: Current practices and recent trends. International Journal of Anaplastology 2007; 1: 30-6 Raizada K, Deepa Rani D. Review on ocular prosthesis. Cont Lens Anterior Eye 2007; 30: 152-62 Raizada K, Deepa R, Bhaduri A, Honavar S G, Naik M. Indications and cosmetic outcome of dermis fat graft: A tertiary eye care study. Optometry Today 2007; 56: 21-3

Kuldeep Raizada, D Orth

Head, Ocularistry Services Kuldeep Raizada graduated from Aligarh, and completed his Diploma in Orthoptics & Pleoptics from Gandhi Eye Hospital, Lucknow. He did a fellowship in Clinical Optometry from LVPEI before joining the Institute. He became involved in the fitting and fabricating of ocular prostheses, helping to establish the Department of Ocularistry at the Institute. He has done a fellowship in ocularistry and anaplastology and trained at institutes like MD Anderson Cancer Center, Houston, USA. He has won several awards, including Best Video Presentation at the International Congress of Ocular Oncology in 2004. He has published in national and international journals and is South India representative for the Indian Optometry Association. He is on the Editorial Review Board of the International Journal of Anaplastology and Associate Editor of the Indian Journal of Optometry. His research interests lie in developing medical devices in close coordination with cornea and anterior segment and ophthalmic plastics services, as well as in the field of ocularistry and anaplastolgy. Email: ocularist@lvpei.org Some recent representative publications
Raizada K, Honavar SG, Murthy R, Naik MN, Deepa R. Enucleation and orbital implants: Current practices and recent trends. International Journal of Anaplastology 2007; 1: 30-6 Naik MN, Honavar SG, Murthy RK, Raizada K, Thomas R. Ethanolamine oleate sclerotherapy versus simple cyst aspiration in the management of orbitopalpebral cyst associated with congenital microphthalmos. Ophthal Plast Reconstr Surg 2007; 23: 307-11 Raizada K, Shome D, Honavar SG. New measurement device and technique for assessing implant and prosthetic motility. Ophthal Plast Reconstr Surg 2007; 23: 59-60 Raizada K, Deepa Rani. Review on ocular prosthesis. Cont Lens Anterior Eye 2007; 30: 152-62 Raizada K, Deepa R, Bhaduri A, Honavar S G, Naik M, Indications and cosmetic outcome of dermis fat graft: A tertiary eye care study. Optometry Today 2007; 56: 21-3

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Gullapalli N Rao, MD Distinguished Chair of Eye Health Chairman, Hyderabad Eye Institute Founder, L V Prasad Eye Institute
Gullapalli N Rao returned to India in 1986 to establish L V Prasad Eye Institute, after a successful career in the United States as an academic ophthalmologist. Dr Rao received his basic medical education in Guntur, Andhra Pradesh, and completed his postgraduate training in ophthalmology at the All India Institute for Medical Sciences, New Delhi. He went to the United States in 1974, where he was trained first at Tufts University School of Medicine in Boston, and later at the University of Rochester School of Medicine, where he continued on the faculty until his return to India in 1986. His areas of specialization include diseases of the cornea, eye banking and corneal transplantation, community eye health, eye care policy and planning. He has published over 250 papers in national and international journals, and has contributed several book chapters. He is currently President of the International Agency for the Prevention of Blindness, in which role he leads VISION 2020: The Right to Sight, the global initiative to eliminate avoidable blindness by the year 2020. E-mail: gnrao@lvpei.org Some recent representative publications
Rao GN, Shaw EL, Arthur EJ and Aquavella JV. Endothelial cell morphology and corneal deturgescence. Ann Ophthalmol 1979; 11: 885-99 Rao GN, Lohman LE and Aquavella JV. Cell size-shape. Relationship in human corneal endothelium. Invest Ophthal Vis Sci 1982; 22: 271-4 Dandona L, Dandona R, Naduvilath TJ, McCarty CA, Nanda A, Srinivas M, Mandal P, Rao GN. Is the current eye-care policy focus almost exclusively on cataract adequate to deal with business in India? Lancet 1998; 351:1312-6 Sangwan VS, Matalia PH, Vemuganti GK, Ifthekar G, Fatima A, Singh S, Rao GN. Early results of penetrating keratoplasty after cultivated limbal epithelium transplantation. Arch Ophthalmol 2005; 123: 334-40 Nutheti R, Shamanna BR, Nirmalan PK, Keeffe JE, Krishnaiah S, Rao GN, Thomas R. Impact of impaired vision and eye diseases on quality of life in Andhra Pradesh. Invest Ophthalmol Vis Sci 2006; 47: 4742-8

G Ashok Kumar Reddy, PhD Microbiologist, Jhaveri Microbiology Centre

G Ashok Kumar Reddy obtained his masters in Medical Microbiology from Kasturba Medical College, Mangalore, and PhD in Medical Microbiology from the Nizams Institute of Medical Sciences, Hyderabad. Before joining LVPEI in May 2007, he was Assistant Professor at the Prathima Institute of Medical Sciences, Karimnagar. He has made presentations at scientific meetings nationally and has publications to his credit. His current research interest is in ocular infections. Email: ashok kumar@lvpei.org Some recent representative publications
Shenoy S, Baliga S, Kuruvilla TA, Reddy AK. Induced sputum as a diagnostic test for the diagnosis of Pneumocystis carinii pneumoniae in HIV positive patients. Journal of Association of Physicians of India 2001; 49: 858-60 Reddy AK, Dakshinamurthy KV, Neelaprasad P, Gangadhar T, Lakshmi V. Prevalence of HBV and HCV dual infection in patients on Hemodialysis. Indian Journal of Medical Microbiology 2005; 23: 41-3 Reddy AK, Murthy KVD, Lakshmi V. Prevalence of HCV infection in patients on hemodialysis: Survey by antibody and core antigen detection. Indian Journal of Medical Microbiology 2005; 23: 106-10 Reddy AK, Dakshinamurthy KV, Lakshmi V. Utility of HCV core antigen ELISA in the screening for Hepatitis C virus infection in patients on hemodialysis. Indian Journal of Medical Microbiology 2006; 24: 55-7 Lakshmi V, Reddy AK, Dakshinamurthy KV. Evaluation of commercially available third-generation anti HCV ELISA in patients on hemodialysis. Indian Journal of Medical Microbiology 2007; 25: 140-2

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P Rajeev K Reddy, MS
Consultant, Smt. Kanuri Santhamma Retina Vitreous Centre P Rajeev Kumar Reddy completed his basic medical education and MS in Ophthalmology from Osmania Medical College, Hyderabad. He did a clinical research fellowship from 2001 2002 and a vitreoretinal fellowship from 2001 to 2004 from Sankara Nethralaya, Chennai. After working for two years at Sankara Nethralaya as Associate Consultant in the Vitreoretinal Services, he joined LVPEI as a consultant. Dr Reddy has worked on several projects; His areas of interest are uveitis, trauma and macular disorders. Email: rajeev@lvpei.org

Virender Singh Sangwan, MD Associate Director, L V Prasad Eye Institute Head, Cornea and Anterior Segment, Ocular Immunology & Uveitis Services
Virender Singh Sangwan completed his basic medical education from Maharshi Dayanand University, Haryana, in 1986 and MS Ophthalmology in 1991. He did a fellowship in Cornea & Anterior Segment at L V Prasad Eye Institute, and another in Immunology & Uveitis Services at Harvard Medical School, USA, before joining LVPEI. He has worked as Field Medical Director at ORBIS International, Inc., New York, and chief fellow, immunology & uveitis service of Harvard Medical School, Boston. He is also Adjunct Associate Professor of Ophthalmology, University of Rochester, New York, USA. He has received several prestigious awards, including the Shanti Swaroop Bhatnagar Award 2006 and the Biotech Products and Process Development and Commercialization Award 2007 from the Government of India. He has published several papers in peer-reviewed journals, presented widely and served as faculty for workshops and instruction courses on uveitis, limbal stem cell deficiency and limbal stem cell transplantation, nationally and internationally. He is reviewer for the Indian Journal of Ophthalmology, Cornea, Comprehensive Ophthalmology Update and Clinical & Experimental Ophthalmology. He is on the editorial board of International Ophthalmology and section editor of British Journal of Ophthalmology. He is an honorary member of the North African Centre of Sight, National Ophthalmic Society of El Salvador and National Ophthalmic Society of Peru. He is secretary of the Asia Cornea Society and Vice-President, Uveitis Society of India. He is also founder secretary/ treasurer of Uveitis Society of India and the LVPEI Alumni Association. Email: vsangwan@lvpei.org Some recent representative publications
Sangwan VS, Matalia HP, Vemuganti GK, Ifthekar G, Fatima A, Singh S, Rao GN, Nutheti R. Clinical outcome of autologus cultivated limbal transplantation. Indian J Ophthalmol 2006; 54: 29-34 Sangwan VS, Burman S, Tejwani S, Sankaranarayana PM, Murthy R. Amniotic membrane transplantation: A review of current indications in the management of ophthalmic disorders. Indian J Ophthalmol 2007; 55: 251-60 Sahu SK, Govindswamy P, Sangwan VS, Thomas R. Midterm results on ocular surface reconstruction using cultivated autologous oral mucosal epithelial transplantation. Am J Ophthalmol 2007; 143: 189 Fatima A, Vemuganti GK, Iftekhar G, Rao GN, Sangwan VS. In vivo survival and stratification of cultured limbal epithelium. Clin Experiment Ophthalmol 2007; 35: 96-8 Murthy SI, Moreker MR, Sangwan VS, Khanna RC, Tejwani S. The spectrum of Vogt-koyanagi-Harada disease in South India. Int Ophthalmol 2007; 27: 131-6

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G Chandra Sekhar, MD
Director, L V Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad After receiving his basic medical degree in Kurnool, Andhra Pradesh, Dr G Chandra Sekhar completed his residency in ophthalmology at the All India Institute for Medical Sciences, New Delhi. He has delivered several named orations including the prestigious Professor P Siva Reddy Gold Medal Oration of the All India Ophthalmological Society/Conference. He holds the position of Adjunct Assistant Professor at the State University New York, School of Optometry, and Clinical Professor at the University of Rochester Medical School, Rochester, USA. He has been a visiting Professor at the University of Wisconsin, Madison, USA, and University of Southern California, San Diego, USA. Dr Chandra Sekhar received the Junior Honors achievement award from the American Academy of Ophthalmology (AAO) in November 2003. He has published 55 papers in peer-reviewed journals and contributed five book chapters. His research interests include optic disc imaging in glaucoma, psychophysical tests in glaucoma, plateau iris syndrome and angle closure glaucoma. He was President of Glaucoma Society of India, 2004 2006. He is currently a member of the Glaucoma Research Society (ICO) and President, AP State Ophthalmological Society for 2007 2008. Email: gcs@lvpei.org Some recent representative publications
Garudadri CS, Chelerkar V, Nutheti R. An ultrasound biomicroscopic study of anterior segment in Indian eyes with primary angle closure glaucoma. J Glaucoma 2002; 11: 502-7 Thomas R, Sekhar GC, Kumar RS. Glaucoma management in developing countries: medical, laser, and surgical options for glaucoma management in countries with limited resources. Curr Opin in Ophthlmol 2004; 15: 127-31 Thomas R, Kumar RS, Chandrasekhar G, Parikh R. Applying the recent clinical trials on primary open angle glaucoma: The developing world perspective. J Glaucoma 2005; 14: 324-7 Chakrabarti S, Kaur K, Komatireddy S, Acharya M, Devi KR, Mukhopadhyay A, Mandal AK, Hasnain SE, Chandrasekhar G, Thomas R, Ray K. Gln48His is the prevalent myocilin mutation in primary open angle and primary congenital glaucoma phenotypes in India. Mol Vis 2005; 11: 111-3 Parikh RS, Parikh S, Sekhar GC, Kumar RS, Prabakaran S, Babu JG, Thomas R. Diagnostic capability of optical coherence tomography (Stratus OCT 3) in early glaucoma.Ophthalmology 2007;114: 2238-43

