2005 Evaluation Questions

Jan.
2005
1. which of the following functional groups
are tertiary hydroxyl group
A. ..
B. ..
C. ..
D. ..
E. ..
2. which of the following groups have
geometrical isomers:
A. Hexane and cyclohexane
B. Pentane and pentene
C. Butene and !Butene
D. Ben"ene and hexane
E. #on of the a$ove
3. %hich of the following statements
concerning cytochrome en"yme are
C&''EC()
*. (he C+P,- C+P..- C+P, are
cytochrome en"yme responsi$le
for cholesterol meta$olism.
**. C+P/A is most common
meta$oli"ing en"yme in the $ody.
***. C+P/A does phase * reductive
reactions.
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
0. (he following statements are C&''EC(
a$out a muscarinic antagonist Atropine :
A. Atropine structure contain piperidine a
pyridines rings.
B. Piperidine and pyrrolidine
C. Pirmidine and pyrrolidine
D. 1uasi ring structure $ut not tertiary
amine
E. Pyridine and 1uasi rings structure.
2. *f a structure of drug contain / sterogenic
centers 3chiral centers4- their will $e how
many isomers possi$le for this structure)
A. 5
B. .
C. /
D.
E. .
6. .!propanol and !propanol they are:
A. Conformational *somer
B. 7eometric *somer
C. Constitutional *somer
D. Diasteroisomers *somer
E. Enatiomers *somer
,. hexane and !methyl pentane are:
A. Conformational *somer
B. 7eometric *somer
C. Constitutional *somer
D. Diasteroisomers *somer
E. Enatiomers *somer
5. All the following statements are C&''EC(
a$out Enatiomers E8CEP(:
A. Enatiomers are optical isomers that are
mirror images of another
B. Enatiomers are rotate pan of polari"ed
light in cloc9wise direction are 9now as
dextrorotatory :D; or :<;
C. Enatiomers have identical physical and
chemical properties
PEBC Preparation E.R.L.2005
1
D. Enatiomers are rotate plan polari"ed
light in anticloc9wise direction are 9now
as levorotatory.
E. .==> mixture of :D; or :?; Enatiomers
is called racemic mixture.
9. All of the following statements are
C&''EC( a$out Diasteroisomers
E8CEP(:
A. Diasteroisomers are neither mirror
image no superimposi$le images
B. Diasteroisomers must contain at least
two chiral centers
C. Diasteroisomers differ in properties
such as solu$ility- volatility and melting
point
D. Diasteroisomers contain different
physical and chemical properties
E. Diasteroisomers contain non
superimposi$le mirror images
.=. Conversion of tetracycline to 0!epi
tetracycline process in 9nown as:
A. *someri"ation
B. Epimeri"ation
C. Conversion
D. @u$stitution
E. Chemical reaction
11. D:<; ?actic acid and ? :!; ?actic acid are:
A. Diasteroisomers
B. Enatiomers
C. Constitutional isomers
D. 7eometrical isomers
E. @tereoisomer
.. 'esult of restriction around dou$le $ond a
result in the following isomers:
A. Diasteroisomers
B. Enatiomers
C. Constitutional isomers
D. Conformational isomers
E. 7eometrical isomers
./. Aeta$olic reactions that may $e affected $y
a protein deficiency diet include:
I. &xidative 'eaction
**. Hydrolysis
***. 7lycine ConBugation
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.0. *n amino acid conBugation which of the
following reactions are involved:
A. Amino acid < Alcohol
B. Amino acid < Amino acid
C. Amino acid < 7lycine
D. 7lycine < Alcohol
E. Amino Acid < 7lutamine
.2. %hich is strongest Base:
A. !!!!
B. !!!!
C. !!!!
D. !!!
E. !!!
.6. C+( P02= is :
A. En"yme
B. Citamin
C. #eurotransmitter
D. Catalyst
E. Amino acid
17. %here is the hydrolysis occur:
A. D
B. D
C. D
D. D
E. D
.5. %here is the hydrolysis occur:
A. E
2
B. E
C. E
D. e
E. E
.E. All the following are meta$olic en"ymes
E8CEP(:
A. C+P 02=
B. C+P /A0
C. C+P =
D. C+P .A0
E. C+P A.
=. All the following are cytochrome en"ymes
meta$oli"e drug xeno$iotics :Biological
Product; E8CEP(:
A. C+P 02=
B. C+P /A0
C. C+P .,
D. C+P .A0
E. C+P A.
21. Antidepressants are meta$oli"ed $y:
A. C+P 02= And C+P .A
B. C+P /A0 And C+P .A
C. C+P D6 And C+P .A
D. C+P .A0 And C+P .A
E. C+P A. And C+P .A
. @tatins are meta$oli"ed $y:
A. C+P .,
B. C+P .A
C. C+P /A
D. C+P A.
E. C+P 02=
/. Ben"odia"epines Are meta$oli"ed $e:
A. C+P .,
B. C+P .A
C. C+P /A
D. C+P A.
E. C+P 02=
0. 7rapefruit Buice inhi$it the following
en"yme:
A. C+P .,
B. C+P .A
C. C+P /A0
D. C+P A.
E. C+P 02=
2. @mo9ing induces the following Cytochrome
en"yme:
A. C+P .,
B. C+P .A
C. C+P /A
D. C+P A.
E. C+P 02=
6. %hich en"yme does glucourdiation
reaction:
A. FDP7A
B. G.
C. G.
D. G.
E. G.
,. %hat characteristics of an organic
compound allow it to undergo conBugation
with glutathione)
A. Electrophilic functional groups
B. G
C. G
D. G
E. G
5. Amino acids conBugation involve the
following group:
A. Amino acid and glycin
B. Amino acid and glutamine
C. Amino acid
D. Activated amino acid
3
E. Amino acid and glutamine
E. 7lutamine ConBugation very important in
preventing toxicity of variety of drugs- toxic
products are excreted as:
A. @!adono"yl transferase
B. 7lutamic acid
C. Aercaptoric acid
D. Amino acid
E. @ulfadryl groups
/=. which of the following statements a$out
drugs meta$olism correct:
A. drug meta$oli"ing en"yme are found
only in liver
B. all meta$olites are pharmacologically
inactive
C. phase * meta$olite can cross cell
mem$rane
D. all drugs are cataly"ed $y cytochrome
E. commonly one meta$olite is excreted for
each drug administered
/.. *mida"oline ring present in the following
class of structure:
A. (hia"ide diuretics
B. C&8 ** inhi$itors
C. Direct H

