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Manesty Coating Presentation - 2009
Manesty Coating Presentation - 2009
Manesty Coating Presentation - 2009
Coating System
brian.helsdon@oystar.manesty.com
Coating System
Coating System
Key Benefits
High process efficiency high air flow mixing ability Flexibility all forms of suspensions
sugar aqueous organic solvent tablets and pellets
Reproducibility
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HMI / PC
PLC
COATER
EXHAUST SYSTEM
SPRAY SYSTEM
CIP
FILTER
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Solution Vessel
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Process variables
Drum Mixing
Drum mixing Airflow Inlet, outlet and bed temperature Tablet size and shape Batch size
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Drum Mixing
Drum Mixing
Smaller tablets pack together more tightly and rise higher up the
drum, increasing bed angle and hence tablet velocity
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Drum speed
Directly influences:
Fitted to older machines Available on current machines Low batch version also available Available on current machines
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B est suited Long processes Highly friable tablets S ugar coating and low batch sizes Film coating of Low friability tablet
M oderate
Aggressive
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Airflow
Temperature
Volume passing through drum Balance between inlet and outlet air volumes which control the
pressure in the drum
Drying efficiency is high in side vented pan Airflow can be influenced by tablet size and shape
Excessive heating can cause thermal degradation of active Consider thermal expansion of cores
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Temperature
Excessive heat can cause spray drying or pinhole formation Under steady conditions of inlet temperature, inlet air volume,
spray rate and batch size, exhaust temperature is a good guide to tablet bed temperature
the length of time between each pass through the spray (circulation
time)
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Core shape
During coating the cores will be tacky while the applied coating
formulation is drying
For example, decreasing core size will: To minimise agglomeration cores must be in constant motion and
increase the specific surface area (m2/g) to be covered increase the amount of polymer needed to reach the required coat
level (i.e. thickness)
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Core shape
Core shape
Most tablets for coating should have rounded surfaces - the more
convex, the less likely is agglomeration.
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Batch size
Spray rate
Influences mixing efficiency Influences air flow Can influence process efficiency
Apply at as fast a rate as possible but avoid overwetting Low spray rates can lead to small droplet size which spread poorly
and can lead to orange peel effect
High spray rates can lead to picking or twinning Spray rate can influence process efficiency
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Spray Position
Gun Position
Sprays should be positioned radially so that the spray hits the bed
at the undisturbed area between where baffles enter and leave
Gun to bed distance controls droplet size and hence spreading and
coalescence of droplets at tablet bed
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Gun Position
Gun Position
1/3
900 Angle
2/3
Drying area
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Increasing atomising air pressure decreases mean droplet size Increasing atomising air pressure decreases the range in droplet
diameter
Increase fan air pressure changes spray shape from a solid to a flat
ellipse
At high fan air pressures droplet size distribution widens Different gun designs are influenced differently by changes in
atomising or fan air pressure
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Enhanced droplet performance The Opti Coat spray gun is the ultimate choice
for Pharmaceutical tablet film coating.
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Recirculation option
61 Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809 62 Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809
OYSTAR Manesty Kitling Road Knowsley Merseyside England L34 9JS T +44 (0)151 547 8000 F +44 (0) 151 547 8001 Info@oystar.manesty.com www.oystar.manesty.com
63 Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809 64 Manesty Coating Presentation - 2009 | Brian A Helsdon | 260809
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