Sirisha Senthil, MS, FRCS Consultant, VST Centre for Glaucoma Care
Sirisha Senthil completed her basic medical education from Rajah Muthiah Medical College, Annamalai University, followed by postgraduate training in ophthalmology from Aravind Eye Hospital, Madurai, Tamil Nadu. She obtained the first rank in ophthalmology and otorhinolaryngology in the university in 1993-94. She obtained her FRCS in Ophthalmology from Edinburgh in 2000. She did a fellowship in glaucoma at LVPEI and underwent training in contact lens, phacoemulsification and small incision cataract surgery at Chennai and Madurai. She served several hospitals as registrar, assistant professor and consultant before joining LVPEI. She is an investigator for several studies and has published scientific papers and co-authored a book Clinical Ophthalmology Made Easy. Email: sirishasenthil@lvpei.org Some recent representative publications
Senthil S, Reddy KP, Ravisankar, Srilakshmi. A retrospective analysis of the first Indian experience on phakic intraocular lens implantation. Indian J Ophthalmol 2006; 54: 251-6 Senthil R, Senthil S, Raghunadharao D. Choroidal metastasis from lung cancer a case report and review of literature. Indian Journal of Medical and Pediatric Oncology 2005; 26: 44-6

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Sethu Sheeladevi, M Com, MHM

Associate Public Health Specialist, International Centre for Advancement of Rural Eye care Sethu Sheeladevi received two Masters degrees in commerce and hospital management, from Madurai Kamaraj University, Tamil Nadu, after which she worked with the Aravind Eye Care System for over seven years as a Research Program Manager. She has done an International Health Practitioner Residency Program from the School of Public Health (SPH), University of Berkeley, California, USA. She has wide experience in managing both epidemiological and hospital-based clinical trials in ophthalmology and in public health. Her research interests include epidemiology of eye diseases with a focus on children and women, primary health care and community development. Email : sheela@lvpei.org Some recent representative publications
Rahmathullah L, Tielsch JM, Thulasiraj RD, Katz J, Coles C, Sheeladevi S, et al. Impact of supplementing newborn infants with Vitamin A on early infant mortality: Community-based randomized trial in south India. Br Med Journal 2003; 327: 1-6 Nirmalan PK, Vijayalakshmi P, Sheeladevi S, et al. The Kariapatty pediatric eye evaluation project. Baseline ophthalmic data of children aged 15 years or younger in south India. AJO 2003; 136: 703-9 Garab JN, Sheeladevi S, Shamanna BR, Nirmalan PK, et al. Blindness and vision impairment in the elderly of Papua New Guinea. Clin Experiment Ophthalmol 2006; 34: 335-341 Garab JN, Sheeladevi S, Brian G, Shamanna BR, Nirmalan PK, et al. Cataract and its surgery in Papua New Guinea. Clin Experiment Ophthalmol 2006; 34: 880-5 James M. Tielsch, Lakshmi Rahmathullah, Joanne Katz, R. D. Thulasiraj, Christian Coles, S. Sheeladevi, Kartik Prakash. Newborn Vitamin A Dosing Reduces Case Fatality but not Incidence of Common Childhood Morbidities in South India. The Journal of Nutrition, In Press

Rishi Swarup,

DO, FRCS Consultant, Cornea and Anterior Segment Services Rishi Swarup completed his basic medical education from Kasturba Medical College, MAHE, Manipal, in January 2000. While doing his MBBS, he won several awards and medals including a gold medal in General Surgery and the R L Adiga Award for highest marks in the final examinations. He did a Diploma in Ophthalmology from Christian Medical College, Vellore, in 2003 and received the Ebenezer prize for best outgoing student. After a two-year clinical fellowship in cornea from Sankara Nethralaya, Chennai (2003-2005), he did a short-term fellowship at LVPEI in oculoplasty, orbit and ocular oncology. He subsequently joined LVPEI as consultant in 2006. He has presented papers, posters, videos and instruction courses at national and international conferences and has been actively involved in teaching and research. He is currently principal investigator in a research project on role of recombinant human epidermal growth factor in healing of corneal epithelial defects. His current areas of interest are lamellar corneal surgery, ocular surface and advances in cataract and refractive surgery. Email: rishiswarup@lvpei.org

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Geeta K Vemuganti, DCP, MD, DNB Head, Ophthalmic Pathology Service Scientist, Sudhakar and Sreekanth Ravi Stem Cell Biology Laboratory
Geeta Vemuganti received her basic medical education at Ajmer, Rajasthan, in 1985 and then took a diploma course in clinical pathology from Osmania Medical College, followed by MD and DNB in pathology from Nizams Institute of Medical Sciences, Hyderabad. Before joining LVPEI in 1998, she served as consultant pathologist at Medwin Hospitals, Hyderabad. She has done short observation courses in ophthalmic pathology at institutes in the United States, such as Doheny Eye Institute, Wills Eye Hospital, Philadelphia, and the Armed Forces Institute of Pathology (AFIP), Washington, DC. She is a visiting pathologist at Eye and Ear Infirmary, and Department of Pathology, University of Illinois, Chicago, and a fellow of the National Academy of Medical Sciences. She has 5 PhD students registered with her. Her areas of interest are stem cell research, ocular tumors, corneal dystrophies and infections, culturing limbal and conjunctival epithelium for clinical application, and transdifferentiation of bone marrow stromal cells to neuroglial and retinal lineage. She is also engaged in work on pathogenesis and apoptotic cell death in corneal infections, genotype-phenotype correlation in retinoblastoma, and isolation and characterization of bone marrow derived stromal cells and evaluating the stem cells in ocular tumors. She is a reviewer for several journals and granting agencies. She has published widely, written book chapters and won many awards. Email: geeta@lvpei.org Some recent representative publications
Fatima A, Sangwan VS, Iftekhar G, Reddy P, Matalia H, Balasubramanian D, Vemuganti GK. Technique of cultivating limbal derived corneal epithelium on human amniotic membrane for clinical transplantation. J Postgrad Med 2006; 52: 257-61 Jyotsna M, Vemuganti GK, Reddy P, Chandra KS. Autologous bone marrow-derived progenitor cell myocardial delivery for recent myocardial infarction patients following early angioplasty: Results from a pilot study. Cardiovasc Revasc Med 2006; 7: 217-21 Vemuganti GK, Garg P, Sharma S, Joseph J, Gopinathan U, Singh S. Is microsporidial keratitis an emerging cause of stromal keratitis a case series study. BMC Ophthalmol 2005; 5: 19 Vemuganti GK, Naik M, Honavar SG, GC Shekar. Rapid intraoperative diagnosis of tumors of the eye and orbit by squash and imprint cytology. Ophthalmology 2004; 111: 1009-15 Vemuganti GK, Kashyap S, Sangwan VS, Singh S. Ex-vivo potential of cadaveric and fresh limbal tissues to regenerate cultured epithelium. Indian J Ophthalmol 2004; 52: 113-20

Jachin D Williams A, MA, DCEH, BMS Assistant Public Health Specialist, International Centre for Advancement of Rural Eye care
Jachin David Williams did his MA in Sociology at Annamalai University, Tamil Nadu, and obtained a Diploma in Community Eye Health (DCEH) from L V Prasad Eye Institute, Hyderabad. He did a Bachelor of Mobility Science for the disabled (BMS) from the Madras University, Tamil Nadu. He is also involved in community health needs assessment, community and school eye screening and awareness programs, human resource development, schoolteachers training and is faculty for Diploma in Community Eye Health Course and BS Optometry course, among others. He is principal investigator of a study on 'Impact of refractive error correction on activity based performance and other vision based functions of children aged 10 to 15 years,' being conducted by LVPEI in collaboration with Vision CRC, Australia. He is also involved in several other collaborative international studies and has compiled handbooks for community eye health workers and schoolteachers training programs. Email: jachin@lvpei.org Recent representative publication
L Dandona, JD Williams, BC Williams, GN Rao. Population-based assessment of childhood blindness in southern India. Arch Ophthalmol 1998; 116: 545-546

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Kovai Vilas, MA, MPhil (Anthropology) Associate Public Health Specialist, International Centre for Advancement of Rural Eye care
Kovai Vilas received his Masters and M Phil degrees in Anthropology from the University of Hyderabad. He has been working with LVPEIs International Centre For Advancement of Rural Eye care since 1996, and is also pursuing his PhD from the University of New South Wales, Sydney, Australia. He is currently heading the Vision Centres program that aims to provide a model of preventive, promotive and affordable eye care at the grassroots. He was also involved in the Andhra Pradesh Eye Disease Study (APEDS) and the Refractive Error Study in Children (RESC), conducted by LVPEI. His professional skills lie in project management, social science research, advocacy, and teaching. His interests include concept development and operational research. He has won several competitive research grants and has published in national and international journals. Email: vilaskovai@lvpei.org Some recent representative publications
Vilas K, Krishnaiah S, Shamanna BR, Thomas R, Rao GN. Barriers to accessing eye care services among visually impaired populations in rural Andhra Pradesh, South India. Indian J Ophthalmol 2007; 55: 365-71 Krishnaiah S, Vilas K, Shamanna BR, Rao GN, Thomas R, Balasubramanian D. Smoking and its association with cataract: Results of Andhra Pradesh Eye Disease Study. Invest Ophthalmol Vis Sci 2005; 46: 59-65 Krishnaiah S, Vilas K, Shamanna BR, et al. Awareness of glaucoma in the rural population of southern India. Indian J Ophthalmol 2005; 53: 205-8 Dandona R, Dandona L, Vilas K, Giridhar P, Prasad MN, Srinivas M. Population-based study of spectacle use in southern India. Indian J Ophthalmol 2002; 50: 145-55 Dandona L, Dandona R, Srinivas M, Giridhar P, Vilas K, Prasad MN, John RK, McCarty CA, Rao GN. Blindness in the Indian state of Andhra Pradesh. Invest Ophthalmol Vis Sci 2001; 42: 908-16

