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Estra-1,3,5(10)-triene-3,17-diol(17b)- (cas 50-28-2) MSDS

1. 1.1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Product identifiers
Product name Product Number Brand CAS-No. : : : : :

Estradiol
E1024 50-28-2 Laboratory chemicals, Manufacture of substances

1.2 2. 2.1

Relevant identified uses of the substance or mixture and uses advised against
Identified uses

HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Carcinogenicity (Category 2) Reproductive toxicity (Category 1A) Effects on or via lactation

Classification according to EU Directives 67/548/EEC or 1999/45/EC

May impair fertility. Limited evidence of a carcinogenic effect. Possible risk of harm to the unborn child. May cause harm to breastfed babies.

2.2

Label elements Labelling according Regulation (EC) No 1272/2008 [CLP]

Pictogram Signal word Hazard statement(s) H351 H360Fd H362 Precautionary statement(s) P201 P263 P281 Danger Suspected of causing cancer. May damage fertility. Suspected of damaging the unborn child. May cause harm to breast-fed children. Obtain special instructions before use. Avoid contact during pregnancy/ while nursing. Use personal protective equipment as required. IF exposed or concerned: Get medical advice/ attention. none

- E1024

P308 + P313 Supplemental Hazard Statements Restricted to professional users.

According to European Directive 67/548/EEC as amended.

Hazard symbol(s) R-phrase(s) R60 R40 R63 R64 S-phrase(s) S45 S53 Restricted to professional users.

May impair fertility. Limited evidence of a carcinogenic effect. Possible risk of harm to the unborn child. May cause harm to breastfed babies. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid exposure - obtain special instructions before use.

2.3 3.

Other hazards - none COMPOSITION/INFORMATION ON INGREDIENTS

3.1

Substances
Synonyms :

3,17 -Dihydroxy-1,3,5(10)-estratriene -Estradiol 1,3,5-Estratriene- 3,17 -diol Dihydrofolliculin 17 -Estradiol C18H24O2 272,38 g/mol Concentration 50-28-2 200-023-8 -

Formula Molecular Weight Component

: :

Estradiol
CAS-No. EC-No.

4. 4.1

FIRST AID MEASURES Description of first aid measures General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Flush eyes with water as a precaution.

If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

- E1024

4.2

Most important symptoms and effects, both acute and delayed

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

4.3 5. 5.1

Indication of any immediate medical attention and special treatment needed

no data available

FIRE-FIGHTING MEASURES Extinguishing media Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 5.3 5.4 6. 6.1

Special hazards arising from the substance or mixture

Carbon oxides

Advice for firefighters

Wear self contained breathing apparatus for fire fighting if necessary.

Further information
no data available

ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.

6.2 6.3

Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4 7. 7.1

Reference to other sections

For disposal see section 13.

HANDLING AND STORAGE Precautions for safe handling

Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.

7.2 7.3 8. 8.1 8.2

Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Specific end uses

no data available

EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

- E1024

Personal protective equipment Eye/face protection

Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Body Protection
impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

9. 9.1

PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties
a) Appearance b) Odour c) Odour Threshold d) pH e) Melting point/freezing point f) Initial boiling point and boiling range g) Flash point h) Evaporation rate i) j) Form: powder Colour: white no data available no data available no data available Melting point/range: 176 - 180 C - lit. no data available no data available no data available

Flammability (solid, gas) no data available Upper/lower no data available flammability or explosive limits k) Vapour pressure no data available l) Vapour density no data available m) Relative density n) Water solubility o) Partition coefficient: noctanol/water p) Autoignition no data available no data available no data available no data available

temperature q) Decomposition temperature

- E1024

no data available

r) Viscosity s) Explosive properties t) Oxidizing properties

no data available no data available no data available

9.2

Other safety information

no data available

10. STABILITY AND REACTIVITY 10.1 Reactivity

no data available

10.2 Chemical stability

no data available

10.3 Possibility of hazardous reactions

no data available

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Strong oxidizing agents

10.6 Hazardous decomposition products

Other decomposition products - no data available

11. TOXICOLOGICAL INFORMATION 11.1 Information on toxicological effects Acute toxicity

no data available

Skin corrosion/irritation
no data available

Serious eye damage/eye irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

Genotoxicity in vitro - rat - Other cell types DNA damage Genotoxicity in vivo - rat - Oral Morphological transformation.

Carcinogenicity
The National Toxicology Program (Tenth Report on Carcinogens) has determined that steroidal estrogens are known to be human carcinogens based on sufficient evidence of carcinogenicity in humans, which indicates a causal relationship between exposure to steroidal estrogens and human cancer. This is or contains a component that has been reported to be carcinogenic based on its IARC, OSHA, ACGIH, NTP, or EPA classification. Suspected human carcinogens IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity
Suspected human reproductive toxicant Damage to fetus cannot be excluded.
- E1024

Known human reproductive toxicant Effects on or via lactation May damage fertility. Suspected of damaging the unborn child.

Specific target organ toxicity - single exposure

no data available

Specific target organ toxicity - repeated exposure

no data available

Aspiration hazard
no data available

no data available

Potential health effects Inhalation May be harmful if inhaled. May cause respiratory tract irritation. Ingestion May be harmful if swallowed. Skin May be harmful if absorbed through skin. May cause skin irritation. Eyes May cause eye irritation. Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Additional Information
RTECS: KG2975000

12. ECOLOGICAL INFORMATION 12.1 Toxicity

Toxicity to fish no data available LC50 - Oncorhynchus mykiss (rainbow trout) - > 0,5 mg/l - 96 h

12.2 Persistence and degradability 12.3 Bioaccumulative potential

no data available

12.4 Mobility in soil

no data available

12.5 Results of PBT and vPvB assessment

no data available

12.6 Other adverse effects 13. DISPOSAL CONSIDERATIONS 13.1 Waste treatment methods Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.

Contaminated packaging
Dispose of as unused product.

14. TRANSPORT INFORMATION 14.1 UN number

ADR/RID: IMDG: IATA: -

14.2 UN proper shipping name

ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

14.3 Transport hazard class(es)

ADR/RID: - E1024

IMDG: -

IATA: -

14.4 Packaging group

ADR/RID: IMDG: IMDG Marine pollutant: no IATA: IATA: no

14.5 Environmental hazards

ADR/RID: no

14.6 Special precautions for user

no data available

15.

REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available

15.2 Chemical Safety Assessment

no data available

16.

OTHER INFORMATION Further information

The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information this document is based on the resent state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. guidechem shall not be held liable for any damage resulting from handling or from contact with the above product.

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