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Key of Nomenclature Test 2008
Key of Nomenclature Test 2008
Key of Nomenclature Test 2008
Nomenclature Exam August 18, 2008 Dr. Adams PHAR 412 Principles o P!arm " #ed $!em NAME_______KEY_____________________
Make sure you write your name on the top of the first page and on your answer sheet. Choose the single %est answer unless otherwise indicated. n the answer sheet pro!ided" please clearly mark your answers with a dark pencil. Erase errors completely. Each #uestion is worth one $%& point. 'here are () #uestions. &E '(RE )* +N$,(DE -*(R P+N " )E') .ER'+*N *N )HE AN'/ER 'HEE)0 *rug names marked with an asterisk $+& are 'op ,-- drugs. %. The
A. .. C. *. E.
A single ketone functional group. 'wo ketone functional groups. 'hree ketone functional groups. A car/o0ylic acid. .oth C 1 *. HCl (Atarax)* is a first generation antihistamine that contains:
(. Hydroxyzine
N CH2CH2
2ydro0y3ine $Atarax&+
CH2CH2OH
Cl
A. .. + C. *. E.
,. The
A secondary $( & amine" a primary $% & alcohol" and an ether. o o A tertiary $, & amine" a secondary $( & alcohol" and an ether. o o A tertiary $, & amine" a primary $% & alcohol" and an ether. o o A secondary $( & amine" a secondary $( & alcohol" and an ester. o o A tertiary $, & amine" a primary $% & alcohol" and an ester.
O OH
A. .. C. *. E.
.en3oic Acid Cycloheptane Car/o0ylic Acid 2e0anoic Acid Cyclohe0ane Car/o0ylic Acid 2eptanoic Acid
4. The
A. .. C. *. + E.
6. Buspirone
5henol 5henyl .en3aldehyde Cyclohe0yl .en3yl (Buspar)* a serotonin receptor agonist used as an anxiolytic contains a
O N N (CH2)4 N
.uspirone $Buspar&
(an):
N N
A. .. C. *. + E.
). !eostigmine
(Prostigmin) is an acetylcholinesterase inhibitor used to treat myasthenia gra"is that contains a(an):
O O
Neostigmine
N(CH3)2
N(CH3)3 Br
A. + .. C. *. E.
:. The
Car/amate and a tertiary $, & amine. o Car/amate and a #uarternary $4 & amine. o Car/onate and a tertiary $, & amine. o Car/onate and a #uarternary $4 & amine. Ester and a car/onate.
O HO CCH2CHCH2CH3 CH2CH3
A. .. + C. *. E.
,;methyl;he0anoic acid (;ethyl;/utanoic acid ,;ethyl;pentanoic acid ,;heptanoic acid (;ethyl;pentanoic acid
<. Chlorpromazine
(Thorazine) is a phenothiazine compound with "arious uses' #t may be metabolized in the body to the structure shown on the right below that is called a (an):
S N Cl N Cl CH2CH2CH2N(CH3)2 O S
A. .. + C. *. E.
>. The
A. .. C. *. + E.
%-. Based
on the #$%&C system what is the substituent in the ) position on the molecule below*
H3CO CH3CH2CH2 CH3CH2CH2CH Br CHCH2CH3 CH2CH3
A. .. + C. *. E.
%%. $sing +
Ethyl 5ropyl .romo Metho0y ctene the al+ene abo"e what is the name of the parent chain* ctene ?onene 2eptene 2e0ene .utene
A. .. C. *. E.
%(. ,smolol
O O CH3
Esmolol Brevibloc
o
A. + .. C. *. E.
A primary $% & alcohol and a secondary $( & amine. o o A secondary $( & alcohol and a secondary $( & amine. o o A secondary $( & alcohol and a primary $% & amine. o o A primary $% & alcohol and a primary $% & amine. o o A secondary $( & alcohol and a tertiary $, & amine. (Biaxin)* is an antibiotic that contains:
CH3 O HO HO H3C H3CH2C H3 C H3CO CH3 OCH3 CH3 OH CH3 HO O (H3C)2N O
%,. Clarithromycin
CH3
O O CH3
$larit!rom4cin Biaxin O
O H3 C
A. + .. C. *. E.
%4. The
Amide Ester Car/onate Car/amate Aldehyde configuration of this geometric isomer is:
CH3CH2CH2 CH2CH2CH3
ClCH2CH2
CH3
A. .. C. + *. E.
%6. &
possible route of metabolism for felbamate (Felbatol) is shown below' .hat is the new functional group*
O O
Bel/amate Felbatol
C C O
A. .. C. *. E.
%). Haloperidol
decanoate (Haldol) an anti-psychotic gi"en as an #/ depot contains all of the following EXCEPT:
O O F O Cl N C(CH2)8CH3
A. Ester .. Ketone C. Amine + *. Car/onate E. 2alogen %:. Ciprofloxacin (Cipro)* is a fluoro0uinolone antibiotic that contains all of the following EXCEPT:
O F COOH
N HN
Ciproflo0acin Cipro
A. A secondary $( & amine. o .. A tertiary $, & amine. C. A ketone. *. A car/o0ylic acid. + E. An imide. %<. Captopril (Capoten)* is an &C, #nhibitor that contains:
O HS CH2 CH C
Captopril $Capoten&
N COOH
CH3
A. .. + C. *. E.
%>. 1efering
A thioether and a tertiary $, &amine. o A tertiary $, &amine and a car/o0ylic acid. A car/o0ylic acid and an amide. A thioether and a car/o0ylic acid. A thioether and an amide.
to the structure of captopril what is the relationship of the thiol group (2H) to the carbonyl* A. alpha + .. /eta C. gamma *. C E. =
(-. Torsemide
(Demadex)* is a diuretic' .hat is the relationship between the amine connecting the aromatic rings and the methyl group*
CH3 CH3 CH CH3 NH NH
'orsemide $Demadex&
NH
SO2
N
+
A. .. C. *. E.
o $ortho& m $meta& p $para& alpha /eta (an analgesic 3 cough suppressant respecti"ely) & hydroxyl &n amine & methoxy ether
(%. Both
CH3 N H N
CH3
HO
Morphine
OH
H3CO
Codeine
OH
A. .. C. *. E.
nly 9 1 99 are true. nly 9 1 999 are true. nly 99 1 999 are true. All of the a/o!e $ 9" 99" 1 999& are true. ?one of the a/o!e are true.
((. !ystatin
(Mycostatin) an antifungal contains a (an): #' ,ster ##' ,ther ###' &mine
OH OH H3C O OH
HO
O CH3
OH
OH
OH
OH
O COOH
N4statin
A. .. C. + *. E.
(,. The
nly 9 1 99 are true. nly 9 1 999 are true. nly 99 1 999 are true. All of the a/o!e $9" 99" 1 999& are true. ?one of the a/o!e are true.
mono-amine oxidase-B (/&4-B) inhibitor selegiline (Eldepryl) is a chiral molecule' The generic name is often written: (-)1-selegiline' The (1) indicates: A. 'he direction of the rotation of plane;polari3ed light. + .. 'he a/solute configuration of the chiral center /ased on the Cahn;9ngold;5relog con!ention. C. 'he configuration /ased on glyceraldehyde as a reference. *. 'he a/solute configuration /ased on the direction of the rotation of plane;polari3ed light. E. 'he fact that this drug has serious negati!e effects and should only /e used as a last resort.
(4. 2ulbactam
=ul/actam COOH
A. .. C. *. + E.
(6. 2ulfamethoxazole
N O CH3
A. .. C. + *. E.
(). The
group below is the pharmacophore for a class of antidiabetic agents including glipizide ( lucotrol)*' The circled group is called:
O R1 S O N H O N H R2
A. .. C. *. + E.