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L V Prasad Eye Institute

Bhubaneswar Soumyava Basu, MS
Head, Retina Vitreous Services Dr Soumyava Basu obtained his graduate and post-graduate degrees from the University of Mumbai, following which he completed fellowships in retina from Shri Ganapati Netralaya, Jalna, and L V Prasad Eye Institute, Hyderabad, before heading the vitreo-retinal services at L V Prasad Eye Institute, Bhubaneswar. His areas of special interest are posterior uveitis and 23 gauge vitrectomy. He is currently principal investigator for 'A double-masked multi-centric study of the safety and efficacy of LX-211 in active/quiscient uveitis' and co-investigator for several other studies. E-mail: drbasu@bei-lvpei.org

Sujata Das, MS, FRCS Head, Cornea & Anterior Segment Services Medical Director, drushti daan Eye Bank
Sujata Das received her basic medical education from MKCG Medical College, Orissa in 1994, and completed her postgraduate training in Ophthalmology at MKCG Medical College, Orissa, in 1997. She did a fellowship in cornea and anterior segment from L V Prasad Eye Institute in 1999, and an ICO fellowship in Cornea at the Department of Ophthalmology & Eye Hospital, University of Erlangen-Nrnberg, Germany, in 2004. She also did a corneal fellowship at the Royal Victorian Eye & Ear Hospital and Centre for Eye Research Australia, Melbourne University, before joining LVPEI Bhubaneswar as faculty in 2006. She was instrumental in establishing drushti daan Eye Bank at LVPEI Bhubaneswar and has published widely in peer-reviewed international journals, and authored several book chapters. She is a reviewer for Archives of Ophthamology and Clinical Ophthalmology. Her areas of specialization include corneal disease and surgery, eye banking & corneal transplantation, contact lens, and refractive surgery. Her current interests include C3R treatment for various corneal disorders, management of dry eye syndrome, and keratoprosthesis. E-mail: sujatadas@bei-lvpei.org Some recent representative publications
Das S, Sheorey H, Taylor HR, Vajpayee RB. Association between cultures of contact lens and corneal scraping in contact lens related microbial keratitis. Arch Ophthalmol 2007; 125: 1182-5 Das S, Constantinou M, Ong T, Taylor HR. Microbial keratitis following corneal transplantation. Clin Experiment Ophthalmol 2007; 35: 427-31 Das S, Whiting M, Taylor HR. Corneal wound dehiscence after penetrating keratoplasty. Cornea 2007; 26: 526-9 Das S, Sullivan LJ. Comparison of residual stromal bed and flap thickness in primary and repeat laser in situ keratomileusis in myopic patients. J Cataract Refract Surg 2006; 32: 2080-4 Das S, Constantinou M, Daniell M, Taylor HR. Moraxella keratitis: predisposing factors and clinical review of 95 cases. Br J Ophthalmol 2006; 90: 1236-8

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Sanghamitra Das
Consultant, Glaucoma Services After completing her basic medical education and masters in ophthalmology from MKCG Medical College in 1994 from Berhampur, Orissa, Sanghamitra Das did a fellowship in glaucoma at L V Prasad Eye Institute, Hyderabad. She also did short-term fellowships in pediatric ophthalmology and cornea and anterior segment at L V Prasad Eye Institute, and in glaucoma from Aravind Eye Hospital, Madurai. From 1996 to 2004, Sanghamitra worked at J P M Rotary Eye Institute, Cuttack, as chief of glaucoma services and, subsequently, as chief of pediatric ophthalmology services. She is currently a consultant in glaucoma services at L V Prasad Eye Institute, Bhubaneswar. Her areas of interest are adult and pediatric cataract and preventive ophthalmology. E-mail: sanghamitra@bei-lvpei.org

T P Das, MS, DOMS, FRCS Director, L V Prasad Eye Institute, Bhubaneswar

Taraprasad Das received his basic medical education in Sambalpur University, Orissa, and completed his postgraduate training in ophthalmology at the Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, and at Aravind Eye Hospital, Madurai. After receiving his diploma in ophthalmic medicine and surgery from Kanpur University, he went on to work as a retina consultant with Aravind Eye Hospital. He also received further subspecialty clinical training at University of Illinois Medical School, Wills Eye Hospital, Jefferson University, Philadelphia, and at the Massachusetts Eye and Ear Infirmary, Harvard University. He joined LVPEI in 1991. He has an international reputation as a retinal surgeon. He has published more than 124 papers in international and national journals, written 24 book chapters, and authored/ edited five books. He was editor of the Indian Journal of Ophthalmology from 1999 to 2004. E-mail: tpd@bei-lvpei.org Some recent representative publications
Das T, Vedantham V. Intravitreal sodium fluorescein enhances visualization of clear vitreous during vitreous surgery for macular hole. A safety and efficacy study. Clin Expt Ophthalmol 2004; 32: 55-7 Das T, Simanjuntak G, Sumasri K. Optical coherence tomography titrated photocoagulation in diabetic clinically significant macula edema. In Binder S (Ed) The Macula: Diagnosis, Treatment, and Future Trends. Springer-Verlag, Wein. 2004; 185-94 Das T, Sharma S. Current management strategies of acute postoperative endophthalmitis. Seminars in Ophthalmology 2003; 18: 109-15 Das T, Sharma S, Muralidhar AV, Endophthalmitis research Group. Effect of vancomycin on Staphylococcus epidermidis adherence to poly (methyl methacrylate) intraocular lenses. J Cat Refract Surg 2002; 28: 703-8 Das T, Jalali S, Gothwal VK, Sharma S, Naduvilath TJ. Intravitreal dexamethasone in exogenous bacterial endophthalmitis. Results of a prospective randomized study. Br J Ophthalmol 1999; 83: 1050-5

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Tapas Ranjan Padhi

Consultant, Retina Vitreous Services Tapas Ranjan Padhi completed his basic medical education from Berhampur University, Orissa, in 2000. He completed his postgraduate training in ophthalmology at JIPMER, Pondicherry, in 2004, and was awarded a gold medal for best outgoing student in MS. He obtained his DNB degree in Ophthalmology in 2004 and worked as research fellow in retina at LVPEI, Hyderabad, briefly before doing a two-year vitreoretinal fellowship from Sankara Nethralaya, Chennai. His area of special interest is pediatric retina. He is co-investigator in several ongoing clinical trials at LVPEI, Bhubaneswar. E-mail: tapas@bei-lvpei.org

Suryasnata Rath, MS, FRCS (Glas) Consultant, Ophthalmic Plastic Surgery, Orbit and Ocular Oncology Service
Suryasnata Rath completed his basic medical education in 1995, followed by an MS in 2000, from SCB Medical College and Hospital, Utkal University, Orissa. He became a member of the International Council of Ophthalmology in 2002. In 2003 he did a fellowship in comprehensive ophthalmology at LVPEI, Hyderabad, and received an FRCS (Glasgow) in 2004. He also did a fellowship in oculoplastics, orbit and ocular oncology at LVPEI, Hyderabad, in 2006 before joining LVPEI, Bhubaneswar. E-mail: suryasnata@bei-lvpei.org Recent representative publication Naik MN, Medsinghe A, Rath S, Honavar SG. Management of canalicular lacerations: epidemiological aspects and experience with Mini-Monoka monocanalicular stent". Am J Ophthalmol (In press)

Srikant Kumar Sahu

Consultant, Cornea and Anterior Segment Services Srikant Kumar Sahu completed his basic medical education at SCB Medical College, Utkal University, Orissa. After an MS in ophthalmology (1999-2002) from VSS Medical College, Sambalpur University, Orissa, he worked as consultant for three years at St. Gregorious Balagram Eye Hospital at Yacharam, Andhra Pradesh - a unit of ICARE - LVPEI. He did a fellowship in Cornea and Anterior Segment at L V Prasad Eye Institute, Hyderabad, before joining the Cornea and Anterior Segment Services at LVPEI, Bhubaneswar. E-mail: srikantsahu@bei-lvpei.org Some recent representative publications Sahu SK, Murthy SI, Sangwan VS, Thomas R. Effect of the fourth-generation fluoroquinolones on corneal reepithelialization after penetrating keratoplasty. Cornea 2006; 25: 1130 Sahu SK, Govindswamy P, Sangwan VS, Thomas R. Midterm results on ocular surface reconstruction using cultivated autologous oral mucosal epithelial transplantation. Am J Ophthalmol 2007; 143: 189

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Savitri Sharma, MD, MAMS Associate Director, Laboratory Services

After completing her postgraduation in medical microbiology at the Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, Savitri Sharma specialized in ocular microbiology at Aravind Eye Hospital in Madurai, Tamil Nadu. She joined LVPEI in 1991. Her research interests are ocular infections and inflammation with a special focus on fungal, bacterial, protozoal and viral infections of the eye. She has published 141 papers in national and international journals and has won several competitive grants from industrial and government bodies such as Bausch & Lomb, British Contact Lens Association, Department of Biotechnology and the Council of Scientific and Industrial Research - both Government of India. She has been editor-in-chief of the Indian Journal of Medical Microbiology for the past six years and is on the review board of several ophthalmology and microbiology journals. She has received commendations from several professional bodies including the Indian Association of Medical Microbiologists, All India Ophthalmology Society and the American Academy of Ophthalmology. She has guided several PhD students under BITS, Pilani. Email: savitri@bei-lvpei.org Some recent representative publications
Sharma S, Pasricha G, Das D, Aggarwal RK. Acanthamoeba keratitis in non-contact lens wearers in India: DNA typing-based validation and a simple detection assay. Arch Ophthalmol 2004; 122: 1430-4 Gupta R, Sharma S, Rao D V, Das T, Endophthalmitis Research Group. Applicability of rapid antibiotic susceptibility testing in the management of bacterial endophthalmitis. Retina 2004; 24: 391-8 Joseph J, Sharma S, Murthy SI, Krishna PV, Garg P, Nutheti R, Kenneth J, Balasubramanian D. Microsporidial keratitis in India: 16S rRNA gene-based assay for diagnosis and species identification of Microsporidia in clinical samples. Invest Ophthalmol Vis Sci 2006; 47: 4468-73 Sharma S, Taneja M, Gupta R, Upponi A, Gopinathan U, Nutheti R, Garg P. Comparison of clinical and microbiological profiles in smearpositive and smear-negative cases of suspected microbial keratitis. Indian J Ophthalmol 2007; 55: 21-5 Duggirala A, Kenchappa P, Sharma S, Peters JK, Ahmed N, Garg P, Das T, Hasnain SE. High-resolution genome profiling differentiated Staphylococcus epidermidis isolated from patients with ocular infections and normal individuals. Invest Ophthalmol Vis Sci 2007; 48: 3239-45

