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RECORD FORMAT
Chapter heading
Non-English title
Author name(s)
Abstract in English
1. GENERAL ASPECTS
306. Analysis of the kinetic isotope effects on initial rates in
transient kinetics - Palfey B.A. and Fagan R.L. [B.A. Palfey, Department of Biological Chemistry, University of Michigan Medical
School, 1301 Catherine Road, Ann Arbor, MI 48109-0606, United
States] - BIOCHEMISTRY 2006 45/45 (13631-13640) - summ in
ENGL
A method was described recently for circumventing the difculties in determining intrinsic kinetic isotope effects from eigenvalues
obtained in transient kinetic experiments (Maniscalco, Tally, and
Fisher (2004) Arch. Biochem. Biophys. 425, 165-172). The
method, based on the isotope effects on initial rates of formation of
intermediates, was validated by numerical simulation for only a few
linear reaction sequences. A general analytical proof of the validity
of the method is given in this work. The mathematical approach,
using rate laws and LH pitals rule, allows more complex reaction
o
schemes to be analyzed. Several are analyzed in this article, illustrating the broad applicability and possible complications in this
approach for determining intrinsic isotope effects. Some possible
applications are noted, with particular attention being paid to nonlinear reaction schemes, the effect of measuring signals rather than
concentration, and the ability to distinguish stepwise from concerted
reactions. 2006 American Chemical Society.
2. RADIOBIOLOGY
307. The development of cryoprobe nuclear magnetic resonance
spectroscopy for the rapid detection of organic contaminants in
potable water - Charlton A.J., Donarski J.A., Jones S.A. et al.
[A.J. Charlton, Department for Environment, Food and Rural Affairs, Central Science Laboratory, Sand Hutton, York, YO41 1LZ,
United Kingdom] - J. ENVIRON. MONIT. 2006 8/11 (1106-1110) summ in ENGL
The detection of trace levels of a range of organic contaminants
(including pesticides, toxins and an explosive) in potable water, using cryoprobe NMR spectroscopy with limited sample preparation
and rapid acquisition times, is described. Emphasis is placed on the
applicability of NMR spectroscopy for use in emergency scenarios
as the unbiased nature of the technique facilitates the detection and
characterization of unknown compounds at levels as low as 50 g
L-1 . The Royal Society of Chemistry 2006.
308. Ranges of 40 keV ions in polycrystalline tungsten and gold
- Santry D.C. [D.C. Santry, National Research Council of Canada,
Institute for National Measurement Standards, Ottawa, Ont., K1A
OR6, United States] - APPL. RADIAT. ISOT. 2006 64/12 (15281537) - summ in ENGL
Integral range proles for various 40 keV radioactive ions from
7 Be to 204 Tl were measured in tungsten and gold using sectioning techniques based on anodizing and stripping. Measured range
distributions exhibited long tails extending into the metals. Median
range values for a given ion were the same in tungsten as in gold, but
were about 1.7 times greater than calculations of projected ranges
based on the SRIM computer code. 2006 Elsevier Ltd. All rights
reserved.
309. Accreditation experience of radioisotope metrology laboratory of Argentina - Iglicki A., Mil M.I., Furnari J.C. et al.
a
[A. Iglicki, Laboratorio de Metrologa de Radiois topos, Comisi n
o
o
Nacional de Energa At mica, , Argentina] - APPL. RADIAT. ISOT.
o
2006 64/10-11 (1171-1173) - summ in ENGL
This work presents the experience developed by the Radioisotope
Metrology Laboratory (LMR), of the Argentine National Atomic
Energy Commission (CNEA), as result of the accreditation process of the Quality System by ISO 17025 Standard. Considering
the LMR as a calibration laboratory, services of secondary activity determinations and calibration of activimeters used in Nuclear
Medicine were accredited. A peer review of the ( / ) - coincidence system was also carried out. This work shows in detail
the structure of the quality system, the results of the accrediting
audit and gives the number of non-conformities detected and of
observations made which have all been resolved. 2006 Elsevier
Ltd. All rights reserved.
Section 23 vol 70.2
310. Radionuclide metrology in the life sciences: Recent advances and future trends - Zimmerman B.E. [B.E. Zimmerman,
Dosimetry and Medical Radiation Physics Section, Division of
Human Health, International Atomic Energy Agency, Wagramer
Strasse 5, Box 200, A-1400 Vienna, Austria] - APPL. RADIAT.
ISOT. 2006 64/10-11 (1351-1359) - summ in ENGL
This paper reviews activities in the eld of radionuclide metrology
applied to the life sciences between the years 2000 and 2005. The
requirements for accuracy and consistency in making radioactivity
measurements in radiation medicine, coupled with an increased
awareness of the role of measurement standards in quality assurance programmes, has prompted a great deal of research in this area.
During the past 5 years, particular emphasis has been on: (1) the development of primary standards for radionuclides, (2) development
of secondary/transfer standards, (3) development of radionuclide
standards for brachytherapy, and (4) inter-laboratory comparisons
at the end-user level. Activities carried out by National Metrology
Institutions in these areas are reviewed and a look at future trends
is presented. 2006 Elsevier Ltd. All rights reserved.
See also: 529, 540, 583.
to perform. A simplied method may be more appropriate especially from radiation safety point of view. More importantly, for
short-lived halogens, advantage may be gained utilizing a shorter
reaction time. Recently we reported on the radioiodination of interleukin-8 (IL-8) using the pyridine carboxylate-derived activated
ester. We have successfully conjugated this prosthetic group to
tri- and tetrapeptides harboring the somatostatin (SST) receptor
recognition units and characterized by HPLC and MS. The radioiodination was accomplished using the Iodogen method in a
reasonable yield (mean = 60 %). The total synthesis time was approximately 60 min, which was 3-4 times shorter than the classical
two-step method. Preliminary biodistribution of the radiolabeled
peptide showed uptake in some of the organs known to express SST
receptors. Injection of a low specic activity tracer signicantly
decreased the retention of radioactivity in these organs. 2005
Elsevier Ltd. All rights reserved.
321. Regression analysis for comparing protein samples with
labeled mass spectrometry - Eckel-Passow J.E., Oberg A.L., Therneau T.M. et al. [J.E. Eckel-Passow,
Division of Biostatistics, Mayo Clinic, 200 First Street SW,
Rochester, MN 55905, United States] - BIOINFORMATICS 2006
22/22 (2739-2745) - summ in ENGL
Motivation: Using stable isotopes in global proteome scans,
labeled molecules from one sample are pooled with unlabeled
molecules from another sample and subsequently subjected to massspectral analysis. Stable-isotope methodologies make use of the fact
that identical molecules of different stable-isotope compositions are
differentiated in a mass spectrometer and are represented in a mass
spectrum as distinct isotopic clusters with a known mass shift. We
describe two multivariable linear regression models for 16 O/18 O stable-isotope labeled data that jointly model pairs of resolved isotopic
clusters from the same peptide and quantify the abundance present
in each of the two biological samples while concurrently accounting for peptide-specic incorporation rates of the heavy isotope.
The abundance measure for each peptide from the two biological
samples is then used in down-stream statistical analyses, e.g. differential expression analysis. Because the multivariable regression
models are able to correct for the abundance of the labeled peptide
that appear as an unlabeled peptide due to the inability to exchange
the natural C-terminal oxygen for the heavy isotope, they are particularly advantageous for a two-step digestion/labeling procedure.
We discuss how estimates from the regression model are used to
quantify the variability of the estimated abundance measures for
the paired samples. Although discussed in the context of 16 O/18 O
stable-isotope labeled data, the multivariable regression models are
generalizable to other stable-isotope labeled technologies. 2006
Oxford University Press.
16 O/ 18 O stable-isotope
322. International guidance on the establishment of quality assurance programmes for radioactivity measurement in nuclear
medicine - Zimmerman B.E., Herbst C., Norenberg J.P. and Woods
M.J. [B.E. Zimmerman, Dosimetry and Medical Radiation Physics
Section, Division of Human Health, International Atomic Energy
Agency, Wagramer Strasse 5, P.O. Box 200, A-1400 Vienna, Austria] - APPL. RADIAT. ISOT. 2006 64/10-11 (1142-1146) - summ
in ENGL
A new guidance document for the implementation of quality
assurance (QA) programmes for nuclear medicine radioactivity measurement, produced by the International Atomic Energy
Agency, is described. The proposed programme is based on the
principles of ISO 17025 and will enable laboratories, particularly in
developing countries, to provide consistent, safe and effective radioactivity measurement services to the nuclear medicine community.
2006 Elsevier Ltd. All rights reserved.
323. Photon-photon coincidences for activity determination:
I-125 and other radionuclides - Schrader H. [H. Schrader,
Physikalisch-Technische Bundesanstalt, Bundesallee 100, 38116
Braunschweig, Germany] - APPL. RADIAT. ISOT. 2006 64/10-11
(1179-1185) - summ in ENGL
Theory and experiment of photon-photon coincidence counting
with distance variation for activity standardisation of radionuclide
solutions are described. The activity of an I-125 solution from
an international comparison organised by the BIPM in 2004 was
Section 23 vol 70.2
n
Metrologa de Radiaciones Ionizantes, CIEMAT, Avenida Com
plutense 22, 28040 Madrid, Spain] - APPL. RADIAT. ISOT. 2006
64/10-11 (1193-1197) - summ in ENGL
Efciency extrapolation is a common technique in the standardization of radionuclides by the technique of 4 - coincidences. It
can be achieved in two ways: adding thin lms onto the radioactive
source or by electronic discrimination in a pressurized 4 - system. The last case is the most extensively used actually in metrology
laboratories. There is a need to know the electron energy loss inside
the proportional counter as a function of the electron energies and
working pressures. Calculations of electron energy loss have been
performed for electron energies in a range from a few keV to 2 MeV
in a mixture of Ar(90%) CH4 (10%) and for pressures ranging from
100 to 2000 kPa in a 5 cm radius proportional counter. Wall effects,
such as electron backscattering, are included in the calculations.
Results are provided in the form of graphs and some recommendations are given about the optimal values of the energies that can
be used to perform the extrapolation in the standardization of some
radionuclides. 2006 Elsevier Ltd. All rights reserved.
326. Standardization of 18 F by coincidence and LSC methods
- Roteta M., Garca-Tora o E. and Rodrguez Barquero L. [E.
tes, CIEMAT, Avda. Complutense 22, 28040 Madrid, Spain] APPL. RADIAT. ISOT. 2006 64/10-11 (1199-1202) - summ in ENGL
The nuclide 18 F disintegrates to 18 O by + emission (96.86%)and electron capture (3.14%) with a half-life of 1.8288 h. It is
widely used in nuclear medicine for positron emission tomography
(PET). A radioactive solution of this nuclide has been standardized
by two techniques: coincidence measurements with a pressurized
proportional counter and liquid scintillation counting using the
CIEMAT/NIST method. One ampoule containing a solution calibrated in activity was sent for measurement at the International
Reference System maintained by the BIPM. Results are in excellent agreement with SIR values. 2006 Elsevier Ltd. All rights
reserved.
327. Standardization of tritiated water by two improved methods - Stanga D., Moreau I. and Cassette P. [D. Stanga, National
Institute of R and D for Physics and Nuclear Engineering Horia Hulubei IFIN-HH, P.O.Box MG-6, Bucharest-Magurele, R-077125,
Romania] - APPL. RADIAT. ISOT. 2006 64/10-11 (1203-1206) summ in ENGL
Tritiated water has been standardized in the framework of a
French-Romanian cooperation by two improved methods: liquid
65
344. Monte Carlo calculations of spectra and interaction probabilities for photons in liquid scintillators for use in the
standardization of radionuclides - Zimmerman B.E. [B.E.
Zimmerman, Dosimetry and Medical Radiation Physics Section,
Division of Human Health, International Atomic Energy Agency,
Wagramer Strasse 5, Box 200, A-1400 Vienna, Austria] - APPL.
RADIAT. ISOT. 2006 64/10-11 (1492-1498) - summ in ENGL
The probabilities for the interaction of photons, Pint , in three
different liquid scintillators (toluene, Ultima Gold, and Hionic
Fluor) were calculated as a function of energy for three different
geometries using the Monte Carlo codes PENELOPE and EGSnrcMP. The agreement in Pint values between the two codes in
all of the geometries and scintillators for energies above 100 keV
was within 0.5 %. The agreement was better than 4 % for
energies between 20 and 100 keV. No substantive differences in
the normalized absorbed energy spectra were observed for initial
photon energies in the range of 20-1000 keV. The inuence of scintillator composition on the simulation results was investigated in
the context of a possible conict in the published composition data
for Hionic Fluor. A difference in interaction probability of about
27% was observed at 20 keV when an alternate composition having
lower amounts of S and P is used. At 100 keV, the differences were
within the calculational uncertainties. 2006 Elsevier Ltd. All
rights reserved.
345. Implementation of the TDCR liquid scintillation method at
CNEA-LMR, Argentina - Arenillas P. and Cassette P. [P. Arenillas,
Laboratorio de Metrologa de Radiois topos, Comisi n Nacional de
o
o
Energa At mica, , Argentina] - APPL. RADIAT. ISOT. 2006 64/10
o
11 (1500-1504) - summ in ENGL
During the last two years, a triple-to-double coincidence ratio
(TDCR) system was assembled and adjusted at the CNEA-LMR,
Argentina. The new counting system will add complementary capabilities to the absolute measurements section of the CNEA-LMR.
This work describes its implementation and validation. Several
checks and a set of beta-emitting standard solutions were used
in order to perform the validation experiments. In preliminary
measurements, a 3 H LNHB solution with reference activity concentration of (119.7 0.9) kBq/g on 11 November 2003 was used.
The CNEA-LMR TDCR counter gave, at the same reference date,
an activity concentration of (120 1) kBq/g. Results and improvements are presented in detail. Concerning the asymmetry of the
system, the quantum efciency of the three photomultiplier tubes
was studied for different operating conditions of the focusing voltage. The counter also includes an automatic system to change the
efciency by defocusing the photomultipliers and on the other hand,
it was coupled to a HPGe detector to also measure beta-gamma
coincidences. 2006 Elsevier Ltd. All rights reserved.
346. The IFIN-HH triple coincidence liquid scintillation counter
- Razdolescu A.C., Broda R., Cassette P. et al. [A.C. Razdolescu,
National Institute of R and D for Physics and Nuclear Engineering
Horia Hulubei- IFIN-HH, Atomistilor str. 407, Bucharest, Romania] - APPL. RADIAT. ISOT. 2006 64/10-11 (1510-1514) - summ in
ENGL
The paper summarizes the IFIN-HH triple coincidence liquid
scintillation counter used for the implementation of the TDCR
method. The electronic unit was recently extended to record the
three individual double coincidence ratios to take into account the
differences in the quantum efciencies of the three-photomultiplier
tubes. Some details of the electronic system and the data processing are given. The critical point of a TDCR counter is to adjust
correctly the discriminator levels on the three channels under the
single electron peak. The paper describes the method of adjustment
based on the evolution of the dark counting rate versus the discriminator level. Also indicated is the inuence of the discrimination
level on the activity results as measured at IFIN-HH using a 3 H
standard. The performances of the IFIN-HH TDCR counter was
checked against the measurement results of the TDCR counters of
CSIR NML (South Africa), RC (Poland) and LNHB (France). A
set of ready-to-measure 63 Ni sources in liquid scintillator, in sealed
counting vials, was prepared and dispatched for measurement to
all these laboratories. The paper describes designs of the TDCR
counters used. An analysis and discussion of the measurement
results is given. 2006 Elsevier Ltd. All rights reserved.
68
347. A low-level activation technique for monitoring thermonuclear fusion plasma conditions - Gasparro J., Hult M., Bonheure
G. and Johnston P.N. [M. Hult, EC-JRC-IRMM, Institute for Reference Materials and Measurements, Retieseweg 111, B-2440 Geel,
Belgium] - APPL. RADIAT. ISOT. 2006 64/10-11 (1130-1135) summ in ENGL
Optimisation of the connement and sustainability of a thermonuclear plasma requires methods to monitor processes in the plasma.
In this work three materials were used as activation targets (Ti,
MgF2 and a TiVAl compound). They were placed inside the joint
European Torus (JET) vacuum chamber. Certain gamma-ray emitting radionuclides (7 Be, 54 Mn, 56 Co, 57 Co, 58 Co and 46 Sc) were
measured using ultra low-level gamma-ray spectrometry in an underground laboratory 1-2 months after activation. They were found
to arise from neutron activation of bulk sample material and surface contaminants sputtered from other Tokamak parts. Decision
thresholds for some activation products were determined in order
to aid in giving upper bounds for the ux of charged particles.
2006 Elsevier Ltd. All rights reserved.
348. Response calculation for standard ionization chambers in
the APMP using EGS4 Monte Carlo code - Sato Y., Yunoki A.,
Hino Y. and Yamada T. [Y. Sato, National Metrology Institute of
Japan, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 2, 1-1-1, Umezono, Ibaraki, 305-8568,
Japan] - APPL. RADIAT. ISOT. 2006 64/10-11 (1211-1214) - summ
in ENGL
In the APMP radioactivity group (TCRI), a series of intercomparisons were conducted between member laboratories, with the aim to
improve the calibration of ionization chambers used as secondary
standards for radioactivity measurement. Several sources were sent
to the participating institutes and the measurement results of calibration factors have been compared. Good agreement between
laboratories was found for radioisotopes where the major contribution to the ionization current stems from high-energy gamma rays.
It was expected in this energy region that these ratios would become
unity for any type of chamber by normalizing with the same type
of reference sources. However, where the dominating contribution
to the measured ionization current is due to the presence of low-energy gamma rays, there were some serious discrepancies between
participating institutes. In order to understand these differences,
Monte Carlo simulation has been utilized by studying the effects of
changing the wall thickness of the re-entrant well, the materials of
the sample holder and the composition of the ionizing gas. 2006
Elsevier Ltd. All rights reserved.
349. Standardization of 152 Eu and 154 Eu by 4 -4
coincidence method and 4 ( + ) integral counting - Yamada T.,
Nakamura Y., Kawada Y. et al. [T. Yamada, Japan Radioisotope
Association, 2-28-45, Hon-komagome, Bunkyo, Tokyo, 113-8941,
Japan] - APPL. RADIAT. ISOT. 2006 64/10-11 (1220-1224) - summ
in ENGL
The 4 -4 coincidence counting and 4 ( + ) integral counting techniques were applied for the standardization of 152 Eu and
154 Eu. In these techniques, the -detector is composed of two thin
plastic scintillators sandwiching the source coupled with a slender
photomultiplier tube. This -detector was inserted into a large
well-type NaI(Tl) scintillation detector for -ray detection, making
a 4 -4
detector conguration. The results obtained by the
above two techniques were in good agreement and consistent with
the results of international comparisons. 2006 Elsevier Ltd. All
rights reserved.
350. Primary standardization of 72 Ga - Koskinas M.F., Moreira
D.S., Takeda M.N. et al. [M.F. Koskinas, Instituto de Pesquisas
Energ ticas e Nucleares (IPEN-CNEN/SP), Centro do Reator de
e
Pesquisas - CRPq, C.P. 11049, Pinheiros, 05422-970 Sao Paulo,
SP, Brazil] - APPL. RADIAT. ISOT. 2006 64/10-11 (1225-1228) summ in ENGL
The activity of 72 Ga sources produced by irradiation at the IEAR1 reactor have been performed in a 4
- coincidence system
by using the extrapolation technique. The measurements were undertaken selecting two windows in the -channel, in order to check
the consistency of the results. A Monte Carlo calculation was
Section 23 vol 70.2
Fe Ni, Cu, Zn, As, Br, Rb, Sr, Zr and Hg have been determined using
emission transmission method with Mo target. K, Ca and Fe were
detected in all samples and their concentrations ranged from 0.352.88%, 0.346-8.65% and 0.007-36.7%, respectively. Maximum
concentration measured in other elements ranged from 0.006% to
40.7%. The multi element and non-destructive nature of the method
offers a simple way to establish the quality of the drugs that contain
heavy metals in considerable concentration. 2006 Akad miai
e
Kiad .
o
359. Complex formation of uranium(VI) with 4-hydroxy-3methoxybenzoic acid and related compounds - Vulpius D.,
Geipel G., Baraniak L. et al. [D. Vulpius, Forschungszentrum
Rossendorf, Institute of Radiochemistry, P.O. Box 510119, D-01314
Dresden, Germany] - J. RADIOANAL. NUCL. CHEM. 2006 270/3
(661-667) - summ in ENGL
The complex formation of uranium(VI) with 4-hydroxy-3-methoxybenzoic acid as well as with benzoic acid and 4-hydroxybenzoic
acid was studied. In aqueous solution weak carboxylic 1 : 1
complexes, are formed in which the carboxyl group is bidentately coordinated to the metal atom. The logarithmic stability
constants of these complexes regarding the reaction of the uranyl ion with the single charged anion of the respective ligands are
2.78 0.02, 2.68 0.04, and 2.71 0.04 at an ionic strength of 0.1
mol/l (NaClO4 ) and at 25C. Bis(4-hydroxy-3-methoxybenzoato)dioxouranium(VI) was obtained as a crystalline compound if the
concentrations of the starting components for the synthesis are increased. The monoclinic compound has a reections-rich X-ray
powder diffraction pattern. The lattice constants are a = 13.662(9)
e
o
3111(2) A.3 2006 Akad miai Kiad .
360. Emergent magnetic moments produced by self-damage in
plutonium - McCall S.K., Fluss M.J., Chung B.W. et al. [S.K. McCall, Lawrence Livermore National Laboratory, 7000 East Avenue,
Livermore, CA 94550, United States] - PROC. NATL. ACAD. SCI.
U. S. A. 2006 103/46 (17179-17183) - summ in ENGL
Plutonium possesses the most complicated phase diagram in the
periodic table, driven by the complexities of overlapping 5f electron
orbitals. Despite the importance of the 5f electrons in dening the
structure and physical properties, there is no experimental evidence
that these electrons localize to form magnetic moments in pure
Pu. Instead, a large temperature-independent Pauli susceptibility indicates that they form narrow conduction bands. Radiation
damage from the -particle decay of Pu creates numerous defects
in the crystal structure, which produce a signicant temperaturedependent magnetic susceptibility, (T), in both -Pu and -Pu
(stabilized by 4.3 atomic percent Ga). This effect can be removed
by thermal annealing above room temperature. By contrast, below 35 K the radiation damage is frozen in place, permitting the
evolution in (T) with increasing damage to be studied systematically. This result leads to a two-component model consisting of
a Curie-Weiss term and a short-ranged interaction term consistent
with disorder-induced local moment models. Thus, it is shown
that self-damage creates localized magnetic moments in previously
nonmagnetic plutonium.
361. Standardisation of 54 Mn and 65 Zn using a software coincidence counting system - Havelka M., Auerbach P. and Sochorov J.
a
[M. Havelka, Czech Metrology Institute, Inspectorate for Ionizing
Radiation, Radiov 1, 102 00 Prague, Czech Republic] - APPL.
a
RADIAT. ISOT. 2006 64/10-11 (1215-1219) - summ in ENGL
The activities of 54 Mn and 65 Zn have been determined by 4 (PC)coincidence counting, with efciency variation performed by the
conventional method of altering the self-absorption in the sources
as well as by the computer discrimination method. The standardisation of 65 Zn presents some complications requiring optimisation
of the -ray energy window settings to achieve a linear efciencyextrapolation curve. Determination of these optimal settings by the
conventional coincidence method is a tedious task. These difculties have been reduced by the utilisation of a software coincidence
counting system that records time and amplitude information of
individual pulses from coincidence measurements, where the coincidence parameters are set after the data collection process has
70
10 and 15 ml. The calculation was done for two different cocktails:
toluene and a widely used commercial cocktail, Ultima Gold . The
paper describes the results obtained by nine participants using a total
of 12 calculation codes. 2006 Elsevier Ltd. All rights reserved.
