SEBAZOLE

VIRBAC DERMATOLOGY SEBORRHOEIC CONDITIONS

PROPERTIES
Antibacterial and Antifungal Keratolytic and keratoplastic Antipruritic Ideal to treat greasy smelly skin

COMPOSITION
Econazole nitrate (10mg/mL) Sulphur as sodium thiosulphate 75mg (19.4mg/mL)

SEBAZOLE

Sodium salicylate (35mg/mL) Chloroxylenol (5mg/mL)

Keratolytic, Keratoplastic, Antibacterial, Antifungal and Antipruritic shampoo

Keratolytic and Keratoplastic activity Sebazole contains sulphur and sodium salicylate which are keratolytic (soften, losen and remove crusts and scales on the skin) and keratoplastic (healing effect on the skin when applied topically). These active ingredients also have antibacterial and antipruritic properties. Sebazole is the ideal product to treat greasy smelly skin. Broad spectrum activity Sebazole contains econazole nitrate, which has broad spectrum activity against fungi (dermatophytes), yeasts (Malassezia) and gram postitive bacteria (Staphylococcal). Antibacterial and Antiseptic Sebazole also contains chloroxylenol, which is an antiseptic with broad spectrum activity against gram positive and gram negative bacteria to help combat secondary skin infections. It can be used concurrently with systemic treatments to treat bacterial and yeast overgrowths, including Staphylococcus intermedius and Malassezia pachydermatis.

PRESENTATION
250mL

INDICATIONS
For the treatment of keratinisation disorders (seborrhoea) associated with bacterial (Staphylococcal) and yeast (Malassezia) overgrowth in dogs and cats. An aid in the treatment of ringworm (dermatophytosis) in dogs and cats.

DIRECTIONS FOR USE

Wet coat thoroughly with warm water. Massage Sebazole into wet hair and lather freely. Rinse. Repeat the above, but this time allow the lather to remain on the skin for 5 to 10 minutes before rinsing. Two or three applications per week for up to 4 weeks may be necessary to treat some skin disorders. If skin condition is severe or does not appear to improve suitably after 2 shampoo applications, consult your veterinarian for advice.

Passionate about animal health

ABN 77 003 268 871

Clinical trial with Sebazole, a keratolytic, keratoplastic, antibacterial, antifungal and antipruritic shampoo for dogs and cats1

INTRODUCTION
This study was designed to assess the efficacy and safety of Sebazole during its use on dogs and cats under the conditions of usual veterinary practice and to also assess its acceptability by the veterinarian and the pet owners.

METHOD
Fifteen dogs of varying breeds and ages, and 2 cats were selected. The animals were selected based on the presence of seborrhoea with or without the following: superficial pyoderma or dermatophyte infection or yeast infection and / or pruritus After selection the animals were washed at the veterinary clinic using Sebazole. The pet owner repeated treatments at home. Efficacy was assessed by observing the skin condition after shampooing, both immediately after the initial treatment and again after several days of usage of the product. The response was rated as poor, moderate, good or excellent. Safety was assessed by a standard clinical examination by the veterinarian, both immediately after the initial treatment and again after several days of usage of the product.

RESULTS
Symptom No. of cases 16 17 17 17 17 16 7 2 Immediate 2.5 0.2 2.4 0.2 2.6 0.1 1.5 0.2 N/A 2.1 0.1 1.8 0.2 Insufficient data

Efficacy*
Delayed 2.1 0.2 2.1 0.2 2.1 0.1 1.9 0.1 1.9 0.2 2.2 0.3 1.8 0.2 Insufficient data good - excellent good - excellent good - excellent moderate - good moderate - good good - excellent moderate good

Flakey seborrhoea Crusty seborrhoea Odour Pruritus Alopecia Pyoderma Dermatophyte infection Yeast infection

* Numbers represent mean standard error of the mean where 0 = poor response, 1 = moderate response, 2 = good response and 3 = excellent response. N/A = not applicable.

CONCLUSION
Sebazole shampoo was effective in treating flakey seborrhoea, crusty seborrhoea, odour, pruritus, pyoderma and dermatophyte infections in dogs and cats. The product was not used in a sufficient number of cases of yeast infections for its efficacy in this condition to be assessed. In addition, no adverse reactions were observed in any of the dogs or the cats in which the product was tested.

Sebazole is the ideal formulation to treat greasy, smelly skin

1

Data on file.

Virbac (Australia) Pty Limited

ABN 77 003 268 871

www.virbac.com.au Toll Free: 1800 242 100

Passionate about animal health

ABN 77 003 268 871

V2051