agonist :Clonidin;
D. Direct H
.
agonist
E. Direct H

antagonist
/. the following diuretics is most similar in
chemical structure to antihypertensive
daia"oxide:
A. Chlorothia"ide
B. Iurosemide
C. Aannitol
D. @pironolactone
E. G.
//. (he a$ove reaction is :
A. &xidation
B. Hydrolysis
C. ConBugation
D. 'eduction
E. @ulforation
/0. (o protect integrity of the cell. %hich of the
following is most important:
A. Phospholipids
B. C+( P 02=
C. C+( P 0.=
D. ?ysosomal En"yme
E. #on of the a$ove
/2. Aeta$olism is enhanced $y:
*. Passive reaction
**. Excretion
***. (u$ular secretion
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/6. *ndol ring:
*. Histamine
**. @erotonin
***. (ryptopahn
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/,. conversion of histidine to histamine is
cataly"ed $e:
*. ?.Histidine Decar$oxylase
**. ?.Histidine Car$oxylase
***. ?.Histidine Hydoxylase
A. * &nly
4
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
38. H
.
'eceptors function on the following
symptoms:
*. Allergies
**. 7astric secretion
***. Bronchodilation
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/E. the following drugs are contraindicated in
first trimester of pregnancy:
*. Aecli"ine
**. Cycla"ine
***. Cetiri"ine
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
0=. (he following groups are essential for
antihistamine pharmacological activity:
*. Aromatic and heteroaromatic rings
structure
**. (ertiary amine in structure
***. Chain of al9yl group in structure
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
0.. All of the following are side effect of
Atropine E8CEP(:
A. Dry mouth
B. Frinary retention
C. Constipation
D. Blurred vision
E. Diarrhea
42. which of the following drugs decrease
stomach acid secretions- Aechanistically
$loc9ing of H
Histamine receptors:
A. Hydroxy"ine
B. Cetra"ine
C. Iluxa"ine
D. &mepra"ole
E. 'anitidine
0/. @erotonin
A. Histidine
B. (ryptophan
C. Dopa
D. Epinephrine
E. G
00. @umatriptan are medication used in
migraine therapy is act on the following
receptorsJ
A. 2H(
.D
B. 2H(
(
C. 2H(
(/
D. 2H(
(0
E. 2H(
(2
02. %hat is H( - 2 H( receptors:
A. Hydroxyl amine
B. 2!hydroxyl tryptamine
C. 2!hydroxyl tryptophan
D. G
E. G
5
06. %hich of the following is C&8 ** inhi$itor:
A. Aspirin
B. *$uprofen
C. Celocoxi$
D. #alaxone
E. #altraxone
0,. Aspirin is :
*. C&8 * inhi$itor
**. C&8 ** inhi$itor only
***. C&8 * and C&8 ** inhi$itor
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
05. All the following re correct side effect of
Aspirin E8CEP(:
A. @alicylism
B. Hemorrhage
C. Hypoglycemia
D. #ausea
E. 7* irritation
0E. All the following re correct side effect of
enteric coated Aspirin E8CEP(:
A. @alicylism
B. Hemorrhage
C. Hyperglycemia
D. #ausea
E. 7* irritation
50. Aisopristol 3C+(&(&EC4 is used for
prevention of #@A*D induced ulcers- is
classified as:
*. P7 *
**. P7 **
III. P7E
.
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
2.. %hat is the prevention for #@A*D induced
7* ulcers:
A. &mepra"ole
B. Kantac
C. Aisopristol
D. Cetri"ine
E. Calcium hydroxide
2. (he following drug is indicated to induce
cervical ripening in pregnancy:
A. ?atanoprost :8alatan;
B. (ravoprost :(ravatan;
C. Bimatoprost :?umigan;
D. Aisopristol :Cytotec;
E. Dinoprostone
2/. %hich of the following P7 inhi$itors
indicated in treatment of open angle
7laucoma)
A. ?atanoprost :8alatan;
B. (imolol
C. Bimatoprost :?umigan;
D. Aisopristol :Cytotec;
E. Dinoprostone
20. P7 @tructure contain the following
fragment in the structure:
*. Cyclopentane ring contain car$onyl
and hydroxyl group
**. ?ong chain al9yl group
***. Leto and hydroxyl position indicate
su$script of P7 analogs
A. * &nly
B. *** &nly
6
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
22. %hich of the following is mechanism of
action fro (ylenol :acetaminophen;:
A. 'evisa$le P7 synthesis
B. *nhi$its C&8 * synthesis
C. *nhi$it C&8 ** synthesis
D. *nhi$it central P7 synthesis
E. *rreversi$le inhi$its P7 @ynthesis
26. %hich of the following preparation reMuire
only written prescriptions:
A. (ylenol .
B. (ylenol
C. (ylenol /
D. (ylenol 0
E. (ylenol / and 0
2,. %hich of the following preparation reMuire
prescriptions:
A. (ylenol .
B. (ylenol
C. (ylenol /
D. (ylenol 0
E. (ylenol - / and 0
25. %hich of the following drugs does not have
sulfa allergy)
A. Celecoxi$
B. Aspirin
C. @ulfamethoxa"ole
D. Hydrochlorothia"ide
E. Cortimoxa"ole :(APN@A8;
59. %hich is the mechanism of action of
montelu9ast :@ingulair;
A. ?eu9otrines inhi$itors
B. ?(C
0
and ?(D
0
inhi$itors
C. Cyclooxygenase inhi$itors
D. 2H(
.D
inhi$itors
E. Antihistamines
6=. #itroglycerines are classified as:
*. #itrates
**. #itrites
***. #itro group
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
6.. All of the following are propionic acid
derivatives E8CEP(:
A. #aproxen
B. *$uprofen
C. Letoprofen
D. Aspirin :acetyl salicylic acid;
E. Caprofen
6. Pyra"ole ring is present in the following
structure:
A. Aspirin
B. Acetaminophen
C. Celocoxi$
D. *$uprofen
E. Letotofen
6/. All the following conditions are essential for
thia"ide structure:
*. @ulfonamide group $en"ene ring
II. Chloro or trifluromethyl group on
position 6
***. Dou$le $ond on position / and 0
a. * &nly
$. *** &nly
c. * and ** &nly
d. ** And *** &nly
e. All &f the a$ove
7
60. All the following drugs contain sterol in
their structure- E8CEP(
A. @piranolactone
B. Estrogen
C. Progesterone
D. Androgen
E. @til$esterol
62. Cholesteramine is a:
A. Bile acid resin
B. %ater insolu$le
C. %ater solu$le
D. Hydropho$ic
E. Bind to the $ile acids in the intestine
66. All of the following are ?A%H E8CEP(:
A. Enoxaprin
B. Dalteprin
C. (in"aparin
D. Adreparin
E. Heparin
6,. %hich of the following molecular structure
contain Muinoline structure:
A. %arfarin
B. Heparin
C. ?A%H
D. Citamin L
E. #iacin
65. %hich phase * Aeta$olism reoccur in
stomach:
A. Hydroxylation
B. Hydrolysis
C. &xidation
D. 'eduction
E. Demethylation
6E. %hat is similarity $etween hemoglo$in and
Cytochrome P02=:
*. Heme
**. @ame proteins
***. Prophyrin ring
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
,=. All of the following are antiplatelets agent
E8CEP(:
A. Aspirin
B. (iclopidine
C. Ia$ Iragment
D. Clopidogrel
E. %arfarin
,.. %hich of the following is produced $y
$iotechnology methods:
*. Ia$ Iragment
**. Altiplase
III. tPA :(issue Plasminogen Activators;
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
,. %hich of the following parenteral iron dose
form:
A. Ierrous @ulfate
B. Ierrous 7luconate
C. Ierrous Iumarate
D. *ron Dextran
E. Elemental *ron
,/. *n the oral treatment of *ron Deficiency
anemia- choice of administration of iron is:
*. Elemental *ron
**. *ron complex form
***. Ierrous *ron
8
a. * &nly
$. *** &nly
c. * and ** &nly
d. ** And *** &nly
e. All &f the a$ove
74. (he correct statements a$out Citamin B
.
:
*. Contain prophyrin ring
**. Contain cyanide ion
***. (etravalent co$alt ion
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
,2. An antienemic agent folic acid contain the
following nucleus that $onded to folate
en"yme:
*. Pteridine nucleus
**. PABA
***. 7lutamic acid
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
,6. Iolic acid a$sor$ed in:
A. ?iver
B. 7* tract
C. (issue
D. Lidney
E. Colon
,,. Iolic acid deficiency Causes:
*. Aegaloplastic anemia
**. #urologic impairment
***. Aicrocytic anemia
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
,5. ?ac9 of cyanoco$alamine causes:
*. Aegaloplastic anemia
II. Deficiency of Citamin B
.
***. *ntrinsic factor
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
,E. %hich of the following cardiovascular
medications chemically classified as
glycoside:
A. Digixin
B. %arfarin
C. #itrates
D. #itrites
E. Cholesteramine
5=. Avoid the following vitamin while
anticoagulants medication:
A. Citamin A
B. Citamin B
C. Citamin C
D. Citamin D
E. Citamin L
5.. &ral anticoagulants such as warfarin has
the following properties:
*. *nterfere with Citamin L dependent
coagulant factor **- C**- *8 and 8
**. *nterfere with Citamin L dependent
coagulant factor *- **- *8 and 8
***. *nterfere with Citamin L dependent
coagulant factor **- C**- *8 and 8
9
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
5. %hich of the following prolonged the
clotting time of $oth in vivo and in vitro
*. Heparin
**. ?A%H
***. %arfarin
a. * &nly
$. *** &nly
c. * and ** &nly
d. ** And *** &nly
e. All &f the a$ove
5/. Protamine sulfate is an anticoagulant of
heparin $ecause:
A. Chelating action
B. Acid $ase interaction
C. Plasma protein $inding displacement
D. *nhi$its 7* a$sorption of heparin
E. Prothro$in li9e activity of protamine
50. A /5 years old $us operator with history of
arrhythmias suffering from seasonal
rhinitis. %hich of the following is the $est
choice for his condition:
A. Aecli"ine
B. Iexofenadie
C. Iamotidine
D. Diphenhydramine
E. Dimenhydrinate
52. %hich of the following drug decrease pain
associated with 7E'D without apprecia$ly
changing gastric pH:
A. 'anitidine
B. &mepra"ole
C. Any H
Antagonist
D. Cisparide
E. Iexofenadine
56. %hich of the following $ind to
Car$onmonoxide
*. Hemoglo$in
**. Ayoglo$in
***. Cytochrome oxidase
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
5,. Citamin A is a mixture of :
*. 'etinol
**. 'etinal
***. 'etinoic acid
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
55. (he following is precursor of vitamin A:
*. 'etinal
II. 'etinol
***. Carotenoids
a. * &nly
$. *** &nly
c. * and ** &nly
d. ** And *** &nly
e. All &f the a$ove
5E. %hich of the following drugs is the isomer
of vitamin A:
*. 'etinoic acid
II. 'etinol
***. *sotrentinoin
10
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
E=. (ype * error :Ialls Positive error;:
A. 'eBecting the hypothesis when H
=
is
Ialls
B. 'eBecting the null hypothesis when H
=
is
true
C. Accepting null hypothesis when H
=
is
falls
D. Accepting null hypothesis when H
=
is
true
E.. *nfluen"a season in Canada:
A. @tart in #ovem$er to April
B. @tart in Decem$er to April
C. @tart in &cto$er to April
D. @tart in @eptem$er to April
E. @tart in August to April
E. Epidermology studies are carried out in the
following categories:
A. Hospital patient
B. Certain population and defined
geographical area
C. Pharmacy and patients of defined
geographical area
D. Certain hospital and their patients
E. Hospital doctors and infected
populations
93. All the following activities meet the criteria
of primary prevention Except:
A. (etanus vaccination for teenagers
B. Aeasles N Aumps N 'u$ella :AA';
vaccination for first time
C. Pap smear screening
D. @ex education
E. G.
E0. 2 su$Bects given a single oral dose of drug
have the following elimination half lives
0-2-6-6 and E hours- the mean half life is :
A. 2.0
B. 2.=
C. 0.2
D. 6
E. .=
E2. *n given data /-2-,-E and , what is the
median:
A. 6
B. ,
C. /
D. E
E. 2
E6. #ormal population EE> of values fall
within:
A. / standard Deviations
B. standard Deviations
C. . standard Deviations
D. 0 standard Deviations
E. 2 standard Deviations
E,. 2-/-5-2 and E days- calculate the mean:
A. 2
B. 6
C. ,
D. 5
E. E
E5. Ior the a$ove 1uestion Aedian is:
A. 2
B. 6
C. ,
D. 5
E. E
EE. Ior the a$ove Muestion the mode is:
A. 2
11
B. 6
C. ,
D. 5
E. E
.==. %hat is the standard deviation of the
following num$ers /-2-0 and 5:
A. 2
B. ..
C. 5
D. 2.
E. .=
.=.. =- /- 0- 6 and 5 standard
deviation is 2 what is the percent of
coefficient variation
A. 0
B. .
C. /
D. 5
E. E
102. *I the standard deviation of an
experiment is and sample si"e is 5 what is
the standard error of mean:
A. =.5.
B. =.,.
C. =.6.
D. =.2.
E. =.0.
.=/. (ype ** error :O error;
=
is
false
B. Accepting the null hypothesis when H
=
is
false
C. 'eBecting the null hypothesis when H
=
is
(rue
D. Accepting the null hypothesis when H
=
is
true
.=0. Correct decision:
=
is
false
B. Accepting the hypothesis when H
=
is
false
C. 'eBecting the hypothesis when H
=
is true
D. Accepting the hypothesis when H
=
is
true
.=2. All of the following are statistical test
except:
A. @tudent t test
B. I distri$ution test
C. Chi!@Muare test
D. Distri$ution test
E. A#&CA analysis of variance
.=6. (he 0 groups A- B- C and AB were
studied to compare the Muantitative
hematological differences among their
hemoglo$in structure. (he most
appropriate statistical test to ma9e
determination is:
A. Paired t (est
B. I test :A#&CA; :1uantitative;
C. 'egression analysis
D. @tudent t test
E. Chi!@Muare (est
107. *n the clinical trial at (oronto
Hospital conducted over 0 years- a specific
serious side effect with a therapy 8 is seen
in =.2 > of the study sample in patients
who receive a newly discovered drug +.
&nly =.02 > experiences the same side
effects. Based on results- the minimum
num$er of patients that would have to
receive the new drug for / years to
statistically demonstrate the prevention of
one episode of the side effect in at least one
patient is:
A. .===
B. ===
C. /===
D. 0===
E. 2===
12
108. *n clinical trials conducted over
years- the desired clinical outcome with a
new drug is achieved in 2 > of the study
sample. *n the patients who received a
place$o- only .2 > o$tain the same clinical
$enefit. (he relative ris9 reduction
achieved with the new drug over the period
is:
A. 2=>
B. .==>
C. 0=>
D. .=>
E. #o difference
.=E. %hen standard error compared with
standard deviation :@D;
A. *ts smaller than @D
B. *ts Bigger than @D
C. EMual (o @D
D. #on of the a$ove
..=. Healthy human volunteers are tested
in the following phase of clinical trials
*. Preclinical trials
**. Phase * testing
***. 7eneric drug development for
A#DA su$mission
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.... A product line extension contain the
new drug and :
*. #ew therapeutic indication
**. #ew dosage strengths
***. #ew dosage form
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
... Ior patent expired $rand drug
product can $e mar9eted as generic drug
product if:
*. (herapeutically eMuivalents
**. @ame amount of drug and same
dosage form
***. Different strengths
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
113. (he generic product may differs
with $rand product:
*. @hape
**. Color
III. (ype of excipients in ta$let only
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
..0. A generic product must have the
same as $rand name product:
*. BioeMuivalent
**. 'ate of a$sorption
***. Extent of a$sorption
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
..2. A test measures what it was
originally designed to measure is said to
have:
13
A. 'elia$ility
B. Precision
C. Calidity
D. Accuracy
E. @pecificity
..6. *n choosing an instrument to
measure the health related 1uality of life-
attention should $e paid to the following:
*. ?ength of instrument :life time;
**. @ensitivity and specificity of
instrument
***. 'elia$ility and validity of
instrument
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
..,. A pharmacist did not counsel patent
a$out side effect of drug- considering that
patient may not ta9e this drug- which of the
following ethical principle has $een
violated)
A. Ceracity
B. Beneficently
C. Iidelity
D. Autonomy
E. #onmaleficiency
118. At a significance level of p P =.=.- the
null hypothesis states:
*. #ull hypothesis says there is no
difference $etween experimental and
o$served values
**. #ull hypothesis says there is
o$served values
***. Alternate hypothesis says there is
o$served values
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
..E. (he loading dose of drug always
$ased on:
**. Apparent volume of distri$ution and
desired plasma concentration
***. Plasma concentration curve
*C. Iraction of free drug excreted in
urine
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
120. (he time it ta9e to infuse drug to
reach plasma steady state concentration
:C
ss
; depends on:
*. Elimination half life of the drug
**. Iraction of free drug excreted in
urine
***. Plasma concentration curve
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
121. A 0= years old patient weight ,= Lg
needs *C infusion of amoxicillin. (he
desired C
ss
of drug is .E mgNdl.
(he physician ordered anti$iotic
infused for .= hours. Amoxicillin has
t
.N
Q . hour and C
d
Q E?.
%hat rate of *C is recommended for
this patient) :#o loading dose was
given;
A. ./2 mgNhr
B. E/6 mgNhr
14
C. .=== mgNhr
D. /// mgNhr
E. 0== mgNhr
.. %hat is recommended loading dose
in the a$ove patient:
A. ./2= mg
B. .== mg
C. ../2= mg
D. ./.2= mg
E. ./2.= mg
./. %hich of the following results in a
dou$ling of the steady state concentration
of drug:
A. (ripling the rate of infusion
B. 1uadrupling the rate of infusion
C. Dou$ling the rate of infusion
D. Dou$ling the concentration of infused
drug and rate of infusion
E. Dou$ling loading dose
.0. %hich of the following most closely
descri$e as clearance rate of drug that is
infused at rate of 0 mgNmin and produces a
steady state concentration of 6 mgN? in
plasma
A. .== mlNmin
B. 66, mlNmin
C. /== mlNmin
D. ./ mlNmin
E. 6, mlNmin
.2. %hich of the following statements is
correct:
A. A competitive antagonist increase ED2=
B. (he greater the efficacy and greater the
potency of drug
C. *f .= mg of drug A produces the same
response as .== mg of drug B- drug A is
more effective than B
D. Cariation of response in different
individual occurs with drug showing a
large therapeutic response
E. *n selecting drug- a drug potency is
more important than efficacy
.6. A drug with half life of . hours is
administrated $y continuous intravenous
infusion. How long will it ta9e for drug to
reach E= > of final steady state level
A. 5= hrs
B. = hrs
C. 0= hrs
D. .== hrs
E. 0 hrs
.,. Drugs that show "ero order
elimination 9inetics is:
A. @how a constant fraction of drug
elimination per unit of time
B. Decrease concentration exponentially
with time
C. Have half life independent of dose
D. @how plot of drug concentration versus
time- that is linear
E. Kero order 9inetic are more common
than first order 9inetic
.5. #on linear pharmaco9inetic do not
depend on the following
*. Iirst order 9inetic
**. Concentration and time
***. AichelRs D Aenten 9inetics
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.E. Drug that show non linear model
pharmaco9inetics have which of the
following properties:
A. All doses follow first order elimination
15
B. AichelRs Aenten 9inetic are used in
non linear 9inetic
C. AFC increase indirectly proportional
to dose
D. At steady state drug concentration
increase with direct proportion to
dosing rate
E. A constant ratio of drug meta$olites is
formed as the dose increase
./=. *f aspirin pH 6.2 and pLa 6.2 what is
the ioni"ation of drug is unioni"ed)
A. .==
B. =
C. 2=
D. 0=
E. /=
./.. Atropine :$ase; solution pH is 0.2
and pLa 2.2 what percent of solution is
unioni"ed)
A. E= >
B. E. >
C. E >
D. . >
E. EE >
./. Aspirin :acid; solution pH is 0.2 and
pLa 2.2 what percent of solution is
unioni"ed)
A. E= >
B. E. >
C. E >
D. . >
E. EE >
.//. %hich of the following site of 7* has
highest a$sorption of dug:
A. ?arge intestine
B. @tomach
C. @mall intestine
D. Esophagus
E. Aouth
./0. %hich of the following site of 7*
has highest a$sorption of drugs
A. ?arge intestine
B. Duodenum
C. SeBunum
D. *leum
./2. Iic9s law descri$e the following:
*. Predicts the rate of moments of
molecules across mem$rane
**. Predicted the percent of ioni"ed and
unioni"ed drugs
***. Predict the a$sorption of drugs in
epithelial cells
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
./6. Determine the I value of a capsule
AFC = mg N dl N hrs with 2= mg dose when
*.C. of the same drug AFC is 2 mgNdlNhr
with .== mg dose :
A. = >
B. 6= >
C. 0= >
D. 5= >
E. .== >
./,. (he following drugs are
$ioeMuivalent:
*. Drugs with the same $ioavaila$ility
**. Drugs with same AFC
***. Drugs with same rate of a$sorption
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
16
./5. (he following factors effects the
drugs that cross into $reast mil9
*. Plasma protein $inding
**. Partition coefficient
***. Aem$rane permea$ility
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
./E. Al$umin is maBor plasma protein
and has strongest affinity to the following
protein:
A. Acid drugs
B. @
C. @
D. @
E. @
.0=. Plot of log of concentration against
time produces a straight line with a:
A. @lope of DLN./=/
B. @lop of DLNt
.N
C. @lope of DL
=
D. @lope of LN./=/
E. @lope of LN=.6E/
.0.. .== mg a drug with hr of half life-
to eliminate E= mg of it ta9e how many
hours)
A. ,.,
B. 2.6
C. 6.6
D. 0.6
E. .6
142. A drug was found to have Kero
order 9inetics .== mg after 6 days EE mg
How long it will ta9e to eliminate the
entire drug from the $ody)
A. .==
B. ==
C. /==
D. 6==
E. E==
143. A dose was given- after hrs- the
plasma concentration was 60 mg- t
.T
Q=.,
hr- after , hours from the initial dose- what
is the drugs concentration)
A. =.= mg
B. ..= mg
C. .= mg
D. /.= mg
E. 0.= mg
.00. %hich of the following is used as
standard to measure 7I':
A. *nulin
B. Creatinin
C. 7lucose
D. *nsulin
E. Iructose
.02. 'enal clearance of inulin is used as a
measurement of:
A. Active renal secretion
B. Effective renal $lood flow
C. 'ate of renal drug excretion
D. 7I'
E. *ntrinsic renal activity
.06. 'enal clearance of Creatinin is used
as a measurement of:
A. Active renal secretion
B. Effective renal $lood flow
C. 'ate of renal drug excretion
D. 7I'
E. *ntrinsic renal activity
.0,. %hich of the following forms of
nitroglycerine that are minimally affected
$y the first pass effect include)
17
*. @u$lingual
**. (ransdermal Patches
***. *ntravenous
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.05. %hich of he following li9ely t
increase in elderly :7eriatric; Patients:
A. Plasma protein al$umin level
B. En"ymatic meta$olism
C. Cd of water solu$le drugs
D. Cd of lipophilic drugs
E. Hypervolimia
.0E. *n dosing drugs that are primarily
excreted $y the 9idney- one must have some
idea of the patient renal function. %hich of
the following pharmaco9inetics parameter
gives the estimate of renal function:
A. BF#
B. @erum Creatinin
C. Frine Creatinin
D. Creatinin clearance
E. Iree water clearance
150. if the rate of elimination of drug is
reduced $ecause renal insufficiencies- the
effect on drug half life and C
ss
will $e:
A. Half life and C
ss
decrease
B. Half life and C
ss
increase
C. *ncrease in Half ?ife and Decrease in C
ss
D. Decreasing in Half ?ife $ut increase in
C
ss
E. #o change in $oth
.2.. %hich of the following statement are
correct)
I. *ncrease Cd increase C
ss
II. *ncrease loading dose increase C
ss
III. Decrease in Cd increase C
ss
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.2. (he difference $etween pea9 and
trough concentration is greater when a
drug is given at dosing intervals
A. EMual to half life of drug
B. ?onger than half life of drug
C. @horter than half life of drug
D. EMual to C
ss
E. EMual to half life serum creatinin
.2/. ?ethal dose ?D2= is classified as
*. Dose cause 2= > of toxic response in
tests
**. Dose cause 2= > of effect response in
tests
***. Dose cause 2= > of death response
in tests
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.20. (he relative $ioavaila$ility of a drug
product can $e determined $y:
A. Comparing AFCUs and total drug
urinary excretion
B. Comparing plasma concentration and
total drug urinary excretion
C. Comparing elimination and plasma
concentration
D. #on of the a$ove
E. sss
18
.22. (he excretion of wea9ly acidic drug
will $ecome more rapid in al9aline urine
than in acidic urine $ecause:
A. (he drug will exist primarily in ioni"ed
form which cannot easily rea$sor$ed
B. 1
C. 1
D. 1
E. 1