365. Synergic quenching effects of water and carbon tetrachloride in liquid scintillation gel samples - Grau Carles A. [A. Grau
Carles, IMAFF, CSIC, C/ Serrano 113b, 28006 Madrid, Spain]
- APPL. RADIAT. ISOT. 2006 64/10-11 (1505-1509) - summ in
ENGL
Although both water and carbon tetrachloride induce chemical
quenching when incorporated to Insta Gel, the quenching power
of carbon tetrachloride is nearly two orders of magnitude greater
than that of water. This huge difference shows how different the
chemical quenching mechanisms among quenchers can be. One
remarkable fact of all pure -ray nuclides is that calibration curves
do not depend on the water to scintillator volume ratio or on the
nature of the quencher. The fact is clearly surprising, because two
tritium samples of different water to scintillator and quencher to
scintillator volume ratios may have identical counting efciencies.
As we shall prove, this fact is only possible when the external quench
parameter of both samples is the same. We study the synergies in
quenching generated when carbon tetrachloride is added to a sample
in gel phase. 2006 Elsevier Ltd. All rights reserved.
366. Computational aspects in modelling the interaction of lowenergy X-rays with liquid scintillators - Grau Carles A. and
Grau Malonda A. [A. Grau Carles, IMAFF, CSIC, C/ Serrano
113b, 28006 Madrid, Spain] - APPL. RADIAT. ISOT. 2006 64/10-11
(1515-1519) - summ in ENGL
The commercial liquid scintillators available nowadays are
mostly complex cocktails that frequently include non-negligible
amounts of heavier elements than the commonly expected carbon
or hydrogen. In May 1993, nine laboratories agreed to participate
in the frame of the EUROMET project in a comparison of the activity concentration measurement of 55 Fe. One particular aspect of
the results that caught ones eye was a small systematic difference
between the activity concentrations obtained with Ultima GoldTM
and Insta Gel. The detection of the radiation emitted by EC nuclides involves, in addition to the atomic rearrangement generated
by the capture of the electron by the nucleus, a frequently ignored
secondary atomic rearrangement process due to photoionization.
Such a process can be neglected for scintillators that only contain
hydrogen and carbon, e.g., toluene, but must be taken into account
when the EC nuclide solution is incorporated to cocktails with heavier elements, e.g., Ultima GoldTM . All along the present year, an
improved version of the program EMI has been developed. This
code adds the photoionization reduced energy correction to the previous versions, and successfully explains the systematic difference
between the measured activity concentrations of 55 Fe in Ultima
GoldTM and Insta Gel. 2006 Elsevier Ltd. All rights reserved.
367. Implementation of a national metrology network of radionuclides used in nuclear medicine - dos Santos J.A., Iwahara
A., Ncoli I.G. et al. [J.A. dos Santos, Coordenacao de Instalacoes
Radiativas (CORAD)/Comissao Nacional de Energia Nuclear (CNEN), Rua General Severiano 90, Botafogo, CEP 22290-040 RJ,
Brazil] - APPL. RADIAT. ISOT. 2006 64/10-11 (1114-1118) - summ
in ENGL
The Nuclear Medicine Services (NMS) in Brazil routinely use
dose calibrators to measure the activity of solutions containing radiopharmaceuticals. These solutions are administered to patients
with the intention to diagnose or treat illnesses. However, for
optimal results, the activity of these radiopharmaceuticals must be
determined as accurately as possible. The National Laboratory for
Ionizing Radiation Metrology (LNMRI) led, since 1998, a comparison program for activity measurements of radiopharmaceuticals
administered to patients in the NMS with the purpose promoting
quality control. This program has been carried out successfully in
Rio de Janeiro, but there is a need to implement it around the country. This can be resolved through the implementation of a network
of regional laboratories at various locations throughout the national
territory. Currently, such a network is active at a second site, located
in Braslia, covering the needs of the Center-West Region, and at a
third site, located in Porto Alegre, in the South Region. This work
Section 23 vol 70.2
369. Radiopharmaceutical management of 90 Y/111 in labeled antibodies: Shielding and quantication during preparation and
administration - Van Hemert F.J., Sloof G.W., Schimmel K.J.M.
et al. [Dr. F.J. Van Hemert, Department of Nuclear Medicine,
Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam,
Netherlands] - ANN. NUCL. MED. 2006 20/8 (575-581) - summ in
ENGL
Background: The combined application of potent -emitting isotopes for therapy with -emitting isotopes for scintigraphy requires
a profound regimen concerning team member safety and radionuclide quantication. Methods: We have developed materials
and methods for a proper and easy manipulation of 90 Y during
preparation and administration of 90 Y/ 111 In pharmaceuticals used
for radioimmunotherapy. Results: The efcacy of the shielding
measures is documented. Protocols for the calibration of -dose
calibrators with respect to 90 Y are extended to the assessment of
quench-corrected liquid scintillation counting of 90 Y. The contribution of 90 Y backscatter to 111 In counting is quantied. Newly
developed shielding equipment allows an adequate administration
of relatively large volumes (100 ml) of 90 Y/ 111 In labeled pharmaceuticals to patients. Conclusions: The procedures described
combine pharmaceutical (Good Manufacturing Practice) and radiation safety requirements with an accurate logging of relevant data.
See also: 379, 393, 397, 398, 399, 407, 410, 412, 413, 419, 420,
421, 422, 423, 424, 426, 428, 430, 445, 458, 488, 489, 525, 528,
530, 587.
2.2. Radiation hygiene
370. Assessment of errors caused by X-ray scatter and use
of contrast medium when using CT-based attenuation correction in PET - Ay M.R. and Zaidi H. [H. Zaidi, Division of
Nuclear Medicine, Geneva University Hospital, 1211 Geneva 4,
Switzerland] - EUR. J. NUCL. MED. MOL. IMAGING 2006 33/11
(1301-1313) - summ in ENGL
Purpose: Quantitative image reconstruction in positron emission
tomography (PET) requires an accurate attenuation map of the object under study for the purpose of attenuation correction. Current
dual-modality PET/CT systems offer signicant advantages over
stand-alone PET, including decreased overall scanning time and increased accuracy in lesion localisation and detectability. However,
the contamination of CT data with scattered radiation and misclassication of contrast medium with high-density bone in CT-based
attenuation correction (CTAC) are known to generate artefacts in
71
the attenuation map and thus the resulting PET images. The purpose
of this work was to quantitatively measure the impact of scattered
radiation and contrast medium on the accuracy of CTAC. Methods:
Our recently developed MCNP4C-based Monte Carlo X-ray CT
simulator for modelling both fan- and cone-beam CT scanners and
the Eidolon dedicated 3D PET Monte Carlo simulator were used to
generate realigned PET/CT data sets. The impact of X-ray scattered
radiation on the accuracy of CTAC was investigated through simulation of a uniform cylindrical water phantom for both a commercial
fan-beam multi-slice and a prototype cone-beam at panel detectorbased CT scanner. The inuence of contrast medium was studied by
simulation of a cylindrical phantom containing different concentrations of contrast medium. Moreover, an experimental study using an
anthropomorphic striatal phantom was conducted for quantitative
evaluation of errors arising from the presence of contrast medium by
calculating the apparent recovery coefcient (ARC) in the presence
of different concentrations of contrast medium. Results: The analysis of attenuation correction factors (ACFs) for the simulated
cylindrical water phantom in both fan- and cone-beam CT scanners
showed that the contamination of CT data with scattered radiation
in the absence of scatter removal causes underestimation of the true
ACFs, namely by 7.3% and 28.2% in the centre for the two geometries, respectively. The ARC was 190.7% for a cylindrical volume
of interest located in the main chamber of the striatal phantom containing contrast medium corresponding to 2,000 Hounseld units,
whereas the ARC was overestimated by less than 5% for the main
chamber and by 2% for the left/right putamen and caudate nucleus
compared with the absence of contrast medium. Conclusion: Without X-ray scatter compensation, the visual artefacts and quantitative
errors in at panel detector-based cone-beam geometry are substantial and propagate cupping artefacts to PET images during CTAC.
Likewise, contrast-enhanced CT images may create considerable
artefacts during CTAC in regions containing high concentrations of
contrast medium. 2006 Springer-Verlag.
See also: 396.
e
of Marine Sediment IAEA-433 are included. 2006 Akad miai
Kiad .
o
373. Elemental analysis of leaves and extracts of Casearia
medicinal plants by instrumental neutron activation analysis
- Yamashita C.I., Saiki M. and Serti J.A.A. [C.I. Yamashita, Neue
tron Activation Analysis Laboratory, IPEN-CNEN/SP, Av. Prof.
Lineu Prestes 2242, 05508-000 S o Paulo, Brazil] - J. RADIOANAL.
a
NUCL. CHEM. 2006 270/1 (181-186) - summ in ENGL
Instrumental neutron activation analysis (ESIAA) was applied to
determine the inorganic composition of leaves and extracts from
three different species of Casearia genus plant (C. sylvestris, C. decandra and C. obliqua). Statistical analysis of the analytical data of
leaf showed that the three Casearia species present similar elemental
composition. Extract from C. sylvestris showed signicantly different inorganic content in comparison with the two other species.
Certied reference material NIST SRM-1515 Apple Leaves was
analyzed for quality control. 2006 Akad miai Kiad .
e
o
374. Short irradiation instrumental neutron activation analysis
of essential and trace elements in curry leaves (Murraya Koenigii) and their organic constituents by GC-MS - Choudhury
R.P., Jain G. and Garg A.N. [R.P. Choudhury, Department of Chemistry, Indian Institute of Technology, Roorkee, 247 667, India] J. RADIOANAL. NUCL. CHEM. 2006 270/1 (187-195) - summ in
ENGL
Fourteen samples of fresh curry leaves (Murraya Koenigii) were
collected from 13 states of India and analyzed for 6 minor (Ca,
Cl, K, Mg, Na and P) and 14 trace (Br, Ce, Co, Cr, Cs, Fe, Hg,
Mn, Rb, Sb, Sc, Se Th and Zn) elements by 2-minute irradiation
in a reactor followed by high resolution -ray spectrometry. Peach
Leaves (SRM-1547) and Mixed Polish Herbs (MPH-2) were used
as comparator standards. Phosphorus was determined by counting
the -activity from 32 P using an end-window GM counter. Most
elements were found to vary in a wide range depending on their
origin of location, e.g., Na (104-455 g/g), K (10.3-30.3 mg/g), Ca
(9.44-28.3 mg/g), Mg (1.14-7.19 mg/g), P (0.43-1.69 mg/g), Mn
(24.8-63.0 /g), Fe (72.5-195 g/g), Se (40.1-131 ng/g) and Zn
(7.90-70.5 g/g). Variation in the elemental concentrations of the
same species of different origin may be attributed to ecological and
geographical variations. Further, column and thin layer chromatography were used for separating three organic constituents from
the ethanolic extract; 3-methylthiopropanenitrile; 1,2-benzenedicarboxylic acid, mono (2-ethylhexyl ester) and 1-penten-3-ol and
characterized by IR and GC-MS. Inorganic elements may be present
as complexes with the organic compounds. 2006 Akad miai
e
Kiad .
o
375. Analysis of the chemical elements in leaves infected by
fumagina by X-ray uorescence technique - Blonski M.S., Appoloni C.R., Parreira P.S. et al. [M.S. Blonski, State University
of Londrina, Center of Exact Sciences, Department of Physics,
C.P. 6001, 86051-990 Londrina, Brazil] - J. RADIOANAL. NUCL.
CHEM. 2006 270/1 (197-201) - summ in ENGL
Energy dispersion X-ray uorescence technique (EDXRF) was
employed to study the effects of the fumagina disease through the
elementary chemical composition of leaves. The experimental setup
consisted of a Mo X-ray tube (K = 17.44 keV) with Zr lter and
a Si(Li) detector. The measurements were performed with infected
and healthy leaves of citric plants. The elements Ti, Mn, Fe, Cu and
Zn were quantied. For all the elements of interest the measured
detection limit was at the order of g g -1 . 2006 Akad miai
e
Kiad .
o
376. Differences between elemental composition of orange juices
and leaves from organic and conventional production systems
- Turra C., Fernandes E.A.N., Bacchi M.A. et al. [C. Turra, Universidade de S o Paulo, Centro de Energia Nuclear na Agricultura,
a
Caixa Postal 96, 13400-970 Piracicaba, Brazil] - J. RADIOANAL.
NUCL. CHEM. 2006 270/1 (203-208) - summ in ENGL
A comprehensive sampling of organic and conventional oranges
was carried out in Bebedouro, an important citrus producing region of Brazil. The soils, leaves and fruits of the variety Valencia
(Citrus sinensis [L.] Osbeck) budded on Rangpur lime (Citrus limonia Osbeck) were analyzed. The chemical characterization was
Section 23 vol 70.2
with previous production methods conrms that our results are superior to other reports published to date. 2005 Elsevier Ltd. All
rights reserved.
380. In vivo quantitation of intratumoral radioisotope uptake
using micro-single photon emission computed tomography/computed tomography - Carlson S.K., Classic K.L., Hadac E.M.
et al. [Dr. S.K. Carlson, Department of Radiology, Mayo Clinic,
200 First Street SW, Rochester, MN 559005, United States] - MOL.
IMAGING BIOL. 2006 8/6 (324-332) - summ in ENGL
Purpose: This study was undertaken to determine the ability
of micro-single photon emission computed tomography (micro-SPECT)/computed tomography (CT) to accurately quantitate
intratumoral radioisotope uptake in vivo and to compare these measurements with planar imaging and micro-SPECT imaging alone.
Procedures: Human pancreatic cancer xenografts were established
in 10 mice. Intratumoral radioisotope uptake was achieved via intratumoral injection of an attenuated measles virus vector expressing
the NIS gene (MV-NIS). On various days after MV-NIS injection, 123 I planar and micro-SPECT/CT imaging was performed.
Tumor activity was determined by dose calibrator measurements
and region-of-interest (ROI) image analysis. Agreement and reproducibility of tumor activity measurements were assessed by
Bland-Altman plots and Lins concordance correlation coefcient
(CCC). Results: Intratumoral radioisotope uptake was detected in
all mice. Scatterplots demonstrate strong agreement (CCC=0.93)between micro-SPECT/ CT ROI image analysis and dose calibrator
tumor activity measurements. The differences between dose calibrator activity measurements and those obtained with ROI image
analysis of micro-SPECT alone and planar imaging are less accurate
and more variable (CCC=0.84 and 0.78, respectively). Conclusions:
Micro-SPECT/CT can be used to accurately quantify intratumoral
radioisotope uptake in vivo and is more reliable than planar or
micro-SPECT imaging alone. Academy of Molecular Imaging
2006.
381. 99m Tc-Sestamibi, A sensitive probe for In Vivo imaging of
P-Glycoprotein inhibition by modulators and mdr1 antisense
oligodeoxynucleotides - Jekerle V., Wang J.-H., Scollard D.A. et
al. [M. Piquette-Miller, Department of Pharmaceutical Sciences,
University of Toronto, 144 College St., Toronto, ON M5S 3M2,
Canada] - MOL. IMAGING BIOL. 2006 8/6 (333-339) - summ in
ENGL
Purpose: We tested the suitability of 99m Tc-sestamibi to image
the inhibition of P-glycoprotein (Pgp)-mediated multidrug resistance in tumor cells and xenografts after antisense treatment and/
or inhibition with a novel Pgp modulator WK-X-34. Procedure:
Pgp inhibition was measured by daunorubicin transport assays and
uorescence microscopy in resistant A2780/Adr cells treated with
WK-X-34 and antisense. A2780/Adr xenograft mice were dosed
with mdr1 antisense oligodeoxynucleotides intratumorally for three
days; next, mice were treated with WK-X-34, followed by 99m Tcsestamibi injection. Mice were imaged, sacriced, and tissues
collected. Images and isolated tissues were analyzed for 99 Tc distribution. Pgp expression was analyzed by immunouorescence
and reverse transcription-polymerase chain reaction. Results: Both
WK-X-34 and mdr1 antisense treatments signicantly inhibited Pgp
activity in vitro and in xenografts. Biodistribution results correlated with results from the 99m Tc-sestamibi images. Mdr1 mRNA
and Pgp were signicantly down-regulated by antisense treatments.
Conclusions: 99m Tc-sestamibi is a sensitive probe to monitor Pgp
inhibition by different mechanisms in vivo in tumor xenografts.
Academy of Molecular Imaging 2006.
382. Current status of alpha-particle spectrometry - Garca
Tora o E. [E. Garca-Tora o, Laboratorio de Metrologa de
n
386. Exercise acutely increases renal transit time of Tc-99m mercaptoacetyltriglycine (MAG3) in a post-liver transplant patient
- Murthy R., Chahal M., Appel G. et al. [Dr. R. Van Heertum,
Department of Radiology, New York-Presbyterian Hospital, Harkness Pavillion, 180 Fort Washington Avenue, New York, NY 10032,
United States] - CLIN. NUCL. MED. 2006 31/12 (829-834) - summ
in ENGL
This case demonstrates the effect of exercise on the clearance
of Tc-99m MAG3 in a patient with renal insufciency status postliver transplant. Even after furosemide administration, the tracer
was retained in the kidneys after exercise. This is in contrast to
normal clearance demonstrated on a baseline study performed 3
days previously. 2006 Lippincott Williams & Wilkins, Inc.
388. Reducing renal uptake of 90 Y- and 177 Lu-labeled alphamelanocyte stimulating hormone peptide analogues - Miao
Y., Fisher D.R. and Quinn T.P. [Y. Miao, Department of Internal
Medicine, University of Missouri-Columbia, Columbia, MO 65211,
United States] - NUCL. MED. BIOL. 2006 33/6 (723-733) - summ
in ENGL
Objective: The purpose of this study was to improve the
tumor-to-kidney uptake ratios of 90 Y- and 177 Lu-[1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-Re-Cys3,4,10 , d-Phe7 ,
Arg11 ] -melanocyte stimulating hormone3-13 fDOTA-Re(Arg11)CCMSHg through coupling a negatively charged glutamic acid
(Glu) to the peptide sequence. Methods: A new peptide
of DOTA-Re(Glu2 , Arg11 )CCMSH was designed, synthesized
and labeled with 90 Y and 177 Lu. Pharmacokinetics of 90 Yand 177 Lu-DOTA-Re(Glu2, Arg11 )CCMSH was determined in
B16/F1 murine melanoma-bearing C57 mice. Results: 90 Yand 177 Lu-DOTA-Re(Glu2, Arg11 )CCMSH exhibited signicantly
(P<.05) less renal uptake values than 90 Y- and 177 Lu-DOTARe(Arg11 )CCMSH at 30 min and at 2, 4 and 24 h after dose
administration. The renal uptake values of 90 Y- and 177 Lu-DOTARe(Glu2 , Arg11 )CCMSH were 28.16% and 28.81% of those of
90 Y- and 177 Lu-DOTA-Re(Arg11)CCMSH, respectively, at 4 h
postinjection. 90 Y- and 177 Lu-DOTA-Re(Glu2, Arg11 )CCMSH
displayed higher tumor-to-kidney uptake ratios than 90 Y- and 177 LuDOTA-Re(Arg11)CCMSH at 30 min and at 2, 4 and 24 h after
dose administration. The tumor-to-kidney uptake ratio of 90 Y- and
177 Lu-DOTA-Re(Glu2, Arg11 )CCMSH was 2.28 and 1.69 times
of 90 Y- and 177 Lu-DOTA-Re(Arg11)CCMSH, respectively, at 4 h
postinjection. The 90 Y- and 177 Lu-DOTA-Re(Glu2, Arg11 )CCMSH
activity accumulation was low in normal organs except for kidney.
Conclusions: Coupling a negatively charged amino acid (Glu) to
the CCMSH peptide sequence dramatically reduced the renal uptake
values and increased the tumor-to-kidney uptake ratios of 90 Y- and
177 Lu-DOTA-Re(Glu2, Arg11 )CCMSH, facilitating their potential
applications as radiopharmaceuticals for targeted radionuclide therapy of melanoma. 2006 Elsevier Inc. All rights reserved.
See also: 401, 431, 435, 441, 446, 451, 460, 461, 462, 466, 468,
469, 474, 475, 477, 479, 482, 489, 491, 496, 503, 504, 513, 516,
517, 518, 520, 525, 539, 541, 542, 543, 547, 548, 553, 560, 562,
563, 564, 566, 575, 586, 591, 596, 598, 602, 603.
389. The apparent positive cooperativity of in vivo [3 H]PK11195 binding in mouse brosarcoma - Momosaki S., Hosoi R.,
Takai N. et al. [S. Momosaki, Course of Allied Health Sciences,
74
Graduate School of Medicine, Osaka University, Suita, Osaka, 5650871, Japan] - NUCL. MED. BIOL. 2006 33/6 (797-800) - summ in
ENGL
To evaluate the binding properties of peripheral benzodiazepine
receptor (PBR) in mouse brosarcoma, [3 H]PK-11195 binding, in
vitro and in vivo, was investigated using either tissue dissection
or autoradiographic method. The binding characteristics in brosarcoma were compared with those in the kidney. The results of
an in vitro saturation study revealed that the maximal numbers of
PBR binding sites (Bmax ) in brosarcoma and in the kidney were
almost the same (kidney: 5.2 pmol/mg protein; brosarcoma: 5.0
pmol/mg protein). On the other hand, the binding afnity (Kd ) in
brosarcoma was lower than that in the kidney (kidney: 0.45 nM;
brosarcoma: 1.34 nM). It is noteworthy that the in vivo binding
of [3 H]PK-11195 in brosarcoma increased with increasing doses
of [3 H]PK-11195 (in the dose range of 0.03-1 mg/kg), whereas that
in the kidney decreased with competitive inhibition. The apparent
positive cooperativity of [3 H]PK-11195 binding in brosarcoma
was only observed under in vivo conditions and might be possibly
related to the incoordination of PBR subunits. 2006 Elsevier Inc.
All rights reserved.
390. Natural radioactivity traces in South-Brazilian cereal ours
by gamma-ray spectrometry - Scheibel V., Appoloni C.R. and
Schechter H. [V. Scheibel, Department of Physics, State University of Londrina, CCE, C.P.6001, 86051-990 Londrina, Brazil] J. RADIOANAL. NUCL. CHEM. 2006 270/1 (163-165) - summ in
ENGL
Cereal ours are the major component of the Brazilian diet and are
also important exportation products. Radioactivity concentrations
of 232 Th, 226 Ra, 40 K and 137 Cs were determined in commercial samples of South-Brazilian cereal ours (soy, wheat, corn, manioc, rye
and oat our) to verify the radiological security of these foodstuffs.
