Key to abbreviations

ATV Atazanavir (Reyataz

) LPV Lopinavir (Kaletra

)
DRV Darunavir (Prezista

) NFV Nelfinavir (Viracept

)
FPV
Fosamprenavir
(Telzir

, Lexiva

)
RTV Ritonavir (Norvir

)
SQV Saquinavir (Invirase

)
IDV Indinavir (Crixivan

) TPV Tipranavir (Aptivus

Key to symbols
Filled symbols indicate further information on the interaction is available at
www.hiv-druginteractions.org.
Empty symbols indicate the combination has not been studied; an
interaction has been predicted based on the metabolic profiles of the drugs.
/ These drugs should not be coadministered
/
Potential interaction may require close monitoring,
alteration of drug dosage or timing of administration
/ No clinically significant interaction expected
/
There are no clear data, actual or theoretical, to indicate
whether an interaction will occur
Where advice differs between countries, and/or between boosted and
unboosted regimens, the charts reflect the more cautious option.
Liverpool HIV Pharmacology Group, University of Liverpool
Pharmacology ResearchLabs, 1st Floor Block H, 70Pembroke Place, LIVERPOOL, L69 3GF
We aim to ensure that information is accurate and consistent with current
knowledge and practice. However, the University of Liverpool and its servants or
agents shall not be responsible or in any way liable for the continued currency of
information in this publication whether arising from negligence or otherwise
howsoever or for any consequences arising therefrom. The University of Liverpool
expressly exclude liability for errors, omissions or inaccuracies to the fullest extent
permitted by law.

I nt er ac t i ons w i t h Pr ot ease I nhi bi t or s

Charts revi sed February 2014. Ful l i nformati on avai l abl e at www.hi v-drugi nteracti ons.org and www.hi v-drugi nteracti onsl i te.org Page 1 of 4
www. hi v - d r ug i nt e r a c t i o ns . o r g

A
T
V

D
R
V

F
P
V

I
D
V

L
P
V

N
F
V

R
T
V

S
Q
V

T
P
V

Anaesthetics & Muscle Relaxants
Alcuronium
Bupivacaine
Cisatracurium
Desflurane
Dexmedetomidine
Enflurane
Ephedrine
Halothane
Isoflurane
Ketamine
Nitrous oxide
Propofol
Rocuronium
Sevoflurane
Sufentanil
Suxamethonium (succinylcholine)
Tetracaine
Thiopental
Vecuronium
Analgesics
Alfentanil
Aspirin
Buprenorphine
Celecoxib
Codeine
Dextropropoxyphene
Diamorphine (diacetylmorphine)
Diclofenac
Dihydrocodeine
Fentanyl
Ibuprofen
Mefenamic acid
Methadone
Morphine
Naproxen
Nimesulide
Oxycodone
Paracetamol (Acetaminophen)
Pethidine (Meperidine)
Piroxicam
Tramadol
Anthelmintics
Albendazole
Diethylcarbamazine
Ivermectin
Levamisole (Ergamisol)
Mebdendazole
Niclosamide
Oxamniquine
Praziquantel
Pyrantel
Suramin sodium
Triclabendazole
Antiarrhythmics
Amiodarone
Bepridil
Disopyramide
Flecainide
Lidocaine (Lignocaine)
Mexiletine
Propafenone
Quinidine

A
T
V

D
R
V

F
P
V

I
D
V

L
P
V

N
F
V

R
T
V

S
Q
V

T
P
V

Antibacterials
Amikacin
Amoxicillin
Ampicillin
Azithromycin
Capreomycin
Cefalexin
Cefazolin
Cefazolin
Cefixime
Cefotaxime
Ceftazidime
Ceftriaxone
Chloramphenicol
Ciprofloxacin
Clarithromycin
Clavulanic acid
Clindamycin
Clofazimine
Cloxacillin
Cycloserine
Dapsone
Doxycycline
Ertapenem
Erythromycin
Ethambutol
Ethionamide
Gentamicin
Imipenem/Cilastatin
Isoniazid
Kanamycin
Meropenem
Metronidazole
Moxifloxacin
Nitrofurantoin
Ofloxacin
Para-aminosalicylic acid
Penicillins
Pyrazinamide
Rifabutin
Rifampicin
Rifapentine
Spectinomycin
Streptomycin
Sulfadiazine
Tetracyclines
Trimethoprim/Sulfamethoxazole
Vancomycin
Anti-coagulant, Anti-platelet and Fibrinol ytic
Acenocoumarol
Clopidogrel
Dabigatran
Heparin
Phenprocoumon
Rivaroxaban
Streptokinase
Warfarin

