LEVETIRACETAM

BRAND INDICATION DOSAGE FORM COST/PACKING

1. Ivetra (Torrent) Adjunctive therapy in the
treatment of partial
seizures with or without
secondary generalization
Adult and adolescent
>16 years 500mg BID,
may be increased to
1500mg BID. Dose
titration can be made in
500mg increments or
decrements.

Elderly and patients with
renal impairment
individualized dosage
1000 film-coated
tablet 1000mg

250 film-coated
tablet 250mg

500 film-coated
tablet 500mg
60s (P4945.50/pack)


60s (P1283.78/pack)


60s (P2538.27/pack)
2. Letram (Hetero drugs) Adjunctive therapy in the
treatment of partial
seizures with or without
secondary generalization
Monotherapy adult and
adolescent >16 years
initially 250mg BID
increased to 500mg BID
after 2weeks. May be
further increased by
250mg BID twice weekly.
Max: 1500mg BID

ADD-ON THERAPY
adult and adolescent
>12 years >50kg initially
500mg BID, may be
increased up to 1500mg
BID. Dose may be titrated
by increment/ decrement
of 500mg BID 2-4 times
weekly.

4-17 years <50kg initially
10mg/kg BID, may be
250mg film-
coated tablet

500mg film-
coated tablet
100s


100s
increased up to 30mg/kg
BID. Dose
increment/decrement
should not exceed
10mg/kg BID 2x weekly.

Children >50kg adult
dose
3. Vexlev (VE Pharma) Adjunct in the treatment of
partial seizures with or
without secondary
generalizations
Adult >16 years 250mg,
increase in increments of
500mg every 2weeks.
Max: 1500mg.

Pedia (20kg body
weight) 4-16 years
10mg/kg, increased
increments of 10mg/kg
every 2 weeks to
30mg/kg; 6months-
4years 10mg/kg,
increased increments of
10mg/kg every 2weeks to
25mg/kg; 1 to <6 months
7mg/kg, increased
increments of 7mg/kg
every 2weeks to
21mg/kg.

Myoclonic seizures adult
and ped >12 years
500mg, increased by
500mg every 2weeks to
1500mg.

250mg film-
coated tablet

500mg film-
coated tablet
30s


30s
Primary generalized
tonic-clonic seizures
adult >16 years 500mg,
increased by 500mg
every 2weeks to 1500mg;
Pedia 6-16 years
10mg/kg, increase in
increments of 10mg/kg
every 2weeks to
30mg/kg. All doses to be
taken BID
4. Keppra
(GlaxoSmithKline)
Monotherapy in the
treatment of partial onset
seizures with or without
secondary generalization in
patients > 16 years with
newly diagnosed epilepsy.

Adjunctive therapy in the
treatment of partial
seizures with or without
secondary generalizations
in adults and children >4
years with epilepsy

Myoclonic seizures in
adults and adolescents >12
years with juvenile
myoclonic epilepsy

Primary generalized tonic-
clonic seizures in adults and
children >4 years with
idiopathic generalized
Monotherapy adult and
adolescent >16 years
initially 250mg BID,
increased to 500mg BID
after 2 weeks. May be
further increased by
250mg BID 2x weekly.
Max: 1500mg BID.

Add on therapy adult
(>18 years) & adolescent
12-17 yrs >50kg initially
500mg BID, may b
increased up to 1500mg
BID. Dose may be titrated
by increment/decrement
of 500mg BID 2-4x
weekly.

Children and adolescent
>50kg adult dose; 4-
17yrs <50kg initially
10mg/kg BID, may be
1000mg film-
coated tablet

250mg film-
coated tablet

500mg film-
coated tablet

500mg/5mL
infusion
concentration

100mg/mL oral
solution
60s (P7187.00/pack)


60s (P1977.00/pack)


60s (P3952.00/pack)


Vial x 5mL x 5 x 1s
(P30477.70/box)


300mL x 1s
(P1927.80/bottle)
epilepsy increased up to 30mg/kg
BID. Dose
increment/decrement
should not be >10mg/kg
BID 2x weekly; children
<25kg start the
treatment with
100mg/mL oral solution.
5. Levit (InnoGen
Pharmaceuticals)
Adjunctive therapy in the
treatment of partial
seizures with or without
secondary generalization

Second-line drug in
generalized tonic clonic
seizures, myoclonus
including juvenile
myoclonic epilepsy and
atonic or tonic seizures
Initially 1g on day 1 in 2
divided doses. May be
increased in increments
of 1g every 2-4 weeks up
to max of 3g daily.
1g film-coated
tablet

500mg film-
coated tablet
60s (P4260.00/pack)


60s (P2100.00/pack)