The measurements were carried out by gamma-ray spectrometry
using a 66% relative efciency HPGe detector. The 40 K our activities, at 95% of condence level were in: soy 474 3 Bq kg-1 ;
corn 30.0 0.3 Bq kg-1 ; rye 94 1 Bq kg-1 ; manioc 67 1 Bq kg-1 ;
oat 76 1 Bq kg-1 and wheat 36.2 0.4 Bq kg-1 . The lower limit
of detection for 40 K ranged from 0.54 to 1.43 Bq kg-1 . The 137 Cs
activities in our samples were: soy 0.07 Bq kg-1 , corn 0.01
Bq kg-1 , oat 0.03 Bq kg-1 and in wheat, manioc and rye 0.02
Bq kg-1 . The highest concentrations levels of 232 Th and 226 Ra
were 0.69 0.04 Bq kg-1 and 0.44 0.03 Bq kg-1 , respectively, in
soy our. 2006 Akad miai Kiad .
e
o
391. Analysis of beers from Brazil with synchrotron radiation
total reection X-ray uorescence - Moreira S., Vives A.E.S.,
Zucchi O.L.A.D. et al. [S. Moreira, State University of Campinas,
FEC/UNICAMP, P. O. Box 6021, 13083-852 Campinas, Brazil] J. RADIOANAL. NUCL. CHEM. 2006 270/1 (167-171) - summ in
ENGL
In this study the concentrations of P, S, Cl, K, Ca, Mn, Fe, Zn
and Br in twenty-nine brands of national and international beers
were determined by synchrotron radiation total reection X-ray
uorescence analysis (SR-TXRF). The results were compared with
the limits established by the Brazilian legislation and the nutritional
values established by National Agricultural Library (NAL, USA). The measurements were performed at the X-Ray Fluorescence
Beamline at Brazilian National Synchrotron Light Laboratory, in
Campinas, S o Paulo, Brazil, using a polychromatic beam for exa
citation. A small volume of 5 l of beers containing an internal
standard used to correct geometry effects was analyzed without pretreatment. The measuring time was 100 seconds and the detection
limits obtained varied from 1 g l -1 for Mn and Fe to 15 g l-1 for
e
o
P. 2006 Akad miai Kiad .
392. The role of emission tomography in pharmacokinetic and
pharmacodynamic studies in clinical psychopharmacology Malizia A.L. [A.L. Malizia, Psychopharmacology Unit, University
of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1
3NY, United Kingdom] - J. PSYCHOPHARMACOL. 2006 20/4
SUPPL. (100-107) - summ in ENGL
Position Emission Tomography (PET) and Single Photon Emission Tomography (SPECT) can be used for both pharmacokinetic
and pharmacodynamic measures in vivo in man. As such they have
Section 23 vol 70.2
a wide range of applications including description of neurochemical changes in disease, occupancy, brain effects of medicines and
discovery and validation of biomarkers. The power of these tools
is in their chemical specicity and sensitivity, and in the ability to
describe processes in vivo, thus documenting the effects of genetic
and environmental interactions. The future of these technologies
is dependent on an investment in bringing out and validating new
radiotracers. 2006 British Association for Psychopharmacology.
393. Preparation of 18 F labeled amino acid O-(2-[18 F] uoroethyl)-L-tyrosine using indirect and direct labeling methods Wang M., Yin D., Cheng D. et al. [M. Wang, Radiopharmaceutical
Centre, Shanghai Institute of Applied Physics, Chinese Academy
of Sciences, Shanghai 201800, China] - J. RADIOANAL. NUCL.
CHEM. 2006 270/2 (439-443) - summ in ENGL
18 F-labeled amino acid O-(2-[18 F]uoroethyl)-L- tyrosine ([18 F]FET) has been used as an in vivo positron emission tomography
(PET) tracer for tumor metabolitic imaging. Here, the synthesis
of [18 F]FET using two different methods is reported. The rst
Method (I) for the [18 F]FET synthesis was an indirect labeling
route, which was a two-step reaction consisting of uorination of
1,2-bis(tosyloxy)ethane and uoroalkylation of unprotected L-tyrosine. The second Method (II) was a direct labeling route which was
the direct nucleophilic radiouorination of the protected precursor
N-BOC-(O-(2-tosyloxyethyl))-L-tyrosine methyl ester, followed by
a rapid removal of the protecting group. For the rst method, the
radiochemical yield was about 45% at the end of synthesis (EOS),
and the radiochemical purity was over 97%. The radiochemical
yield in the second method was 40% (EOS) on an average, and the
radiochemical purity was over 96%. Microwave heating was also
introduced into the synthesis of [18 F]FET. For Method I, each of
two steps could be completed within 2-3 minutes under microwave
conditions and the radiochemical yields were 85% and 95%, respectively, which was reasonably high and reproducible. For Method II,
the highest labeling efciency in the radiouorinated step was 37%
in the synthesis time of 3 minutes under microwave conditions.
2006 Akad miai Kiad .
e
o
394. Scintigraphic imaging of P-glycoprotein expression with
a radiolabelled antibody - Van Eerd J.E.M., De Geus-Oei L.F., Oyen W.J.G. et al. [J.E.M. Van Eerd, Department of Nuclear
Medicine, Radboud University Nijmegen Medical Centre, P.O. Box
9101, 6500 HB Nijmegen, Netherlands] - EUR. J. NUCL. MED.
MOL. IMAGING 2006 33/11 (1266-1272) - summ in ENGL
Purpose: P-glycoprotein (P-gp) is a membrane efux pump protein that is involved in multidrug resistance (MDR). Tumour cells
with high P-gp expression show poor response to cancer treatment
with several chemotherapeutics. In vivo targeting and visualisation
of P-gp expression would allow MDR to be evaluated non-invasively prior to treatment. The aim of this study was to investigate
the feasibility of visualising P-gp expression in tumours using a
monoclonal anti-P-gp antibody, 15D3. Methods: Nude BALB/c
mice with subcutaneously growing human uterine sarcoma cell tumours with either high (MES-SA/D 5 1977) or low (MES-SA
1976) P-gp expression were used. When tumours were 0.2-0.4 g,
mice received 131 I-15D3 or 111 In-DTPA-15D3 monoclonal anti-Pgp antibody intravenously. Images were acquired up to 3 days p.i.
and radioactivity concentration in various tissues was determined after euthanisation of the animals. Results: The images demonstrated
that radioactivity accumulated to a higher concentration in high P-gp
expressing tumours than in the low P-gp expressing MES-SA 1976
tumour. Furthermore, visualisation of the P-gp expressing tumours
was superior with 111 In-DTPA-15D3 than with 131 I-15D3. After
injection of 111 In-DTPA-15D3, the high P-gp expressing MESSA/D 5 1977 tumours were clearly visualised at 3 days p.i. The
biodistribution data indicated that radioactivity concentration in the
high P-gp expressing tumours was higher than in the tumours with
low P-gp expression (20.78 1.42 %ID/g for MES-SA/Dx5 1977
tumours and 8.39 3.78 %ID/g for MES-SA 1976 tumours for
111 In-DTPA-15D3). Conclusion: The 111 In-labelled monoclonal
anti-P-gp antibody clearly visualised P-gp expression in a human
uterine sarcoma tumour in nude mice. 2006 Springer-Verlag.
395. Risk assessment in liposarcoma patients based on FDG PET
imaging - Brenner W., Eary J.F., Hwang W. et al. [W. Brenner,
75
Department of Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany] EUR. J. NUCL. MED. MOL. IMAGING 2006 33/11 (1290-1295) summ in ENGL
Purpose: Tumor grade and subtype are considered standard parameters for risk assessment in patients with liposarcoma. The
aim of this study was to assess the clinical value of [18 F]uorodeoxyglucose (FDG) PET-derived maximum standardized uptake
value (SUVmax ) for prediction of outcome in liposarcoma patients.
Methods: 18 F-FDG PET was performed in 54 patients with liposarcoma prior to therapy. SUVmax was calculated for each tumor
and results were correlated with tumor grade, subtype, and relapsefree survival. Results: SUVmax ranged from 0.4 to 15.9 (mean
3.6) and was signicantly lower in grade I than in grade II and
grade III tumors. SUVmax was 2.3 1.7, 3.5 1.5, 4.8 2.5, and
5.6 5.8 in well-differentiated, myxoid/round cell, dedifferentiated,
and pleomorphic subtypes, respectively. Borderline differences
(p=0.059) were found between tumor SUVmax in patients with and
without relapse. Using a SUV of 3.6 as cut-off, the accuracy in
predicting a relapse was 75%. Tumor grade yielded a lower accuracy for predicting relapse (50%), as did tumor subtype (35%). In
Kaplan-Meier survival analysis, patients with a SUVmax >3.6 had
a signicantly shorter disease-free survival of 21 months compared
with 44 months in patients with a SUV max 3.6. Tumor grading
and tumor subtype did not yield signicant differences. Conclusion: Pretherapy tumor SUV obtained by FDG PET imaging was
a more useful parameter for risk assessment in liposarcoma than
tumor grade or subtype. A SUVmax of more than 3.6 resulted in
a signicantly reduced disease-free survival and identied patients
at high risk for developing early local recurrences or metastatic
disease. 2006 Springer-Verlag.
396. Radiation protection in radionuclide therapies with 90 Yconjugates: Risks and safety - Cremonesi M., Ferrari M.,
Paganelli G. et al. [G. Paganelli, Division of Nuclear Medicine,
European Institute of Oncology, via Ripamonti, 435, 20141 Milan,
Italy] - EUR. J. NUCL. MED. MOL. IMAGING 2006 33/11 (13211327) - summ in ENGL
Purpose: The widespread interest in 90 Y internal radionuclide
treatments has drawn attention to the issue of radiation protection
for staff. Our aim in this study was to identify personnel at risk
and to validate the protection devices used. Methods: 90 Y-MoAb
(Zevalin, 15 cases, 1.1 GBq/patient) and 90 Y-peptide (90 Y-DOTATOC) systemic (i.v., 50 cases, 3.0 GBq/patient) and locoregional
(l.r., 50 cases, 0.4 GBq/patient) treatments were considered. Radiolabelling was carried out in a dedicated hot cell. Tele-tongs, shielded
(PMMA: polymethylmethacrylate) syringes/vials and an automatic
dose fractionating system were used. Operators wore anti-X-ray
and anti-contamination gloves, with TLD dosimeters placed over
the ngertips. For i.v. administration, activity was administered by
a dedicated system; for l.r. administration, during activity infusion
in the brain cavity, tongs were used and TLDs were placed over the
ngertips. The air kerma-rate was measured around the patients.
Results: The use of devices provided a 75% dose reduction, with
mean ngertip doses of 2.9 mGy (i.v. MoAbs), 0.6 mGy (i.v. peptides)/ radiolabelling procedure and 0.5 mGy/l.r. administration.
The mean effective dose to personnel was 5 Sv/patient. The air
kerma-rate around the patients administered i.v. 90 Y-peptides were
3.5 (1 h) and 1.0 (48 h) Gy/h at 1 m. Patient hospitalisation
of 6 h (l.r.)/48 h (i.v.) guaranteed that the recommended limits
of 3 mSv/year to family members and 0.3 mSv/year to the general population (Council Directive 97/43/Euratom) were respected.
Conclusions: When specic procedures are adopted, a substantial
improvement in 90 Y manipulation is attainable, reducing doses and
increasing safety. For the widespread clinical use of 90 Y-conjugates,
a completely automatic labelling procedure is desirable. 2006
Springer-Verlag.
397. Preparation and evaluation of 89 Zr-Zevalin for monitoring
of 90 Y-Zevalin biodistribution with positron emission tomography - Perk L.R., Visser O.J., Stigter-Van Walsum M. et al.
[G.A.M.S. Van Dongen, Department of Otolaryngology/Head and
Neck Surgery, VU University Medical Centre, De Boelelaan 1117,
1007 MB, Amsterdam, Netherlands] - EUR. J. NUCL. MED. MOL.
IMAGING 2006 33/11 (1337-1345) - summ in ENGL
76
columns are described. A highly efcient trap for [11 C]HCN is presented. The whole radiosynthesis is automated, takes about 45 min
and leads to more than 80% decay corrected overall radiochemical
yield of each enantiomer (up to 2.5 GBq) with over 99% radiochemical, chemical and enantiomeric purity. The specic activity at the
end of the synthesis is about 400 GBq/ mol. 2006 Elsevier Ltd.
All rights reserved.
400. Use of PET for evaluation of treatment response in oncology
(Fren) - PLACE ACTUELLE DE LA TEP DANS LEVALUATION DES TRAITEMENTS EN ONCOLOGIE - Bourguet P. [P. Bourguet, D partement
e
dimagerie m dicale, centre Eug` ne-Marquis, rue Bataille-dese
e
Flandres-Dunkerque, 35042 Rennes cedex, France] - CANCER
RADIOTHER. 2006 10/6-7 (334-337) - summ in FREN, ENGL
18 FDG -PET is now usually included in the treatment strategy,
for the staging or the diagnosis of recurrence. In lymphoma, PET
is well documented for evaluation of tumour response. For solid
tumours, despite good published results, the accuracy of PET has
to be conrmed by large series of patients. A good interpretation of
PET needs a SUV analysis. New radiotraceurs of the nuclear synthesis could certainly improve the accuracy of response evaluation
by PET. 2006 Elsevier Masson SAS. All rights reserved.
401. Amplication strategies in MR imaging: Activation and
accumulation of sensing contrast agents (SCAs) - Querol M.
and Bogdanov Jr. A. [Dr. A. Bogdanov Jr., Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave.
North, Worcester, MA 01655, United States] - J. MAGN. RESON.
IMAGING 2006 24/5 (971-982) - summ in ENGL
We review new strategies for the development of Gd3+ -based T1relaxation agents and paramagnetic chemical exchange saturation
transfer (PARACEST) "sensing" contrast agents (SCAs) designed
specically to detect small molecules or enzymatic activity in living systems. The rst class of agents exhibits molecular "sensing"
properties as a result of water coordination sphere effects, cleavage, or synthesis of reactive precursor compounds that recombine
with macromolecules with the resultant formation of immobilized
or rotationally constrained paramagnetic cations. This effect results in changes of water proton relaxation times. The second class
(PARACEST) comprises a family of lanthanide-based paramagnetic
compounds suitable for CEST imaging. The need for both types
of MR agents is justied by efforts to utilize magnetic resonance
imaging (MRI) to visualize ne structures in living tissue, and to
increase the molecular specicity of MRI. 2006 Wiley-Liss, Inc.
402. Can administration of metoclopramide reduce artefacts
related to abdominal activity in myocardial perfusion SPECT?
- Gr ning T., Brogsitter C., Khonsari M. et al. [Dr. T. Gr ning, Deu
u
partment of Nuclear Medicine, Derriford Hospital, Plymouth PL6
8DH, United Kingdom] - NUCL. MED. COMMUN. 2006 27/12
(953-957) - summ in ENGL
OBJECTIVES: Myocardial perfusion SPECT is frequently affected by artefacts related to abdominal activity. Metoclopramide
has been suggested to relieve this, but two previous studies
have shown conicting results. METHODS: Ninety-ve patients
received 10 mg metoclopramide orally after injection of Tc-tetrofosmin for the stress scan and 86 patients had metoclopramide
after their rest injection. A control group of 82 patients did not
receive metoclopramide. Scans were evaluated visually by three
readers. RESULTS: Metoclopramide given before the stress scan
led to abdominal activity being visually better in 16 scans, worse
in 10, and unchanged in 67 scans, compared to the same patients
rest scan without metoclopramide administration. Metoclopramide
administered before the rest scan resulted in abdominal activity in 11
scans being visually better, in 19 worse, and 53 scans were deemed
unchanged. These differences were not signicant. The number of
repeat stress or rest scans was not signicantly different between patients who had received metoclopramide and those who had not. The
administration of metoclopramide, irrespective of whether it was
given before the stress or rest scan, made no signicant difference
to inferior wall-to-abdomen count ratio. CONCLUSION: Neither
qualitative nor quantitative analysis showed an effect of metoclopramide on abdominal activity in myocardial perfusion SPECT.
2006 Lippincott Williams & Wilkins, Inc.
Section 23 vol 70.2
447,
471,
494,
513,
537,
561,
601,
448,
472,
495,
514,
538,
565,
604,
449,
473,
496,
515,
544,
568,
605,
450,
476,
497,
519,
545,
570,
606,
4. TREATMENT
427. A 99m Tc-labeled gemcitabine bisphosphonate drug conjugate as a probe to assess the potential for targeted chemotherapy
of metastatic bone cancer - El-Mabhouh A.A., Angelov C.A.,
Cavell R. and Mercer J.R. [J.R. Mercer, Faculty of Pharmacy and
Pharmaceutical Sciences, University of Alberta, Edmonton, Alta.
T6G 2N8, Canada] - NUCL. MED. BIOL. 2006 33/6 (715-722) summ in ENGL
Introduction: A novel compound with the potential for "targeted"
therapy for cancer patients was prepared using a conjugate between
the potent anticancer drug Gemzar (gemcitabine) and a bisphosphonate. This conjugate would be expected to accumulate at sites of
bone metastatic cancer by virtue of an afnity of the bisphosphonate for bone undergoing osteoclastic and osteoblastic remodeling.
Release of the anticancer drug at the site of the tumor would provide
high local concentrations of the drug but avoid systemic toxicity.
Methods: The conjugate was tested for bone binding by labeling
81
Serratia marcescens as a specic radiotracer for the detection of invasive fungal infections. Methods. CBP21 was labeled with 99m Tc
via hydrazinonicotinamide (HYNIC) and its characteristics were
analyzed. In vitro binding studies with polymorphic chitin forms
and microorganisms (fungi as well as bacteria) were performed. In
vivo biodistribution of the compound was studied in immunocompromised mice with bacterial and fungal infections in the left and
right thigh muscle, respectively, using 99m Tc-HYNIC-myoglobin as
size-matched control and 67 Ga-citrate as positive control. Scintigraphic images were acquired at 1 and 7 h postinjection of the tracer.
Results. 99m Tc-HYNIC-CBP21 was labeled with a radiochemical
yield of 61% and a specic activity of 22.3 MBq/nmol. Highest in
vitro binding percentages were found with -chitin (86.8 2.4%).
Binding interactions to fungi were higher than to bacteria (P<0.05).
In vivo, best ratios of fungal infection versus bacterial infection were
seen at 5 and 7 h (3.6 1.2 and 2.9 1.4, respectively) postinjection
of the tracer. Maximum uptake of the tracer in fungal infections
(0.63 0.11%ID/g) at 7 h was signicantly (P<0.05) higher than
uptake seen in bacterial infections (0.34 0.11%ID/g) or the uptake of 99m Tc-HYNIC-myoglobin (P<0.05) in the same infections
(0.35 0.11%ID/g, respectively, 0.3 0.01%ID/g). Conclusion.
This study shows that 99m Tc-HYNIC-CBP21 is able to specically
interact with chitin in vitro. Scintigraphy and postmortem in vivo
data indicate that 99m Tc-HYNIC-CBP21 is able to distinguish fungal infection from bacterial infection probably due to a specic
interaction of the protein with the chitin in the fungal cell wall.
433. Treatment of infection with radiolabeled antibodies - Dadachova E. and Casadevall A. [Dr. E. Dadachova, Department of
Nuclear Medicine, Albert Einstein College of Medicine, 1695A
Eastchester Rd., Bronx, NY 10461, United States] - Q. J. NUCL.
MED. MOL. IMAGING 2006 50/3 (193-204) - summ in ENGL
The eld of infectious diseases is in urgent need of new approaches to antimicrobial therapy. Radio-immunotherapy (RIT) has
evolved into successful therapy for certain malignancies. Published
preclinical and clinical investigations have demonstrated that radiolabeled microorganism-specic antibodies localize to tissue sites
of bacterial and fungal infection. The potential of RIT as an antimicrobial treatment strategy has not been developed clinically,
which could reect lack of awareness of the difcult problems
in clinical infectious diseases by the nuclear medicine community
and of RIT by the infectious diseases physicians. We have recently demonstrated the feasibility of using RIT for treating murine
cryptococcosis using a monoclonal antibody to Crypto-coccus neoformans capsular glocuronoxylomannan labeled with Bismuth-213
or Rhenium-188. Subsequently, we showed the applicability of
RIT to bacterial (Strepto-coccus pneumonia) and viral (HIV-1)infections. Treatment did not cause aqute hematologic toxicity
in treated animals. The mechanisms of RIT of infection include
killing of microbial cells by "direct hit" and "cross-re" effects,
promotion of apoptosis-like death, cooperation with macrophages
and modulation of the inammatory response. RIT for infection
is theoretically useful for any microbe susceptible to radiation, including bacteria, fungi, viruses and parasites. The promise of this
technique is based on the fact that the technology is largely in place
and that the only requirements are availability of microbe-specic
monoclonal antibodies and suitable radionuclides. In fact, one could
anticipate that targeting microbes will be easier than targeting neoplastic cells when the enormous antigenic differences between host
and microbes are taken into consideration. However, considerable
basic work remains to be done to ascertain the optimal conditions
for the efcacy of RIT for infection.
434. Stem cells: A regenerative pharmaceutical - Shanthly N.,
Aruva M.R., Zhang K. et al. [Dr. M.L. Thakur, Radiopharmacological Division, Department of Radiology, Thomas Jefferson
University, 1020 Locust Street, Philadelphia, PA 19107, United
States] - Q. J. NUCL. MED. MOL. IMAGING 2006 50/3 (205-216) summ in ENGL
Stem cells (SC), found in both adult and fetal tissues, are selfrenewing elements that can generate the various cell types in the
body. There are 3 classes of SC: totipotent, multipotent, and pluripotent. The SC with a signicant developmental potential are
the embryonic stem (ES) cells, which are derived from the early
stages of mammalian embryo. SC possess regenerative properties
Section 23 vol 70.2
DEMISSION DE POSITONS EN MEDECINE INTERNE : APPLICATIONS ACTUELLES ET PERSPECTIVES DAVENIR - Raynaud F.-R., Huglo D. and
15.6 3.9, P < 0.01) (AD-progressive) while the rest of the patients
were cognitively more stable (MMSE score = 25.6 3.1 to 25.9
3.7) (AD-stable) compared with baseline. A positive correlation
(P = 0.001) was observed in the parietal cortex between Rey Auditory Verbal Learning (RAVL) test score and rCMRGlc at follow-up
while a negative correlation (P = 0.018) was observed between
RAVL test and PIB retention in the parietal at follow-up. Relatively
stable PIB retention after 2 years of follow-up in patients with mild
Alzheimers disease suggests that amyloid deposition in the brain
reaches a plateau by the early clinical stages of Alzheimers disease
and therefore may precede a decline in rCMRGlc and cognition. It
appears that anti-amyloid therapies will need to induce a signicant
decrease in amyloid load in order for PIB PET images to detect
a drug effect in Alzheimer patients. FDG imaging may be able
to detect a stabilization of cerebral metabolism caused by therapy
administered to patients with a clinical diagnosis of Alzheimers
disease. The Author (2006). Published by Oxford University
Press on behalf of the Guarantors of Brain. All rights reserved.
448. Neuroimaging in late-life depression - Vaishnavi S. and
Taylor W.D. [S. Vaishnavi, Behavioral Neurology and Neuropsychiatry Fellowship Hopkins Hospital, 550 N. Broadway, Baltimore,
MD 21205, United States] - INT. REV. PSYCHIATRY 2006 18/5
(443-451) - summ in ENGL
Late-life depression may be associated with vasculopathy. Neuroimaging has been a critical tool in exploring the relationship between
this form of depression and vascular factors. Magnetic resonance
imaging has been the most widely used tool, but there is potential
to use other structural imaging techniques as well as functional
neuroimaging methodologies. Neuroimaging may potentially be
utilized at some point as a biomarker for late-life depression, thus
helping with diagnosis and guiding treatment. 2006 Informa UK
Ltd.
449. Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: A positron emission
tomography imaging study with [11 C]WAY 100635 - Frankle
W.G., Lombardo I., Kegeles L.S. et al. [W.G. Frankle, Departments
of Psychiatry and Radiology, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, United States]
- PSYCHOPHARMACOLOGY 2006 189/2 (155-164) - summ in
ENGL
Background: Postmortem and positron emission tomography
(PET) studies have reported several alterations in serotonin 1A receptor (5-HT1A ) binding parameters in patients with schizophrenia.