Key to abbreviations
ATV Atazanavir (Reyataz

) LPV Lopinavir (Kaletra

)
DRV Darunavir (Prezista

) NFV Nelfinavir (Viracept

)
FPV
Fosamprenavir
(Telzir

, Lexiva

)
RTV Ritonavir (Norvir

)
SQV Saquinavir (Invirase

)
IDV Indinavir (Crixivan

) TPV Tipranavir (Aptivus

Key to symbols
Filled symbols indicate further information on the interaction is available at
www.hiv-druginteractions.org.
Empty symbols indicate the combination has not been studied; an
interaction has been predicted based on the metabolic profiles of the drugs.
/ These drugs should not be coadministered
/
Potential interaction may require close monitoring,
alteration of drug dosage or timing of administration
/ No clinically significant interaction expected
/
There are no clear data, actual or theoretical, to indicate
whether an interaction will occur
Where advice differs between countries, and/or between boosted and
unboosted regimens, the charts reflect the more cautious option.
Liverpool HIV Pharmacology Group, University of Liverpool
Pharmacology ResearchLabs, 1st Floor Block H, 70Pembroke Place, LIVERPOOL, L69 3GF
We aim to ensure that information is accurate and consistent with current
knowledge and practice. However, the University of Liverpool and its servants or
agents shall not be responsible or in any way liable for the continued currency of
information in this publication whether arising from negligence or otherwise
howsoever or for any consequences arising therefrom. The University of Liverpool
expressly exclude liability for errors, omissions or inaccuracies to the fullest extent
permitted by law.

I nt er ac t i ons w i t h Pr ot ease I nhi bi t or s

Charts revi sed February 2014. Ful l i nformati on avai l abl e at www.hi v-drugi nteracti ons.org and www.hi v-drugi nteracti onsl i te.org Page 2 of 4
www. hi v - d r ug i nt e r a c t i o ns . o r g

A
T
V

D
R
V

F
P
V

I
D
V

L
P
V

N
F
V

R
T
V

S
Q
V

T
P
V

Anticonvulsants
Carbamazepine
Clonazepam
Ethosuximide
Gabapentin
Lacosamide
Lamotrigine
Levetiracetam
Oxcarbazepine
Phenobarbital (Phenobarbitone)
Phenytoin
Pregabalin
Topiramate
Valproate (Divalproex)
Vigabatrin
Antidepressants
Amitriptyline
Bupropion
Citalopram
Clomipramine
Desipramine
Doxepin
Escitalopram
Fluoxetine
Fluvoxamine
Imipramine
Lithium
Maprotiline
Mianserine
Mirtazapine
Nefazodone
Nortriptyline
Paroxetine
Sertraline
Trazodone
Trimipramine
Venlafaxine
Anti-diabetics
Exanatide
Glibenclamide (Glyburide)
Gliclazide
Glipizide
Insulin
Linagliptin
Liraglutide
Metformin
Nateglinide
Pioglitazone
Repaglinide
Rosiglitazone
Saxagliptin
Sitagliptin
Tolbutamide
Vildagliptin
Antifungals
Amphotericin B
Caspofungin
Fluconazole
Flucytosine
Griseofulvin
Itraconazole
Ketoconazole
Miconazole
Nystatin
Posaconazole
Terbinafine
Voriconazole

A
T
V

D
R
V

F
P
V

I
D
V

L
P
V

N
F
V

R
T
V

S
Q
V

T
P
V

Antihistamines
Astemizole
Cetirizine
Chlorphenamine
Fexofenadine
Loratadine
Promethazine
Terfenadine
Antimigraine Agents
Dihydroergotamine
Ergotamine
Sumatriptan
Antiprotozoals
Amodiaquine
Artemisinins
Atovaquone
Benznidazole
Chloroquine
Diloxanide
Eflornithine
Halofantrine
Lumefantrine
Mefloquine
Meglumine antimoniate
Melarsoprol
Miltefosine
Nifurtimox
Paromomycin
Pentamidine
Primaquine
Proguanil
Pyrimethamine
Quinine
Sodium stibogluconate
Sulfadoxine
Antipsychotics/Neuroleptics
Amisulpride
Aripiprazole
Asenapine
Chlorpromazine
Clozapine
Fluphenazine
Haloperidol
Olanzapine
Paliperidone
Perphenazine
Pimozide
Quetiapine
Risperidone
Sulpiride
Thioridazine
Anti virals
Aciclovir
Adefovir
Amantadine
Boceprevir
Cidofovir
Entecavir
Famciclovir
Foscarnet
Ganciclovir
Oseltamivir
Ribavirin
Rimantadine
Telaprevir
Valaciclovir
Zanamivir