.26. (he following are $ioeMuivalent in
Canada:
*. @ame color- physical appearance
**. @ame dose and same dosage form
***. @ame rate and same extent
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.2,. @umatriptan is mainly used in
migraine treatment acting as:
A. 2H(
.D
N .B agonist
B. 7ABA D A
C. B D .
D. En9ephelin
E. Dopamine
158. (he following is Nare catechole amine
neurotransmitter:
*. Dopamine
**. #or epinephrine
***. Epinephrine
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.2E. (he following are the amino acid
and neurotransmitters:
*. 7lutamic acid
**. (ryptophan
***. 7lycine
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.6=. All of the following are side effects
symptoms of isoflurophate E8CEP(:
A. Convulsion
B. *ncrease H'
C. Aiosis
D. @9eletal muscle paralysis
E. *ncrease $ronchial secretion
.6.. All of the following Are
neuromuscular $loc9ers E8CEP(:
A. @uccinylcholine
B. Pancuronium
C. Atracurim
D. #icotine
E. Aivcurium
.6. All of the following drugs have
diarrhea as side effect E8CEP(:
*. #eostigmine
**. Bethanechol
***. Atropine
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.6/. %hich of the following is used in
long term treatment of myasthenia 7ravies
A. #eostigmine
19
B. A
C. A
D. A
E. A
.60. All of the following drugs can $e
used in open angle and closed angle
7laucoma:
*. (imilol
**. Aethyldopa
***. Pilocarpine
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.62. Chemical mediator that is released
from the end nerve of parasympathetic
system :
*. Adrenalin
**. #or adrenalin
***. Acetylcholine
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.66. (he following products can $e used
in smo9ing cessation:
*. #icotine 7ums
**. Ky$an
***. Buspirone
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.6,. (he following statements are correct
a$out smo9ing cessation:
*. @top smo9ing from the day when
start using nicotine products
**. Can continue smo9ing for . to
wee9s when non nicotine :Ky$an;
products
***. @tart . mg of nicotine patches and
slowly taper the dose to .0 mg after
0 !6 wee9s
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.65. Aary // years old pregnant woman
she smo9es . pac9 a day- she is see9ing
your help in Muitting her smo9ing ha$its-
which of the following would $e your
recommend)
*. @uggest to use non pharmacological
steps to reduce smo9ing ha$its
**. @uggest nicotine patches- to use
every day
***. @uggest Ky$an oral drug smo9ing
cessation
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.6E. Pancuronium is :
A. 7anglionic $loc9er
B. Depolari"ing #AS $loc9er
C. #on depolari"ing #AS $loc9er
D. Cholinergic antagonist
E. Anti cholinesterase
.,=. (he following drug most closely
resem$les atropine in its pharmacological
action E8CEP(
A. Acetylcholine
20
B. Ben"otropine
C. @copolamine
D. *pratropium
E. (ropicamide
.,.. %hich of the following drugs does
not produce miosis:
A. @copolamine
B. Car$achole
C. Pilocarpine
D. #eostigmine
E. *soflurophate
172. %hich of the following drugs with
little change in heart rate $ut increases
cardiac output. (his drug indicated in CHI
does not increase &
demand.
*. *soproteronolol
**. Aethyldopa
***. Do$utamine
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.,/. (he following medications are used
is asthma emergencies
*. Al$uterol
**. *pratropium
***. @almeterol
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.,0. Epinephrine is com$ined with
local anesthetic . in .==-=== parts for the
following effect of epinephrine
*. Casoconstriction
**. 'educed distri$ution of local
anesthetic in $lood flow
***. *ncrease the locali"ed effect
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.,2. (he action of acetylcholine in motor
endoplate and in the celiac ganglia is
descri$ed as:
A. #icotinic stimulation
B. Auscarinic stimulation
C. Dopaminic stimulation
D. Adrenergic stimulation
E. @erotonin stimulation
.,6. Drug commonly used with local
anesthetic to decrease the a$sorption and
increase the time of action of anesthesia
include:
A. Epinephrine
B. Adrenaline @C
C. *soproterenol
D. Aminophiline
E. @almeterol
.,,. %hich one of the following in
characteristic of parasympathetic
stimulation
A. *ncrease Heart rate
B. Contraction of sphincter urinary
$ladder
C. *nhi$ition of $ronchial secretion
D. Aiosis effect contraction of iris
E. Decrease intestinal motility
21