This study examines 5-HT 1A availability in vivo in individuals with
schizophrenia and schizo-affective disorder. Materials and methods: Twenty-two medication-free individuals with schizophrenia
or schizo-affective disorder and 18 healthy subjects underwent PET
scans with [11 C]WAY 100635. Regional distribution volumes (V T ,
in milliliters per gram) were derived using a two-tissue compartment
kinetic model. Outcome measures for 5-HT 1A availability included
binding potential (BP) and the specic to nonspecic equilibrium
partition coefcient (V 3 ). Eleven brain regions with high density
of 5-HT1A were included in the analysis. Results: No signicant
differences were observed in regional BP or V 3 between patients
and controls. No signicant relationships were observed between
regional 5-HT1A availability and symptom severity. Conclusion:
The postmortem literature reports increased 5-HT 1A binding in the
prefrontal cortex in schizophrenia. This study did not detect differences in 5-HT1A binding. Whereas in two recently published PET
studies, one reports increased binding in the temporal lobe while
the other reports decreased binding in the amygdala. These inconsistencies suggest that the alterations demonstrated in postmortem
studies cannot be reliably detected at the resolution achieved with
PET. This raises the question as to whether major changes in the
level of expression of the 5-HT1A receptor play a role in the pathophysiology of schizophrenia. 2006 Springer-Verlag.
450. Spect measurements of regional cerebral perfusion and
carbondioxide reactivity: Correlation with cerebral collaterals
in internal carotid artery occlusive disease - De Boorder M.J.,
Van Der Grond J., Van Dongen A.J. et al. [Dr. J. Hendrikse, Dept.
of Radiology (Hp E 01.132), University Medical Center Utrecht,
Section 23 vol 70.2
and 14 individually matched patient volunteers diagnosed with MDDwere recruited via advertisement and through outpatient clinics.
Interventions: Sustained neutral and sadness states, randomized and
counterbalanced in order, elicited by the cued recall of an autobiographical event associated with that emotion. Following imaging
procedures, patients underwent a 10-week course of treatment with
20 to 40 mg of uoxetine hydrochloride. Main Outcome Measures:
Changes in -opioid receptor BP during neutral and sustained sadness states, negative and positive affect ratings, plasma cortisol and
corticotropin levels, and clinical response to antidepressant administration. Results: The sustained sadness condition was associated
with a statistically signicant decrease in -opioid receptor BP in
the left inferior temporal cortex of patients with MDD and correlated with negative affect ratings experienced during the condition.
Conversely, a signicant increase in -opioid receptor BP was observed in healthy control subjects in the rostral region of the anterior
cingulate. In this region, a signicant decrease in -opioid receptor
BP during sadness was observed in patients with MDD who did not
respond to antidepressant treatment. Comparisons between patients
with MDD and controls showed signicantly lower neutral-state opioid receptor BP in patients with MDD in the posterior thalamus,
correlating with corticotropin and cortisol plasma levels. Larger
reductions in -opioid system BP during sadness were obtained
in patients with MDD in the anterior insular cortex, anterior and
posterior thalamus, ventral basal ganglia, amygdala, and periamygdalar cortex. The same challenge elicited larger increases in the
BP measure in the control group in the anterior cingulate, ventral
basal ganglia, hypothalamus, amygdala, and periamygdalar cortex.
Conclusions: The results demonstrate differences between women
with MDD and control women in -opioid receptor availability
during a neutral state, as well as opposite responses of this neurotransmitter system during the experimental induction of a sustained
sadness state. These data demonstrate that endogenous opioid neurotransmission on -opioid receptors, a system implicated in stress
responses and emotional regulation, is altered in patients diagnosed
with MDD. 2006 American Medical Association. All rights reserved.
457. Elevated monoamine oxidase A levels in the brain: An
explanation for the monoamine imbalance of major depression
- Meyer J.H., Ginovart N., Boovariwala A. et al. [Dr. J.H. Meyer,
College Street Site, Centre for Addiction and Mental Health, PET
Centre, 250 College St, Toronto, Ont. M5T 1R8, Canada] - ARCH.
GEN. PSYCHIATRY 2006 63/11 (1209-1216) - summ in ENGL
Context: The monoamine theory of depression proposes that
monoamine levels are lowered, but there is no explanation for how
monoamine loss occurs. Monoamine oxidase A (MAO-A) is an
enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine. Objective: To determine whether MAO-A
levels in the brain are elevated during untreated depression. Setting:
Tertiary care psychiatric hospital. Patients: Seventeen healthy and
17 depressed individuals with major depressive disorder that met
entry criteria were recruited from the care of general practitioners
and psychiatrists. All study participants were otherwise healthy
and nonsmoking. Depressed individuals had been medication free
for at least 5 months. Main Outcome Measure: Harmine labeled
with carbon 11, a radioligand selective for MAO-A and positron
emission tomography, was used to measure MAO-A DVS (specic distribution volume), an index of MAO-A density, in different
brain regions (prefrontal cortex, anterior cingulate cortex, posterior
cingulate cortex, caudate, putamen, thalamus, anterior temporal
cortex, midbrain, hippocampus, and parahippocampus). Results:
The MAO-A DVS was highly signicantly elevated in every brain
region assessed (t test; P = .001 to 3 10 -7 ). The MAO-A DVS was
elevated on average by 34% (2 SDs) throughout the brain during major depression. Conclusions: The sizable magnitude of this nding
and the absence of other compelling explanations for monoamine
loss during major depressive episodes led to the conclusion that elevated MAO-A density is the primary monoamine-lowering process
during major depression. 2006 American Medical Association.
All rights reserved.
458. LINAC radiosurgery for intracranial cavernous malformation: 10-year experience - Huang Y.-C., Tseng C.-K., Chang
C.-N. et al. [P.-W. Hsu, Department of Neurosurgery, Chang Gung
Section 23 vol 70.2
u
M., Shaw M. et al. [B.J. Harrison, Melbourne Neuropsychiatry
Centre, Department of Psychiatry, The University of Melbourne,
, Australia] - PSYCHIATRY RES. NEUROIMAGING 2006 148/1
(23-31) - summ in ENGL
Reports of abnormal activation of the dorsolateral prefrontal cortex (dlPFC) are common in functional neuroimaging studies of
schizophrenia, although very few have examined brain activity in
patients close to the onset of illness. In this H15 O PET study, eight
2
young male patients with rst-episode schizophreniform psychosis
and age-matched control subjects performed a version of the Stroop
task that we have previously shown to engage the middle-frontal
gyrus. At the time of testing, patients were antipsychotic-nave
and were scanned within 1 week of initial contact with our clinical
program. All patients received a later diagnosis of schizophrenia 6
months after participating in the study. Whole-brain (within-group)and region-of-interest (between-group) analyses were carried out
and data underwent spatial reproducibility testing. Compared with
healthy subjects, patients showed signicantly greater reaction-time
(RT) interference but normal RT accuracy on the Stroop task. This
pattern correlated with signicant under-activation of the posterior
left middle-frontal gyri in the patient versus control group. These
Section 23 vol 70.2
causes of CP, the number of patients has remained essentially unchanged and the pathophysiological mechanisms related to motor
dysfunction remain poorly understood. In this study, statistical parametric mapping (SPM) analysis of cerebral gamma-aminobutyric
acid (GABA) receptor PET imaging using [18 F]-uoroumazenil
showed increased GABAA receptor binding in the bilateral motor and visual cortices in spastic diplegia (SD) type CP patients
(n = 20) compared with normal controls (n = 10). As GABAA
receptor signaling modulates biological perception and production
of movement, complex motor skills and use-dependent plasticity in
the motor cortex, increased GABAA receptor binding in the motor
cortex might play a important role in poor motor control. Decreased
GABAA receptor binding was seen in the brain stem in SD CP patients, which appears to be related to spastic symptom. 2006
Elsevier Inc. All rights reserved.
473. Variations in the human pain stress experience mediated by
ventral and dorsal basal ganglia dopamine activity - Scott D.J.,
Heitzeg M.M., Koeppe R.A. et al. [Dr. J.-K. Zubieta, University
of Michigan, Molecular and Behavioral Neuroscience Institute, 205
Zina Pitcher Place, Ann Arbor, MI 48109-0720, United States] - J.
NEUROSCI. 2006 26/42 (10789-10795) - summ in ENGL
In addition to its involvement in motor control and in encoding
reward value, increasing evidence also implicates basal ganglia dopaminergic mechanisms in responses to stress and aversive stimuli.
Basal ganglia dopamine (DA) neurotransmission may then respond
to environmental events depending on their saliency, orienting the
subsequent responses of the organism to both positive and negative
stimuli. Here we examined the involvement of DA neurotransmission in the human response to pain, a robust physical and emotional
stressor across species. Positron emission tomography with the DA
D2 receptor antagonist radiotracer [11 C]raclopride detected significant activation of DA release in dorsal and ventral regions of the
basal ganglia of healthy volunteers. Activation of nigrostriatal
(dorsal nucleus caudate and putamen) DA D2 receptor-mediated
neurotransmission was positively associated with individual variations in subjective ratings of sensory and affective qualities of the
pain. In contrast, mesolimbic (nucleus accumbens) DA activation,
which may impact on both D2 and D3 receptors, was exclusively
associated with variations in the emotional responses of the individual during the pain challenge (increases in negative affect and
fear ratings). These data demonstrate that basal ganglia dopamine
D2 receptor-mediated neurotransmission is involved in responses to
pain and that it contributes to individual variations in the pain experience at the levels of physical and emotional elements, albeit with
different neuroanatomical substrates. Copyright 2006 Society
for Neuroscience.
474. Asymptomatic carotid artery stenosis: Past, present and future: How to improve patient selection? - Rijbroek A., Wisselink
W., Vriens E.M. et al. [A. Rijbroek, Department of General Surgery,
Kennemer Gasthuis, PO Box 417, NL-2000 AK Haarlem, Netherlands] - EUR. NEUROL. 2006 56/3 (139-154) - summ in ENGL
Background: The role of carotid endarterectomy (CEA) for
asymptomatic carotid artery stenosis (aCAS) remains a matter of
debate. It seems that not only the degree of stenosis, but also other
factors have to be taken in account to improve patient selection
and increase the benet of CEA for aCAS. Methods and Results:
The literature pertaining aCAS was reviewed in order to describe
the natural history, risk of stroke and benet of CEA for patients
with aCAS in regard to several factors. Conclusion: The benet
of CEA for aCAS is low. Current factors inuencing the indication for CEA are severity of stenosis, age, contralateral disease,
stenosis progression to >80%, gender, concomitant operations and
life expectancy. To improve patient selection investigations will
concentrate on plaque characteristics and instability and cerebral
hemodynamics and metabolism. Copyright 2006 S. Karger AG.
475. The impact of auditory cortex activity on characterizing
and treating patients with chronic tinnitus - First results from
a PET study - Langguth B., Eichhammer P., Kreutzer A. et al.
[Dr. B. Langguth, Department of Psychiatry and Psychotherapy,
University of Regensburg, Universitaetsstrae 84, 93053 Regensburg, Germany] - ACTA OTO-LARYNGOL. 2006 126/SUPPL. 556
(84-88) - summ in ENGL
91
value, and diagnostic accuracy were calculated and receiver operating characteristic (ROC) analysis was performed. RESULTS:
One hundred thirty-seven patients were clinically diagnosed with
Alzheimer disease and 178 patients were diagnosed with other disorders and age-associated cognitive decline. Sensitivity, specicity,
positive predictive value, negative predictive value, and diagnostic
accuracy calculated using standard transaxial display were 61%,
70%, 61%, 70%, and 66%, respectively, and using the 3D-SSP
z-score map were 90%, 74%, 73%, 90%, and 81%, respectively.
Particularly, the sensitivity value improved in mild cases compared
with severe cases using 3D-SSP. Diagnostic performance with 3DSSP was superior in both mild dementia (Az = 0.64 [section] vs 0.81
[3D-SSP], P = 0.001) and severe dementia (Az = 0.75 [section] vs
0.90 [3D-SSP], P = 0.002). CONCLUSIONS: Brain perfusion
SPECT was useful for diagnosis in patients who come to the cognitive disorder clinic for initial evaluation using 3D-SSP. 2006
Lippincott Williams & Wilkins, Inc.
478. Evaluation of primary brain tumors with FLT-PET: Usefulness and limitations - Saga T., Kawashima H., Araki N. et
al. [Dr. T. Saga, Department of Diagnostic Imaging, Molecular
Imaging Center, National Institute of Radiological Sciences, 4-9-1
Anagawa, Inage-ku, Chiba 263-8555, Japan] - CLIN. NUCL. MED.
2006 31/12 (774-780) - summ in ENGL
PURPOSE OF THE REPORT: The purpose of this report was
to investigate the potential of positron emission tomography using
F-18 uorodeoxythymidine (FLT-PET) in evaluating primary brain
tumors. MATERIALS AND METHODS: FLT-PET was performed
in 25 patients with primary brain tumors. FLT uptake in the lesion
was semiquantitatively evaluated by measuring the maximal standardized uptake value (SUVmax) and the tumor-to-normal tissue
ratio (TNR). SUVmax and TNR were compared with the histologic
grade and the expression of the proliferation marker (Ki-67). RESULTS: FLT uptake in normal brain parenchyma was very low,
resulting in the visualization of brain tumors with high contrast.
Both SUVmax and TNR signicantly correlated with the malignant grade of brain gliomas, in which high SUVmax/TNR was
obtained for high-grade gliomas. Patients with primary lymphoma
also showed SUVmax/TNR equivalent to glioblastoma. There was
a positive correlation between SUVmax/TNR and the Ki-67 index.
In contrast, spuriously high SUVmax and TNR were obtained in 3 of
6 patients with suspected recurrent tumors (2 patients with recurrent
grade 2 glioma and one patient with postoperative granuloma), all of
which showed lesion enhancement on MRI after Gd administration.
CONCLUSIONS: FLT-PET can be used to evaluate the malignant
grade and proliferation activity of primary brain tumors, especially
malignant brain tumors. However, the presence of benign lesions
showing blood-brain barrier disruption cannot be distinguished from
malignant tumors and needs to be carefully evaluated. 2006
Lippincott Williams & Wilkins, Inc.
479. Parietal lobe epileptic focus identied on SPECT-MRI fusion imaging in a case of epilepsia partialis continua - Matthews
R., Franceschi D., Xia W. et al. [Dr. Prof. R. Matthews, Department of Radiology, HSC Building, SUNY at Stony Brook, Stony
Brook, NY 11794, United States] - CLIN. NUCL. MED. 2006 31/12
(826-828) - summ in ENGL
Epilepsia partialis continua, or "Kozhevnikov syndrome," is a
rare condition characterized by persistent localized motor seizures
usually localized in a distant limb. It is most often seen in children
under 16 years old without gender preference. We report a 12year-old girl with epilepsia partialis continua who presented to the
emergency room after the onset of seizures. Routine electroencephalography (EEG) was performed with no clear ictal localization.
Magnetic resonance imaging (MRI) was unremarkable. Ictal single photon emission computed tomography (SPECT) images with
Tc-99m exametazime fused with MRI images revealed a parietal
lobe epileptic focus within the superior segment of the postcentral
gyrus. This case illustrates a rare disorder with an unusual epileptic
localization identied by SPECT-MRI fusion. 2006 Lippincott
Williams & Wilkins, Inc.
480. Differential uptake of [18 F]FET and [3 H]l-methionine in
focal cortical ischemia - Salber D., Stoffels G., Pauleit D. et al.
[K.-J. Langen, Department of Medicine, Institute of Neuroscience
Section 23 vol 70.2
503. Characteristics of skeletal stress fractures in female military recruits of the Israel defense forces on bone scintigraphy
- Hod N., Ashkenazi I., Levi Y. et al. [Dr. T. Horne, P.O. Box
6396, Jerusalem 91063, Israel] - CLIN. NUCL. MED. 2006 31/12
(742-749) - summ in ENGL
AIM: Clinical surveys on stress fractures (SF) in female military
recruits are scarce. The aim of this study was to characterize the
scintigraphic ndings and classify the distribution and pattern of SF
in a group of female recruits of the Israel Defense Forces (IDF).
MATERIALS AND METHODS: The bone scans of 146 female
recruits (age range, 19-20.6 years) with suspected SF were assessed
retrospectively. The SF lesions were classied qualitatively into 4
grades of bone response according to the classication criteria introduced by Zwas et al. SF location and distribution were analyzed, and
in several cases, the abnormalities were correlated radiographically.
RESULTS: One hundred forty-six female recruits were examined,
of which 93 (64%) had bone scan ndings of SF with a total of 247
SF. Forty-eight patients (with or without SF) had shin splints, 32 had
thigh splints, and 34 had normal scans. Several SF were detected in
sites that were not clinically suspected. Thirty-nine percent of the
SF were located in the feet (tarsal bones 22.7%, metatarsal 16.2%),
36.8% in tibiae (predominantly in the midthird), 15.7% in femurs,
6.5% in the pubic and sacroiliac regions, and 2% in the bula. SF
in the tibiae and femurs were mainly located in the posterior aspect
of the medial cortical region. Forty-nine percent of the patients
had bilateral SF. The SF were classied on a 4-grade scale: 41.3%
were grade I, 37.2% grade II, 15.8% grade III, and 5.7% grade IV.
Thirty-three percent of the patients had one site of SF, 31% had 2
sites, 7.5% had 3 sites, 12% had 4 sites, 7.5% had 5 sites, and 9%
had more than 5 sites of SF. Different grades of lesions were often
found in the same patient. Sixty-ve percent of the patients had
SF in the feet, 59% in the tibiae, 26% in the femurs, 14% in the
pubic or sacroiliac regions, and 5% in the bula. Radiography was
performed in 15% of the patients. Only one patient had a positive
nding on radiography. CONCLUSIONS: This study shows that
lower leg SF are not uncommon in female military recruits. We
clearly distinguished between SF and shin splints, which have important clinical consequences on treatment. Most of the SF were
mild (grade I and II) located in the feet and tibiae. This study
supports the experience gained in other studies, and emphasizes the
signicant number of pubic and sacroiliac SF in female soldiers,
which is signicantly higher in comparison with previous reports
on male soldiers. 2006 Lippincott Williams & Wilkins, Inc.
504. MRI-negative, bone scintigram-positive in early osteonecrosis of the knees - Warwick B.J.M., Caristo V., Hartin N. et al.
[Dr. H. Van Der Wall, Department of Nuclear Medicine, Concord
Hospital, Hospital Road, Concord, NSW 2139, Australia] - CLIN.
NUCL. MED. 2006 31/12 (750-753) - summ in ENGL
Nontraumatic avascular necrosis (AVN) of bone is a well-reported complication of glucocorticoid therapy for immunologic and
malignant disease. We present the case of a 13-year-old girl with
no history of trauma who presented with a 5-day history of increasing pain in both knees after cord blood transplantation for
acute lymphoblastic leukemia. Plain lm and magnetic resonance
imaging (MRI) were reported as normal. Bone scintigraphy revealed evidence of bilateral avascular necrosis in the distal femora.
MRI subsequently became abnormal several weeks later. The case
illustrates the natural history of AVN, in which changes that are detected by MRI can take several weeks to develop. The scintigraphic
ndings inuenced early management of the condition. 2006
Lippincott Williams & Wilkins, Inc.
505. F-18 FDG PET/CT evaluation of osseous and soft tissue
sarcomas - Iagaru A., Quon A., McDougall I.R. and Gambhir S.S.
[Dr. S.S. Gambhir, Stanford University School of Medicine, James
H. Clark Center, 150 East Wing, 318 Campus Drive, Stanford,
CA 94305-5427, United States] - CLIN. NUCL. MED. 2006 31/12
(754-760) - summ in ENGL
INTRODUCTION: Osseous and soft tissue sarcomas (OSTS)represent a histologic heterogeneous group of malignant tumors.
Most of the current clinical data on the role of F-18 FDG PET
in sarcomas come from patients studied with dedicated PET and
less frequently with hardware fusion PET/CT. Therefore, we were
prompted to review our experience with F-18 FDG PET/CT in
97
OSTS. METHODS: This is a retrospective study (January 2003December 2005) of 44 patients with histologic diagnoses of OSTS
who had F-18 FDG PET/CT at our institution. The group included
22 men and 22 women with an age range of 2 of 84 years (average,
37 20.2 years). The administered doses of F-18 FDG range 4.1 to
19.5 mCi (average, 14.3 3 mCi). Reinterpretation of the imaging
studies for accuracy and data analysis from medical records was
performed. RESULTS: The sensitivity and specicity of combined
F-18 FDG PET/CT were 100% (95% condence interval [CI] =
75.7-100) and 93.3% (95% CI = 78.7-98.1) for the primary OSTS,
and 80% (95% CI = 58.4-91.9) and 86.4% (95% CI = 66.7-95.2) for
metastases. When interpreted separately, CT outperformed PET
for pulmonary metastases detection: CT was 76.5% sensitive and
88% specic, whereas PET was only 57.1% sensitive but 96.4%
specic. For detection of other metastases, CT was 82.3% sensitive and 76% specic, with PET demonstrating 78.6% sensitivity
and 92.8% specicity. CONCLUSION: Relatively similar results
(except better specicity for PET and PET/CT) were noted when
examining the rate of metastases detection, excluding pulmonary
lesions. However, CT had a better detection rate for pulmonary
metastases when compared with PET alone. A negative PET scan
in the presence of suspicious CT ndings in the chest cannot reliably exclude pulmonary metastases from OSTS. 2006 Lippincott
Williams & Wilkins, Inc.
506. Instability of spine - Remarks to radiological-clinical
3D MCG data. The corrected RT (RTc ) and corrected Tpeak -negative dT/dt were then calculated using Bazetts formula. The 3D
RTc and the corrected Tpeak -negative dT/dt dispersion map were
superimposed on the heart outline generated by MCG. Results: The
RTc was signicantly longer for the MI group than in the control
group (67 25 ms1/2 vs. 16 6 ms1/2 ) (p <0.0001). The corrected
Tpeak -negative dT/dt dispersions in each patient was also signicantly longer for the MI group than in the control group (35 27
ms1/2 vs. 10 5 ms1/2 ) (p<0.0001). Furthermore, the 3D RTc
and Tpeak -negative dT/dt dispersion maps corresponded with the
space location of MI, as dened by Tc-99m tetrofosmin myocardial
imaging Conclusions: 3D RTc and Tpeak -negative dT/dt dispersion
maps in the ST segment, obtained by 64-channel MCG may be used
demonstrate the location of a myocardial injury and heterogeneities
of repolarization. Springer Science+Business Media, Inc. 2005.
508. 99m Tc-NC100668, a new tracer for imaging venous thromboemboli: Pre-clinical biodistribution and incorporation into
plasma clots in vivo and in vitro - Edwards D., Lewis J., Battle
M. et al. [D. Edwards, Research and Development, GE Healthcare
Bio-Sciences, Grove Centre, White Lion Road, Little Chalfont, HP7
9LL, United Kingdom] - EUR. J. NUCL. MED. MOL. IMAGING
2006 33/11 (1258-1265) - summ in ENGL
Purpose: 99m Tc-NC100668 is a new radiotracer being developed to aid the diagnosis of thromboembolism. The structure of
NC100668 is similar to a region of human 2 -antiplasmin, which is
a substrate for factor XIIIa (FXIIIa). The purpose of this study was
to conrm the uptake of 99m Tc-NC100668 into forming plasma clot
and to establish the biodistribution of 99m Tc-NC100668 in Wistar
rats. Methods: The in vitro plasma clot uptake of 99m Tc-NC100668
and other compounds with known afnities to FXIIIa was measured using a plasma clot assay. The biodistribution and blood clot
uptake of radioactivity of 99m Tc- NC100668 in normal Wistar rats
and those bearing experimentally induced deep vein thrombi were
investigated. Results: The in vitro uptake of 99m Tc-NC100668
was greater than that for [14 C]dansyl cadaverine, a known substrate
of FXIIIa in the plasma clot assay. The biodistribution of 99m TcNC100668 in male and female Wistar rats up to 24 h p.i. showed
that radioactivity was rapidly excreted, predominantly into the urine,
with very little background tissue retention. In vivo the uptake and
retention of 99m Tc-NC100668 into the blood clot was greater than
could be accounted for by non-specic accumulation of the radiotracer within the blood clot. Conclusion: 99m Tc-NC100668 was
retained by plasma clots in vitro and blood clots in vivo. No significant tissue retention which could interfere with the ability to image
thrombi in vivo was observed. This evidence suggests that 99m TcNC100668 might be useful in the detection of thromboembolism.
