flu, small pox, HIV, polio, Ebola, rhinovirus, hepatitis, measles Can only reproduce inside cells Foreign nucleic acids (double stranded RNA, single stranded DNA, foreign methylation patterns), reduced antigen presentation by infected cells So viruses are usually recognized by something unusual in their nucleic acids.(Double RNA, normally, RNA is a single strain)
Reproduce intracellularly or extracellularly, depending on type Characteristic surface carbohydrates (peptidoglycan, mannose repeats), flagellar proteins (flagellin), lipids (lipotechoic acid) characteristic DNA methylation patterns Fungi
Candida (thrush) athletes foot, Cryptococcus, Ringworm(Dermatophytos is )
Eukaryotic, unicellular, multicellular or multinucleate Cell wall: zymosan ( 1-3 glucan) and chitin (cellulose with N-acetyl glucosamine instead of just glucose)
Primarily members of Platyhelminthe s (flatworms) and Nematoda (roundworms) Characteristic cell surface proteins
PAMPs (Pathogen Associated Molecular Patterns) Recognized by PRRs pattern recognition receptors Pathogen-associated molecular patterns, or PAMPs 1 , are molecules associated with groups of pathogens that are recognized by cells of the innate immune system. These molecules can be referred to as small molecular motifs 2
conserved within a class of microbes. They are recognized by Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs) in both plants and animals. PRR 3 s are proteins expressed by cells of the innate immune system to identify PAMPs 1. Proteins - So far, we have identified very few proteins that we recognize innately by their overall structure. The ones weve found are:
1 son pequeas secuencias de molculas encontradas en patgenos. 2 The smallestgroup of atoms in a polymer that, whenunder the influence of a rotation-translationoperator, will assemble the rest of the atoms in the chain. 3 son protenas presentes en las clulas del sistema inmunitario, comofagocitos, para identificar molculas asociadas con patgenos microbianos o estrs celular.
a. Flagellin bacteria b. profilin surface protein of protozoan (toxoplasmosis) 2. carbohydrates and glycopeptides a. zymosan component of fungal cell walls a vague term because it has not been exactly characterized. b. peptidoglycan 4 the cell wall component of both gram positive and gram negative bacteria, although gram positive have a much thicker wall. 3. lipids, especially attach to signature carbohydrates or peptides. 4. Nucleic acids a. DNA with specific methylation patterns - recall restriction endonucleases 5 . b. wrong strandedness single stranded DNA and double stranded RNA are usually signs of a potential threat. c. Mice can specifically recognize the 23s component of bacterial ribosomes. C. Categories of PRRs: Specific receptors bind to characteristic pathogen molecules. 1. Extracellular a. Lysozyme (mucus and tears) against peptidoglycans (figure 21) b. Psoriacin (skin) against E. coli. Can be induced by sunlight (UVB) via vitaminD. c. AMPS 6 defensive peptides that that typically kill by disrupting bacterial membranes. d. Mannose-binding lectin 7 (plasma) activates complement C-reactive protein (CRP) (plasma) also recognizes microbes and damaged self cells
4 El peptidoglucano es muy resistente y protege a las bacterias de una ruptura osmtica en ambientes acuticos y da a los tipos diferentes de bacterias sus formas. Granpositivas violetas, gramnegativas rojizas 5 es aquella que puede reconocer una secuencia caracterstica de nucletidos dentro de una molcula de ADN y cortar el ADN en ese punto en concreto, 6 2-Acrylamido-2-methylpropane sulfonic acid (AMPS 7 MBL recognizes carbohydrate patterns, found on the surface of a large number of pathogenic micro-organisms, including bacteria, viruses, protozoa andfungi. Binding of MBL to a micro- organism results in activation of the lectin pathway of the complement system.