.,5. %hich of the following statement
a$out the parasympathetic system is correct
A. (he parasympathetic system control the
secretion of adrenal medulla
B. (he parasympathetic system involved in
movement of food and urination and
accommodation of near vision
C. Parasympathetic system uses nor
epinephrine as neurotransmitter
D. Post 7anglionic fi$er of
parasympathetic system are long
compared to sympathetic system
E. Aa
.,E. %hich of the following is the correct
action of sympathomemitic
*. *ncrease the drainage of aMueous
humor in the eye
**. Decrease in aMueous humor in the
eye
***. *ncrease of *&P 3*ntra &cular
Pressure4
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.5=. H adrenergic $loc9ers causes
syncope as a side effect- in order to manage
syncope effect- the following precaution
should $e ta9en:
*. (a9e medication at $ed time
**. 'educe first dose to one fourth
III. (a9e medication with full glass of
water
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.5.. %hich of the following is atenolol
side effect:
*. Hypotension
**. (remor
***. Cisual distur$ance
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
182. A patent currently on O Bloc9ers and
sildenafil which of the following side effect
can $e seen
*. Hypotension
**. (remor
***. Cisual distur$ance
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.5/. #itrates and sildenafil cannot $e
used together $ecause
I. Enhance hypotension effect of
nitrates
**. Enhance hypotension effect of
sildenafil
***. Enhance hypertension effect of
nitrates
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
184. A patient currently on phenel"ine
3#ardil4 for his depression disorder- he
22
should avoid all of the following food
E8CEP(
A. Age old cheese
B. %ine
C. +ogurt
D. &range
E. Aargarine
.52. A patient currently on phenel"ine
3#ardil4 for his depression disorder- he
should avoid all of the following Aedication
E8CEP(
A. Iluoxetine
B. @ertarline
C. Iluoxamine
D. Aeperidine
E. Amoxicillin
.56. @erotonin involved in all E8CEP(:
*. @leep disorder
**. Aotor activity :physical Activity;
***. Aood disorder
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.5,. %hich of the following statement are
correct a$out ?ithium
*. ?ithium effect seen after two wee9s
**. Before lithium has effect- patient are
treated with $en"odia"epine for
manic depression
***. ?ithium is drug of choice for manic
depression
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
188. Aary- // years old pregnant woman-
reMuiring a$out the safer drug for
hypotension condition- which of the
following she can use:
*. Aethyldopa
**. Hydrala"ine
***. ?a$etolol
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
189. All of the following are the side effect
of O $loc9ers E8CEP(:
A. ?ower heart rate
B. ?ower $lood pressure
C. Higher $lood pressure
D. Iatigue
E. Avoid driving after medication for a few
hours
.E=. Ar. Brown 22 years old asthmatic
patient have difficulty in urination and goes
freMuent urination wa9es us several time in
night. His $lood pressure indicate .6=NE2
mmHg. %hich of the following medication
would $e appropriate to treat Ar. Brown
condition
A. Ace$utolol
B. ?a$etolol
C. Hydrala"ine
D. Doxa"ocine
E. +ohim$ine
.E.. All of the following are side effect of
H antagonist E8CEP(
A. A
B. A
23
C. A
D. @exual dysfunction
E. Frinary retention
.E. (he following drugs can $e used to
reduce male impotency
*. @ildenafil
**. +ohim$ine
***. Phentolamine
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
193. %hich of the following statements
are correct a$out (CAUs
*. (CA shows immediate effects
**. &rthostatic hypertension is common
side effect
***. All (CA shows similar therapeutic
effects
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.E0. (he following drugs can $e used
with caution to correct internal sphincter of
$ladder 3$ed wetting4
*. Amitriptyline
**. (hixamine
***. *mipramine
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.E2. (he following are common side
effect of (CAUs and AA& inhi$itors
*. @erotonin syndrome
**. Psychological and physical
dependence
***. Postural hypotension
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.E6. All of the following are side effects
have o$served in patients using
antipsychotic drugs E8CEP(
A. &rthostatic hypotension
B. Constipation
C. *ncrease $lood pressure
D. @exual dysfunction
E. Change in endocrine hormone function
.E,. @econd generation antipsychotic
such as resperidone have the following
advantage over traditional antipsychotics:
*. Have high extrapyrimidal side
effects than traditional
antipsychotics
**. Have less weight gain side effect
than traditional antipsychotics
***. Have less EP@ than traditional
antipsychotic
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove

.E5. (he following is protype of opioid
A. Aorphine
B. A
C. A
24
D. A
E. A
.EE. (he following narcotic active
meta$olite exhi$it analgesic activity
A. Aeperidine
B. 7lucuronide
C. Ientanyl
D. Aorphine
E. Codeine
==. Activation of witch of the following
principal opioid receptor does #&( cause
significant respiratory depression
*. Au
**. Delta
***. Lappa
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
=.. %itch of the following is N are the
most common side effect of opioids:
*. Constipation
**. 'espiratory depression
***. @edation
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
=. %hich of the following opioid has
toxic meta$olite that may accumulate in
renal dysfunction:
A. Aorphine
B. Aeperidine
C. Aethadone
D. Codeine
E. Ientanyl
=/. Par9inson patients are characteri"ed
$y:
*. *ncrease ratio of dopaminergic N
cholinergic activity in neostratum
**. Aost commonly occurs in elderly
over 0= years of age patients
***. Decrease ratio dopaminergic N
cholinergic activity in neostratum
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
=0. All of the following are withdrawal
symptoms of C#@ stimulant E8CEP(:
A. Anxiety
B. *nsomnia
C. *ntestinal cramps
D. 'estlessness
E. Craving
=2. &pioid overdose presents with the
following symptoms
*. Pinpoint pupil
**. Coma
***. 'espiratory depression
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
=6. (he following anesthetics produce
paraamino$en"oic acid 3PABA4 upon
meta$olism :
*. 7eneral anesthetic
25
II. Amide type of local anesthetics
***. Ester (ype of local anesthetics
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
=,. All of the following statement a$out
Aethadone are correct E8CEP(:
A. *t is effective $y oral administration
B. Has longer half life than morphine
C. Has less analgesic activity than
morphine
D. Has greater action on mu receptors
E. Aethadone used in opioid withdrawal to
reduce withdrawal symptoms
=5. %itch of the following have
meta$olic acidosis as side effect:
*. Car$onic anhydrase diuretics
**. Potassium sparing diuretics
***. (hia"ide diuretics
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
=E. All of the following causes meta$olic
al9alosis E8CEP(:
A. Hydrochlorothia"ide
B. Aceta"olamide
C. Iurosemide
D. Bumetanide
E. Chlorithalidone
.=. (hrom$ocytopenia is side effect of
the following drugs:
*. Hydrochlorothia"ide
**. Aceta"olamide
***. Iurosemide
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All of the a$ove
... All of the following correct a$out
spironolactone E8CEP(:
A. *t renders with distal tu$ular
aldosterone mediated sodium-
potassium exchange
B. Cause al9aline urine
C. Cause hyper9alemia
D. Cause gynecomastia and menstrual
irregularities
E. (he principle site of action is at thic9
ascending loop
.. All of the following are correct a$out
Iurosemide Except:
A. (he principal site of action of this drug
is on the thic9 ascending loop
B. *t is useful in treating pulmonary edema
and ascites
C. Fseful in reducing cere$ral edema and
intracranial pressure
D. Cause meta$olic al9alosis
E. Cause ototoxicity

./. %hat are the following
characteristics of mannitol are correct:
*. Ireely filtered- limits the tu$ular
rea$sorption of water
**. Fseful in treatment of $rain tumor
***. Cause hyper9alemia
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
26
.0. All of the following are the
withdrawal symptoms of C#@ stimulant
E8CEP(:
A. Anxiety
B. *nsomnia
C. *ntestinal cramps
D. 'estless
E. Craving
.2. 'ha$domyolisis is the side effect of
all of the following E8CEP(
A. @imavastatin
B. ?ovastatin
C. 7emfi$ro"il
D. Colestipol
E. Atrovastatin
.6. %hich of the following is mechanism
of action of e"etimi$e
A. ?owering ?D?-(7 and increase HD?
with anti!inflammatory effect
B. *nhi$ition of intestinal a$sorption of
cholesterol
C. 7lycoprotein **$N***a antagonist that
inhi$it platelet aggregate
D. HA7 Co A inhi$itors
E. Anion exchange resin
.,. %hich of the following can $e used
in treatment of DC(
*. %arfarin
**. @trepto9inase
***. Heparin
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.5. All of the following are anti platelet
agent E8CEP(
A. Ia$ fragments
B. (iclopidine
C. Clopidogrel
D. Aspirin
E. %arfarin

.E. %hich of the following are produced
$y $iotechnicological methods:
*. Ia$ fragments
**. Ateplase
***. tPA
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
=. %hich of the following medication
can $e used in pulmonary edema and DC(
*. Heparin
**. %arfarin
***. @trepto9inase
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
.. *n order to measure effectiveness of
warfarin therapy the following monitoring
test are used
I. *#' must $e !/
**. Prothrom$in test :P(;
***. aP((
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove

27
. %hich of the following is N are the
ischemic heart disease
A. A*
B. Angina
C. Arrhythmias
D. CHI
E. A and B only
/. Pulmonary edema causes Because of
*. ?eft sided heart failure
**. 'ight sided heart failure
***. *schemic condition
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
0. %hich of the following drugs has
lowering ?D?- (7 and increase HD? with
anti inflammatory effects
A. @imavastatin
B. Clopidogrel
C. E"etimi$e
D. (icofi$an
E. Enoxapril
2. %hich of the following side effect
associated wit nitroglyceride
A. Hypertension
B. (ro$$ing headache
C. Anemia
D. Bradycardia
E. VVV
6. All of the following are used in
digitalis toxicity except
A. Phenytoin
B. ?idocaine
C. Ia$ fragment
D. 1uinidine
E. Potassium supplement
227. %hich of the following drugs or
disease induce arrhythmias
A. Dia$etes
B. Digitalis
C. 1uinidine
D. ?idocaine
E. Hypertension
5. %hich of the following not
appropriate with potassium sparing
diuretics:
*. Captopril
**. Enalopril
***. Be"opril
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
E. All of the following statement are
correct a$out nitroglycerin E8CP(:
A. *t can cause postural hypotension
B. *t can cause reflex tachycardia
C. *t has first pass meta$olism
D. *t has *C formulations and spray
E. *t significantly decrease AC conduction
230. A patient with megalo$lastic anemia
reMuires Cit. B
.
supplement. %hich of the
following is true a$out Cit. B
.
supplement)
I. 2= mg of oral B
.
supplements
helps to recover his anemic
condition
II. Iolic acid supplement helps to
acMuire Cit. B
.
III. Cit. B
.
*C supplement helps to
recover his anemic condition
28
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/.. A patient with constipation condition
may reMuire the following ant acids:
*. Calcium anti acids
II. Al :&H;
/
Anti acids
III. Ag :&H;
Anti acids
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/. %hich of the following anti acids
have cathartic side effects
A. Al :&H;
/
B. Ag :&H;
C. CaHC&
/
D. @odium $icar$onate
E. #on of the a$ove
//. Alginic acid is used in the following
condition:
A. Heart$urn symptom relief
B. Heart$urn prophylaxis
C. Heart$urn treatment
D. Peptic ulcer treatment
E. PPPPPPP
/0. %hich of the following is most
important method in peptic ulcer
treatment:
A. #eutrali"ing gastric acidic content
B. *nhi$iting receptor activation of gastric
acid secretions
C. Eradication of H. pylori infection
D. Coating a layer on ulcers
E. Bloc9ing protein pump

/2. %hich of the following inhalers
reMuire sha9ing $efore use:
A. @ervant 3@almeterol4
B. Centolin 3Al$uterol4
C. Atrovent 3*pratropium4
D. Pulmicort 3Budesonide4
E. All of the a$ove
/6. %hich of the following inhalers
reMuire rinsing mouth after use:
I. @ervant 3@almeterol4
7. Centolin 3Al$uterol4
H. Atrovent 3*pratropium4
*. Pulmicort 3Budesonide4
S. All of the a$ove
/,. %hich of the following are correct
a$out $eclomethasone patient counseling
*. Do not rinse mouth if used spacer
with oral inhalants
**. 'inse mouth after use of all
corticosteroids inhalants
***. Aouth rinse after corticosteroids
inhalant reduce the systemic side
effects
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
238. %hich of the following is most
appropriate treatment for emergency
asthma
A. Al$uterol
B. *pratropium
C. Beclomethasone
D. Al$uterol < *pratropium
E. Iluticasone
29
/E. All of the following asthmatic
medications are useful in pregnancy
E8CEP(:
A. O

Agonist
B. Coromolyn
C. *nhaled corticosteroids
D. (hyophyllin
E. Kafirlu9ast
0=. Emphysema is characteri"ed $y:
*. Permanent enlargement of small
sacs in lungs
**. Permanent damage of alveolar in
lungs
***. @hortness of $reath
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
0.. All of the following pituitary
hormones secreted from anterior pituitary
gland E8CEP(:
A. ?H
B. I@H
C. A@H
D. ADH
E. AC(H
0. All of the following statement are
correct a$out hyperparathyroidism
E8CEP(:
*. Causes deficiency of Cit. D
II. Decrease Ca ion in $lood
***. *ncrease Ca ion rea$sorption from
renal tu$ules
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove

0/. *pratropium $romide in C&PD is
more effective when com$ined with:
*. O adrenergic
**. Has less side effect tat atropine
***. %hen administrated inhalation
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
00. %hich of the following condition
limit the use of (hyophyllin in treatment of
C&PD:
A. Peptic ulcer disease
B. All age
C. CHI
D. Dia$etics
E. All of the a$ove
02. Corticosteroids are used in the
treatment of C&PD:
*. *n patient who have the response to
$ronchodilator therapy
**. *n patient with no whee"ing effect
***. Before maximum (hyophyllin
therapy received
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove

06. *n hyperparathyroidism condition-
the following statements are correct
E8CEP(:
A. Hypercalcimia
B. High production of P(H
C. Hyperphosphetemia
30
D. Auscle ache
E. Auscle atrophy
0,. %hich of the following is not the
correct match:
A. Hypothyroidism !!! Hypocalcemia
B. Hpoparathyroidism
!!!Hyperphosphetemia
C. Hyperparathyroidism !!!
Hypercalcimia
D. Hyperparathyroidism !!! cause
deficiency phosphates
E. Hyperparathyroidism !!! cause
deficiency of Ca ions
05. Hypocalcimia occurs in the following
condition:
*. Comiting
**. Hypoparathyroidism
***. Cit. D deficiency
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
0E. %hich of the following drugs does
not cause hypoglycemia
A. Aetformin
B. 'epaglinide
C. Acar$ose
D. 7ly$uride
E. Chlorpropamide
2=. %hich of the following hormones
play important rules in male reproductive
system)
*. I@H
**. ?H
***. (@H
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
2.. %hich of the following statement is
correct)
A. Protamine is added to insulin to
decrease the rate of a$sorption
B. Protamine is added to insulin to
increase the rate of a$sorption
C. *nsulin can $e administrated orally
D. *nsulin administered *C only
E. *nsulin administrated *A only