2006 Springer-Verlag.
509. The relationship between variables of 123-I-metaiodobenzylguanidine cardiac imaging and clinical status of the patients
with diastolic heart failure - Sugiura M., Yamamoto K., Takeda Y.
et al. [Y. Takeda, Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences,
Nagoya, Japan] - INT. J. CARDIOL. 2006 113/2 (223-228) - summ
in ENGL
Background: The status of cardiac sympathetic nerve activity
in patients with diastolic heart failure has not been fully understood. 123-I-metaiodobenzylguanidine cardiac images are valuable
for evaluating cardiac sympathetic nerve activity. Methods: We
obtained 123-I-metaiodobenzylguanidine cardiac images from 34
consecutive patients with moderate heart failure and an ejection
fraction of 45%. Results: The decay-corrected washout rate of
123-I-metaiodobenzylguanidine correlated with each plasma concentration of brain natriuretic peptide (standardized correlation
coefcient = 0.305, p < 0.05), New York Heart Association functional class (standardized correlation coefcient = 0.364, p < 0.02),
and exercise capacity (standardized correlation coefcient = - 0.388,
p < 0.04). A multiple regression analysis revealed that the washout
rate independently predicted plasma concentration of brain natriuretic peptide (standardized regression coefcient = 0.367, p <
0.02). In a univariate regression, the washout rate did not significantly correlate with the presence of ischemic heart disease (p =
0.254); in a multivariate regression, the presence of ischemic heart
disease did not predict the washout rate. For the 14 patients with
Section 23 vol 70.2
aortic stenosis. With the advent of gated SPECT imaging the additive value of determining rest and post stress EF, as demonstrated
in this case, aided in the recognition of TID and transient decrease
in the left ventricular ejection fraction. These are not necessarily
related to obstructive epicardial coronary disease, but are a result
of severe aortic valve disease causing subendocardial ischemia in
the setting of multilple other non-ischemic etiologies of TID such
as left ventricular hypertrophy and diabetes mellitus. Springer
Science+Business Media B.V. 2006.
515. Noninvasive Imaging in Myocarditis - Skouri H.N., Dec
G.W., Friedrich M.G. and Cooper L.T. [Dr. L.T. Cooper, Cardiovascular Department, Mayo Clinic, Rochester, MN, United States]
- J. AM. COLL. CARDIOL. 2006 48/10 (2085-2093) - summ in
ENGL
Increased recognition of the role of inammation in acute and
chronic dilated cardiomyopathy has revived an interest in noninvasive imaging for detection of myocarditis. Diagnostic strategies
that are based on molecular imaging promise to further advance
our understanding and improve diagnostic precision. This article
reviews the strengths and limitations of common clinical tests used
for the diagnosis of myocarditis, with a focus on the emerging
role of cardiovascular magnetic resonance imaging. Novel imaging
modalities that are currently in preclinical development are discussed with recommendations for future clinical research. 2006
American College of Cardiology Foundation.
516. Noninvasive Characterization of Myocardial Molecular Interventions by Integrated Positron Emission Tomography and
Computed Tomography - Wagner B., Anton M., Nekolla S.G. et
al. [Dr. F.M. Bengel, Nuklearmedizinische Klinik und Poliklinik, Technische Universit t M nchen, , Germany] - J. AM. COLL.
a u
CARDIOL. 2006 48/10 (2107-2115) - summ in ENGL
Objectives: We sought to investigate the usefulness of integrated
positron emission tomography (PET) and computed tomography
(CT) for in vivo characterization of an angiogenesis-directed
molecular intervention. Background: Controversies about the effectiveness of molecular therapies for cardiovascular disease have
prompted the need for more powerful noninvasive imaging techniques. Methods: In a model of regional adenoviral transfer of
the VEGF121 gene to myocardium of healthy pigs, PET-CT using
multiple molecular-directed radiotracers was employed. Results:
Two days after gene transfer, successful transgene expression was
noninvasively conrmed by a reporter probe targeting co-expressed
HSV1-sr39tk reporter gene. The CT-derived ventricular function
and morphology remained unaltered (left ventricular ejection fraction 57
5% in adenovirus-injected animals vs. 53
5% in
controls; p = 0.36). Increased regional perfusion was identied in
areas overexpressing VEGF (myocardial blood ow during adenosine-induced vasodilation 1.47 0.49 vs. 1.14 0.27 ml/g/min in
remote areas; p = 0.01), corroborating in vivo effects on microvascular tone and permeability. Finally, regional angiogenesis-associated
v 3 integrin expression was not enhanced, suggesting little contribution to the perfusion increase. Fusion of CT morphology
and tracer-derived molecular signals allowed for accurate regional
localization of biologic signals. Findings were validated by control vectors, sham-operated animals, and ex vivo tissue analysis.
Conclusions: Integrated PET-CT has the potential to dissect cardiovascular biologic mechanisms from gene expression to physiologic
function and morphology. The VEGF overexpression in healthy
myocardium increases myocardial perfusion without signicant upregulation of v 3 integrin adhesion molecules early after the
intervention. 2006 American College of Cardiology Foundation.
517. Imaging Stem Cells Implanted in Infarcted Myocardium
- Zhou R., Acton P.D. and Ferrari V.A. [Dr. R. Zhou, Department
of Radiology, University of Pennsylvania, Philadelphia, PA, United
States] - J. AM. COLL. CARDIOL. 2006 48/10 (2094-2106) - summ
in ENGL
Stem cell-based cellular cardiomyoplasty represents a promising
therapy for myocardial infarction. Noninvasive imaging techniques
would allow the evaluation of survival, migration, and differentiation status of implanted stem cells in the same subject over time.
This review describes methods for cell visualization using several
corresponding noninvasive imaging modalities, including magnetic
100
523. Usefulness of rapid low-dose/high-dose 1-day 99m Tc-sestamibi ECG-gated myocardial perfusion single-photon emission
computed tomography - Matsumoto N., Sato Y., Suzuki Y. et
al. [Dr. Y. Sato, Department of Cardiology, Nihon University,
Surugadai Hospital, 1-8-13 Kanda-surugadai, Chiyoda-ku, Tokyo
101-8309, Japan] - CIRC. J. 2006 70/12 (1585-1589) - summ in
ENGL
Background: The clinical usefulness of a rapid rest lowdose/stress high-dose (dose ratio =1:5) 99m Tc-sestamibi myocardial
perfusion single-photon emission computed tomography (SPECT)protocol for the detection of coronary artery disease was evaluated.
Methods and Results: In 89 patients, rest images were obtained
immediately after the injection of 99m Tc-sestamibi (256.1 28.4
MBq) followed by drinking water (400 ml). Exercise or vasodilator stress test was performed immediately after the completion of
rest imaging with the injection of 99m Tc-sestamibi (1312.3 167.6
MBq). Prior to the post-stress imaging, patients were asked again to
drink water (400 ml) in order to eliminate subdiaphragmatic tracer
activity. The myocardial count ratio (stress/rest) of 99m Tc-sestamibi
was calculated. Image quality was scored using a 4-point scale system (4= excellent, 3= good, 2= poor, 1= unacceptable). Coronary
angiography was performed in 56 patients within 1 month of the
SPECT scan. All patients successfully performed the protocol and
total examination time was 108 7 min. The myocardial count ratio
of 99m Tc-sestamibi was always greater than 6. The image quality
was satisfactory both at rest (3.4 0.9) and after stress (3.9 0.2).
The sensitivity and specicity to detect coronary artery stenosis
>50% was 84% and 97%, respectively. Conclusions: This rapid
one-day 99m Tc-sestamibi protocol provides adequate image quality
and diagnostic accuracy for detecting coronary artery disease.
524. Syntheses of [14 C]BAY 59-7939 and its radiolabeled metabolite M-4 - Pleiss U., Seidel D. and Grosser R. [U. Pleiss, Bayer
HealthCare AG, Aprather Weg 18a, 42096 Wuppertal, Germany] J. LABEL. COMPD. RADIOPHARM. 2006 49/11 (929-934) - summ
in ENGL
BAY 59-7939 is a novel, oral, direct Factor Xa inhibitor in clinical
development for the prevention and treatment of thromboembolic
diseases. Radiolabeled BAY 59-7939 was required for drug absorption, distribution, metabolism and excretion (ADME studies). The
BAY 59-7939 was labeled with carbon-14 in the carboxamide group
in one step in an overall radiochemical yield of 85% starting from 4-f
4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl] phenylgmorpholin-3-one and 5-chlorothiophene-2-[14 C]carboxylic acid. The
radiolabeled metabolite M-4 was prepared in 77% yield starting
from [1-14 C]glycine and 5-chlorothiophene-5-carboxylic acid. Copyright 2006 John Wiley & Sons, Ltd.
525. Comparative binding of 125 I-and 99m Tc-labeled native and
glycated low-density lipoprotein to human microvascular endothelial cells-potential for atherosclerosis imaging? - Sobal G.,
Menzel E.J. and Sinzinger H. [G. Sobal, Department of Nuclear
Medicine, Medical University of Vienna, Spitalgasse 23, A-1090,
Vienna, Austria] - J. RECEPT. SIGNAL TRANSDUCTION 2006
26/5-6 (693-707) - summ in ENGL
Native (n), glycated (g), and glycoxidated (go) low-density lipoproteins (LDL) were labeled with 125 I or 99m Tc, and the labeling
efciency and binding were assessed for potential use of these LDL
compounds in imaging analysis of atherosclerotic lesions (PPARreceptors) by determining the number of specic receptors for
nLDL, gLDL or goLDL on human microvascular endothelial cells
as well as the KD s using either 125 I-or 99m Tc-labeled LDLs. The
specic activity of labeled gLDL and goLDL was much higher
(for goLDL 20 times higher) than that of nLDL. Gel ltration
of labeled LDLs revealed, however, that 99m Tc-g/goLDL is signicantly degraded by the labeling reaction. No fragmentation
was observed for 99m Tc-nLDL and all the 125 I-labeled LDL forms.
Binding studies using both 125 I-and 99m Tc-nLDL indicated a weak
binding afnity (KD s 10-7 mol/L) to human microvascular endothelial cells. The bindin afnity of 125 I-g/goLDL to these cells was
signicantly higher (KD 10-9 mol/L) and could be increased further
by preactivation of the endothelial cells using TNF . Incubation
with 99m Tc-goLDL, however, did not result in specic binding of
the ligand, possibly as a consequence of the fragmentation of the
101
cell transplantation (HSCT) in patients with hematologic malignancies. The results after treatment with various TBI regimens were
compared, and dose-effect relationships for the endpoints relapse
incidence, disease-free survival, treatment-related mortality, and
overall survival were derived. The aim was to dene requirements
for an optimal treatment schedule with respect to leukemic cell
kill and late normal-tissue morbidity. Material and Methods: A
literature search was performed. Three randomized studies, four
studies comparing results of two or three TBI regimens, and nine
reports with results of one specic TBI regimen were identied.
Biologically effective doses (BEDs) were calculated. The results
of the randomized studies and the studies comparing results of two
or three TBI regimens were pooled, and the pooled relative risk
(RR) was calculated for the treatments with high BED values versus
treatments with a low BED. BED-effect relationships were obtained.
Results: RRs for the high BED treatments were signicantly lower
for relapse incidence, not signicantly different for disease-free
survival and treatment-related mortality, and signicantly higher
for overall survival. BED-effect relationships indicate a decrease
in relapse incidence and treatment-related mortality and an increase
in disease-free and overall survival with higher BED values. Conclusion: "More dose is better", provided that a TBI setting is used
limiting the BEDs of lungs, kidneys, and eye lenses. Urban &
Vogel.
529. Induction of G2 arrest and apoptosis of raji cells by continuous low-dose beta irradiation with 188 Re-perrhenate - Lim
S.J., Kim E.H., Woo K.S. et al. [S.M. Lim, Laboratory of Cyclotron
Application, Korea Institute of Radiological and Medical Science
(KIRAMS), 215-4 Gongleung-Dong, Nowon-Gu, Seoul, 139-706,
South Korea] - CANCER BIOTHER. RADIOPHARM. 2006 21/4
(314-320) - summ in ENGL
Continuous irradiation with exponentially reducing -rays induces cell death, known as apoptosis. The aim of this study was
to investigate the G 2 arrest and apoptosis caused by the -ray
emitted by the radioisotope 188 Re. Doses of 0.4 Gy (3.7 MBq),
4 Gy (37 MBq), and 40 Gy (370 MBq), were added to B-lymphoma Raji cells, and cell viability, apoptosis, and DNA cell-cycle
changes were assayed. 188 Re showed time- and dose-dependent
effects on cell viability and on cell apoptosis and necrosis. At a
188 Re dose of 0.4 Gy, G cell-cycle arrest was observed after 16
2
hours, and 4,6-diamidino-2-phenylindole (DAPI) staining indicated
a slow, time-dependent increase in apoptotic bodies. At a 188 Re dose
of 40 Gy, DNA fragmentation was observed at 2 hours, indicative
of early damage in the nucleus. In summary, our results showed that
continuous irradiation with low-dose -rays induced G? arrest and
progressive apoptosis, which may be characteristic mechanisms of
radionuclide therapy. Mary Ann Liebert, Inc.
530. Characterization of a radiolabeled small molecule targeting leukocyte function-associated antigen-1 expression in
lymphoma and leukemia - Poria R.B., Norenberg J.P., Anderson
T.L. et al. [J.P. Norenberg, University of New Mexico, College
of Pharmacy, 1 University of New Mexico, 2502 Marble NE,
Albuquerque, NM 87131, United States] - CANCER BIOTHER.
RADIOPHARM. 2006 21/5 (418-426) - summ in ENGL
Objective: Leukocyte function-associated antigen-1 (LFA-1) is
constitutively expressed on leukocytes, including overexpression
on lymphomas and leukemias. We have developed a derivative of BIRT 377, an allosteric inhibitor of LFA-1, which may
be chemically tagged without affecting binding. In this study,
we modied this derivative, (R)-1-(4-aminobutyl)-5-(4-bromobenzyl) -3-(3,5-dichlorophenyl)-5-methylimidazolidine-2,4-dione
(butylamino-NorBIRT), and demonstrated its potential as a
noninvasive imaging agent. Methods: Specic binding of uorescein-labeled butylamino-NorBIRT to both human and murine
cells was demonstrated using equilibrium binding and dissociation techniques. A radiometal, lutetium-177 (Lu-177), was
incorporated into the butylamino-NorBIRT through 1,4,7,10-tetraazacyclododecane-N,N ,N ,N -tetraacetic acid (DOTA) as a
chelator. Results: Equilibrium-binding experiments demonstrated
that uorescein-labeled butylamino-NorBIRT specically binds human and murine LFA-1 with afnity constants of 135 and 186
nM, respectively. Dissociation kinetic experiments demonstrated
an off-rate of 0.168/second -1 on murine cells, consistent with the
Section 23 vol 70.2
respectively. Qualitative 18 F-FDG PET interpretations were positive in 24 of the 25 malignant nodules and in four benign nodules.
Fluourine-18-FDG PET was considered negative in one malignant
nodule and in 13 of the 17 benign nodules. This correlates with a
sensitivity and specicity of 96% and 76%, respectively, and with a
PPV and NPV of 86% and 93%, respectively. Original prospective
18 F-FDG PET and semiquantitative SUV analysis showed sensitivity, specicity, PPV, and NPV of 88%, 76%, 85%, and 81% and
84%, 82%, 88%, and 78%, respectively. CONCLUSION. Due to its
much higher specicity and only slightly reduced sensitivity, 18 FFDG PET is preferable to nodule-enhancement CT in evaluating
indeterminate pulmonary nodules. However, nodule-enhancement
CT remains useful due to its high NPV, convenience, and lower
cost. Qualitative 18 F-FDG PET interpretation provided the best
balance of sensitivity and specicity when compared with original
prospective interpretation or SUV analysis. American Roentgen
Ray Society.
542. Improving the diagnostic performance of lung scintigraphy
in suspected pulmonary embolic disease - Gleeson F.V., Turner
S. and Scarsbrook A.F. [F.V. Gleeson, Department of Radiology,
Churchill Hospital, Oxford Radcliffe NHS Trust, Oxford, United
Kingdom] - CLIN. RADIOL. 2006 61/12 (1010-1015) - summ in
ENGL
Aim: to determine the effectiveness of a new imaging algorithm
in the investigation of suspected pulmonary embolism (PE). Materials and methods: A new imaging algorithm for suspected PE
was introduced following the installation of a multisection computed tomography (CT) machine at our institution. Before its
installation, patients with suspected PE were evaluated with ventilation/perfusion (V/Q) scintigraphy. Subsequently, patients were
triaged according to chest radiography (CR) and respiratory history
to either lung scintigraphy or CT pulmonary angiography (CTPA).
Patients with a normal CR and no history of lung disease were
evaluated using perfusion (Q) scintigraphy [ventilation (V) scintigraphy was no longer performed]. Patients with an abnormal CR,
asthma or chronic lung disease were evaluated using CTPA. All
V/Q images in a continuous 3-year period before the introduction
of the new imaging algorithm and all Q images performed in a
3-year period after its introduction were retrospectively reviewed.
Imaging reports were categorized into normal, non-diagnostic (low
or intermediate probability) or high probability for PE. Patients in
the later group who subsequently underwent CTPA, were also reviewed. Results: After the policy change the percentage of normal
scintigrams signicantly increased (39 to 60%; p < 0.001). There
was a non-signicant increase in the percentage of high probability
scintigrams (15 to 18%; p = 0.716). Overall the diagnostic yield of
lung scintigraphy improved signicantly (54 to 78%; p < 0.001).
Conclusion: the diagnostic performance of lung scintigraphy can
be improved by careful triage of patients to either Q scintigraphy
or CTPA based on clinical history and CR ndings. Q scintigraphy
remains a valuable diagnostic test in the investigation of suspected
PE in carefully selected patients. 2006 The Royal College of
Radiologists.
543. 18F-FDG PET imaging in assessing exudative pleural effusions - Duysinx B.C., Larock M.-P., Nguyen D. et al. [Dr. B.C.
Duysinx, Division of Pulmonary Medicine, CHU Sart Tilman B35,
B-4000 Li` ge, Belgium] - NUCL. MED. COMMUN. 2006 27/12
e
(971-976) - summ in ENGL
BACKGROUND: This study evaluates the accuracy of [F]uorodeoxyglucose positron emission tomography (F-FDG PET) imaging
with semi-quantitative analysis for differentiating benign from malignant pleural exudates and for guiding the search for the primary
tumour of pleural metastases. METHODS: Whole-body F-FDG
PET was performed in 79 patients with exudative pleurisy. Standard
uptake values were normalized for body weight, body surface area,
lean body mass (SUVbw, SUVbsa, SUVlbm) with and without
correction for blood glucose levels. Thoracoscopy was systematically performed to reveal pathological diagnosis. RESULTS:
All SUVs were signicantly higher in all malignant pleural diseases (n=51) than in benign (n=28) (P<0.001). Moreover SUVs
were greater in the pleural metastases from pulmonary primaries
(n=25) and in mesotheliomas (n=8) than in extrathoracic primaries
Section 23 vol 70.2
(n=18) (P<0.01) with no signicant difference between lung cancers and mesotheliomas. Receiver operating curve (ROC) analysis
between benign and malignant lesions showed areas under the curves that ranged from 0.803 (SUVbsa g) to 0.863 (SUVbw). The
cut-off value for SUVbw which gave the best accuracy (82.3%)was 2.2. When comparing thoracic with extrathoracic primaries
the highest accuracy (80.4%) was found for a cut-off value of 2.6.
CONCLUSION: Semi-quantitative analysis of F-FDG PET imaging
helps to differentiate malignant from benign pleural exudates and
to distinguish between thoracic or extrathoracic primaries. 2006
Lippincott Williams & Wilkins, Inc.
544. Relationship between cancer cell proliferation, tumour angiogenesis and 201Tl uptake in non-small cell lung cancer Fujita S., Nagamachi S., Nishii R. et al. [Dr. S. Fujita, Department
of Radiology, Miyazaki Medical College, 5200 Kihara, Kiyotake,
Miyazaki Pref. 889-1692, Japan] - NUCL. MED. COMMUN. 2006
27/12 (989-997) - summ in ENGL
PURPOSE: To investigate whether Tl uptake is associated with
cell proliferation and angiogenesis in non-small-cell lung carcinoma (NSCLC). METHODS: Eighty-four patients with scheduled
NSCLC underwent Tl single photon emission computed tomography (SPECT) imaging: 15 min (early scan) and 240 min (delayed
scan) after intravenous injection of 111 MBq of Tl chloride. Tl
indices were calculated on early images (early ratio: ER) and delayed images (delayed ratio: DR). The retention index (RI) was
also calculated from these two parameters. Using surgically resected cancer specimens (54 adenocarcinoma, 24 squamous cell
carcinoma (SCC), six large-cell carcinoma), immunohistochemical
stains for both Ki-67 (MIB-1 index) and CD34 were performed
to examine the proliferative activity and the micro-vessel density
(MVD), respectively. RESULTS: The mean value of Tl index
was 1.69 0.77 (ER) and 2.31 1.08 (DR). The average RI was
42.6 42.9%, respectively. Both DR and RI positively correlated
with MIB-1 index (r=0.68, P<0.05 and r=0.52, P<0.05). When we
analyse adenocarcinoma and SCC separately, there was a signicant
positive correlation (r=0.62, P<0.05) between RI and MIB-1 index
in adenocarcinoma but not in SCC (r=0.20, P=NS). The value of ER
positively correlated with MVD (r=0.75, P<0.05). It demonstrated
strong positive correlation with both histological types (adenocarcinoma: r=0.80, P<0.05, SCC: r=0.66, P<0.05). CONCLUSION:
Tl SPECT imaging is effective non-invasive method for assessing
both the proliferation and the angiogenesis in NSCLC. Both DR
and RI are useful indicators for assessing cancer cell proliferation
in lung adenocarcinoma. ER is a useful marker for assessing the
tumour angiogenesis in NSCLC. 2006 Lippincott Williams &
Wilkins, Inc.
545. Radiology-Pathology Conference: sclerosing hemangioma
of the lung - Neuman J., Rosioreanu A., Schuss A. et al. [D.S.
Katz, Department of Radiology, Winthrop-University Hospital, 259
First Street, Mineola, NY 11501, United States] - CLIN. IMAGING
2006 30/6 (409-412) - summ in ENGL
Sclerosing hemangioma (SH) is a relatively rare, benign neoplasm
of the lung. Although there are relatively characteristic imaging
ndings, biopsy remains the denitive diagnostic test. We report
the radiology and pathology of a patient with a SH, with emphasis
on the computed tomographic and 18 F-uorodeoxyglucose positron
emission tomography ndings, and review the literature on this
unusual tumor. 2006 Elsevier Inc. All rights reserved.
546. Incidental detection of malignant pleural effusion on
sestamibi myocardial perfusion scan - Eftekhari M. and Gholamrezanezhad A. [A. Gholamrezanezhad, Research institute for
Nuclear Medicine, Tehran University of Medical Sciences, Shariati
Hospital, Northern Kargar St., Tehran 14114, Iran] - INT. J. CARD.