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L V Prasad Eye Institute

GMR Varalakshmi Campus, Visakhapatnam
Merle Fernandes, MS Director, L V Prasad Eye Institute, Visakhapatnam Consultant, Cornea and Anterior Segment Services
Merle Fernandes completed her basic medical training and a residency program in ophthalmology at Goa Medical College, Goa, followed by a fellowship in cornea and anterior segment at LVPEI in 2001. She has several publications in international and national peer reviewed journals and has presented papers at conferences in India and abroad. She is a reviewer for Clinical and Experimental Ophthalmology and Indian Journal of Ophthalmology. Her main interests are in pediatric penetrating keratoplasty, ocular surface disorders and microbial keratitis. She is also interested in making educational videos, one of which (Epkeratoplasty for Keratoglobus with Mechanical Lagophthalmos) received the first prize in the Refractive Surgery category at the American Society of Cataract and Refractive Surgeons, Washington, USA, 2004. Email: merle@vizag-lvpei.org Some recent representative publications
Aasuri MK, Fernandes M, Pathan PP. Comparison of acrylic and polymethyl methacrylate lenses in pediatric population. Ind J Ophthalmol 2006; 54: 105-9 Fernandes M, Sangwan VS, Bansal AK, Gangopadhyay N, Sridhar MS, Garg P, Aasuri MK, Nutheti R, Rao GN. Outcome of Pterygium surgery: Retrospective analysis over 14 years. Eye 2005; 19: 1182-90 Fernandes M, Sridhar MS, Sangwan VS, Rao GN. Amniotic membrane transplantation for ocular surface reconstruction. Cornea 2005; 24: 643-53 Sangwan VS, Fernandes M, Bansal AK, Vemuganti GK, Rao GN. Early results of penetrating keratoplasty following limbal stem cell transplantation. Ind J Ophthalmol 2005; 53: 31-5 Fernandes M, Sangwan VS, Vemuganti GK. Limbal stem cell deficiency and Xeroderma Pigmentosum: A case report. Eye 2004: 18: 741

Meena Lakshmipathy, MS
Consultant, Cornea and Anterior Segment Services Meena Lakshmipathy completed her basic medical education from Stanley Medical College, Chennai, in 1997. She did her MS Ophthalmology from the Government Rajaji Hospital, Madurai, followed by a fellowship in cornea and anterior segment from L V Prasad Eye Institute, Hyderabad, in 2004. She received the best presentation award in the cornea session, at the All India Ophthalmological Society meeting at Varanasi, 2004. She worked with a charitable institute, before joining the Cornea and Anterior Segment Services at L V Prasad Eye Institute, Visakhapatnam. Email: meena@vizag-lvpei.org Recent representative publication
Kannabiran C, Sridhar MS, Chakravarthi SK, Vemuganti GK, Lakshmipathi M. Genotype-phenotype correlation in 2 Indian families with severe granular corneal dystrophy. Arch Ophthalmol 2005; 123: 1127-33

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Avinash Pathengay, MBBS, DO, FRCS (Glas)

Consultant, Retina Vitreous Services Avinash Pathengay received his basic medical training at Stanley Medical College, Chennai, and specialized in retina-vitreous at Sankara Nethralaya, Chennai. His major area of interest is endophthalmitis. Email: avinash@vizag-lvpei.org Some recent representative publications
Pathengay A, Shah GY, Das T, Sharma S. Intravitreal triamcinolone acetonide in the management of exogenous bacterial endophthalmitis. Am J Ophthalmol 2006; 141: 938-40 Joseph J, Pathengay A, Michael V, Raju B, Sharma S, Das T. In vitro efficacy of cefazolin and povidone-iodine 5% in eradicating microbial organisms adhered to broad scleral buckles. Clin Experiment Ophthalmol 2006; 34: 390-1 Pathengay A, Shah GY, Das T, Sharma S. Curvularia lunata endophthalmitis presenting with a posterior capsular plaque. Indian J Ophthalmol 2006; 54: 65-6 Kenchappa P, Duggirala A, Ahmed N, Pathengay A, Das T, Hasnain SE, Sharma S. Fluorescent amplified fragment length polymorphism (FAFLP) genotyping demonstrates the role of biofilm-producing methicillin-resistant periocular Staphylococcus epidermidis strains in postoperative endophthalmitis. BMC Ophthalmol 2006; 6: 1 Kenchappa P, Sangwan VS, Ahmed N, Rao KR, Pathengay A, Mathai A, Mansoori T, Das T, Hasnain SE, Sharma S. High-resolution genotyping of Pseudomonas aeruginosa strains linked to acute post cataract surgery endophthalmitis outbreaks in India. Ann Clin Microbiol Antimicrob 2005; 4: 19

PVKS Varma, MS Head, Glaucoma Services

PVKS Varma completed his basic medical education from M S Ramaiah Medical College, Bangalore, followed by an MS in Ophthalmology from J N Medical College, Belgaum. In 1995, he did a fellowship in Comprehensive Ophthalmology from L V Prasad Eye Institute, with training in glaucoma, retina and cornea services and received the best outgoing fellow award for the year. He worked as Assistant Professor at Maharajahs Institute of Medical Sciences, Nellimarla, after which he did a glaucoma fellowship in 2006 and joined L V Prasad Eye Institute, Visakhapatnam. His areas of interest include angle closure glaucoma, psychophysical tests, optic disc imaging and medical retina. Email: varma@vizag-lvpei.org

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Honors and Awards

2002 2007

2002 2003
Murali K Aasuri won second prize for his video in the Bausch & Lomb video competition on Phacopearls.com 2002. D Balasubramanian was awarded the Padma Shri by the Government of India in recognition of his services to the people of India through his contributions to medicine and science. D Balasubramanian received the honour Chevalier de lOrdre National du Merite of France, 2002 from the President of France. D Balasubramanian received National Award for best efforts in science popularization from National Council for Science and Technology Communication, Department of Science and Technology, Government of India. D Balasubramanian honoured by the Indian Science Congress Association with the Jawaharlal Nehru Birth Centenary Award for significant achievements in biophysical chemistry, bio-molecular interaction and research in ocular bio-chemistry and protein structure at Bangalore, India. Subhabrata Chakrabarti awarded International Genetics Federation Fellowship, USA. Taraprasad Das received American Academy of Ophthalmology Achievement Award, at its annual meeting, Anaheim, California, USA. Taraprasad Das conferred Fellow of the Royal College of Surgeons by the Royal College, Glasgow, UK. Vijaya Kumari Gothwal received Constance W Atwell Award for excellence in low vision research, at ARVO 2002, Fort Lauderdale, Florida, USA. Santosh Honavar received Best of Show Award for video film from American Academy of Ophthalmology. Santosh Honavar received Achievement Award from American Academy of Ophthalmology. Santosh Honavar received Vengala Rao Award from Andhra Pradesh State Ophthalmic Society Guntur, Andhra Pradesh, India. Chitra Kannabiran received RO1 grant from the National Institutes of Health, Washington, USA, under the Global Health Research Initiative Program (GRIP). Ajit B Majji received the Dr V Raghavachar Gold Medal from Andhra Pradesh State Ophthalmic Society, Guntur, Andhra Pradesh, India. Ajit B Majji won Vengal Rao Award for best paper presentation from Andhra Pradesh State Ophthalmic Society Guntur, Andhra Pradesh, India. Anil K Mandal received the ICMR Award 2002 for scientists working in bio-medical research. Anil K Mandal won Quality Teaching award for his video at the American Society of Cataract and Refractive Surgery, Philadelphia, USA.

Anil K Mandal won Award for Best Instruction Film at 61st All India Ophthalmological Society conference, New Delhi. Anil K Mandal won Col Rangachary Award for best paper at special plenary session of 61st All India Ophthalmological Society conference. Kuldeep Raizada awarded a Gold medal for his presentation. Gullapalli N Rao awarded the Padma Shri by the Government of India in recognition of his services to the people of India, through his contributions to medicine and science. Gullapalli N Rao presented the Vocational Excellence Award by Rotary International, Hyderabad. Gullapalli N Rao received Rustom Merwanji Alpaiwalla Memorial Award at the National Association for the Blind, Mumbai, India. Gullapalli N Rao awarded the First Global Visionary Award instituted by Bausch and Lomb at the annual meeting of the American Academy of Ophthalmology at Anaheim, California, USA. Gullapalli N Rao conferred Fellow qua Surgeon ad eundem of the Royal College of Physicians and Surgeons of Glasgow, University of Glasgow, UK. Virender S Sangwan received Dr P Siva Reddy Endowment Award for research work in stem cells by the Andhra Pradesh Akademi of Sciences in Hyderabad. Savitri Sharma won Best Paper award in Parasitology at the 26th National Congress of Indian Association of Medical Microbiologists, Bangalore, India. Savitri Sharma received American Academy of Ophthalmology Achievement Award at Anaheim, California, USA. K Sreelatha awarded Amjad Rahi Prize for best basic science paper at Indian Eye Research Group meeting. M S Sridhar won third prize in Special Cases category of Alcon Video competition, European Society of Cataract and Refractive Surgery (ESCRS), Munich, Germany. Ravi Thomas received Joseph Gnanadickam Gold Medal in 2002. Geeta K Vemuganti awarded Col Rangachary Gold Medal for best paper at 61st All India Ophthalmological Society meeting, New Delhi.

2004 2005
Subhabrata Chakrabarti awarded Indian Academy of Sciences Young Associateship. Subhabrata Chakrabarti awarded International Society for Eye Research Fellowship, USA. Aparna Duggirala won Amjad Rahi Best Scientific Poster Award at 13th annual meeting of Indian Eye Research Group, Chennai, India.

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Nibaran Gangopadhyay invited by Dr Robert Osher to publish video Management of Posterior Lenticonus with Cataract in Video Journal of Cataract and Refractive Surgery. Nibaran Gangopadhyay won First Prize in New Contributors Category and Second Prize in Educational Category at XXII European Society of Cataract and Refractive Surgery (ESCRS) Congress, Paris, France. Prashant Garg received American Academy of Ophthalmology Achievement Award at Anaheim, California, USA. Ajit B Majji received Dr Ravi Kumar Reddy Endowment Award from Sarojini Devi Eye Hospital, Hyderabad, India. Anil K Mandal received Shanti Swarup Bhatnagar Award from Council of Scientific and Industrial Research, New Delhi, India. Anil K Mandal received U N Brahmachari Oration Award for 2004 at 72nd Reunion Session, at Nilratan Sircar Medical School and College, Kolkata, India. Anil K Mandal awarded C S Reshmi Gold Medal Award for his video at All India Ophthalmological Society conference. D Nagarajan received group award for his role in moving forward the goals of VISION 2020: The Right to Sight and the International Agency for Prevention of Blindness (IAPB) in the South-East Asian Region at IAPBs seventh General Assembly, Dubai, UAE, September 2004. Milind Naik awarded Associate membership of European Society of Ophthalmic Plastics and Reconstructive Surgery. Gunisha Pasricha awarded PhD for her work by Birla Institute of Technology and Science (BITS), Pilani, India. Sreedevi Penmetcha received citation and award at the International Agency for the Prevention of Blindness (IAPB) seventh General Assembly, Dubai, UAE. Kuldeep Raizada received Best Video Award at XI International Congress of Ocular Oncology, Hyderabad. Deepa Rani won Best Scientific Paper award at 7th All India Optometric Conference, Kolkata, India. Gullapalli N Rao received HRH Prince Abdulaziz bin Ahmed bin Abdulaziz Al-Saud Award for prevention of blindness at Riyadh, Saudi Arabia. Gullapalli N Rao elected Chairman of Board of Trustees, President, and Chief Executive Officer of International Agency for the Prevention of Blindness (IAPB) at the seventh General Assembly, Dubai, UAE. K Purushotham Reddy won Best Poster Award at the 73rd annual general meeting of the Society of Biological Chemists (India). G Chandra Sekhar received American Academy of Ophthalmology Achievement Award at Anaheim, California, USA.