Key to abbreviations
ATV Atazanavir (Reyataz

) LPV Lopinavir (Kaletra

)
DRV Darunavir (Prezista

) NFV Nelfinavir (Viracept

)
FPV
Fosamprenavir
(Telzir

, Lexiva

)
RTV Ritonavir (Norvir

)
SQV Saquinavir (Invirase

)
IDV Indinavir (Crixivan

) TPV Tipranavir (Aptivus

Key to symbols
Filled symbols indicate further information on the interaction is available at
www.hiv-druginteractions.org.
Empty symbols indicate the combination has not been studied; an
interaction has been predicted based on the metabolic profiles of the drugs.
/ These drugs should not be coadministered
/
Potential interaction may require close monitoring,
alteration of drug dosage or timing of administration
/ No clinically significant interaction expected
/
There are no clear data, actual or theoretical, to indicate
whether an interaction will occur
Where advice differs between countries, and/or between boosted and
unboosted regimens, the charts reflect the more cautious option.
Liverpool HIV Pharmacology Group, University of Liverpool
Pharmacology ResearchLabs, 1st Floor Block H, 70Pembroke Place, LIVERPOOL, L69 3GF
We aim to ensure that information is accurate and consistent with current
knowledge and practice. However, the University of Liverpool and its servants or
agents shall not be responsible or in any way liable for the continued currency of
information in this publication whether arising from negligence or otherwise
howsoever or for any consequences arising therefrom. The University of Liverpool
expressly exclude liability for errors, omissions or inaccuracies to the fullest extent
permitted by law.

I nt er ac t i ons w i t h Pr ot ease I nhi bi t or s

Charts revi sed February 2014. Ful l i nformati on avai l abl e at www.hi v-drugi nteracti ons.org and www.hi v-drugi nteracti onsl i te.org Page 3 of 4
www. hi v - d r ug i nt e r a c t i o ns . o r g

A
T
V

D
R
V

F
P
V

I
D
V

L
P
V

N
F
V

R
T
V

S
Q
V

T
P
V

Anxiol ytics/Hypnotics/ Sedatives
Alprazolam
Bromazepam
Buspirone
Chlordiazepoxide
Clorazepate
Diazepam
Estazolam
Flunitrazepam
Flurazepam
Lorazepam
Lormetazepam
Midazolam (oral)
Midazolam (parenteral)
Oxazepam
Temazepam
Triazolam
Zaleplon
Zolpidem
Zopiclone
Beta Blockers
Atenolol
Bisoprolol
Carvedilol
Metoprolol
Propranolol
Timolol
Bronchodilator
Ipratropium bromide
Montelukast
Salbutamol
Salmeterol
Theophylline
Calcium Channel Blockers
Amlodipine
Diltiazem
Felodipine
Nicardipine
Nifedipine
Nisoldipine
Verapamil
Contraceptives/HRT
Desogestrel
Drospirenone
Dydrogesterone
Estradiol
Ethinylestradiol
Etonogestrel
Levonorgestrel
Medroxyprogesterone (IM depot injection)
Medroxyprogesterone (oral)
Norethisterone (Norethindrone)
Norgestimate
Ulipristal

A
T
V

D
R
V

F
P
V

I
D
V

L
P
V

N
F
V

R
T
V

S
Q
V

T
P
V

Cytotoxics
Asparginase
Bleomycin
Bortezomib
Caprecitabine
Carboplatin
Chlorambucil
Cisplatin
Cyclophosphamide
Cytarabine
Dacarbazine
Dactinomycin
Dasatinib
Daunorubicin
Docetaxel
Doxorubicin
Epirubicin
Erlotinib
Etoposide
Everolimus
Fluorouracil
Gefitinib
Gemcitabine
Ifosfamide
Imatinib
Irinotecan
Lapatinib
Mercaptopurine
Mesna
Methotrexate
Nilotinib
Oxaliplatin
Paclitaxel
Pazopanib
Procarbazine
Sorafenib
Sunitinib
Tamoxifen
Temsirolimus
Vinblastine
Vincristine
Erectile Dysfunctional Agents
Sildenafil (Erectile Dysfunction)
Tadalafil (Erectile Dysfunction)
Vardenafil
Gastrointestinal Agents
Aluminium hydroxide
Antacids
Cimetidine
Cisapride
Esomeprazole
Famotidine
Lansoprazole
Loperamide
Mesalazine
Omeprazole
Pantoprazole
Rabeprazole
Ranitidine
Senna
Gastrointestinal Agents (anti-emetics)
Domperidone
Dronabinol
Metoclopramide
Ondansetron
Prochlorperazine