2. %hich of the following statement
a$out oral hypoglycemic is N are correct
A. Chlorpropamide $loc9s insulin
receptors
B. 7lipi"ide increase glucagons secretion
C. @ulfonylureas increase release of insulin
and increase sensitivity of target tissues
D. PPPP
E. PPPP
2/. %hich of the following increase
during &vulation)
*. Progestin
**. hC7
***. ?H and I@H
a. * &nly
$. *** &nly
c. * and ** &nly
d. ** And *** &nly
e. All &f the a$ove
20. %hich of the following hormones
secreted $y corpus leutum to maintain
pregnancy
A. Estrogen
B. Progestin
31
C. (estosterone
D. ?H and I@H
E. 7n'H
22. Hormone that increase water
permea$ility in collecting tu$ules:
*. Casopressin
**. &xytocin
***. @pironolactone
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
26. Hormone that sustained after
pregnancy:
*. Estrogen
**. Progestin
***. Androgen
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
2,. Hypothyroidism is related to the
following:
*. 7raves disease
**. Hashimoto syndrome
III. *
./.
treatment
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
25. &steoporosis is a condition of
s9eletal muscle fragility due to:
*. Progressive loss of $one mass
**. *t occurs mainly in post
menopausal women
***. *s characteri"ed $y freMuent $one
fractions
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
2E. Do not lay dawn for /= after ta9ing
aldendronate that may cause:
*. Esophageal ulcers
**. Aouth ulcers
***. @tomach ulcers
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
6=. &steoporosis is a disease
characteri"ed $y loss of $one mass and may
$e aggravated $y:
*. Corticosteroids
**. Aenopause
***. 7raves disease
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
6.. &steoporosis is characteri"ed $y loss
of $one mass and may predispose $y the
following factors:
*. 'ace
**. Iamily history
***. @mo9ing
A. * &nly
B. *** &nly
32
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
6. Calcitonin is mainly classified as
hormone li$erated $y thyroid gland which
stimulate the release of Calcitonin)
A. Hypercalcimia
B. Hypocalcemia
C. Hypophosphetemia
D. Hyperphosphetemia
E. High concentration of Cit. D
6/. (he following estrogen receptor
modulator :@E'A; increase women $one
density without increasing the ris9 of
endometrial cancer:
*. Aisopristol
**. (amoxifen
***. 'alaxifen
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
60. %hich of the following drugs are
classified as receptor modulator :@E'A;:
*. Aisopristol
**. (amoxifen
***. 'alaxifen
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
62. All of the following reMuire
monitoring for methotrexate therapy
E8CP(:
A. Chest 8!'ay
B. Creatinin level
C. CBC
D. ?eu9otrienes counts
E. ?iver function test
66. E Coli is the most common causative
microorganism for F(*- classified as:
A. 7ram <ve cocci
B. 7ram Dve cocci
C. 7ram <ve $acilli
D. 7ram Dve $acilli
E. #on of the a$ove
6,. %hich of the following is N are viral
infection:
*. 'a$ies
**. Poliomyelitis
III. ?egiomores disease
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
65. Chloramphenicol is one of the drugs
of choice in all E8CEP(:
A. (yphoid
B. @almonella infection
C. Aeningitis when a O lactam anti$iotics
cannot $e used
D. 'ectisial infection responding to
tetracycline or in which tetracycline
cannot $e used
E. S. aures infection
6E. Aetronidal"ole is first choice in all
E8CEP(:
A. Bacterial infection
B. Clostridium difficile colitis
C. (richomaniasis
D. (yphoid
33
E. &nly anaero$ic $acteria
,=. %hat is true a$out influen"a
treatment:
*. Amantadine indicated in influen"a A
and B
**. 'imantadine indicated in influen"a A
only
***. &seltamivir indicated n influen"a A and
B
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
,.. ?yme disease commonly occur in
Aississippi river valley- this infection
caused $y:
A. (ic9 $ite
B. AosMuito $ite
C. Dog $ite
D. Human $ite
E. Coc9roach $ite
272. %hich is not correct a$out
trepenema palladium
A. (reated $y penicillin 7
B. Causative organism of syphilis
C. @pread $y lymphatic
D. Causative organism of typhoid
E. PPPPP
,/. %hat is N are correct a$out
anti$iotics regimen used in tooth
extraction:
A. Amoxicillin 2== mg ta$lets one hour $efore
appointment and 2 ta$lets 6 hours after
tooth extraction
B. Erythromycin is alternate therapy in
tooth extraction
C. Cephalosporin 2== mg once daily for / days
D. Aminoglycosides 2= mg once daily for /
days
E. PPPPPPPPP

,0. O!lactams anti$iotics are ineffective
in the treatment of the following infection:
A. S. aures
B. 7ram <ve $acteria
C. 7roup A strep.
D. Mycolpasma pneumonia
E. Streptococcus species
,2. (he lower part gut contain the
following microorganism:
A. .= ! 2=> anaero$ic $acteria
B. E= D E2> anaero$ic $acteria
C. .= D 2=> aero$ic $acteria
D. E= D E2> aero$ic $acteria
E. lower part of gut does not have any
micro$es
,6. Aost common causative organism of
community acMuired pneumonia :CAP; is:
A. S. pneumonia
B. M. pneumonia
C. H. influenza
D. S. aureus
E. E. coli
,,. (he following organism least li9ely
causative pneumonia:
A. S. pneumonia
B. M. pneumonia
C. H. influenza
D. S. aureus
E. E. coli
34
,5. Aetronidal"ole indicated in the
following E8CEP(:
A. C. difficile
B. 7iardiasis
C. (richomaniasis
D. S. aureus
E. Anaero$ic infection only
279. All of the following are D#A virus
E8CEP(:
A. Adenovirus
B. Papilloma virus
C. Poxyvirus
D. &rthomyxovirus
E. Poliovirus
5=. 7erman measles:
A. Aumps
B. 'u$ella
C. Endocarditis
D. Cericella
E. Koster
5.. All of the following are penicillin
resistant : O D lactamase ; anti$iotics
E8CEP(:
I. Amoxicillin
**. Aethicillin
***. #aficillin
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
5. %hich of the following is acid
sensitive and O lactamase resistant
anti$iotic:
A. Amoxicillin
B. Penicillin 7
C. Aethicillin
D. &xacillin
E. PPPPPPPP
283. (he following isN are
aminopenicillin:
*. Amoxicillin
**. Ampicillin
***. Penicillin 7
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
50. %hich of the following is fourth
generation cephalosporin:
A. Cefaxitine
B. Cefatoxine
C. Cefipine
D. Cefuroxime
E. PPPPP
52. %hich of the following clinical
condition is the prophylactic use anti
$acterial is #&( reMuired:
A. Preoperative treatment of 7* condition
B. IreMuent respiratory disease
C. Preoperative treatment of hip surgeries
D. Prevention of meningitis among
individual in close contact with infection
patient
E. Patient with tooth surgeries or tooth
removed