G Chandra Sekhar elected unanimously as President of Glaucoma Society of India. M S Sridhar invited by Dr Robert Osher to publish video Late Spontaneous Dislocation (or Disenclavation) of Iris Claw Intraocular Lens in Video Journal of Cataract and Refractive Surgery. Ravi Thomas received Special award for LVPEI for organization of the seventh General Assembly of the International Agency for the Prevention of Blindness (IAPB), Dubai. Geeta K Vemuganti selected for National Bioscience Award for Career Development for 2003-04, from Department of Biotechnology, Government of India.

2005 2006
D Balasubramanian selected as organizer of the USIndo Workshop on Collaborative Research at Fort Lauderdale, Florida, USA. D Balasubramanian delivered an invited talk at Royal Society, London, UK, on stem cell research efforts in India, July 2005. D Balasubramanian delivered the Pushpa Sriramachari Oration of the Indian Council of Medical Research, New Delhi. D Balasubramanian chosen as Senior Fellow, Ophthalmology, University of Melbourne, Australia. Shubhabrata Chakrabarti selected as Indian participant for US-Indo Workshop on Collaborative Research at Fort Lauderdale, Florida, USA. Shubhabrata Chakrabarti won Clinician Scientist Award at the World Glaucoma Congress in Vienna, Italy. Taraprasad Das elected Vice President of All India Ophthalmological Society. Taraprasad Das selected as Indian participant for USIndo Workshop on Collaborative Research at Fort Lauderdale, Florida, USA. Taraprasad Das elected President of Vitreo Retinal Society of India for 2005-2006. Anees Fatima awarded Senior Scholarship (science) by Lady Tata Memorial Trust for 2005-2006 for research in stem cell. Usha Gopinathan received Mr T L Kapadia Award for outstanding contribution to eye banking and delivered the Mr T L Kapadia Endowment Lecture at Sarojini Devi Eye Hospital, Hyderabad, India. Vijaya K Gothwal received International Society for Low Vision Research and Rehabilitation travel fellowship to attend Vision 2005 at London, UK. Subhadra Jalali invited to be part of an international ROP working team under the VISION 2020: Right to Sight program, to meet at World Congress of Ophthalmology 2006, So Paulo, Brazil.

57

Sarfaraz Khan received International Society for Low Vision Research and Rehabilitation travel fellowship to attend Vision 2005 at London, UK. Vilas Kovai received best prize for Vision Centre concept paper presentation at conference on Transforming India - Agenda for Research, at Narsee Monjee Institute of Management Studies (NMIMS), Mumbai, India. Pravin Krishna received Young Investigator Award for Outstanding Achievement in Clinical Ophthalmology at Singapore Eye Research Institute Association for Research in Vision Ophthalmology (SERI-ARVO) meeting, Singapore. Ajit B Majji elected Member, Scientific Committee, All India Ophthalmological Society for 2005-2007. Ajit B Majji elected Joint Secretary of Vitreo Retinal Society of India for 2005-2006. Anil K Mandal selected as Indian participant for US-Indo Workshop on Collaborative Research at Fort Lauderdale, Florida, USA. Anil K Mandal authored a book The Pediatric Glaucomas along with Peter A Netland, MD, PhD, of the University of Tennessee, Memphis, USA; published by Elsevier Inc. UK. Anil K Mandal won Apollo Award of Medical Excellence for 2004-2005, New Delhi. Praveen K Nirmalan selected as Indian participant for US-Indo Workshop on Collaborative Research at Fort Lauderdale, Florida, USA. Kuldeep Raizada received membership to American Society of Ocularists, USA, and the American Anaplastology Association, USA. Gullapalli N Rao delivered Susruta Lecture at 20th Congress of Asia Pacific Academy of Ophthalmology (APAO), Kuala Lumpur, Malaysia. Gullapalli N Rao delivered first Prof L P Agarwal Memorial Lecture at Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. Gullapalli N Rao selected as organizer for the US-Indo Workshop on Collaborative Research at Fort Lauderdale, Florida, USA. Gullapalli N Rao received the first G B Bietti International Award for Prevention of Blindness for outstanding contribution through creation of systems and models for the alleviation of avoidable blindness among the worlds most disadvantaged people from the Italian Society for Prevention of Blindness, Italian Ophthalmological Society meeting, Florence, Italy. Virender S Sangwan won Col V Rangachary Award for best paper at All India Ophthalmological Society meeting. Savitri Sharma elected Chief Editor of Indian Journal of Medical Microbiology for second term at 27th Annual

Congress of Indian Association of Medical Microbiologists, Lucknow, India. Savitri Sharma nominated by Department of Biotechnology, Government of India, to the Institutional Board of Safety Committee of Shanta Biotech Pvt. Ltd., Hyderabad. M Sharmila received International Society for Low Vision Research and Rehabilitation travel fellowship to attend Vision 2005, London, UK. Afia Sultana won a prize for a poster at the International Symposium on Human Origins & Genetics, National Centre for Biological Sciences, Bangalore, India. Geeta K Vemuganti received CHEMTECH PHARMABIO Outstanding Contribution Award (Biotech) for 2005 from the CHEMTECH Foundation. Geeta K Vemuganti won best paper (non PG category) award at annual meeting of the Indian Association of Pathologists and Microbiologists, AP chapter. Also nominated Coordinator for Twin Cities Pathologists meetings for 2005-2006. Inderjeet Kaur won best paper award in basic science at 14th annual meeting of Indian Eye Research Group (IERG), Hyderabad, India. Snigdha, Bausch and Lomb School of Optometry student, won best poster award in clinical science at 14th annual meeting of Indian Eye Research Group (IERG), Hyderabad, India. Honorary mention at World Cornea Congress for LVPEI poster authored by LVPEI alumni Sushmita Shah and M S Sridhar, LVPEI faculty V S Sangwan and Gullapalli N Rao, Washington, DC, USA.

2006 2007
Subhabrata Chakrabarti nominated Member of Associate Advisory Board, Association of International Glaucoma Societies (AIGS): The Global Glaucoma Network. Subhabrata Chakrabarti received INSA Young Scientist Medal of Indian National Science Academy, New Delhi. Subhabrata Chakrabarti elected to Executive Council of Indian Society of Human Genetics (ISHG) for 2007-2009. Subhabrata Chakrabarti awarded International Society for Eye Research Fellowship, USA. Taraprasad Das received Distinguished Service Award at Asia Pacific Academy of Ophthalmology Congress meeting, Singapore. Taraprasad Das elected Science Secretary, Asia Pacific Vitreo Retinal Society. Taraprasad Das elected Member, International Advisory Board, Asia-ARVO (Association for Research in Vision and Ophthalmology) meeting, Singapore.

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Taraprasad Das installed as President of All India Ophthalmological Society. Prashant Garg appointed international advisory member of Canadian Journal of Ophthalmology. Usha Gopinathan elected Vice President of Eye Bank Association of India (EBAI) for the triennium 2007-2010. Santosh Honavar awarded Dr Surya Prasad Rao Oration and Gold Medal by Andhra Pradesh State Ophthalmological Society, Hyderabad. Santosh Honavar received Dr Siva Reddy International Award and Dr R Hanumantha Reddy Award for Best Paper from the All India Ophthalmological Society, Hyderabad. Santosh Honavar elected Chairman, South Asian Retinoblastoma Group. Subhadra Jalali appointed member of All India Ophthalmological Society Task Force on Strategies to prevent childhood blindness in india, specifically in the field of retinopathy of prematurity (ROP). Convenor of first meeting of ROP interest Group in India. Joveeta Joseph received IAMM Junior Best Paper Award at XXX National Congress of Indian Association of Medical Microbiologists (IAMM), Nagpur. Inderjeet Kaur received Young Investigator Award (Merit) in basic sciences at Asia-ARVO (Association for Research in Vision and Ophthalmology) meeting, Singapore. Rohit Khanna selected to be part of a 3-member working group for selecting a regional training centre in each of the WHO regions and a centre in East Africa, under VISION 2020: Right to Sight initiative. C Madhavi Latha received Young Investigator Award (Merit) in basic sciences at the Asia-ARVO (Association for Research in Vision and Ophthalmology) meeting, Singapore. Soundarya Lakshmi Madhira won Best Poster award at 11th International Conference of Asia Pacific Association of Surgical Tissue Banks, Mumbai. Ajit B Majji elected Secretary of Vitreo-Retina Society of India. Somasheila Murthy appointed treasurer of Uveitis Society of India. Somasheila Murthy appointed reviewer of Expert Review of Ophthalmology. Rajul Parikh invited to join Associate Advisory Board (AAB) of Association of International Glaucoma Societies (AIGS) for five years. Naresh Polisetty won Best Poster Special Award in clinical biochemistry (B Narsingarao), National Meet of Society of Biological Chemists (India), New Delhi. Naresh Polisetty won Young Scientist and Best Paper award, National Seminar on Stem Cells and Clinical

Applications, Society for Regenerative Medicine and Tissue Engineering, Nagarjuna University, Guntur. Kuldeep Raizada appointed South India representative for Association of School & College of Optometry, India. Kuldeep Raizada appointed South India representative for Indian Optometric Association. Kuldeep Raizada invited as Peer Reviewer for International Journal of Anaplastology, USA. Gullapalli N Rao awarded International Blindness Prevention Award 2006 by the American Academy of Ophthalmology. Gullapalli N Rao continues to be Member of SightFirst Advisory Committee, International Association of Lions Clubs, Oak Brook, Illinois, USA. V S Sangwan received Shanti Swarup Bhatnagar Award from Council of Scientific and Industrial Research, New Delhi, India. V S Sangwan elected Honorary Secretary of Asia Cornea Society G Chandra Sekhar nominated for membership to Glaucoma Research Society (ICO), Vancouver, Canada. G Chandra Sekhar elected President of Andhra Pradesh State Ophthalmic Society, Kakinada, Andhra Pradesh. G Chandra Sekhar received Best Speaker award at international conference, Laxmi Eye Institute, Panvel, India. G Srinivas selected for Mary Jane ONeill Fellowship in International Eye Banking by the Eye Bank Association of America (EBAA). Rishi Swarup nominated AP State Ophthalmic Society Representative to All India Ophthalmological Society Leadership Development Program; first session held at 65th annual conference of All India Ophthalmological Society, Hyderabad. Rishi Swarup awarded Best Paper of session at 65th annual conference of All India Ophthalmological Society, Hyderabad. Geeta K Vemuganti appointed Life Patron, Al Shifa Trust Eye Hospital, Rawalpindi, Pakistan. Geeta K Vemuganti elected Member of National Academy of Medical Sciences. Geeta K Vemuganti elected President of Indian Association for Ophthalmic Pathologists. Geeta K Vemuganti received Achievement Award by the American Academy of Ophthalmology, Las Vegas, USA. Geeta K Vemuganti Best Oral Presentation award for paper presented at the Stem Cell Research Forum of India and International Stem Cell Meeting, Bangalore.