Key to abbreviations
ATV Atazanavir (Reyataz

) LPV Lopinavir (Kaletra

)
DRV Darunavir (Prezista

) NFV Nelfinavir (Viracept

)
FPV
Fosamprenavir
(Telzir

, Lexiva

)
RTV Ritonavir (Norvir

)
SQV Saquinavir (Invirase

)
IDV Indinavir (Crixivan

) TPV Tipranavir (Aptivus

Key to symbols
Filled symbols indicate further information on the interaction is available at
www.hiv-druginteractions.org.
Empty symbols indicate the combination has not been studied; an
interaction has been predicted based on the metabolic profiles of the drugs.
/ These drugs should not be coadministered
/
Potential interaction may require close monitoring,
alteration of drug dosage or timing of administration
/ No clinically significant interaction expected
/
There are no clear data, actual or theoretical, to indicate
whether an interaction will occur
Where advice differs between countries, and/or between boosted and
unboosted regimens, the charts reflect the more cautious option.
Liverpool HIV Pharmacology Group, University of Liverpool
Pharmacology ResearchLabs, 1st Floor Block H, 70Pembroke Place, LIVERPOOL, L69 3GF
We aim to ensure that information is accurate and consistent with current
knowledge and practice. However, the University of Liverpool and its servants or
agents shall not be responsible or in any way liable for the continued currency of
information in this publication whether arising from negligence or otherwise
howsoever or for any consequences arising therefrom. The University of Liverpool
expressly exclude liability for errors, omissions or inaccuracies to the fullest extent
permitted by law.

I nt er ac t i ons w i t h Pr ot ease I nhi bi t or s

Charts revi sed February 2014. Ful l i nformati on avai l abl e at www.hi v-drugi nteracti ons.org and www.hi v-drugi nteracti onsl i te.org Page 4 of 4
www. hi v - d r ug i nt e r a c t i o ns . o r g

A
T
V

D
R
V

F
P
V

I
D
V

L
P
V

N
F
V

R
T
V

S
Q
V

T
P
V

Herbals/Supplements/Vitamins
Ascorbic Acid (Vitamin C)
Colecalciferol (vitamin D3)
Cyanocobalamin
Echinacea
Folic acid
Garlic
Ginkgo biloba
Grapefruit juice
Hops (Humulus lupulus)
Iodine
Milk thistle
Nicotinamide
Phytomenadione (vitamin K)
Pyridoxine (vitamin B6)
Quercetin
Retinol (vitamin A)
Riboflavin (vitamin B2)
Seville orange juice
St J ohn's Wort
Thiamine (vitamin B1)
Valerian
Vitamin E
Hypertension / Heart Failure Agents
Amiloride
Bendroflumethiazide
Bosentan
Candesartan
Chlortalidone
Cilazapril
Digoxin
Dopamine
Doxazosin
Enalapril
Furosemide
Hydralazine
Indapamide
Irbesartan
Isosorbide dintrate
Ivabradine
Lacidipine
Lercanidipine
Lisinopril
Losartan
Methyldopa
Olmesartan
Perindopril
Quinapril
Ramipril
Sildenafil (PAH)
Sodium nitroprusside
Spironolactone
Tadalafil (PAH)
Telmisartan
Torasemide
Trandolapril
Valsartan
Illicit/Recreational
Alcohol
Cocaine
Gamma-hydroxybutyrate
Marijuana
MDMA (Ecstasy)
Methamphetamine
Immune Modulators
Hydroxyurea (Hydroxycarbamide)
Interferon alpha
Interleukin 2 (Aldesleukin)
Peginterferon alfa-2a
Immunosuppressants
Azathioprine
Ciclosporin
Mycophenolate
Sirolimus
Tacrolimus

A
T
V

D
R
V

F
P
V

I
D
V

L
P
V

N
F
V

R
T
V

S
Q
V

T
P
V

Lipid Lowering Agents
Atorvastatin
Bezafibrate
Clofibrate
Ezetimibe
Fenofibrate
Fish oils
Fluvastatin
Gemfibrozil
Lovastatin
Pravastatin
Rosuvastatin
Simvastatin
Other
Acetazolamide
Adrenaline (Epinephrine)
Alendronic Acid
Alfuzosin
Allopurinol
Atropine
Biperiden
Caffeine citrate
Calcium
Clomifene
Colchicine
Disulfiram
Dutasteride
Ibandronic acid
Isotretinoin
Mannitol
Neostigmine
Nicorandil
Orlistat
Penicillamine
Pilocarpine
Potassium
Probenecid
Propylthiouracil
Protamine sulphate
Pyridostigmine
Sulfasalazine
Tamsulosin
Tolterodine
Tranexamic acid
Varenicline
Oxytocics
Ergometrine (Ergonovine)
Mifepristone
Misoprostol
Oxytocin
Parkinsonism Agents
Apomorphine
Benserazide
Carbidopa
Levodopa
Pramipexole
Steroids
Beclometasone
Budesonide
Dexamethasone
Fludrocortisone
Fluticasone
Hydrocortisone (oral)
Hydrocortisone (topical)
Megestrol acetate
Mometasone
Nandrolone
Oxandrolone
Prednisolone
Stanazolol
Testosterone
Triamcinolone