IMAGING 2006 22/6 (775-777) - summ in ENGL
Incidentally the diagnosis of pleural effusions can be made with
scintigraphic studies. We report a case of incidental detection of
pleural effusion in sestamibi myocardial perfusion scan. A 64year-old man with a history of chest pain was referred for Sestamibi
myocardial perfusion scintigraphy. The review of cine data revealed
an area of radiotracer accumulation in the left hemithorax. Subsequent chest X-ray and computed tomography revealed a relatively
massive pleural effusion. Microscopic evaluation conrmed the
105
The major aims of imaging in esophageal cancer are to distinguish between locoregional and systemic disease (M-stage), to
determine local tumor extension (T- and N-stage), to assess response to chemo- or chemoradiotherapy and to identify recurrence
of cancer. The sensitivity of computed tomography (CT) for detection of distant metastases ranges between <50% and >90%. In
esophageal cancer, F-18-uorodeoxyglucose positron emission tomography (FDG-PET) has been shown to detect metastatic disease
in approximately 20% of patients who are considered as having
only locoregional disease on CT. In locoregional pretherapeutic
tumor staging, FDG-PET specicity of 80% is sufcient, but FDGPET sensitivity of 50% is rather low. However, the initial staging
of regional lymph nodes is less important because at the moment
there is no pretherapeutic therapy stratication based on lymph node
category. The accuracy for correct identication of recurrence in
esophageal cancer is higher for FDG-PET than for CT scan. Unfortunately until today no reliable essays for prediction of response or
prognosis exist for esophageal cancer in clinical practice for patients
with neoadjuvant treatment. Thus the identication of parameters
predicting response and/or prognosis is crucial for the future. Posttherapeutic assessment of tumor response by FDG-PET has been
shown to correlate with histopathologic tumor regression and patient survival. Furthermore, quantitative measurements of tumor
FDG-uptake may allow an early metabolic response evaluation after only 2 weeks of therapy. An association of metabolic response
with histopathologic tumor regression and patient outcome 2 weeks
after initiation of preoperative chemotherapy may be shown for
esophageal cancer. 2006 The Authors Journal compilation
2006 The International Society for Diseases of the Esophagus.
554. FDG-PET for prediction of survival of patients with
metastatic colorectal carcinoma - de Geus-Oei L.F., Wiering
B., Krabbe P.F.M. et al. [Dr. L.F. de Geus-Oei, Department of
Nuclear Medicine, Radboud University Nijmegen Medical Centre,
P.O. Box 9101, 6500 HB Nijmegen, Netherlands] - ANN. ONCOL.
2006 17/11 (1650-1655) - summ in ENGL
Background: The current study focuses on the prognostic
value of pretreatment metabolic activity in metastases as measured with [18 F]uorodeoxyglucose positron emission tomography
(FDG-PET), as an indicator of survival in colorectal cancer. Patients a nd methods: In a prospective series of 152 patients with
metastatic colorectal cancer, of whom 67 were treated with resection
of metastases and 85 with chemotherapy, standardized uptake values
(SUV) as measured with FDG-PET, were calculated prior to treatment. Survival probabilities were estimated by Cox proportional
regression analysis. For Kaplan-Meier analysis SUV was stratied
by the median value. Survival differences were assessed using
the log-rank test. Results: SUV in metastases was a signicant
predictor for overall survival (hazard ratio 1.17, 95% condence
interval 1.06-1.30, P = 0.002), independent of the subsequent treatment. According to the median value of the patient population a
low (SUV <4.26) and high uptake group (SUV >4.26) was dened.
The median survival and the 2- and 3-year survival rates were 32
months, 59% and 45%, respectively, in the low-uptake group and
19 months, 37% and 28%, respectively, in the high-uptake group (P
= 0.017). Conclusion: A signicant survival benet was observed
in patients with low FDG uptake in metastases of colorectal cancer.
2006 Oxford University Press.
555. Regional Yttrium-90 microsphere treatment of surgically
unresectable and chemotherapy-refractory metastatic liver carcinoma - Wong C.-Y.O., Savin M., Sherpa K.M. et al. [C.-Y.O.
Wong, Positron Diagnostic Center and Medical Cyclotron, Department of Nuclear Medicine, William Beaumont Hospital, 3601 West
Thirteen Mile Road, Royal Oak, MI 48073-6769, United States] CANCER BIOTHER. RADIOPHARM. 2006 21/4 (305-313) - summ
in ENGL
Purpose: The aim of this prospective study was to assess the safety
and tumor response of intra-arterial Y-90 microspheres for the treatment of surgically unresectable and chemotherapy-refractory liver
metastases. Materials and Methods: Forty-six (46) patients with
metastatic cancer to the liver from various solid tumors, with tumor
progression despite poly chemotherapy, were included. All patients
had baseline computed tomography (CT), 18-Fluoro-2-deoxy-Dglucose-positron emission tomography (F-18 FDG-PET), hepatic
107
these peptides elicited distinctly different effects on binding afnities in vitro, effects that were largely unchanged by metallation
with nonradioactive nat In. In vivo pharmacokinetic studies in SCID
mice bearing T-84 human colon cancer-derived tumor xenografts
demonstrated tumor uptake of 0.74 0.1 %ID/g at 4 h post-injection
(p.i.) for the 111 In-DOTA-F 19 -STh (2-19) analog, and signicantly
reduced tumor localization (0.27+0.08 %ID/g) for the 111 In-DOTAF 9 -STh (6-19) analog. Conclusion: These results demonstrate that
placement of a DOTA moiety immediately adjacent to Cys 6 in
STh signicantly inhibits receptor binding in vitro and in vivo,
highlighting the need for intervening spacer residues between the
pharmacophore and the DOTA chelating moiety in effective STh based radiopharmaceutical constructs.
558. A comparison of cholecystectomy and observation in children with biliary dyskinesia - Scott Nelson R., Kolts R., Park R.
and Heikenen J. [R. Scott Nelson, Department of General Surgery,
Marsheld Clinic, Marsheld, WI 54449, United States] - J. PEDIATR. SURG. 2006 41/11 (1894-1898) - summ in ENGL
Purpose: The success rate of ameliorating the preoperative symptoms of biliary dyskinesia in a pediatric population has been reported
to be approximately 80%. The purpose of this study was to identify
patient characteristics that may help to predict successful clinical
outcomes in pediatric patients with biliary dyskinesia by comparing
2 groups of pediatric patients: those who underwent cholecystectomy and those who received no surgical intervention (control
group). Methods: The medical charts of pediatric patients who
had an ejection fraction of less than 35% and no other identiable
abnormalities revealed on diagnostic testing were retrospectively reviewed. Information regarding psychological diagnoses/treatment,
diagnostic examination ndings, histologic ndings, and outcomes
were collected. Patients were evaluated at 1 month and 2 years postoperatively. Results: From 1995 through 2003, 55 pediatric patients
were identied. All patients had an abnormal ejection fraction on
hepatobiliary iminodiacetic acid scan. The patients were divided
into 2 groups: those who underwent cholecystectomy (n = 35) and
a control group who did not receive surgical intervention (n = 20).
Of those who underwent cholecystectomy, 74% improved, whereas
75% of the control group showed improvement after 2 years. Of all
patient characteristics evaluated, only weight loss was found to be
signicant for determining patient outcomes. Conclusion: When
followed for a long enough period of time, outcomes were similar
between the 2 groups. Of the patients whose symptoms improved,
those who underwent cholecystectomy had a quicker resolution of
abdominal pain than those who did not undergo surgery. With the
exception of weight loss, none of the patient characteristics evaluated in this study proved to be statistically signicant for predicting
a positive outcome. 2006 Elsevier Inc. All rights reserved.
559. The use of a micro-bubble contrast agent to allow visualization of the biliary tree - Roberts J.P., Neill A. and Goldstein
R. [Dr. J.P. Roberts, University of California San Francisco, 505
Parnassus Ave, San Francisco, CA 94143-0780, United States] CLIN. TRANSPLANT. 2006 20/6 (740-742) - summ in ENGL
Micro-bubble contrast agents have been used as contrast agents
in the vascular system to allow visualization of blood ow by ultrasound. We examined the use of this type of contrast agent for
visualization of bile duct by ultrasound. A laparotomy was performed on a domestic farm pig and the common bile duct was
cannulated with a 20 gauge catheter. The contrast agent, perutren
lipid microspheres (Denity), was injected in different dilutions.
Sonographic images were obtained by scanning directly on the pig
liver. The use of the micro-bubble contrast in the biliary system
provided excellent visualization of the bile duct down to ducts as
small as fth-order branches and demonstrated bile ducts <2 mm.
The use of micro-bubble contrast agents in the biliary tree may
allow for real-time imaging of the bile duct and could be helpful in
living donor liver transplantation. 2006 Blackwell Munksgaard.
560. Coexistence of hepatocellular carcinoma and hepatic metastasis: Advantages of positron emission tomography for liver
561. Assessment of 18 F-FDG-Leukocyte Imaging to Monitor Rejection After Pancreatic Islet Transplantation - Toso C., Zaidi
H., Morel P. et al. [C. Toso, Cell Isolation and Transplantation Center, Clinic for Visceral and Transplant Surgery, University Hospital,
Geneva, Switzerland] - TRANSPLANT. PROC. 2006 38/9 (30333034) - summ in ENGL
Aim: We sought to investigate the feasibility of 18 F-FDGleukocyte imaging to detect islet rejection. Methods: Two
thousand Sprague-Dawley (SD, syngeneic group) or Lewis (allogeneic group) islet equivalents were intraportally injected into SD
rat recipients. Four and 7 days after transplantation, 10818 F-FDGlabeled splenocytes were injected into the jugular vein. Splenocytes
were harvested from nave or sensitized (12 days after intraportal
high biliary excretion, may be potentially advantageous in hepatobiliary imaging, the aim of the study was to investigate the molecular
mechanisms of hepatic transport of the B22956 ion in a cellular
model of hepatic tumor. B22956 ion uptake was measured in tumoral (HepG2) and nontumoral (Chang liver) hepatic cell lines.
Absolute quantitative real-time reverse transcriptase (RT)-polymerase chain reaction (PCR) analyses, using cloned PCR products
as standards, were performed on total RNA of both cell lines and
normal liver to evaluate the transcription of 12 transport genes:
SLCO1A2, SLCO2B1, SLCO1B1, SLCO3A1, SLCO4A1, SLCO1B3, SLC22A7, SLC22A8, SLC22A1, SLC10A1, SLC15A1,
and SLC15A2. B22956 transport was more efcient in Chang liver
than in HepG2 cells and was inhibited by cholecystokinin-8, a specic substrate of OATP1B3. Real-time RT-PCR analyses revealed
different transcription proles in the tumoral and nontumoral cell
lines. Compared with normal liver, the expression of SLCO1B1,
SLCO3A1, and SLCO1B3 was greatly repressed in HepG2 cells,
whereas SLCO2B1, SLC22A7, and SLC22A8 expression was either maintained or increased. On the contrary, in Chang liver cells,
SLC22A7 and SLC22A8 genes were undetectable, whereas the
expression of SLCO3A1, SLCO4A1, and SLCO1B3 was similar
to normal liver. Transport studies and gene expression analyses
indicated that B22956 ion is a good substrate to the liver-specic
OATP1B3, reported to be poorly expressed or absent in human liver
tumors. Therefore, B22956 may be helpful in detecting hepatic
neoplastic lesions by CE-MRI. Copyright 2006 by The American
Society for Pharmacology and Experimental Therapeutics.
564. Contrast-enhanced ultrasonographic spoke-wheel sign in
hepatic focal nodular hyperplasia - Yen Y.-H., Wang J.-H., Lu
S.-N. et al. [J.-H. Wang, Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial
Hospital, 123 Ta-Pei Road, Kaohsiung, 833, Taiwan] - EUR. J.
RADIOL. 2006 60/3 (439-444) - summ in ENGL
Background: To determine the utility of contrast-enhanced ultrasonography (CEUS) in assessing hepatic tumors with central
feeding arteries found by color/power Doppler ultrasonograophy
(CDUS/PDUS). Methods: We prospectively studied 37 hepatic tumors (34 patients), with a mean size of 2.9 cm and each having a
central feeding artery, by CDUS/PDUS. The CEUS was performed
with a galactose-based microbubble contrast agent. The detection
of a spoke-wheel sign was interpreted as evidence of focal nodular
hyperplasia (FNH). All patients underwent tumor biopsies or surgical resection. Results: CEUS showed a central feeding artery
with a spoke-wheel sign in 36 tumors, including 34 FNHs and 2
hepatocellular carcinomas. The remaining tumor was demonstrated
to be FNH despite the absence of a spoke-wheel sign as detected
by CEUS. The sensitivity of the spoke-wheel sign or central scar
for FNH was 97.1% (34/35), 40% (14/35), 28.6% (10/35), 50%
(8/16) and 0% (0/15) for CEUS, CDUS/PDUS, dynamic computed
tomography (CT) or magnetic resonance imaging (MRI), hepatic
angiography and liver scintigraphy, respectively. The two hepatocellular carcinomas showed scirrhous changes histologically.
Conclusions: CEUS is more sensitive than CDUS/PDUS, dynamic
CT, MRI, hepatic angiography and liver scintigraphy in the detection
of the spoke-wheel sign or central scar in FNH. Scirrhous hepatocellular carcinoma should be included in the differential diagnosis
for liver tumors with spoke-wheel sign detected by CEUS. 2006
Elsevier Ireland Ltd. All rights reserved.
565. Positive correlation between standardized uptake values
of FDG uptake in the stomach and the value of the C-13 urea
breath test - Lin C.-Y., Liu C.-S., Ding H.-J. et al. [Dr. C.-H.
Kao, Department of Nuclear Medicine, PET Center, China Medical
University Hospital, Taichung 404, Taiwan] - CLIN. NUCL. MED.
2006 31/12 (792-794) - summ in ENGL
PURPOSE: The distribution of FDG uptake in the stomach is
variable. Gastritis is one of the causes of elevated FDG uptake. Helicobacter pylori (HP) infection was found in approximately 80% of
patients with peptic ulcer and 30% to 60% of symptomatic gastritis.
The C-13 urea breath test (UBT) is one of the gold standard tools
in diagnosis of HP infection. The aim of this study was to assess
the correlation between standardized uptake values (SUVs) of FDG
uptake in the stomach and the value of the C-13 urea breath test
(UBT). METHODS: Sixteen patients, referred from the department
109
after the ARI period was applied. Serum BUN and creatinine
levels were measured for evaluation of renal function. T max-sec ,
glomerular ltration rate (GFR), and Tmax-min results following a
99m Tc-DTPA diuretic renal scintigraphy were used. Histological
examination was performed on nephrectomy specimens. Results:
Groups 2 and 5 showed higher BUN, creatinine, and lower GFR
values than the other groups (p = 0.0001). There was no difference
in BUN, creatinine, and GFR levels between groups 2 and 5 (p =
0.971, p = 0.739, p = 0.393). Also the T max-sec values were higher
in groups 2 and 5 compared with the other groups (p = 0.0001). The
presence of tubular necrosis was different between groups and was
higher in groups 2 and 5 (p = 0.002). Conclusion: The application
of GTN, a nitric oxide donor, has caused signicant improvement
in renal function when applied prior to an experimentally designed
renal ischemia-reperfusion model. But administration of GTN had
no effect after occurrence of ischemia. Copyright 2006 S. Karger
AG.
571. The impact of IMRT and proton radiotherapy on secondary
cancer incidence - Schneider U., Lomax A., Pemler P. et al. [Dr. U.
Schneider, Division of Medical Physics, Department of Radiation
Oncology and Nuclear Medicine, Triemli Hospital Z rich, 8063
u
Z rich, Switzerland] - STRAHLENTHER. ONKOL. 2006 182/11
u
(647-652) - summ in ENGL, GERM
Background and Purpose: There is concern about the increase
of radiation-induced malignancies with the application of modern
radiation treatment techniques such as intensity-modulated radiotherapy (IMRT) and proton radiotherapy. Therefore, X-ray scatter
and neutron radiation as well as the impact of the primary dose
distribution on secondary cancer incidence are analyzed. Material
and Methods: The organ equivalent dose (OED) concept with a
linear-exponential and a plateau dose-response curve was applied
to dose distributions of 30 patients who received radiation therapy
of prostate cancer. Three-dimensional conformal radiotherapy was
used in eleven patients, another eleven patients received IMRT with
6-MV photons, and eight patients were treated with spot-scanned
protons. The treatment plans were recalculated with 15-MV and
18-MV photons. Secondary cancer risk was estimated based on
the OED for the different treatment techniques. Results: A modest
increase of 15% radiation-induced cancer results from IMRT using
low energies (6 MV), compared to conventional four-eld planning
with 15-MV photons (plateau dose-response: 1%). The probability
to develop a secondary cancer increases with IMRT of higher energies by 20% and 60% for 15 MV and 18 MV, respectively (plateau
dose-response: 2% and 30%). The use of spot-scanned protons can
reduce secondary cancer incidence as much as 50% (independent
of dose-response). Conclusion: By including the primary dose
distribution into the analysis of radiation-induced cancer incidence,
the resulting increase in risk for secondary cancer using modern
treatment techniques such as IMRT is not as dramatic as expected
from earlier studies. By using 6-MV photons, only a moderate risk
increase is expected. Spot-scanned protons are the treatment of
choice in regard to secondary cancer incidence. Urban & Vogel.
572. Health-related quality of life after permanent interstitial
brachytherapy for prostate cancer: Correlation with postimplant CT scan parameters - Pinkawa M., Fischedick K., Piroth
M.D. et al. [Dr. M. Pinkawa, Klinik f r Strahlentherapie,
u
Universit tsklinikum Aachen, Pauwelsstrae 30, 52057 Aachen,
a
Germany] - STRAHLENTHER. ONKOL. 2006 182/11 (660-665) summ in ENGL, GERM
Purpose: To determine dosimetric risk factors for increased toxicity after permanent interstitial brachytherapy for prostate cancer.
Patients and Methods: Quality of life questionnaires (Expanded
Prostate Cancer Index Composite) of 60 and 56 patients were analyzed after a median posttreatment time of 6 weeks (A - acute) and
16 months (L - late). The corresponding CT scans were performed
30 days after the implant. The prostate, rectal wall, and base of
seminal vesicles were contoured. Prostate volume, number of seeds
and needles as well as dosimetric parameters were correlated with
the morbidity scores. Results: For a prostate volume of 38
12 cm3 (mean standard deviation), 54 7 125 I sources (Rapid
Strands, activity of 22.6 3.0 MBq [0.61 0.08 mCi]) were
implanted using 20 6 needles. Improved late urinary function
scores resulted from a higher number of sources per cm3 ( 1.35).
Section 23 vol 70.2
A prostate D90 < 170 Gy (A)/< 185 Gy (L) and base of seminal
vesicle D10 < 190 Gy (A and L) were associated with higher urinary function scores. Late rectal function scores were signicantly
higher for patients with a prostate V200 < 50% and V150 < 75%.
Patients with a prostate volume < 40 cm3 reached better sexual
function scores (A and L). A higher number of needles per cm3 (
0.5) resulted in improved late urinary, bowel and sexual function
scores. Conclusion: Quality of life after a permanent implant can
be improved by using an adequate amount of sources and needles.
With an increasing number of seeds per cm3 , dose homogeneity is
improving. A prostate D90 < 170 Gy and a base of seminal vesicle
D10 < 190 Gy (as an indicator of the dose to the bladder neck and
urethral sphincter) can be recommended to maintain a satisfactory
urinary function. Urban & Vogel.
573. Transperineal permanent seed implantation of "low-risk"
prostate cancer: 5-Year-experiences in 118 patients - Block
T., Czempiel H. and Zimmermann F. [Dr. T. Block, Urologische
Praxis Vaterstetten, Bahnhofstrae 36, 85591 Vaterstetten, Germany] - STRAHLENTHER. ONKOL. 2006 182/11 (666-671) - summ
in ENGL, GERM
Purpose: To evaluate 5-year prostate-specic antigen (PSA) relapse-free survival of transperineal permanent seed implantation
(TPSI) in 118 patients with "low-risk" prostate cancer, that means
stage cT1c-T2a, Gleason Score < 7, and initial PSA value < 10
ng/ml. Patients and Methods: From 04/1999 to 06/2002, a total
of 118 patients underwent a mono-TPSI, using ultrasound-based
preplanning and intraoperative verication by both ultrasound and
conventional uoroscopy as well as postoperative CT planning. Patients were monitored during the 1st year in 3-month intervals, and
in 6-monthly intervals from then onward. Biochemical failure was
dened according to ASTRO criteria with three consecutive PSA
rises observed from a posttreatment nadir PSA value. The median
follow-up was 48.9 months (range: 37.0-80.2 months). 114 patients
were eligible, four patients were lost to follow-up. Results: For the
entire group, PSA relapse-free survival at 5 years was 94.7%, with
six patients (5.3%) having a PSA relapse between 8 and 20 months
after implantation. In the bNED patients (no biochemical evidence
of disease), PSA values were < 0.2 ng/ml in 82.5% (94/114 patients), < 0.5 ng/ml in 13.2% (15/114 patients), < 1.0 ng/ml in
2.6% (3/114 patients), and < 1.5 ng/ml in 1.7% (2/114 patients).
In summary, PSA values < 0.2 ng/ml, < 0.5 ng/ml and < 1.0
ng/ml occurred in 82.5%, 95.7% and 98.3%, respectively. Out of
the six patients with recurrent disease, three had a local tumor recurrence only, and three developed distant metastases. Conclusion:
In low-risk prostate cancer patients, TPSI with intraoperative ultrasound-based treatment planning and uoroscopy leads to excellent
local tumor control and PSA relapse-free survival. Urban &
Vogel.
574. 51Cr-EDTA measurements of the glomerular ltration rate
in patients with sickle cell anaemia and minor renal damage Barros F.B., Lima C.S.P., Santos A.O. et al. [Dr. C.D. Ramos, Rua
Murici 207, Bairro Alphaville, Campinas SP, 13098-315, Brazil] NUCL. MED. COMMUN. 2006 27/12 (959-962) - summ in ENGL
BACKGROUND: Creatinine clearance has been reported to be
inaccurate for the estimation of glomerular ltration rate (GFR) in
patients with sickle cell anaemia (SCA). Inulin clearance, the reference method for GFR estimation, is impractical for routine use
in these patients, and Cr-EDTA measurements of the GFR have
been rarely reported in this disease. METHODS: In order to obtain
reference Cr-EDTA values in this disease, we studied 70 patients
(40 females; 13-59 years of age, mean: 31.6 years) with homozygous SCA, normal serum creatinine and urinary albumin excretion
<or=200 g min. All patients were submitted to single-injection
Cr-EDTA GFR, urinary albumin and haematocrit measurements.
Cr-EDTA clearances were calculated in different age groups (<20,
20-29, 30-39, 40-49 and>50 years). RESULTS: The mean GFR
( standard deviation) obtained for the 70 patients was 111.5 23.1
ml min. Analysis of variance for evaluation of the possible interaction effect between Cr-EDTA clearance and sex, age, urinary
albumin and haematocrit demonstrated patient age as the only factor
inuencing Cr-EDTA clearance (P<0.001). The Spearman correlation coefcient showed a signicant relationship between Cr-EDTA
clearance and patient age (r=-0.44, P=0.0001), but not between
111
2BU, United Kingdom] - EUR. J. RADIOL. 2006 60/3 (331-340) summ in ENGL
Fast data acquisition imaging technologies such as modern computed tomography (CT) allow contrast agents to be used as tracers
and nuclear medicine methodology may be used to derive a variety
of functional/physiological information from dynamic CT. This article describes the theoretical basis and some practical applications
of this idea including the measurement of perfusion, capillary permeability, vascular volumes, renal function and tumour responses
to therapy. 2006 Elsevier Ireland Ltd. All rights reserved.