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2007 2008
Soumyav Basu won Dr KR Dutta award for best free paper at Eastern India Zonal Ophthalmic Congress, Dhanbad. Subhabrata Chakrabarti invited to join Editorial Board of International Glaucoma Review (IGR). Subhabrata Chakrabarti received Young Scientist Platinum Jubilee Award from the National Academy of Sciences India (NASI). Subhabrata Chakrabarti appointed Editorial Board Member of International Glaucoma Review (IGR). Subhabrata Chakrabarti appointed Editorial Board member of Journal of Current Glaucoma Practice. Taraprasad Das elected to Retina Section Program Committee of Association for Research in Vision and Ophthalmology (ARVO), USA, for 2007-2009. Taraprasad Das received honour award from Orissa Gourav Samman Ruchi Prativa Foundation, Orissa. Taraprasad Das received Honor of Vision Award from the Ahmednagar Academy of Ophthalmology. Roshmi Gupta won Best Paper in Orbit Session at joint meeting of Oculoplastics Association of India (OPAI) and Asia Pacific Society of Ophthalmic Plastic and Reconstructive Surgery (APSOPRS), Hyderabad. Chitra Kannabiran appointed to Editorial board of Journal of Genetics. Ajit Babu Majji won best presentation award from Delhi Ophthalmic Society, New Delhi. A K Mandal received Pascal Video Award at XVII annual conference of Glaucoma Society of India, Kolkata. Raja Narayanan received International Ophthalmologist Education Award from the American Academy of Ophthalmology, New Orleans, USA. Rajul S Parikh appointed associate editor for Journal of Current Glaucoma Practice.

Gullapalli N Rao presented ANR Swarna Kankanam 2007 Award by Raga Saptha Swaram, an NGO. Gullapalli N Rao given 2007 Pisart Vision Award by Lighthouse International, New York, USA. Gullapalli N Rao awarded Doctor of Medicine (honoris causa) by University of Melbourne, Australia. V S Sangwan awarded Biotech Products and Process Development and Commercialization Award 2007 by Government of India. V S Sangwan nominated for American Academy of Ophthalmologists Honor Award for 2007. V S Sangwan appointed section editor, Cornea & External Disease, for British Journal of Ophthalmology. V S Sangwan appointed Editorial Board Member of International Ophthalmology Journal. V S Sangwan appointed to international steering committee of LUX Biosciences for Uveitis and Corneal Transplantation drug development programs. G Chandra Sekhar installed President of Andhra Pradesh Ophthalmic Society (APOS) and Chairman of Ophthalmic Association of South Indian States (OASIS). Rishi Swarup received Raghavachary award for Best Paper at the Andhra Pradesh Ophthalmic Society (APOS) and the Ophthalmic Association of Southern Indian States (OASIS) conference. Geeta K Vemuganti honoured for 5 best photographs by Ophthalmic Photographic Society at American Society of Cataract and Refractive Surgery (ASCRS) symposium and congress, San Diego, California, USA. Geeta K Vemuganti awarded Biotech Products & Process Development and Commercialization Award 2007 by Government of India. Geeta K Vemuganti elected Fellow of National Academy of Medical Sciences.

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Publications
2002 2007

2002
1. Aasuri MK, Shah U, Veenashree MP, Deshpande P. Performance of truncated-edge silicone foldable intraocular lens in Indian eyes. J Cataract Refract Surg 2002; 28: 1135-40 Ata-ur-Rasheed M, Vemuganti GK, Honavar SG, Ahmed N, Hasnain S, Kannabiran C. Mutational analysis of the RB1 gene in Indian patients with retinoblastoma. Ophthalmic Genet 2002; 23: 121-8 Athmanathan S, Sesha Reddy B, Rao GN. Comparison of the sensitivity of a 24h shell vial assay and conventional tube culture in the isolation of Herpes simplex virus-1 from corneal scrapings. BMC Clin Pathol 2002; 2: 1 Balasubramanian D, Kanwar R. Molecular pathology of dityrosine cross-links in proteins: Structural and functional analysis of four proteins. Mol Cell Biochem 2002; 234: 27-38 Balasubramanian D. Molecular and cellular approaches to understand and treat some diseases of the eye. Curr Sci 2002; 82: 948-57 Bansal AK. Efficacy of amniotic membrane graft for reducing corneal haze after photorefractive and photoreflective keratectomy. Refract Surg 2002; 18: 389 Chowdhury T, Jalali S, Majji AB. Successful treatment of fungal retinitis and retinal vasculitis with oral itraconazole. Retina 2002; 22: 800-2 Cosar CB, Sridhar MS, Cohen EJ, Held EL, Alvim Pde T, Rapuano CJ, Raber IM, Laibson PR. Indications for penetrating keratoplasty and associated procedures, 1996-2000. Cornea 2002; 21: 148-51 Dan JA, Honavar SG, Belyea DA, Mandal AK, Garudadri C, Levy B, Ramakrishnan R, Krishnadas R, Lieberman MF, Stamper RL, Yaron A. Enzymatic sclerostomy: pilot human study. Arch Ophthalmol 2002; 120: 548-53 Dandona R, Dandona L, Srinivas M, Giridhar P, McCarty CA, Rao GN. Population-based assessment of refractive error in India: The Andhra Pradesh Eye Disease Study. Clin Experiment Ophthalmol 2002; 30: 84-93 Dandona R, Dandona L, Srinivas M, Sahare P, Narsaiah S, Muoz SR, Pokharel GP, Ellwein LB. Refractive error in children in a rural population in India. Invest Ophthalmol Vis Sci 2002; 43: 615-22 Dandona R, Dandona L, Srinivas M, Giridhar P, Nutheti R, Rao GN. Planning low vision services in India: A population-based perspective. Ophthalmology 2002; 109: 1871-8

13.

Dandona R, Dandona L, Kovai V, Giridhar P, Prasad MN, Srinivas M. Population-based study of spectacles use in southern India. Indian J Ophthalmol 2002; 50: 145-55 Dandona R, Dandona L, Srinivas M, Giridhar P, Prasad MN, Vilas K, McCarty CA, Rao GN. Moderate visual impairment in India: The Andhra Pradesh Eye Disease Study. Br J Ophthalmol 2002; 86: 373-7 Das T, Sharma S, Muralidhar AV. Effect of vancomycin on S. epidermidis adherence to PMMA intraocular lenses. J Cataract Refract Surg 2002; 28: 703-8 Das T. Old order changeth. Indian J Ophthalmol 2002; 50: 1 Das T. Peer review in health sciences. Indian J Ophthalmol 2002; 50: 79 Demirci H, Shields CL, Shields JA, Eagle RC Jr, Honavar SG. Diffuse iris melanoma: a report of 25 cases. Ophthalmology 2002; 109: 1553-60 Demirci H, Shields CL, Shields JA, Honavar SG, Eagle RC Jr. Ring melanoma of the ciliary body: Report on twenty-three patients. Retina 2002; 22: 698-706 Demirci H, Shields CL, Shields JA, Honavar SG, Mercado GJ, Tovilla JC. Orbital tumors in the older adult population. Ophthalmology 2002; 109: 243-8 Demirci H, Shields CL, Shields JA, Honavar SG. Spontaneous disappearance of presumed retinal astrocytic hyperplasia. Retina 2002; 22: 237-9 Garg P, Sharma S. Corneal biopsy in the management of progressive microbial keratitis. Am J Ophthalmol 2002; 133: 291-2 Garg P, Vemuganti GK, Xie L, Shi W. Lamellar keratoplasty for the treatment of fungal keratitis. Cornea 2002; 21: 734-5 Gaudio PA, Gopinathan U, Sangwan V, Hughes TE. Polymerase chain reaction based detection of fungi in infected corneas. Br J Ophthalmol 2002; 86: 755-60 Giridhar P, Dandona R, Prasad MN, Kovai V, Dandona L. Fear of blindness and perceptions about blind people. The Andhra Pradesh Eye Disease Study. Indian J Ophthalmol 2002; 50: 239-46 Gopinathan U, Garg P, Fernandes M, Sharma S, Athmanathan S, Rao GN. The epidemiological features and laboratory results of fungal keratitis: A 10-year review at a referral eye care center in South India. Cornea 2002; 1: 555-9 Gopinathan U. Drug combination effective for fungal keratitis. Ocular Surgery News 2002; 13-50

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Hazari A, Sangwan VS. Cataract surgery in uveitis. Indian J Ophthalmol 2002; 50: 103-7 Honavar SG, Shields CL, Singh AD, Demirci H, Rutledge BK, Shields JA, Eagle RC Jr. Two discrete choroidal melanomas in an eye with ocular melanocytosis. Surv Ophthalmol 2002; 47: 36-41 Honavar SG, Singh AD, Shields CL, Meadows AT, Demirci H, Cater J, Shields JA. Postenucleation adjuvant therapy in high-risk retinoblastoma. Arch Ophthalmol 2002; 120: 923-31 Hornby SJ, Ward SJ, Gilbert CE, Dandona L, Foster A, Jones RB. Environmental risk factors in congenital malformations of the eye. Ann Trop Paediatr 2002; 22: 67-77 Jalali S. Acquiring skills in management of HIVrelated and other newer infections of the eye. Indian J Ophthalmol 2002; 50: 80-1 Jalali S. On how to create motivation in AIDS eye care. Indian J Ophthalmol 2002; 50: 359-60 Kalyani P, Honavar SG. Ultrasound biomicroscopy in ophthalmol. Chapter in Diagnostic Procedures in Ophthalmol (Ed) HV Nema, Nitin Verma; Jaypee Borthers Medical Publishers (P) Ltd., New Delhi 2002; 196-206 Kompella VB, Sangwan VS, Bansal AK, Garg P, Aasuri MK, Rao GN. Ophthalmic complications and management of Stevens-Johnson syndrome at a tertiary eye care centre in south India. Indian J Ophthalmol 2002; 50: 283-6 Lalitha K, Jalali S, Kadakia T, Kannabiran C. Screening for homozygosity by descent in families with autosomal recessive retinitis pigmentosa. J Genet. 2002; 81: 59-63 Majji AB. Paramacular von-hippel angioma with tractional macular detachment. Ophthalmic Surg Lasers 2002; 33: 145-7 Majji AB, Aasuri MK, Vemuganti GK, Sharma S. Aspergillus iris granuloma in an immunocompetent individual. Eye 2002; 16: 196-8 Mandal AK, Jain SS, Gothwal VK. Migration of seton into the anterior chamber. Eye 2002; 16: 85-6 Mandal AK. Training ophthalmologists for childrens eye care centres. J Community Eye Health 2002; 14: 62-4 Mandal AK, Vemuganti GK, Ladda N, Veenashree MP. Partial excision with a conjunctival advancement flap after a relaxing incision for a dissecting glaucoma filtering bleb. Ophthalmic Surg Lasers 2002; 33: 497-500 Mandal AK, Bhatia PG, Gothwal VK, Reddy VM, Sri Ramulu P, Prasad MS, John RK, Nutheti R, Shamanna BR. Safety and efficacy of simultaneous bilateral primary combined trabeculotomy43.