56. %hich of the following only
anti$iotic which is effective against
Aethicillin resistant @. aureus :AA'@;
35
A. Cancomycin
B. --
C. --
D. --
E. --
5,. 7onorrhea infection in male treated
$y:
A. Cancomycin
B. Aetronidal"ole
C. Ceftrixone *A
D. Penicillin 7
E. Cotrimoxa"ole
55. Pregnant woman have F(* infection-
what is the oral anti$iotic)
A. Ampicillin
B. (etracycline
C. Cotrimoxa"ole
D. Clotrima"ole
E. Cefadroxil
5E. Aminoglycosides are indicated in:
*. 7ram <ve $acterial infection
**. 7ram Dve $acterial infection
***. Prophylaxis in preoperative
procedure
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
E=. @ulfonamide are indicated in:
*. 7ram <ve and certain gram Dve
**. 7ram Dve and certain gram <ve
***. Aainly a typical $acteria
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
E.. All of the following are anti D#A
viral agent E8CEP(:
A. 'imantadine
B. Acyclovir
C. 'i$avirin
D. Ioscarnet
E. Iamciclovir
E. Acacia is classified as:
A. @uspending agent
B. #atural emulsifying agent
C. @emi synthetic emulsifying agent
D. Ilocculating agent
E. (a$let filler
E/. 'ectal suppositories intended for
adult use approximately weight:
A. .= gram
B. 2 gram
C. gram
D. . gram
E. =.2 gram
E0. *n a dispensing pharmacy-
pharmacist usually mix active powder with
large amount of diluents $y:
A. ?evigation
B. 7eometrical dilution
C. (ituration
D. @ifing
E. Pulveri"ation
E2. (he shell of soft gelatin capsule may
made $y addition of plastic!li9e su$stance:
A. Polyethelenglycol PE7
B. Povidone
36
C. ?actose
D. @or$itol
E. Aethyl cellulose
E6. %hich is the smallest si"e of capsule
A. 2
B. .=
C. =
D. .
E. ===
E,. *n extemporaneous preparation of
suspensions- ?evigation is used:
A. 'educe particle si"e
B. 'educe viscosity
C. *ncrease practical si"e
D. increase sedimentation rate
E. reduce sedimentation rate
E5. @terility or sterile
*. Pyrogen free
**. Particulate free
***. Pathogen free : Aicroorganism free ;
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
299. @terile preparations of parenteral
solution:
*C. Pyrogen free
C. Particulate free
C*. Pathogen free : Aicroorganism free ;
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/==. Aseptic techniMue include
decontamination of:
*. Fndesira$le particles
**. Decontamination of pyrogen
***. Decontamination of pathogen
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/=.. A vertical laminar flow hood is the
$est choice when preparing solution of:
A. Penicillin
B. Doxacillin
C. Cytotoxic agent
D. #icotine formulation
E. Aminoglycosides
/=. (he si"e of HEPA used in ?aminar
air flow hood is:
A. =. micron
B. =.// micron
C. =.00 micron
D. =.22 micron
E. =.66 micron
/=/. %hat is the suita$le form of water
can $e used in parenteral preparationsJ
*. @terile water for inBection F@P
**. %ater for inBection F@P
***. Purified water F@P
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/=0. %hich of he following id the output
of Al$uterol inhalation aerosol:
37
*. Dry mist
**. %et mist
***. @ta$le foam
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
305. '
8
Phenol =.2 >
Cimetidine HCl
%ater for inBection F@P
%hat is the rule of phenol in this script)
A. Preservative
B. PPP
C. PPP
D. PPP
E. PPP
/=6. %hich detector is used in HP?C)
A. FC detectors
B. PP
C. PP
D. PP
E. PP
/=,. %hat is true a$out reversal phase of
HP?C:
*. @tationary phase is hydropho$ic
**. Ao$ile phase is polar
III. Ao$ile phase is aMueous $uffer
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/=5. (o find out molecular weight of drug
molecule which of the following instrument
is used :
A. Aass spectrophotometers
B. PP
C. PP
D. PP
E. PP
/=E. A changed particle passing through
a magnetic field is detected along circular
path on a radius that is proportional to
mass to charge ratio- mNe. (his principle is
$asis of the following instrument:
A. FC analysis
B. #uclear magnetic resonance analysis
C. Aagnetic
D. Aass spectrometry
E. PP
/.=. Correct statement regarding
7lossists include which of the following:
*. *nflation of the tongue
II. Presence of pin9ish red central
lesions on the dorsal surface of the
tongue
***. *t can $e chronic condition of the
tongue seen in pernicious anemia
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/... Patient with allergy to sulfonamides-
can ta9e all of the following E8CEP(:
A. Penicillin
B. ?idocaine
C. Celecoxi$
D. Clindamycin
E. (etracycline
/.. All of the following are example of
DA'A 3Disease Aodifying Anti rheumatic
Agent4 E8CEP(:
38
A. Aethotrexate
B. @ulfasala"ine
C. &rganic 7old compound
D. @ulphapyra"one
E. Penicillamine
/./. %hich statement are right regarding
Calcitonin
*. *ts secretion stimulated during
feeding- particularly of high calcium
meals
**. Prevents Hypercalcimia $y
inhi$iting the transport of calcium
into extra cellular fluid and $y
increasing the renal clearance of
Calcitonin
***. *t is a vitamin D derivative
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/.0. (he level should $e adBusted during
treatment with allopurinol:
*. Aercapturic acid
**. (heophyllin
***. Anticoagulants
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/.2. Fricosuric agent used in gout
treatment $y inhi$iting the uric acid
rea$sorption in the proximal tu$ules- the
$est example of uricosuric agent is:
A. Allopurinol
B. @ulphinpyra"one
C. *ndomethacine
D. Penicillamine
E. Aethotrexate
/.6. &ral chelating agent that used in the
treatment of rheumatoid arthritis is:
A. Allopurinol
B. @ulphinpyra"one
C. *ndomethacine
D. Penicillamine
E. Aethotrexate
/.,. *n the treatment of rheumatoid
arthritis the salicylates:
A. @top and often reverse the progressive
Boint involvement
B. @pecifically reverse the cause of disease
C. Provide only analgesic effect
D. Are effective $ecause they are uricosuric
agents
E. Are more effective when given with
allopurinol
/.5. *mportance of Cit. D in osteoporosis:
*. *ncrease a$sorption of calcium from
the small intestine
**. (he $est Cit D analog to treat
osteoporosis Calcitonin
***. Ant acids containing Al and Ag
interfere with proper activity of Cit
D
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/.E. Drug that inhi$it xanthine oxidase
and affect the meta$olism of 6!
mercaptopurine:
A. @ulphinpyra"one
B. Allopurinol
C. Penicillamine
D. Purinethil
E. Celecoxi$
39
/=. Pannus is an inflammatory exudates
characteri"ed $y:
*. @yonvial cells proliferation inside of
a Boint
**. #ormally occurs in patients with
'heumatoid arthritis
***. An immunologic complication
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/.. 7out characteristics include:
*. Hereditary meta$olite disease
mar9ed $y inflammation of the
Boints
II. (he Boints inflammation caused $y
precipitation of uric acid crystals
***. *t is a type of osteoporosis
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/. Al of the following are Allopurinol
side effects- E8CEP(:
A. *ncrease P(
B. Hypersensitivity rashes
C. 7*( intolerance
D. Peripheral neuritis
E. #ecroti"ing vasculitis
//. (he use of estrogen in osteoporosisJ
*. Enhance calcium retention and
retard $one loss
**. Fseful in treatment of osteoporosis
associated to menopause
***. #ot effective at increased $one
mass that has already $een lost
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/0. Ant malarial drug used in the
treatment o rheumatoid arthritis as DA'A
drug
A. ChloroMine
B. 1uinine
C. @ulfasala"ine
D. HydroxychlorMuine
E. PrimaMuine
/2. Correct administration of
Penicillamine in the treatment of
rheumatoid arthritis include:
A. %ith meal
B. *n empty stomach
C. %ith plenty of water
D. %ith orange Buice
E. Before $ed time
/6. Asthmatic patient with 'A with
Aspirin sensitivity. (he drug of choice is:
A. *$uprofen
B. Acetaminophen
C. 7old therapy
D. A"athioprine
E. Cyclophosphamide
/,. Diflunisal is most li9ely to prescri$ed
for the treatment of:
A. %ilsonRs disease
B. 'heumatoid arthritis
C. Cystinuria
D. Psariasis
E. HansenRs disease
40
/5. (he anti $ody with longest serum
half life is:
A. *gA
B. *g7
C. *gD
D. *gE
E. *gA
/E. ( cells that are released from
thymus gland into circulation are:
*. Aemory B cells
II. (
H
cells
***. ( virgin cells
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
//=. %hich type of anti $odies
:immunoglo$ulin; can enter fetal
circulation
A. *gA
B. *g7
C. *gD
D. *gE
E. *gA
//.. (he oxidative release of which of the
following su$stance causes formation of
toxic hypochlorous acid :
I. H
&
**. Peroxidase
***. &xygen
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
//. An example of type *C
hypersensitivity reactions is mediated $y
*gE :
*. Cytotoxicity
**. Bronchial constriction
***. Contact dermatitis
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
///. Preventive vaccine availa$le for the
following condition
*. Hepatitis B
**. *nfluen"a A
***. *nfluen"a B
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
//0. As a result of "witter ion amino acid
solution. *n solution "witter ion exhi$it the
following properties :
*. Anionic
**. Cationic
***. Ampiphilic
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
//2. D#A contain the following
fragment:
A. #ucleotide with deoxyri$ose :sugar;
B. #ucleoside with deoxyri$ose :sugar;
C. #ucleoside with 'i$ose
D. #ucleotide with ri$ose
41
E. #on of the a$ove
//6. H*C viruses has special en"ymes that
form D#A in host- which of the following is
that en"yme:
A. c D#A
B. recom$inant D#A
C. reverse transcriptase
D. restrictive endonulease
E. PPPP
//,. 7enetic information storage place of
eu9aryotics is:
A. ?ysosome
B. #ucleus
C. Cacuoles
D. Aitochondria
E. Chromosomes
//5. %hich of the following vaccines are
given in geriatrics:
*. *nfluen"a
**. Pnumoccocus
***. Aeningoccocus
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
//E. An unconscious patient is $ought
into the emergency department. (he patient
is given 2= ml of 2=> dextrose in water-
thiamine .== ml *C followed $y nalaxone
.mg - the patient most li9ely overdose on
which of the following:
A. Heroin
B. PP
C. PP
D. PP
E. PP
/0=. Parenteral calcium used as antidote
for which of the following:
*. Hyper9alemia
**. Cerapamil
***. Hypo9alemia
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/0.. How is acetaminophen toxicity
treated:
*. 7astric lavage within hours
**. Activated charcoal administration
III. Administration of N!acetylcystein
for hepatotoxicity
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/0. Charcoal used as antidote in
overdose of chemicals and drugs- charcoal
effects as:
*. *ncrease the en"ymatic degradation
of the chemicals in 7*(
**. *ncrease the clearance of the drugs
and chemicals from 7*(
***. Decrease a$sorption of the drugs $y
adsorption
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/0/. How do you treat $en"odia"epine
toxicity)
42
*. Perform gastric lavage
**. Administration of activated charcoal
***. Administration flum"enil- a
competitive $en"odia"epine
antagonist
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/00. @alicylates toxicity of drug are
treated $y al9aline diuresis $ecause:
*. Decrease a$sorption of salicylates
**. *ncrease a$sorption of salicylates
$ecause acid and $ase ma9e neutral
solution
***. Enhance salicylates excretion
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove

/02. @alicylates toxicity of drug are
treated $y al9aline diuresis $ecause:
*. Decrease a$sorption of salicylates
**. Decrease re a$sorption
***. Enhance salicylates excretion
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/06. %hat is not found in deoxyri$ose
nucleic acid
A. Fracil
B. Adenine
C. Cytosine
D. 7uanine
E. (hyamine
/0,. %hat are the common storage land
of most $iotechnological products such as
tPA- @trepto9inase- and lyro9inase
A. Cool pace !5W C
/05. 7lycoproteins are lin9ed to:
*. *nsulin
**. 7onadotropin
***. *nterleu9in
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/0E. Aost common anti$ody:
A. *gA
B. *gD
C. *g7
D. *gE
E. *gA
/2=. All of the following are
$iotechnological products E8CEP(:
A. Alteplase
B. A$cixima$
C. *nterleu9in!/
D. Beta serum
E. %arfarin
/2.. En"yme that clears D#A at a specific
site called:
*. (yrosine
**. 'estrictive ri$onuclease
***. 'estrictive endonuclease
A. * &nly
B. *** &nly
43
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/2. %hich is recom$inant D#A:
*. '!D#A
**. C!D#A
***. rD#A
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/2/. Lm :Aichael menton constant;
lower that C max:
A. Iirst order
B. @econd order
C. Kero order
D. @econd order 9inetic
E. PP
/20. ?ecithins are:
*. Car$ohydrates
**. Proteins
***. Blood fats
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/22. %hich drug cause Cit B6 deficiency
*. *sonia"ide
**. Penicillamine
***. Aethotrexate
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/26. %hich drugs cause folic acid
deficiencyJ
*. *sonia"ide
**. @ulfonamide
***. Aethotrexate
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/2,. ?ac9 of intrinsic factor cause:
A. Cit B
.
deficiency
B. PP
C. PP
D. P
E. PP
/25. %hich of the following molecules
form free radicals:
*. Iatty acid peroxidation result in free
radicals
II. H
&
and other peroxide produce free

