phenylephrine's effectiveness as a decongestant stems from its vasoconstriction of nasal blood vessels, thereby decreasing blood flow to the

sinusoidal vessels, leading to decreased mucosal edema Chlorphenamine is often combined with phenylpropanolamine to form an allergy medication with both antihistamine and decongestant properties Chlorpheniramine is an anticholinergic antihistamine. It also is effective against nausea and motion sickness, with its primary mechanism of action being its ability to reduce acetylcholine levels in the brain. Acetylcholine is a neurotransmitter. In the brain, acetylcholine and dopamine have antagonistic effects on each other, so a proper balance is necessary for a healthy, functioning body and mind. Many antihistamines (Benadryltm included) work the same way; by reducing (or inhibiting the effects of) the level of acetylcholine in the brain, histamine levels decrease throughout the body, alleviating the symptoms of an allergic reaction. The decrease in acetylcholine gives the dopamine more influence within the brain, which is why anticholinergic drugs are often used to alleviate the symptoms of Parkinson's Disease. Anticholinergics also tend to promote urine retention via temporary swelling of the Prostate, making them useful as anti-incontinence drugs.

Phenylpropanolamine acts as a potent and selective releasing agent of norepinephrine and epinephrine, or as a norepinephrine releasing agent (NRA). It also acts as a dopamine releasing agent (DRA) to a lesser extent. It works by mimicking the effects of endogenous catecholamines such as epinephrine and norepinephrine, and to a lesser degree dopamine. Many sympathetic hormones and neurotransmitters are based on the phenethylamine skeleton, and function generally in "fight or flight" type responses- such as increasing heart rate, blood pressure, dilating the pupils, increased energy, drying of mucous membranes, increased sweating, and a significant number of additional effects. The use of it has been shown to potentiate the effects of caffeine. Found on central nervous system and Decreased neurotransmitter release: H3 histamine to a lesser extent peripheral nervous histamine, acetylcholine, norepinephrine, receptor system tissue serotonin
Magnesium hydroxide increases peristaltic activity causing osmotic retention of fluids, thus resulting in bowel evacuation. It also reduces stomach acid by reacting with hydrochloric acid to form Mg chloride