trabeculectomy for developmental glaucoma. Indian J Ophthalmol 2002; 50: 13-9 Mandal AK, Hornby SJ, Jones RB. Congenital hydrocephalus associated with congenital glaucoma and natal teeth. Indian J Ophthalmol 2002; 50: 322-3 Mandal AK, Majji AB, Mandal SP, Das T, Jalali S, Gothwal VK, Jain SS, Nutheti R. Mitomycin-C augmented trabeculectomy for neovascular glaucoma. A preliminary report. Indian J Ophthalmol 2002; 50: 287-93 Naik MN, Tourani KL, Sekhar GC, Honavar SG. Interpretation of computed tomography imaging of the eye and orbit: A systematic approach. Indian J Ophthalmol 2002; 50: 339-53 Panicker SG, Srirangan S, Mandal AK, Reddy ABM, Ahmed N, Hasnain S. Novel mutation in FOXC1 wing region causing Axenfeld-Rieger anomaly. Invest Ophthalmol Vis Sci 2002; 43: 3613-6 Panicker SG, Reddy ABM, Mandal AK, Ahmed N, Nagarajaram HA, Hasnain SE, Balasubramanian D. Identification of novel mutations causing familial primary congenital glaucoma in Indian pedigrees. Invest Ophthalmol Vis Sci 2002; 43: 1358-66 Pasricha G, Sharma S. Acanthamoeba keratitis pathogenesis. Chapter in Recent advances in Ophthalmology, New Delhi. (Ed) HV Neema, Nitin Verma, Jaypee Brothers, Medical Publishers (P) Ltd, New Delhi. 2002; 196-209 Sangwan VS. Limbal stem cells in health and disease. Biosci Rep 2002; 21: 385-405 Sangwan VS, Sridhar U. Surgical management of ocular surface disorder. Chapter in Recent Advances in Ophthalmol (Ed) HV Neema, Nitin Verma, Jaypee Brothers, Medical Publishers (P) Ltd, New Delhi. 2002; 6: 126-42 Sangwan VS. Amniotic membrane transplantation. Indian J Ophthalmol 2002; 50: 169-70 Shah UN, Garg P, Vemuganti GK. Corneal edema with a dislocated anterior polar cataract. Am J Ophthalmol 2002; 133: 399-401 Shah V, Vemuganti GK, Jalali S, Das T. Osseous metaplasia in an epiretinal membrane in Eales disease. Retina 2002; 22: 641-3 Sharma S, Das D, Anand R, Das T, Kannabiran C. Reliability of nested polymerase chain reaction in the diagnosis of bacterial endophthalmitis. Am J Ophthalmol 2002; 33: 142-4 Sharma S, Kunimoto DY, Gopinathan U, Athmanathan S, Garg P, Rao GN. Evaluation of corneal scraping smear examination methods in the diagnosis of bacterial and fungal keratitis: A survey of eight years of laboratory experience. Cornea 2002; 21: 643-7

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treated by debridement and oral itraconazole. Am J Ophthalmol 2003; 136: 745-6 152. Sridhar MS. Hyperopic LASIK. In Step by Step LASIK Surgery, Eds. Vajpayee RB, Sharma N, Malki SA, Sullivan L. Jaypee Brothers, 2003: 155-61 153. Sultana A, Sridhar MS, Jagannathan A, Balasubramanian D, Kannabiran C, Klintworth GK. Novel mutations of the carbohydrate sulfotransferase-6 (CHST6) gene causing macular corneal dystrophy in India. Mol Vis 2003; 9: 730-4 154. Sweeney DF, Jalbert I, Covey M, Sankaridurg PR, Vajdic C, Holden BA, Sharma S, Ramachandran L, Willcox MD, Rao GN. Clinical characterization of corneal infiltrative events observed with soft contact lens wear. Cornea 2003; 22: 435-42 155. Thiagarajan G, Venu T, Balasubramanian D. Approaches to relieve the burden of cataract blindness through natural antioxidants: use of Ashwagandha (Withania somnifera). Curr Sci 2003; 85: 1065-71 156. Thomas R, George R, Parikh R, Muliyil J, Jacob A. Five-year risk of progression of primary angle closure suspects to primary angle closure: A population based study. Br J Ophthalmol 2003; 87: 450-4 157. Thomas R, Parikh R, Muliyil J, Kumar RS. Five-year risk of progression of primary angle closure to primary angle closure glaucoma: A populationbased study. Acta Ophthalmol Scand 2003; 81: 480-5 158. Thomas R, Parikh R, Muliyil J. Comparison between phacoemulsification and the Blumenthal technique of manual small-incision cataract surgery combined with trabeculectomy. J Glaucoma 2003; 12: 333-9 159. Thomas R, Kothari M, Parikh R et al. The incidence of vitreous loss and visual outcome in patients undergoing cataract surgery in a teaching hospital. Indian J Ophthalmol 2003; 51: 45-52 160. Thomas R, Parikh R, George R, Kumar RS, Muliyil J. Five-year risk of progression of ocular hypertension to primary open angle glaucoma: A population based study. Indian J Ophthalmol 2003; 51: 329-33 161. Thomas R, Parikh R, Muliyil JP, George R, Paul P, Abraham LM. Comparison between latanoprost and brimonidine: efficacy and safety in Indian eyes. Indian J Ophthalmol 2003; 51: 123-8 162. Thomas R, Muliyil J, Paul P. Glaucoma in India. J Glaucoma 2003; 12: 81-7 163. Thomas R, Thomas S, Jayaprakash Muliyil. Prevalence of glaucoma in treated multibacillary hansen disease. J Glaucoma 2003; 12: 16-22

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164. Burman S, Tejwani S, Vemuganti GK, Gopinathan U, Sangwan VS. Ophthalmic applications of preserved human amniotic membrane: A review of current indications. Cell Tissue Banking 2004; 5: 161-75 165. Das T, Vedantham V. Intravitreal sodium fluorescein enhances visualization of clear vitreous during vitreous surgery for macular hole. A safety and efficacy study. Clin Experiment Ophthalmol 2004; 32: 55-7 166. Farhatullah S, Kaza S, Athmanathan S, Garg P, Reddy SB, Sharma S. Diagnosis of HSV-1 keratitis using Giemsa stain, IFA, and PCR on corneal scrapings. Br J Ophthalmol 2004; 88: 142-4 167. Fernandes M, Sangwan VS, Vemuganti GK. Limbal stem cell deficiency and xeroderma pigmentosum: A case report. Eye 2004; 18: 741-3 168. Fernandes M, Sangwan VS, Rao SK, Basti S, Sridhar MS, Bansal AK, Dua HS. Limbal stem cell transplantation. Indian J Ophthalmol 2004; 52: 5-22 169. Garg P, Vemuganti GK, Chatarjee S, Gopinathan U, Rao GN. Pigmented plaque presentation of dematiaceous fungal keratitis a clinicopathologic correlation. Cornea 2004; 23: 571-6 170. Gupta R, Sharma S, Rao DV, Das T. Applicability of rapid antibiotic susceptibility testing in the management of bacterial endophthalmitis. Retina 2004; 24: 391-8 171. Hussain N, Das T, Vashist U, Sumashri K. Verteporfin therapy for myopic choroidal neovascularisation (One year results). Indian J Ophthalmol 2004; 52: 227-31 172. Jalali S. Principle of laser treatment and how to get good outcomes in a patient with Diabetic Retinopathy. JK Science 2004; 6: 48 173. Jalali S, Anand R, Kumar H, Dogra MR, Azad R, Gopal L. Program planning and screening strategy in retinopathy of prematurity. Indian J Ophthalmol 2004; 51: 89-99 174. Khan SA. Setting up low vision care services in the developing world. J Community Eye Health 2004; 49: 17-8 175. Krishnaiah S, Kovai V, Nutheti R, Shamanna BR, Thomas R, Rao GN. Awareness of eye donation in the rural population of India. Indian J Ophthalmol 2004; 52: 73-8 176. Kunjam V, Sekhar GC. Optic disc imaging by Heidelberg retinal tomogram in congenital optic disc anomaly. Indian J Ophthalmol 2004; 52: 149-51 177. Malhotra S, Bali T, Thomas, R. The question of radial optic neurotomy in central retinal vein occlusion. Arch Ophthalmol 2004, 122: 1573-4

178. Mandal AK, Bhatia PG, Bhaskar A, Nutheti R. Longterm surgical and visual outcomes in Indian children with developmental glaucoma operated on within six months of birth. Ophthalmology 2004; 111: 283-90 179. Mandal AK, Netland PA. Glaucoma in aphakia and pseudophakia after congenital cataract surgery. Indian J Ophthalmol 2004; 52: 185-98 180. Mittal R, Thomas R, Naik M, Honavar SG. The porous polyethylene (Medpor) spherical orbital implant: a retrospective study of 136 cases. Ophthal Plast Reconstr Surg 2004; 20: 403 181. Murthy R, Honavar SG, Naik M, Reddy VA, Vemuganti GK. Clinicopathologic findings in choroidal melanomas after failed transpupillary thermotherapy. Am J Ophthalmol 2004; 137: 595-6 182. Murthy SI, Sangwan VS. Bilateral senile scleral plaques mimicking post-inflammatory scleral ectasia. Indian J Ophthalmol 2004; 52: 59-60 183. Namperumalsamy P, Kim R, Kaliaperumal K, Sekar A, Karthika A, Nirmalan PK. A pilot study on awareness of diabetic retinopathy among nonmedical persons in south India: The challenge for eye care programmes in the region. Indian J Ophthalmol 2004; 52: 247-51 184. Nirmalan PK, John RK, Gothwal VK, Baskaran S, Vijayalakshmi P, Rahmathullah L. The impact of visual impairment on functional vision of children in rural south India: The Kariapatti pediatric eye evaluation project. Invest Ophthalmol Vis Sci 2004, 45: 3442-5 185. Nirmalan PK, Katz J, Tielsch JM, Robin AL, Thulasiraj RD, Krishnadas R, Ramakrishnan R. Ocular trauma in a rural south Indian population: The Aravind Comprehensive Eye Survey. Ophthalmology 2004; 111: 1778-81 186. Nirmalan PK, Katz J, Robin AL, Krishnadas R, Ramakrishnan R, Thulasiraj RD, Tielsch JM. Utilization of eye care services in rural south India: The Aravind Comprehensive Eye Survey. Br J Ophthalmol 2004; 88: 1237-41 187. Nirmalan PK, Katz J, Robin AL, Ramakrishnan R, Krishnadas R, Thulasiraj RD, Tielsch JM. Female reproductive factors and eye disease in a rural south Indian population: The Aravind Comprehensive Eye Survey. Invest Ophthalmol Vis Sci 2004; 45: 4273-6 188. Nirmalan PK, Robin AL. Indicators to evaluate success of eye care programs. Ophthalmologia 2004; 16: 15-8 189. Nutheti R, Shamanna BR, Krishnaiah S, Gothwal VK, Thomas R, Rao GN. Perceived visual ability for functional vision performance among persons with low vision in the Indian state of Andhra Pradesh. Invest Ophthalmol Vis Sci 2004; 45: 3458-65