radicals
***. &xygen producing free radicals
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/2E. %hich of the following is N are free
radical:
I. H
&
II. &
***. &H
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
44
/6=. %hich of the following can form free
radical:
I. H
&
II. &
***. &H
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/6.. %hich of the following vitamins
contain aminolone
I. Cit. B
.
**. Cit. C
***. Cit. L
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/6. All of the following are immune
system related organs E8CEP(:
A. ?ymph
B. (hymus
C. (hyroid
D. Appendix
E. @pleen
/6/. A patient with inflammation and
infection his %BC count is:
A. P 0=== to ..===
B. V 0=== to ..===
C. EMual to 0== to ..===
D. PP
E. PP
/60. %hich of the following is the maBor
%BC)
A. Eosinophil
B. #eutrophil
C. Basophil
D. Platelet
E. Aonocytes
/62. A // years old woman receive long
term and her dose treatment of
sulfamethoxa"ole after wee9s of treatment
she has low grade of fever- rash- muscle and
Boint pain. (hese symptoms indicate which
of the following type of hypersensitivity
reactions)
A. (ype *
B. (ype **
C. (ype ***
D. (ype *C
E. (ype C
/66. (he anti$ody with the longest serum
half life:
A. *gA
B. *g7
C. *gD
D. *gE
E. *gA
/6,. ?ocal anesthetic $en"ocaine with
caffeine form the following products:
A. Dipole D Dipole
B. *on D Dipole
C. Complexation
D. *on D*on
E. #on of the a$ove
/65. All are $usiness forms in Canada
E8CEP(:
A. *ncorporation
B. Private ownership
45
C. ?easing
D. Cooperative
E. PP
/6E. (he following is most important
factor in an effort to start pharmacy:
A. Iinancial assessment
B. @ite of pharmacy
C. Par9ing space
D. 7eographical location
E. #eigh$orhood
/,=. Balance sheet- is the financial
statement mainly contain the following
information:
*. Profit
**. @ales report
***. ?ia$ilities
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/,.. %hat is P&@ meansJ
A. Point of sale
B. 88
C. 88
D. 88
E. 88
/,. %hat is 1A?+ means:
A. 1uality adBusted life years
B. ..
C. ..
D. ..
E. ..
/,/. 'esponsi$ility of pharmacy manager
E8CEP(:
A. @alaries distri$ution
B. Ftilities
C. So$ distri$ution
D. Product stoc9 management
E. &(C product price
/,0. (he most important factors in
location analysis should $e focused on a:
A. Aar9et area analysis
B. 'egion analysis
C. (rading area- and finally a site
D. Par9ing area
E. @chool area
/,2. %hich form of $usiness enterprise is
most prefera$le:
A. *ncorporation
B. P
C. P
D. P
E. P
/,6. %hich form of $usiness enterprise is
most profita$le
A. @ole proper ship
B. PP
C. PP
D. -P
E. PP
/,,. %hich is the fastest and the effective
way of promotion
A. Advertisement
B. Direct mailing
C. Direct contact with customer in high
freMuency hours
D. PP
E. PP
/,5. %hich is the most effective media of
promotion)
46
A. (C
B. 'adio
C. Bill$oards
D. Ilyers
E. Direct mailing
/,E. Drugs that are converted to salt
form
*. Alter drug $ioavaila$ility
**. Alter pharmacological effects
***. *ncrease potency
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/5=. (acrolimus is an
immunosuppressant agent :IL2=6
or Prograft;- main side effects:
*. #ephrotoxicity
**. #uerotoxicity
***. &steoporosis
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/5.. *n which type of sei"ure there is
$rea9 in the action of patient activity for
long period:
A. (onic D clonic
B. PP
C. PP
D. PP
E. PP
/5. ChronUs Disease is disease of :
A. @mall intestine
B. @tomach
C. Duodenum
D. Colon
E. 'ectum
/5/. pH of the stomach is decreased $y:
*. HCl :hydrochloric acid;
**. PP
***. PP
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/50. %hich structure is not found in the
dermis:
A. #erves
B. Iats
C. Aelanin
D. Blood vessels
E. PP
/52. Hyperdermolysis:
A. Entry of *C fluids in the dermis
B. PP
C. PP
D. PP
E. PP
/56. #ecrosis:
A. Dead area of tissue surrounded $y healthy
tissue
B. PP
C. PP
D. PP
E. PP
/5,. #ecrosin:
A. @u$stance o$tained from inflamed
tissue which induce inflammatory
changes in normal tissue:
47
B. PP
C. PP
D. PP
E. PP
/55. #ecro$iosis:
A. 7radual degradation in depth of tissue
B. PP
C. PP
D. PP
E. PP
/5E. %hich vitamin is not present in
neonate: new $orn;:
A. Citamin A
B. Citamin D
C. Citamin L
D. Citamin C
E. Citamin E
/E=. %hat is true a$out cystic fi$rosis:
*. 7enetic etiology
**. Effects lungs and digestive system
***. Cause $y deficiency of vitamins
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/E.. ?a PlaceRs law descri$e the tension
achieves in $lood vessel wall to:
*. (he interluminal pressure
**. (he radius of $lood vessels
***. (he length of the $lood vessels
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/E. Correct statement of mycrocytic
anemia:
*. Decrease in 'BC si"e
**. Decrease in 'BC
***. Caused $y iron deficiency
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/E/. pernicious anemia :PA; caused due
to:
I. Iolic acid
II. Citamin B
.
III. (hyroid disorder
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/E0. pernicious anemia can $e treated $y:
A. Diet higher in vitamin B
.
B. &ral supplement of Citamin B
.
C. Parenteral supplement of folic acid
D. &ral supplement of iron
E. Parenteral supplement of vitamin B
.
/E2. @ic9le cell anemia:
*. (halassemia
**. Aain etiology is hereditary
***. Deficiency of iron causes sic9le cell anemia
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/E6. @houlder Boint contain:
*. @pine
48
**. Humerous
***. @capula
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/E,. %hat is a"otemia)
*. Excess of BF# in $lood
**. Excess of creatinin clearance
***. Decrease of BF#
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/E5. (he following pathogens commonly
cause travelers diarrhea:
*. E coli
**. @higella sp.
***. Bacteroid fragillis
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
/EE. (he following have effectively used
for prevention of traveler diarrhea
*. Ciprofloxacin and doxycyclin
**. Cotrimoxa"ole
***. Erythromycin
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** And *** &nly
E. All &f the a$ove
400. (he following have effectively
used for prevention of traveler diarrhea:
*. Ciprofloxacin and doxycyclin
**. Cotrimoxa"ole
***. Pepto ! Bismol
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** and *** &nly
E. All of the a$ove
0=.. %hich of the following most
common causative organism for traveler
diarrhea
A. E coli
B. Aeromonas @p.
C. @almonella @p.
D. @higella @p.
E. Ci$ro cholera
0=. (he following unsafe food could
cause traveler diarrhea
*. Coo9ed and unpeeled fruits
**. Iresh soft cheese
***. Iresh vegeta$le salad
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** and *** &nly
E. All of the a$ove
0=/. Preferred laxative used in elderly
patients)
*. Doucsate sodium :emollient laxative;
**. ?actulose
***. 7lycerin suppositories
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** and *** &nly
49
E. All of the a$ove
404. %hat is the advantages of antacids
over H
Antagonists:
A. ?onger duration of action
B. Antacids are indicated for treatment
C. Antacids have faster onset of action
D. Antacids have $etter a$sorption
E. Antacids have slower a$sorption
I. Antacids have more effectiveness
0=2. %hich of the following counseling
for permethrin 2>- indicated in sca$ies
treatment:
*. (horoughly- massage into s9in from head to
soles of feetRs
**. 'emove cream $y washing
***. Fse for all family mem$ers
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** and *** &nly
E. All of the a$ove
0=6. %hich of the following factors
aggravate osteoporosis:
*. 'ace
**. Estrogen use oral contraceptive
***. Estrogen deficiency
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** and *** &nly
E. All of the a$ove
0=,. *n pharmacoeconomics
considerations- the following aspects is the
most important:
A. Pharmacist
B. Doctor
C. Patient
D. Hospital
E. @ociety
0=5. %hich is include in standard data:
*. Coefficient of variance
**. 'ange
***. @tandard deviation
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** and *** &nly
E. All of the a$ove
0=E. %hen standard error of the mean
decrease:
A. (he si"e of the sample increase
B. (he si"e of the sample decrease
C. (he si"e of the sample does not change
D. #on of the a$ove
0.=. (he visual impulse is associated with
photochemical transformation of:
A. 'etinal
B. 'etinol
C. 'etinoic acid
D. 'hodopsin
E. #on of the a$ove
0... Pharmacist advice the patient with
eye pro$lems to see the doctor in which of
the following case:
*. 'ed eye
**. Blurred vision
***. &cular pain
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** and *** &nly
E. All of the a$ove
50
0.. Patient ta9ing diphenhydramine as a
sleep help should $e advised :
*. (o ta9e ta$let every day
**. (o ta9e /= min $efore $ed time
***. *ncreasing the dose will increase the
induction of sleep
A. * &nly
B. *** &nly
C. * and ** &nly
D. ** and *** &nly
E. All of the a$ove
0./. %hen concerning the parents of a .=
years old child with a prescription for
Bacterio$an to treat impetigo- all should $e
said E8CEB(:
A. *mpetigo is common among children in this
age
B. S. Pyrogen is one of the agents that cause
impetigo
C. *mpetigo is very communica$le
D. &ral medication do not wor9 in impetigo
treatment
414. A prescription contains a drug-
which gives side effects to a patient.
Pharmacist does not inform the patient
regarding it and continue to dispense the
prescription. %hat are the following ethical
principle violated:
A. Autonomy
B. Beneficency
C. Sustice
D. Ceracity
E. Honesty
0.2. Ethical principal of nonmaleficiency
reMuires:
A. Act with truthfulness
B. Act with honesty
C. (o do good
D. (o do no harm
E. Act with fairness
0.6. *f a pharmacist dispensed a drug
with different $rand name than the
prescription- what ethical principle is
violated)
A. Autonomy
B. Beneficency
C. Sustice
D. Ceracity
E. Honesty
0.,. All of the following
pharmacoeconomics methods used to assess
in term of cost and conseMuences E8CEP(:
A. Cost $enefit analysis
B. Cost utili"ing analysis
C. Cost minimi"ation analysis
D. Cost of illness
E. Cost effective analysis
0.5. Ampicillin prescription changed to
amoxicillin $y doctor- this su$stitution is
called:
A. 7eneric su$stitution
B. Pharmaceutical su$stitution
C. (herapeutic su$stitution
D. Pharmaceutical alternate
E. Brand name alternate
0.E. a
0=. a
0.. a
0. a
0/.
51

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