578. Contrast agents for functional and cellular MRI of the
kidney - Grenier N., Pedersen M. and Hauger O. [N. Grenier, ERT
CNRS Imagerie Mol culaire et Fonctionnelle, Universit Victor
e
e
Segalen-Bordeaux 2, Bordeaux, France] - EUR. J. RADIOL. 2006
60/3 (341-352) - summ in ENGL
Low-molecular-weight gadolinium (Gd) chelates are glomerular
tracers but their role in evaluation of renal function with magnetic
resonance (MR) imaging is still marginal. Because of their small
size, they diffuse freely into the interstitium and the relationship
between measured signal intensity and concentration is complex.
New categories of contrast agents, such as large Gd-chelates or
iron oxide particules, with different pharmacokinetic and magnetic
properties have been developed. These large molecules could be
useful for both functional (quantication of perfusion, quantication of glomerular ltration rate, estimation of tubular function) and
cellular imaging (intrarenal phagocytosis in inammatory renal diseases). Continuous development of new contrast agents remains
worthwhile to get the best adequacy between the physiological phenomenon of interest and the pharmacokinetic of the agent. 2006
Elsevier Ireland Ltd. All rights reserved.
See also: 615.
in the relative effectiveness of kidney doses cause minor bias. Interobserver variability must be considered when interpreting kidney
doses. 2006 Springer-Verlag.
580. Metastatic Struma Ovarii: Late Presentation, Unusual
Features and Multiple Radioactive Iodine Treatments - Zekri
J.M., Manifold I.H. and Wadsley J.C. [J.M. Zekri, Shefeld Teaching Hospitals NHS Trust, Weston Park Hospital, Whitham Road,
Shefeld, S10 2SJ, United Kingdom] - CLIN. ONCOL. 2006 18/10
(768-772) - summ in ENGL
Metastatic malignant struma ovarii is rare and there is a lack of
agreement on the criteria of diagnosis and the lines of management.
Here we describe a patient with struma ovarii that was initially
diagnosed as benign and presented 10 years later with distant metastases. At this time, a pathological review of the initial lesion
found that it contained invasive well-differentiated follicular carcinoma. The case was associated with a number of unusual features
and challenging management issues, such as a delayed diagnosis
of recurrence, functioning metastases with treatment consequences,
tumour lysis-induced thyrotoxicosis and cerebrospinal uid rhinorrhea. The diagnosis and management of struma ovarii should be led
by an expert multidisciplinary team. Radioactive iodine should be
considered in the management of metastatic disease. 2006 The
Royal College of Radiologists.
581. Evil radioactivity: Subjective perception of radioactivity
in patients with thyroid disease prior to treatment with ra
can be related to a radiation-induced reduction of iodine uptake/metabolism or a modied iodine transport mechanism. For further
in vivo studies, this experimental model using normal rat thyroid
tissue may be useful in investigating the cell death pathways induced
by I-131 and its probable roles in the development of the stunning
phenomenon. Mary Ann Liebert, Inc.
584. Two-day thionamide withdrawal prior to radioiodine uptake sufciently increases uptake and does not exacerbate
hyperthyroidism compared to 7-day withdrawal in graves disease - Kubota S., Ohye H., Yano G. et al. [Dr. S. Kubota, Kuma
Hospital, 8-2-35 Shimoyamate-Dori, Chuo-Ku, Kobe 650-0011,
Japan] - ENDOCR. J. 2006 53/5 (603-607) - summ in ENGL
The appropriate period of antithyroid drug (ATD) discontinuation
before radioiodine therapy is the most critical problem in Graves
disease patients under going treatment with ATD. To determine the
optimal period that does not alter the outcome of radioiodine therapy
or exacerbate hyperthyroidism, we compared serum FT4 levels at
radioiodine uptake (RAIU) and therapy outcomes between a 2-day
withdrawal group and 7-day withdrawal group. We prospectively
recruited 43 patients for the 2-day withdrawal protocol and retrospectively reviewed 49 patients treated with radioiodine following
the protocol of 7-day withdrawal. There was no signicant difference in RAIU between the 2 groups. The mean serum FT4 level
measured on the rst day of 24-h RAIU of the 7-day group was
signicantly higher than that in the 2-day group. There were no
signicant differences in the outcomes at each point (6 months, 1
year, and 2 years after therapy) between the 2 groups. Our results
indicated that withdrawal of ATD for 2 days is superior to 7 days in
that 2 days discontinuation did not exacerbate hyperthyroidism. In
order to prevent serum thyroid hormone increase after ATD withdrawal and radioiodine therapy, a 2-day ATD withdrawal period
before radioiodine therapy may be useful for high-risk patients such
as the elderly and patients with cardiac complications. We believe
that the 2-day ATD withdrawal method may be useful for patients
undergoing treatment with ATD who are to undergo radioiodine
therapy.
585. Frequent, aggressive behaviors of thyroid microcarcinomas in Korean patients - Lee J., Rhee Y., Lee S. et al. [Dr. S.-K.
Lim, Department of Internal Medicine, Yonsei University College
of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752,
South Korea] - ENDOCR. J. 2006 53/5 (627-632) - summ in ENGL
The incidence of thyroid microcarcinoma is rising due to the
frequent use and improvement of ne-needle aspiration biopsy and
ultrasonography. Since the recent update of the TNM (Tumor, Node, Metastasis) staging system for thyroid cancer, the importance
of lymph node metastasis became more prominent. In the present
study, we evaluated the prognostic factors and extension of thyroid
microcarcinomas in Korean patients. The clinical and pathological ndings in patients with thyroid microcarcinomas in a Korean
hospital from January through December 2004 were evaluated. A
total of 302 (50.2%) out of 601 cases of thyroid cancers were microcarcinomas. Evaluation of the histology revealed that nearly all
of the cases (300 of 302) were of the papillary type. Analyzing patients of papillary thyroid microcarcinomas, 273 (91.0%) out of 300
patients of papillary microcarcinomas were women. Seventy-eight
(26.0%) cases contained multiple tumor masses ( 2), including 49
(16.3%) cases that were bilateral. There were 84 (28.0%) cases of
extrathyroidal extensions and 89 cases (29.7%) of lymph node metastasis, but no cases of distant metastases. Application of the new
staging system revealed 7 (2.3%) cases that changed from stage
III to stage IVA. Thyroid microcarcinomas were also associated
with poor prognostic factors and appear to exist at relatively higher
cancer stages. Therefore, it is important to treat them as early and
as vigorously as possible with extensive surgery, radioactive iodine
therapy, and thyroxine suppression.
586. Graves disease in the cervical thyroid and thyroglossal
duct remnant: Case report and review of literature - Buckingham H., Sauerwein T.J. and Golding A.C. [Dr. H. Buckingham,
Division of Endocrinology, Wright-Patterson Air Force Base, 4881
Sugar Maple Drive, Dayton, OH 45433-5529, United States] - ENDOCR. PRACT. 2006 12/4 (401-405) - summ in ENGL
114
38105, United States] - CLIN. NUCL. MED. 2006 31/12 (822-825) summ in ENGL
Pheochromocytomas offer the opportunity to explore multiple pathophysiological mechanisms through functional imaging.
MIBG scintigraphy and PET scanning with tracers of the sympathetic nervous system are based on uptake of catecholamines and
catecholamine-like compounds by hNET, the human norepinephrine
transporter. In-111 pentetreotide scanning involves the imaging of
somatostatin receptors on the cellular surface of tissues. FDG PET
scanning examines the transport and incorporation of FDG into
cells. We present a patient with malignant pheochromocytoma who
underwent multitracer imaging to characterize the tumor and probe
its pathophysiology to direct a therapeutic approach. This case underscores the inherent difculties in the diagnosis and localization of
malignant pheochromocytomas. Multiple approaches to functional
and anatomic imaging may be required to fully delineate the extent
of disease and similarly to direct radionuclide-based therapy.
2006 Lippincott Williams & Wilkins, Inc.
592. Radioactive iodine in thyroid medicine - How it started in
Sweden and some of todays challenges - Mattsson S., Johansson
L., J nsson H. and Nosslin B. [S. Mattsson, Department of Radiation
o
Physics, Malm University Hospital, SE-20502, Malm , Sweden]
o
o
- ACTA ONCOL. 2006 45/8 (1031-1036) - summ in ENGL
In Sweden, radioactive iodine for thyroid diagnostics and therapy was introduced by Jan Waldenstr m (1906-1996) and Bengt
o
Skanse (1918-1963). The paper describes the start of the clinical
use of radioiodine, the various iodine isotopes available, measurement techniques and dosimetry. There are still problems to solve
in relation to an optimal clinical use of radioiodine. One of the
remaining challenges is to get consensus about the goal of the treatment of hyperthyreosis, as well as about a method for individual
absorbed dose calculations. Careful dose estimates will prevent
unnecessary radiation exposure and constitute a base for a future
optimised radioiodine therapy. For the dose calculation, it is important to understand if there is any clinically signicant temporary
reduction in the ability of thyroid tissue to trap or retain 131 I-iodide
following prior administration of a diagnostic activity of 131 I-iodide
(stunning of the thyroid). This may be of special concern in connection with treatment of thyroid cancer and its metastases. Finally,
the production capacity, availability and delivery of 123 I have to
be improved to increase clinical access to this radionuclide, which
is optimal for diagnostic imaging and which gives lower absorbed
dose and therefore also less risk for thyroid stunning than 131 I.
2006 Taylor & Francis.
593. Radioiodine treatment for malignant thyroid disease Berg G. [G. Berg, Department of Oncology, Sahlgrenska University Hospital, S-413 45 G teborg, Sweden] - ACTA ONCOL. 2006
o
45/8 (1041-1045) - summ in ENGL
Radioiodine treatment for thyroid disease has been given for half
a decade in Sweden. The most common indication for treatment is
hyperthyroidism, when iodine uptake is high. The situation in which
radioiodine treatment is used in thyroid cancer is less favourable
and measures therefore have to be taken to optimize the treatment.
Treatment should be performed early in the course of the disease to
achieve the highest possible differentiation. Before treatment the
iodine and goitrogen intake should be kept low. Stimulation of the
thyrocytes by thyroid-stimulating hormone (TSH) should be high. It
is conventionally achieved by thyroid hormone withdrawal rendering the patient hypothyroid, or by the recently available recombinant
human TSH (rhTSH) which can be recommended for ablation of
the thyroid remnant after thyroidectomy and for treatment of metastases in fragile patients unable to undergo hypothyroidism. Finally,
stunning - the negative effect of a prior test dose from radioactive
iodine - should be avoided. 2006 Taylor & Francis.
594. Endocrine ophthalmopathy and radioiodine therapy Karlsson F.A. [F.A. Karlsson, Section of Endocrinology and Diabetes, Institute of Medical Sciences, Uppsala University Hospital,
SE-751 85 Uppsala, Sweden] - ACTA ONCOL. 2006 45/8 (10461050) - summ in ENGL
Endocrine ophthalmopathy is to some degree present in most
patients with Graves disease. In few cases, a severe form of the
condition develops and in the majority of these cases, the course of
115
the eye problems has been inuenced by the treatment for thyrotoxicosis. In this regard, radioiodine therapy has been increasingly
recognized as carrying a special risk. Here, the current understanding of endocrine ophthalmopathy and the risks associated with the
development of severe eye disease are discussed. The results of
a retrospective investigation of patients with severe eye disease in
our hospital, and the experience with corticosteroid administration
following radioiodine in order to reduce the risk of ophthalmopathy,
are also presented. 2006 Taylor & Francis.
595. Radioiodine therapy in non-toxic multinodular goitre. The
possibility of effect-amplication with recombinant human TSH
(rhTSH) - Bonnema S.J., Nielsen V.E. and Heged s L. [S.J.
u
Bonnema, Department of Endocrinology and Metabolism, Odense
University Hospital, DK-5000 Odense C, Denmark] - ACTA ONCOL. 2006 45/8 (1051-1058) - summ in ENGL
There is no consensus regarding the optimum treatment of benign
non-toxic goitre. L-thyroxine suppressive therapy is widely used,
but there is poor evidence of its efcacy, and it may have serious
adverse effects on health. Surgery is rst choice in large goitres or
if malignancy is suspected. 131 I therapy results in a one-year goitre
reduction of around 40% in multinodular goitres, usually with a
high degree of patient satisfaction and improvement of the inspiratory capacity. The effect is attenuated with increasing goitre size.
The risk of hypothyroidism is 22-58% within 5-8 years. A sufcient
thyroid 131 I uptake is mandatory for 131 I therapy to be feasible and
pre-stimulation with recombinant human TSH (rhTSH) increases
this considerably. This leads to an increased absorbed thyroid dose
by approx.75%, mainly in those patients with the lowest thyroid
131 I uptake, and a more homogeneous intrathyroidal isotope distribution. Pre-stimulation with even a small dose of rhTSH seems to
allow a reduction of the 131 I activity while still achieving a mean
goitre reduction of approximately 40% within a year. A signicantly
lower extrathyroidal radiation is achieved by this approach. With an
unchanged 131 I activity, rhTSH pre-stimulation improves the goitre
reduction by 30-50%. However, this is at the expense of a higher
rate of hypothyroidism, cervical pain and transient thyrotoxicosis.
Of particular concern is the observation made in healthy persons,
that rhTSH results in a transient average thyroid volume increase of
35%. A similar goitre swelling may cause problems in susceptible
patients during rhTSH-augmented 131 I therapy. Thus, this concept
still needs a closer evaluation before routine use. 2006 Taylor &
Francis.
598. Standardized uptake values of normal breast tissue with 2deoxy-2-[F-18]uoro-D-glucose positron emission tomography:
Variations with age, breast density, and menopausal status - Kumar R., Chauhan A., Zhuang H. et al. [Dr. R. Kumar, Department
of Nuclear Medicine, All-India Institute of Medical Sciences, New
Delhi 110029, India] - MOL. IMAGING BIOL. 2006 8/6 (355-362) summ in ENGL
Objective: This study was conducted to assess the effect of breast
density, age, and menopausal status on the 2-deoxy-2-[F-18]uoroD-glucose (FDG) uptake in normal breast tissue by quantitative
standardized uptake values (SUV). Methods: A total of 96 patients (premenopausal 54; postmenopausal 42) with histologically
proven unilateral breast cancer who underwent FDG-positron emission tomography (PET) scans for staging were included in this
study. The median age was 52 11 years (range 32-79 years). Fifty-nine patients had grade III or IV mammographic density
(dense breast), whereas 37 patients had grade I or II breast density
(nondense) according to the ACR Lexicon criteria. In the present
study, we analyzed maximum and average SUVs for contralateral
normal breast. Results: Maximum and average SUVs for normal
dense breasts were 1.02 0.30 and 0.84 0.27, respectively. Similar values for the nondense breasts were 0.66 0.24 and 0.53 0.23,
respectively. Both maximum and average SUVs of dense breasts
were signicantly higher than those of nondense breasts (p<0.001).
There was no signicant difference in SUVs of nipple in patients
with dense and nondense breasts. There was no signicant effect
of age and menopausal status on SUVs of normal breast. However, there were trends of negative relationship, i.e., decreasing
SUVs with increasing age. Conclusion: There was a signicant
difference in SUVs between the dense and nondense normal breast.
However, the maximum SUVs in the dense breasts were well below
the threshold of 2.5, a widely used cutoff value for malignancy.
Menopausal status and age do not signicantly affect the uptake of
FDG. Academy of Molecular Imaging 2006.
597. Contrast-enhanced breast ultrasonography reveals an unusual breast tumor in a male patient with gynecomastia - Kwee
599. Usefulness of scintimammography as an adjunct to mammography and ultrasound in the diagnosis of breast diseases -
116
respectively. There was no vessel thrombosis during antiplatelet therapy. Angiographic/clinical follow-up rate was 84%/100%.
MACE rate was 17.6% in the native coronary artery group and
38.1% in the CABG group (p<0.03). Binary restenosis rate was
22.5% and 55.6% (p<0.01), and late loss was 0.38 0.72 mm and
1.33 1.11 mm (p<0.001), respectively. Conclusions: We conclude that intracoronary -brachytherapy with a liquid 188 Re-lled
balloon using 22.5 Gy at a tissue depth of 0.5 mm in restenotic
lesions is safe. It is associated with a low binary restenosis rate,
resulting in a low occurrence rate of MACE within 12 months in
restenotic lesions in native coronary arteries but not in vein grafts.
2006 Springer-Verlag.
6. ADVERSE REACTIONS
607. Comparison of [177 Lu-DOTA0 ,Tyr3 ]octreotate and [177 LuDOTA0 ,Tyr3 ]octreotide: Which peptide is preferable for
PRRT? - Esser J.P., Krenning E.P., Teunissen J.J.M. et al. [J.P.
Esser, Department of Nuclear Medicine, Medisch Spectrum Twente,
Haaksbergerstraat 55, 7513 ER Enschede, Netherlands] - EUR. J.
NUCL. MED. MOL. IMAGING 2006 33/11 (1346-1351) - summ in
ENGL
Purpose: Patients with somatostatin receptor subtype 2-positive
metastasised neuroendocrine tumours can be treated with [177 LuDOTA0 ,Tyr3 ]octreotate. Some use octreotide as the peptide for
peptide receptor radionuclide therapy (PRRT). We compared in
seven patients [177 Lu-DOTA0,Tyr3 ]octreotide ( 177 Lu-DOTATOC)and [177 Lu-DOTA0,Tyr 3 ]octreotate (177 Lu-DOTATATE), to see
which peptide should be preferred for PRRT with 177 Lu. Methods: In the same patients, 3,700 MBq 177 Lu-DOTATOC and 3,700
MBq 177 Lu-DOTATATE was administered in separate therapy sessions. Amino acids were co-administered. Whole-body scanning
was performed on days 1, 4 and 7 post therapy. Blood and urine
samples were collected. We calculated residence times for tumours,
spleen and kidneys. Results: All patients had longer residence
times in spleen, kidneys and tumours after use of 177 Lu-DOTATATE
(p=0.016 in each case). Comparing 177 Lu-DOTATATE with 177 LuDOTATOC, the mean residence time ratio was 2.1 for tumour, 1.5
for spleen and 1.4 for kidneys. Dose-limiting factors for PRRT
are bone marrow and/or kidney dose. Although the residence time
for kidneys was longer when using 177 Lu-DOTATATE, the mean
administered dose to tumours would still be advantageous by a
factor of 1.5, assuming a xed maximum kidney dose is reached.
Plasma radioactivity after 177 Lu-DOTATATE was comparable to
that after 177 Lu- DOTATOC. Urinary excretion of radioactivity was
comparable during the rst 6 h; thereafter there was a signicant
advantage for 177 Lu-DOTATOC. Conclusion: 177 Lu-DOTATATE
had a longer tumour residence time than 177 Lu-DOTATOC. Despite
a longer residence time in kidneys after 177 Lu-DOTATATE, tumour
dose will always be higher. Therefore, we conclude that the better
peptide for PRRT is octreotate. 2006 Springer-Verlag.
605. Improved tumour detection by gastrin receptor scintigraphy in patients with metastasised medullary thyroid carcinoma
- Gotthardt M., B h M.P., Beuter D. et al. [M. Gotthardt, Departe e
ment of Nuclear Medicine, Radboud University Nijmegen Medical
Center, Postbus 9101, 6500 HB Nijmegen, Netherlands] - EUR. J.
NUCL. MED. MOL. IMAGING 2006 33/11 (1273-1279) - summ in
ENGL
Purpose: Radiopeptide imaging is a valuable imaging method in
the management of patients with neuroendocrine tumours (NET). To
determine the clinical performance of gastrin receptor scintigraphy
(GRS), it was compared with somatostatin receptor scintigraphy
(SRS), computed tomography (CT) and 18 F-FDG positron emission tomography (PET) in patients with metastasised/recurrent
medullary thyroid carcinoma (MTC). Methods: Twenty-seven consecutive patients underwent imaging with GRS, SRS (19 patients),
CT and PET (26 patients). GRS and SRS were compared with
respect to tumour detection and uptake. CT, PET, magnetic resonance imaging (MRI), ultrasound (US) and follow-up were used for
verication of ndings. In addition, GRS, CT and PET were directly
compared with each other to determine which method performs best.
Results: Nineteen patients underwent both GRS and SRS. Among
these, GRS showed a tumour detection rate of 94.2% as compared
to 40.7% for SRS [mean number of tumour sites ( SD) and 95%
condence intervals (CI): GRS 4.3 3.1/2.8-5.7, SRS 1.8 1.6/1.12.6]. In 26 patients, GRS, CT and PET were compared. Here, GRS
showed a tumour detection rate of 87.3% (CT 76.1%, PET 67.2%;
mean number of tumour sites and 95% CI: GRS 4.5 4.0/2.9-6.1,
CT 3.9 3.5/2.5-5.3, PET 3.5 3.3/2.1-4.8). If GRS and CT were
combined, they were able to detect 96.7% of areas of tumour involvement. Conclusion: GRS had a higher tumour detection rate
than SRS and PET in our study. GRS in combination with CT
was most effective in the detection of metastatic MTC. 2006
Springer-Verlag.
606. Intracoronary -brachytherapy using a rhenium-188 lled
balloon catheter in restenotic lesions of native coronary arteries
and venous bypass grafts - W hrle J., Krause B.J., Nusser T. et al.
o
[J. W hrle, Department of Internal Medicine II, University of Ulm,
o
Robert-Koch-Strasse-8, 89081 Ulm, Germany] - EUR. J. NUCL.
MED. MOL. IMAGING 2006 33/11 (1314-1320) - summ in ENGL
Purpose: We have previously demonstrated the efcacy of intracoronary -brachytherapy using a liquid 188 Re-lled balloon in a
randomised trial including de novo lesions. Percutaneous coronary
interventions in restenotic lesions and in stenoses of venous bypass
grafts are characterised by a high recurrence rate for restenosis and
re-interventions. Against this background, we wanted to assess
the impact of intracoronary -brachytherapy using a liquid 188 Relled balloon in restenotic lesions in native coronary arteries and
venous bypass grafts. Methods: In 243 patients, -brachytherapy
with 22.5 Gy was applied at a tissue depth of 0.5 mm. Patients
were followed up angiographically after 6 months and clinically
for 12 months. The primary clinical endpoint was the incidence of
MACE (death, myocardial infarction, target vessel revascularisation). Secondary angiographic endpoints were late loss and binary
restenosis rate in the total segment. Results: All irradiation procedures were successfully performed. A total of 222 lesions were in
native coronary arteries; 21 were bypass lesions. Mean irradiation
length was 41.6 17.3 mm (range 20-150 mm) in native coronary
arteries and 48.1 33.9 mm (range 30-180 mm) in bypass lesions;
the reference diameter was 2.57 0.52 mm and 2.83 0.76 mm,
118
608. New radiopharmaceuticals for imaging rheumatoid arthritis - Chianelli M., DAlessandria C., Conti F. et al. [Prof. A.
Signore, Departement de Medicina Nucleare, University of La Sapienza, Ospedale S. Andrea, Via di Grottarossa 1035, 00189 Roma,
Italy] - Q. J. NUCL. MED. MOL. IMAGING 2006 50/3 (217-225) summ in ENGL
Rheumatoid arthritis (RA) is an incapacitating chronic inammatory disease of the joints that, because of frequent relapses, requires
life-long treatment. In patients affected with RA an important treatment objective is to achieve specic immune suppression in order
to extinguish the immune process and arrest the disease, thus preventing or delaying complications and avoiding disease recurrence.
The side effects of anti-inammatory drugs given to improve the
quality of life of these patients can be reduced with the use of
specic immune therapies that block, as selectively as possible, the
pathologic mechanism responsible for the disease. New therapeutic
options for specic, targeted therapies for treating RA are being
developed, and trials to assess the efcacy and safety of these approaches are underway. However, these therapies rely primarily
on clinical assessment to evaluate treatment efcacy. It would be
useful, therefore, to have an objective and reliable method that
directly highlights the immune processes underlying the disease.
