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Spectrophotometric Estimation of Clopidogrel Bisulphate
Spectrophotometric Estimation of Clopidogrel Bisulphate
SPECTROPHOTOMETRIC ESTIMATION OF
CLOPIDOGREL BISULPHATE IN PHARMACEUTICAL
DOSAGE FORMS
NAYANA PIMPODKARa∗∗, YOGITA SHETE, N. S. MAHAJANa,
Y. V. PORE, R. L. JADHAVa and B. S. KUCHEKAR
Government College of Pharmacy, Vidyanagar, KARAD – 415214, Dist., Satara (M. S.) INDIA
a
Department of Pharmaceutical Chemistry, Satara College of Pharmacy, SATARA (M. S.) INDIA
ABSTRACT
A simple, sensitive, rapid, accurate and precise spectrophotometric method has been developed
for estimation of clopidogrel bisulfate in bulk and pharmaceutical dosage forms. clopidogrel bisulfate
shows maximum absorbance at 270 nm with molar absorptivity of 848.3 × 103 L/mol. cm. Beer’s law
was obeyed in the concentration range of 50 – 500 µg/mL. Results of analysis were validated statistically
and by recovery studies.
INTRODUCTION
The objective of this study was to develop simple, rapid, accurate and specific
spectrophotometric method for the estimation of clopidogrel bisulfate using UV
spectrophotometer. The simple method was developed using solvent distilled water with
∗
Author for correspondence; E-mail: pnayanv@yahoo.co.in
Int. J. Chem. Sci.: 7(1), 2009 217
minimum processing steps. The λmax of clopidogrel bisulfate in 0.1N H2SO4 was found to
be 270 nm and Beer’s law was obeyed in the range of 50–500 µg/mL. The result of
analysis was validated statistically and by recovery studies; thus, this method of estimation
of clopidogrel bisulfate was found to be simple precise and accurate.
EXPERIMENTAL
ACKNOWLEDGEMENTS
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