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346. Shome D, Honavar SG, Manderwad GP, Vemuganti GK. Ocular surface squamous neoplasia in a renal transplant recipient on immunosuppressive therapy. Eye 2006; 20: 1413-4 347. Shome D, Vemuganti GK, Honavar SG. Choroidal ganglioneuroma in a patient with neurofibromatosis type 1: A case report. Eye 2006; 20: 1450-1 348. Singh HP, Jalali S, Hejtmancik JF, Kannabiran C. Homozygous null mutations in the ABCA4 gene in two families with autosomal recessive retinal dystrophy. Am J Ophthalmol 2006; 141: 906-13 349. Sridhar MS, Majji AB, Vaddavalli PK. Severe inflammation following iris fixated anterior chamber phakic intraocular lens for myopia. Eye 2006; 20: 1094-5 350. Talla V, Narayanan C, Srinivasan N, Balasubramanian D. Mutations causing self aggregation in human gamma-C-Crystalline loading to congenital cataract. Invest Opthalmol Vis Sci 2006; 47: 5212-7 351. Taneja N, Mathai A. Retinal blood flow and macular edema after radial optic neurotomy for central retinal vein occlusion. Am J Ophthalmol 2006; 142: 710-1 352. Tejwani S, Murthy S, Sangwan VS. Cataract extraction outcomes in patients with Fuchs heterochromic cyclitis. J Cataract Refract Surg 2006; 32: 1678-82 353. Tejwani S, Murthy SI, Sangwan VS. Corneal endothelial cell loss following chemical injury. Asian J Ophthalmol 2006; 8: 115-7 354. Thomas R, Muliyil J, Simha R A, Parikh RS. Heidelberg Retinal Tomograph (HRT 2) Parameters in primary open angle glaucoma and primary angle closure glaucoma: A comparative study in an Indian population. Ophthalmic Epidemiol 2006; 13: 343-50 355. Thomas R, Navin S, Singh T, Chakrabarti S. A tiger with glaucoma. Br J Ophthalmol 2006; 90: 1549 356. Thomas R, Parikh R. How to assess a patient for glaucoma. Community Eye Health Journal 2006; 19: 36-7 357. Vaddavalli PK, Garg P, Sharma S, Thomas R, Rao GN. Confocal microscopy for Nocardia keratitis. Ophthalmology 2006; 113: 1645-50 358. Vemuganti GK. Can we grow retina. Community Eye Health Journal 2006; 19: 6-7 359. Walland MJ, Carassa RG, Goldberg I, Grehn F, Heuer DK, Khaw PT, Thomas R, Parikh R. Failure of medical therapy despite normal intraocular pressure. Clin Experiment Ophthalmol 2006; 34: 827-36

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360. Acharya M, Mookherjee S, Bhattacharjee A, Thakur SKD, Bandyopadhyay AK, Sen A, Chakrabarti S, Ray K. Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change. BMC Mol Biol 2007; 8: 21 361. Bajaj MS, Pushker N, Chaturvedi A, Betharia SM, Kashyap S, Balasubramanya R, Sen S. Orbital space-occupying lesions in Indian children. J Pediatr Ophthalmol Strabismus 2007; 44: 106-11 362. Bansal AG, Narayanan R, Majji AB, Thomas R. Neovascular changes after pegaptanib in diabetics. Ophthalmology 2007; 114: 615-6 363. Chakrabarti S, Devi KR, Komatireddy S, Kaur K, Parikh RS, Mandal AK, Chandrasekhar G, Thomas R. Glaucoma-associated CYP1B1 mutations share similar haplotype backgrounds in POAG and PACG phenotypes. Invest Ophthalmol Vis Sci 2007; 48: 5439-44 364. Chalasani ML, Radha V, Gupta V, Agarwal N, Balasubramanian D, Swarup G. A glaucomaassociated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants.Invest Ophthalmol Vis Sci 2007; 48: 1607-14 365. Das S, Whiting M, Taylor HR. Corneal wound dehiscence after penetrating keratoplasty. Cornea 2007; 26: 526-9 366. Das S, Constantinou M, Ong T, Taylor HR. Microbial following corneal transplantation. Clin Experiment Ophthalmol 2007; 35: 427-31 367. Das S, Sheorey H, Taylor HR, Vajpayee RB. Association between cultures of contact lens and corneal scraping in contact lens related microbial keratitis. Arch Ophthalmol 2007; 125: 1182-5 368. Dawson E L M, Murthy R, Lee J. Does Botulinum toxin have a role in the treatment of Oscillopsia? Neuro-Ophthalmology 2007; 31: 73-78 369. Duggirala A, Kenchappa P, Sharma S, Peters J, Ahmed N, Garg P, Das T, Hasnain SE. High resolution genome profiling differentiated Staphylococcus epidermidis isolated from patients with ocular infections and normal individual. Invest Ophthalmol Vis Sci 2007; 48: 3239-45 370. Duggirala A, Joseph J, Sharma S, Nutheti R, Garg P, Das T. Activity of newer fluoroquinolones against gram-positive and gram-negative bacteria isolated from ocular infections: An in vitro comparison. Indian J Ophthalmol 2007; 55: 15-9 371. Fatima A, Vemuganti GK, Iftekhar G, Rao GN, Sangwan VS. In vivo survival and stratification of cultured limbal epithelium. Clin Experiment Ophthalmol 2007; 35: 96-8

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385. Murthy R, Honavar SG, Vemuganti GK, Naik MN, Reddy VP. Systemic metastasis following hyphema drainage in an unsuspected retinoblastoma. J Pediatr Ophthalmol Strabismus 2007; 44: 120-3 386. Murthy R, Honavar SG, Vemuganti GK, Naik M, Burman S. Isolated giant xanthogranuloma of the orbit. Indian J Ophthalmol 2007; 55: 156-8 387. Murthy SI, Sangwan VS, Sreedharan A, Tejwani S, Rao GN. Atypical manifestations of Herpes Simplex Endotheliitis. Asian J Ophthalmol 2007; 9: 76-81 388. Murthy R. Centurion syndrome: an underdiagnosed entity. DOS Times. 2007: 10: 869-71 389. Naik MN, Honavar SG, Murthy RK, Raizada K, Thomas R. Ethanolamine oleate sclerotherapy versus simple cyst aspiration in the management of orbitopalpebral cyst associated with congenital microphthalmos. Ophthal Plast Reconstr Surg 2007; 23: 307-11 390. Naik MN, Mittal R, Murthy RK, Honavar SG. Prevention of exposure of porous orbital implants following enucleation. Am J Ophthalmol 2007; 144: 161-2 391. Naik MN, Honavar SG, Bhaduri A, Linberg JV. Congenital horizontal tarsal kink: a single-center experience with 6 cases. Ophthalmology 2007; 114: 1564-8 392. Narayanan R, Butani V, Boyer DS, Atilano SR, Resende GP, Kim DS, Chakrabarti S, Kuppermann BD, Khatibi N, Chwa M, Nesburn AB, Kenney MC. Complement Factor H polymorphism in age related macular degeneration. Ophthalmology 2007; 114: 1327-31 393. Nirmalan PK, Thomas R. Sample sizes for clinical trials. Ophthalmology 2007; 114: 615 394. Nutheti R, Keeffe JE, Shamanna BR, Nirmalan PK, Krishnaiah S, Thomas R. Relationship between visual impairment and eye diseases and visual function in Andhra Pradesh. Ophthalmology 2007; 114: 1552-7 395. Parikh RS, Parikh SR, Sekhar GC, Prabakaran S, Babu JG, Thomas R. Normal age-related decay of retinal nerve fiber layer thickness. Ophthalmology 2007; 114: 921-6 396. Pathengay A, Vemuganti GK, Shah GY, Das T, Sharma S. Recurrent endophthalmitis due to Acanthamoeba. Asian J Ophthalmol 2007; 9: 36-8 397. Ponnam SP, Ramesha K, Tejwani S, Ramamurthy B, Kannabiran C. Mutation of the gap junction protein alpha 8 (GJA8) gene causes autosomal recessive cataract. J Med Genet 2007; 44: e85 398. Raizada K, Shome D, Honavar SG. New measurement device and technique for assessing implant and prosthetic motility. Ophthal Plast Reconstr Surg 2007; 23: 59-60

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407. Sultana A, Garg P, Ramamurthy B, Vemuganti G, Kannabiran C. Mutational spectrum of the SLC4A11 gene in autosomal recessive congenital hereditary endothelial dystrophy. Mol Vis 2007; 13: 1327-32 408. Taneja N, Mathai A. Optical coherence tomography in patients with decreased visual acuity after successful surgery for proliferative vitreoretinopathy. Archives Ophthalmol. 2007; 125: 855-6 409. Tejwani S, Kolari RS, Sangwan VS, Rao GN. Role of amniotic membrane graft for ocular chemical and thermal injuries. Cornea 2007; 26: 21-6 410. Thomas R, Chakrabarti S, Parikh RS. Update on glaucoma in India. Ophthalmology International 2007; 63-9 411. Thomas R, Sekhar GC, Parikh R. Primary angle closure glaucoma: a developing world perspective. Clin Experiment Ophthalmol. 2007; 35: 374-8 412. Vemuganti GK, Honavar SG. Eyelid stromal tumors. Clinical Ophthalmic Oncology. eds Arun Singh. Saunders 2007; 99-106 413. Vemuganti GK, Kannabiran C. Gene expression signatures in stem cells lessons for therapy. International Journal of Human Genetics 2007; 7: 83-9 414. Vemuganti GK, Sangwan VS, Rao GN. The promise of stem cell therapy for eye disorders. Clin Experiment Optom 2007; 90: 315-6 415. Vilas K, Krishnaiah S, Shamanna BR, Thomas R, Rao GN. Barriers to accessing eye care services among visually impaired populations in rural Andhra Pradesh, South India. Indian J Ophthalmol 2007; 55: 365-71

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