Currently available radiopharmaceuticals for imaging RA, with a
special emphasis on recently developed agents and their use in therapy decision-making and follow-up are the focus of this articles.
Section 23 vol 70.2
609. Receptor targeting agents for imaging infammatin/infection: Where are we now?
- Signore A., Chianelli M.,
DAlessandria C. and Annovazzi A. [Prof. A. Signore, Departemente de Medicina Nucleare, University La Sapienza, Ospedale S.
Andrea, Via Di Grottarossa 1035, 00189 Roma, Italy] - Q. J. NUCL.
MED. MOL. IMAGING 2006 50/3 (236-242) - summ in ENGL
Over the past 20 years, radiopharmaceutical research has brought
to market a wide variety of drugs that aid in the management of
infection and inammation. Finding the best clinical application
for existing radiopharmaceuticals can be a challenging task, as
clinicians now have to choose from an array of many different
radiopharmaceuticals, each suited to identify a specic type of
inammation. With this review, we describe the features of receptor-targeting agents and present the main advantages and limitations
to their application in the diagnosis of inammations and infection.
The receptor-specic agents described here include peptides and
antibodies as well as radiolabeled antibodies employed for the specic targeting of neutrophils, bacteria, lymphocytes, and molecules
involved in inammatory processes. Because these agents bind to
specic receptors, they allow the mapping of receptor expression
in vivo. Such mapping represents the future of nuclear medicine
imaging, as it aids in diagnosing the type of inammation, in therapy
decision-making, in selecting suitable candidates for therapy, and
in evaluating treatment efcacy.
610. Radiotherapy of Langerhans cell histiocytosis: Results and implications of a national patterns-of-care study Olschewski T. and Seegenschmiedt M.H. [Dr. T. Olschewski, Department of Radiotherapy and Radiation Oncology, Alfried Krupp
Krankenhaus, Alfried-Krupp-Strae 21, 45117 Essen, Germany]
- STRAHLENTHER. ONKOL. 2006 182/11 (629-634) - summ in
ENGL, GERM
Purpose: This patterns-of-care study was performed to dene the
current clinical experience with radiotherapy of Langerhans cell
histiocytosis in adults in Germany and to dene open questions
resulting from this study. Material and Methods: A standardized
questionnaire was sent to 198 German radiotherapy institutions.
Data about patient characteristics, stage of disease, practice and
fractionation of radiotherapy, outcome of therapy, etc. were systematically evaluated. 123 of 198 institutions answered the complete
questionnaire (62.1%). Results: Only 23 of the 123 institutions
(18.7%) reported experience with radiotherapy of Langerhans cell
histiocytosis of adults. 18 institutions with 98 patients were evaluable. The majority of patients (72 of 98) was treated on a linear
accelerator. The median single dose of radiotherapy was 2 Gy,
while the median total dose was 24 Gy. 81 of 89 evaluable patients
(91%) reached a local control of the treated lesion(s), 69 of those had
a complete remission. Eight of 89 patients (9%) developed an ineld recurrence. 87.8% of patients experienced no acute and 97% of
patients no late side effects of radiotherapy. Conclusion: Clinical
experience with radiotherapy of Langerhans cell histiocytosis in
adults in Germany is still very limited. Nevertheless, the clinical
results - with high remission and local control rates - conrm the
effectiveness of radiotherapy in the multidisciplinary treatment of
this disease. Due to the small number of patients in this study
despite higher incidence rates, the knowledge of this disease has to
be multiplied in Germany. Future patients should be systematically
included into a prospective radiotherapy registry. Urban & Vogel.
611. Fractionated stereotactic radiation therapy in the management of benign cavernous sinus meningiomas: Long-term
experience and review of the literature - Milker-Zabel S., ZabelDu Bois A., Huber P. et al. [Dr. S. Milker-Zabel, Department
of Radiation Oncology, Radiotherapy, University of Heidelberg,
69120 Heidelberg, Germany] - STRAHLENTHER. ONKOL. 2006
182/11 (635-640) - summ in ENGL, GERM
Purpose: To analyze own long-term results with fractionated
stereotactic radiotherapy (FSRT) in patients with benign meningiomas of the cavernous sinus and to review the literature on these rare
lesions. Patients and Methods: 57 patients were treated with FSRT
for benign meningiomas of the cavernous sinus between 01/1990
and 12/2003 at the authors institution. Histology was WHO grade
I in 28/57 lesions, and undetermined in 29/57 lesions. 29 patients
received radiotherapy as primary treatment, ten following surgery,
and 18 patients were irradiated for recurrent disease. Median target
Section 23 vol 70.2
volume was 35.2 cm3 . Median total dose was 57.6 Gy with 1.8
Gy per fraction. 51/57 patients showed clinical symptoms before
radiotherapy like reduced vision (n = 19), diplopia (n = 25), or
trigeminal hyp-/dysesthesia (n = 17). Results: Median follow-up
period was 6.5 years. 50/57 patients were followed for > 36 months.
Overall local tumor control was 100%. 39/57 patients had stable
disease based on CT/MRI, while 18/57 had a partial remission of
tumor volume. Overall survival for patients with WHO grade I
meningiomas was 95.5% after 5 and 10 years. Two patients died
2.8 and 4.1 years after radiotherapy due to cardiac failure. In 11/57
patients, preexisting neurologic decits improved. There was one
patient with recurrent hyperlacrimation of one eye on the side of the
irradiated meningioma. Three patients complained about subjective
visual deterioration after FSRT without any objective ndings in an
ophthalmologic examination. No late toxicity RTOG III was
seen. Conclusion: These data demonstrate that FSRT is an effective
and safe treatment modality for local control of benign cavernous
sinus meningiomas with a minimal risk of signicant late toxicity.
Urban & Vogel.
612. "Spot-scanning" proton therapy for rhabdomyosarcomas
of early childhood. First experiences at PSI (Germ) - PROTONENTHERAPIE MIT "SPOT-SCANNING" BEI RHABDOMYOSARKOMEN IM
Schuck A., Niggli F. et al. [Dr. B. Timmermann, Abteilung Strahlenmedizin, Programm Protonen-Therapie, Paul Scherrer Institut,
5232 Villigen-PSI, Switzerland] - STRAHLENTHER. ONKOL. 2006
182/11 (653-659) - summ in ENGL, GERM
Purpose: To evaluate the feasibility and acute toxicity of spotscanning proton therapy under deep sedation in young children with
rhabdomyosarcomas (RMS). Patients and Methods: Since 2004,
children requiring sedation can be admitted for proton therapy at
Paul Scherrer Institute (PSI), Villigen, Switzerland. Children under
5 years of age with RMS of the head and the trunk were analyzed. All children were enrolled in a multidisciplinary treatment
protocol and prospective, standardized evaluation of side effects
was performed. Results: Nine children were included aged 0.93.8 years (embryonal RMS in six, and alveolar, undifferentiated or
nonclassied in one each). The tumor site was parameningeal (n =
4), orbital (n = 3), head and neck (n = 1), and prostate (n = 1). All
children were in IRS group III. Total proton dose was 46-54 CGE
(cobalt-gray equivalent). Only the myelotoxicity exceeded grade 3
or 4 (RTOG/EORTC). Conclusion: Proton therapy for RMS in early
children is feasible and well tolerated. The prospective standardized
evaluation of toxicity and quality of life needs to be continued.
Urban & Vogel.
613. European Society of Urogenital Radiology (ESUR) guidelines on the safe use of iodinated contrast media - Thomsen H.S.
[H.S. Thomsen, Department of Diagnostic Radiology 54E2, Copenhagen University Hospital at Herlev, Herlev Ringvej 75, DK-2730
Herlev, Denmark] - EUR. J. RADIOL. 2006 60/3 (307-313) - summ
in ENGL
Since 1996 the Contrast Media Safety Committee of the European Society of Urogenital Radiology (ESUR) has released 19
guidelines regarding safety in relation to the use of radiographic,
ultrasonographic as well as magnetic resonance contrast media. The
committee has covered both renal and non-renal adverse events as
well as other aspects of contrast media. The present paper is an
overview of the work accomplished over the last 10 years regarding
radiographic iodinated contrast media. 2006 Elsevier Ireland
Ltd. All rights reserved.
614. MR contrast agents, the old and the new - Bellin M.-F.
[M.-F. Bellin, University Paris-Sud XI, Department of Radiology,
University Hospital Paul-Brousse, 12, Avenue Paul Vaillant-Couturier, 94804 Villejuif Cedex, France] - EUR. J. RADIOL. 2006 60/3
(314-323) - summ in ENGL
Magnetic resonance (MR) contrast agents are increasingly being
used to help detect and characterize various neoplastic, inammatory and functional abnormalities. The extracellular, non-specic
contrast agents gadolinium chelates are by far the most widely used.
Over the past few years a number of MR organ specic contrast
agents have been introduced. MRI contrast agents are generally
119
safe and well tolerated. The present review summarizes the properties, main characteristics and imaging applications of commercially
available compounds as well as safety of these agents in normal and
high-risk patients. 2006 Elsevier Ireland Ltd. All rights reserved.
615. Fractionated radioimmunotherapy of intraperitoneally
growing ovarian cancer in nude mice with 211 At-MX35 F(ab )2 :
therapeutic efcacy and myelotoxicity - Elgqvist J., Andersson
H., B ck T. et al. [J. Elgqvist, Department of Radiation Physics, The
a
Sahlgrenska Academy, G teborg University, SE-413 45 G teborg,
o
o
Sweden] - NUCL. MED. BIOL. 2006 33/8 (1065-1072) - summ in
ENGL
Objective: The aim of this study was to investigate the therapeutic
efcacy and myelotoxicity during fractionated radioimmunotherapy
of ovarian cancer in mice. The study was performed using the monoclonal antibody MX35 F(ab )2 labeled with the -particle emitter
211 At. Methods: Animals were intraperitoneally inoculated with
1 107 cells of the cell line NIH:OVCAR-3. Four weeks later,
the mice were given the rst treatment. Six groups of animals were
intraperitoneally injected with 800, 3
267, 400, 3
133,
50 or 3
17 kBq 211 At-MX35 F(ab )2 (n=18 in each group).
The second and third injections for Groups 2, 4 and 6 were given 4
and 8 days after the rst injection, respectively. As controls, animals
were treated with unlabeled MX35 F(ab )2 (n=12). Eight weeks after the last injection, the animals were sacriced and the presence of
macro- and microscopic tumors and ascites was determined. Blood
counts were determined for each mouse in Groups 1 and 2 before
the rst injection and 3, 7, 11, 15 and 23 days after the rst injection.
The calculation of the mean absorbed dose to the bone marrow was
120
SUBJECT INDEX
(gures refer to item numbers)
SUBJECT INDEX
SUBJECT INDEX
SUBJECT INDEX
SUBJECT INDEX
SUBJECT INDEX
SUBJECT INDEX
SUBJECT INDEX
SUBJECT INDEX
SUBJECT INDEX
SUBJECT INDEX
SUBJECT INDEX
11
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Competitively priced, EMCare is the affordable
alternative to other nursing and allied health
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AUTHOR INDEX
(gures refer to item numbers)
Aalto S. 465
Aardaneh K. 355
Abdeen S. 599
Abuelhia E. 352
Acar E. 601
Acton P.D. 517
Ahn G.H. 364
Alauddin M.M. 424
Alavi M.S. 576
Alessio A. 438
Alfassi Z.B. 311
Alinari L. 527
Almkvist O. 447
Almqvist Y. 567
Alves F. 413
Alzitzoglou T. 364
Amartey J.K. 320
Amitani M. 416
Ananthasubramaniam K. 514
Anderson T.L. 530
Andersson H. 615
Andratschke N. 444
Angelov C.A. 427
Annovazzi A. 609
Anton M. 516
Appel G. 386
Appoloni C.R. 375, 390
Araki N. 478
Aras N.K. 371
Arenillas P. 345
Argon A.M. 601
Armstrong J.S. 313
Aruva M.R. 434
Ashkenazi I. 503
Aub C. 560
e
Auerbach P. 361
Awasare S. 603
Ay M.R. 370
Babul A. 583
Babyn P.S. 575
Bacchi M.A. 376
B ck T. 615
a
Balamucki C.J. 452
Bansal A. 414
Bar-Shalom R. 604
Baraniak L. 359
Barros F.B. 574
Bashian G.G. 510
Basiratnia M. 576
Battle M. 508
Bauhofer A. 582
Beamish J. 513
Beer A. 579
B h M.P. 605
e e
Bekker J. 596
Belandi T.J. 315
Bellin M.-F. 614
Ben-Haim S. 604
B nard F. 547
e
Bentourkia M. 484
Berbari E.F. 501
Berg G. 593
Bessesen D.H. 411
Beuter D. 605
Beyer T. 581
Bhakoo K.K. 437
Bischof Delaloye A. 428
Block T. 573
Blonski M.S. 375
Bogdanov Jr. A. 401
Section 23 vol 70.2
Dadachova E. 433
DAlessandria C. 608, 609
Damasceno A.L.O. 318
Das M.K. 398
Dawson P. 577
De Boorder M.J. 450
De Felice P. 328
De Geer L.-E. 384
De Geus-Oei L.-F. 394
de Geus-Oei L.F. 554
De Haas M.J. 596
Dec G.W. 515
Decristoforo C. 551
DeGrado T.R. 414
Derejko M. 455
Dias M.S. 324, 330
Dijkgraaf I. 417
Ding H.-J. 565
Dirnberger G. 485
Dissanayaka K.R. 358
D bert N. 408
o
Dolley S. 355
Donarski J.A. 307
dos Santos J.A. 367
Drandarov K. 399
Drochioiu G. 354
Dryak P. 334
Dufn R. 403
Dupertuis Y.M. 428
Duygun U. 601
Duysinx B.C. 543
Dwivedi G. 518
Eary J.F. 395
Eckel-Passow J.E. 321
Edwards D. 508
Eftekhari M. 546
Eichhammer P. 475
Eijsink V.G.H. 432
El Khuffash A. 513
El Ouamari M. 597
El-Mabhouh A.A. 427
El-Maghraby T.A.F. 493
Elgqvist J. 615
Ellis B. 404
Ellis T.L. 452
Elstrom R. 527
Engenhart-Cabillic R. 443
Engler H. 447
Erselcan T. 583
Esfandiari N.H. 591
Esguerra C. 320
Esser J.P. 607
Estrada J.J.S. 318
Evans A.H. 466
Fagan R.L. 306
Faintuch-Linkowski B. 551
Farhoud A. 443
Farias L.A. 377
Fartoux L. 552
Favaro D.I.T. 377
Fazio A. 328
Fernandes E.A.N. 376
Fernetti C. 563
Ferrari M. 396
Ferrari V.A. 517
Filippi L. 600
Filliben J. 362
Fischedick K. 572
Fischman A.J. 540
AUTHOR INDEX
n
Garg A.N. 372, 374
Gasparro J. 347
Geipel G. 359
Gelovani J.G. 424
George A.J.T. 437
Gholamrezanezhad A. 546
Giblin M.F. 557
Gillin J.C. 471
Gilman M.D. 540
Ginovart N. 457
Gleeson F.V. 542
Gleichmann M. 463
Globas C. 463
Godwin G.A. 587
Gogami A. 387
Goldberg A. 492
Golding A.C. 586
Goldsmith S.J. 538
Goldstein R. 559
Gong L. 438
Gordon I. 404
Gorthordt M. 582
Gostely J.-J. 419
Gotthardt M. 605
Granegger S. 511
Grau Carles A. 365, 366
Grau Malonda A. 366
Gravel P. 467
Grenier N. 578
Grigorescu L. 341
Groppi F. 311
Grosser R. 524
Grosu A.-L. 550
Gr ning T. 402
u
Guimar es M.I.C. 588
a
Gupta R. 599
Gutman F. 552
Hadac E.M. 380
Hadley D.M. 453
Haffaf E.M. 499
Hamilton D. 454
Hammond M. 336
Hanlon L. 445
Hannukainen J.C. 502
Hanyu H. 460
1
Hara T. 414
Harkness B.A. 514
Harrison B.J. 468
Hartin N. 504
Hasegawa M. 512
Hashimoto H. 459
Haskard D.O. 437
Hauger O. 578
Havelka M. 337, 361
Hawkins D.S. 495
Hayashi A. 387
He Z. 425, 521
Heged s L. 595
u
Heijenbrok-Kal M.H. 528
Heikenen J. 558
Heinrich T. 426
Heitzeg M.M. 473
Henneman M.M. 526
Herbst C. 322
Herzog H. 319, 412
Hewamanna R. 358
Hickman M. 518
Higuchi T. 431
Hilker R. 441
Hino Y. 348
Hirao K. 460
Ho C.-H.A. 451
Ho Shon I.A. 435
Hod N. 503
Hon K.-L.E. 451
Hong S.-C. 469
Hosoi R. 389, 483
Hsieh W.-Y. 425, 521
Huang Y.-C. 458
Huber P. 611
Huglo D. 436
Hult M. 347
Humelnicu D. 354
Hwang H.-Y. 410
Hwang W. 395
Iagaru A. 505
Ibarra M.R. 325
Igaki H. 569
Iglicki A. 309
Imperiale A. 566
Inn K.G.W. 362
Inoue O. 483
Ishikita T. 431
Ishimaru Y. 537
Ishiwata K. 487
Ismail M.A. 423
Israel O. 492
Iwahara A. 318, 367
Iyengar G.V. 371
Izumoto H. 507
Jackman M.R. 411
Jaffe C.A. 591
Jahanshahi M. 485
Jain G. 374
James W.D. 313
Janardhanan R. 518
Jansen J.E. 596
Jarkas N. 409
Jekerle V. 381
Jensen M. 413
Jentschel C. 426
Jeong J.M. 440
Jian Z. 422
Jin W. 496
Johansson L. 335, 592
Johnston P.N. 347
Jones C.R.G. 485
Jones L. 422
2
Lang L. 418
Langguth B. 475
Lardie T.S. 421
Larock M.-P. 543
Larstorp A.C.K. 520
Lavely W.C. 497
Leblanc M. 547
Lee C.-H. 589
Lee J. 585
Lee J.-I. 469
Lee J.D. 472
Lee K.B. 332, 410
Lee S. 585
Lee Y.-S. 440
Leonard J.P. 538
Levi Y. 503
Levine J.M. 533
Lewis J. 508
Libra A. 563
Liem I.H. 532
Lim S.J. 529
Lima C.S.P. 574
Lima J.J.P. 413
Lin C.-Y. 565
List A. 454
Liu C.-S. 565
Liu S. 425, 521
Lomax A. 571
Lombardo I. 449
Lorusso V. 563
Lot M. 576
Love C. 500
Love P. 407
Lu S.-N. 564
Lund Sraas C. 520
M Spyrou N. 352
Ma Y. 418
Machac J. 534
Mackey E.A. 314
MacLean P.S. 411
Magata Y. 486
Magnotta V.A. 462
Mahawatte P. 358
Maihara V.A. 377
M kinen S. 476
a
Malhotra A.D. 497
Malhotra G. 603
Malizia A.L. 392
Malonda A.G. 343
Man Lee J. 332
Manabe Y. 482
Manger W.M. 590
Manifold I.H. 580
Marinozzi A. 494
Marks L.B. 549
Marshall V.L. 453
Mateus V.A.P. 429
Matsuda S. 522
Matsui H. 439
Matsumoto N. 523
Matthews R. 479
Mattsson S. 592
Maxwell III S.L. 357
Mazza S. 467
McCall S.K. 360
McDougall I.R. 505
McGuire S.M. 549
McWilliams E. 384
Mel ndez-Alafort L. 420
e
Menapace E. 311
Mendes A.C. 556
Menzel E.J. 525
Mercer J.R. 427
Messina J.A. 442
AUTHOR INDEX
Nieder C. 444
Nielsen V.E. 595
Niggli F. 612
Nishii R. 544
Nishinaka K. 439
Noguchi J. 416
Nomori H. 548
Noohi A.H. 576
Norenberg J.P. 322, 530
Nosslin B. 592
Nusser T. 606
Nuutila P. 502
Nystedt J. 476
Oberg A.L. 321
OBrien L.M. 403
OConnell M.J. 513
Oda K. 487
Oda M. 439
Oh P.-J. 332
Ohtsuka T. 548
Ohye H. 584
Okada S. 477
Olschewski T. 610
Olovcov V. 337
s
a
Section 23 vol 70.2
Oltenfreiter R. 406
Ono Y. 482
Oriuchi N. 431
Ott K. 553
Oufriha N. 499
Outola I. 362
Oxley T.J. 446
Oyen W.J.G. 394
Ozalp F. 570
Ozdemir O. 583
Riondato M. 420
Roach P.J. 435
Roberts J.P. 559
Rodrguez Barquero L. 326
Rosioreanu A. 545
Roteta M. 326
Roumen R.M.H. 532
Rowshanfarzad P. 379
Rubner C. 582
Ryu K.N. 496
Paganelli G. 396
Pal R. 356
Pal S. 398
Palestro C.J. 500
Palfey B.A. 306
Pandey U. 490
Pang H.-F. 368
Papalia R. 494
Park E.S. 472
Park H.-J. 472
Park I.J. 562
Park R. 558
Parr R.M. 371
Parreira P.S. 375
Parsey R.V. 481
Pathak S. 438
Patterson J. 453
Pauleit D. 480
Pauwels E.K.J. 493
Pavese N. 466
Pearce A.K. 419
Pearson N.R. 421
Pedersen M. 578
Pejovi -Mili A. 491
c
c
Pemler P. 571
Perillo-Adamer F. 428
Perk L.R. 397
Perkins A.C. 404
Perrang C. 355
Pham M.K. 363
Pike V.W. 488
Pilette C. 560
Pinkawa M. 572
Piroth M.D. 572
Pleiss U. 524
Plotkin M. 464
Poria R.B. 530
Povinec P.P. 363
Price R.E. 444
Puetter R.C. 575
Pulcini A. 600
Punch G.E. 602
Sawek J. 455
Sabet M. 379
Saga T. 478
Sahagia M. 329, 341
Saiki M. 373
Sakai K. 482
Sakamoto A. 522
Sakata M. 487
Salber D. 480
Sam n E. 568
e
Sanchez-Cabeza J.A. 363
Santos A.O. 574
Santry D.C. 308
Sapienza M.T. 588
Sato Y. 348, 523
Satpati D. 490
Sauerwein T.J. 586
Savin M. 555
Scarsbrook A.F. 542
Schachoff S. 579
Schechter H. 390
Scheibel V. 390
Schembri G.P. 435
Schimmel K.J.M. 369
Schneider U. 571
Schou M. 488
Schrader H. 323
Schretlen D.J. 470
Schubiger P.A. 399
Schuck A. 612
Schuijf J.D. 526
Schultz M.K. 336
Schuss A. 545
Scollard D.A. 381
Scott D.J. 473
Scott Nelson R. 558
Seegenschmiedt M.H. 610
Seidel D. 524
Seifert S. 426
Sellem D.B. 566
Seppenwoolde J.-H. 429
Serti J.A.A. 373
e
Severance A.J. 481
Shanthly N. 434
Shaw M. 468
Sherpa K.M. 555
Shetty-Alva N. 535
Shimizu S. 460
Showler A.T. 313
Shu H. 385
Shulkin B.L. 591
Sia I.G. 501
Siaens R. 432
Sieckman G.L. 557
Siewert J.-R. 553
Signore A. 609
Silva C. 556
Silva E.A. 330
Silva M.A.L. 318
Simpson B.R.S. 339, 342
Simpson J.B. 587
Sinzinger H. 511, 525
Skouri H.N. 515
AUTHOR INDEX