Do you have both viruses & bacteria

COVERED?
Titanium

5
+ PH-M
Single-vaccine solution protects against
BRD-causing viruses & bacteria at every stage of production
Bacteria Viruses
M. haemolytica P. multocida BVD (1 & 2) IBR PI
3
BRSV
Managing the BRD complex enhance immunity;
reduce exposure to disease
The many factors affecting a calfs ability to contract BRD can be grouped into
three categories that interact with one another: the infectious pathogens, the
environment and the status of the calf. While some of these factors are within
our control, many are not.
Thats why your veterinarian uses best management practices and preventive
measures, including vaccinations, to enhance the animals immune system.
Disease prevention can best be described as a two-pronged approach:
Increase the animals ability to overcome disease challenges through
vaccination, which builds a stronger immune system
Lower the level of exposure to disease through best management practices
this is especially critical during stressful events (e.g., weaning,
transporting, commingling)
Titanium 5 + PH-M delivers a broad immune response against the bacteria and viruses most associated
with bovine respiratory disease (BRD) in a single vaccine for cattle as young as 2 months of age.
1-4
Calf
status
Environment
Pathogen
immune system
nutrition
stress
climate
air
management
bacteria
viruses
toxins
BRD is still your No. 1 profit robber
BRD accounts for 75 percent of feedlot morbidity, and
50 to 75 percent of mortality, costing the industry an
estimated $800 to $900 million annually
5-8
BRD-related factors also contribute to a reduction in
average daily gain by as much as 0.3 to 0.5 lbs
9,10
Viruses and bacteria a powerful one-two punch on the immune system
While respiratory viruses can cause BRD on their own, they also can compromise the immune
system that normally protects cattle against bacteria, allowing bacteria to attack their host and
cause severe cases of BRD.
When cattle are exposed to respiratory viruses such as bovine viral diarrhea (BVD),
parainfluenza
3
(PI
3
), infectious bovine rhinotracheitis (IBR) and bovine respiratory syncytial
virus (BRSV) their immune system can be weakened
Once the immune system is compromised, bacteria including Mannheimia haemolytica and
Pasteurella multocida can more easily go deeper into the respiratory tract where they
cause disease
When bacterial pathogens reach the lungs, they are a major cause of severe BRD, causing
increased morbidity, mortality, and labor and treatment costs
And what about subclinical cases? One study
showed that 68 percent of untreated calves had
pulmonary lesions at slaughter, demonstrating that
a significant number of animals never diagnosed
with BRD do, in fact, suffer from some degree of
respiratory disease
11
The BRD Complex
Titanium 5 + PH-M the convenience and flexibility of a single
vaccine that protects against BRD-causing viruses and bacteria
Protects against the two bacteria most associated with BRD:
1
Mannheimia haemolytica the bacterium most frequently isolated from lungs
of cattle with BRD
Pasteurella multocida an important cause of bacterial pneumonia
Also protects against five important virus strains:
2,3
BVD, types 1 and 2 PI
3
IBR BRSV
Approved for use in cattle 2 months of age and older, Titanium 5 + PH-M is flexible
enough to be incorporated into virtually any vaccine protocol. Producers should work
with their veterinarian to determine the best way to incorporate Titanium 5 + PH-M. As a
general guide, it fits well in branding and/or preconditioning vaccine protocols, as well as
in arrival programs for stocker and feedyard operations.
Helping your cattle overcome the one-two punch of
viruses and bacteria requires a vaccine solution
that provides a broad immune response against the
bacteria and viruses most associated with BRD.
Do you have
viruses &
bacteria
covered?
Titanium 5 + PH-M
Protects against the
respiratory viruses and
bacteria most associated
with BRD
Offers the convenience of
a single vaccine at every
stage of production
Contains a research-
proven M. haemolytica
leukotoxoid and other
antigens to stimulate
an immune response to
BRD-causing viruses
and bacteria
Includes a low-reactive,
water-soluble adjuvant,
and is proven safe for
cattle as young as
2 months of age
Its low-volume,
subcutaneous
administration meets
Beef Quality Assurance
SM

(BQA) guidelines
Titanium 5 + PH-M proven effective and
safe at every stage of production
Evaluated under U.S. Department of Agriculture requirements,
Titanium 5 + PH-M was proven safe and effective for cattle at all
stages of production, with no interference between the viral and
bacterial components of the vaccine. Research comparing
vaccinated calves to controls after infection with M. haemolytica
showed Titanium 5 + PH-M:
1
Reduced lung lesions* by 82 percent (P < 0.01)
Reduced clinical signs of infection significantly (P < 0.01)
*Mitigated fraction: the effect of a vaccine in reducing severity of disease.
Studies also showed Titanium 5 + PH-M:
Provided the same viral protection (BVD, types 1 and 2, IBR,
PI
3
, BRSV) as Titanium 5
2,3

Protected against severe clinical signs of BRD
1-3

Resulted in no adverse events beyond minimal injection-site
swelling
4
100%
80%
60%
40%
20%
0%
Day 1 Day 2 Day 3 Day 4
Figure 1. M. Haemolytica Challenge Study Survival Rate
1
S
u
r
v
i
v
a
l

R
a
t
e
Group 1: PH-M
Group 2: Titanium 5 + PH-M
Control
Elanco, Titanium

and the diagonal bar are trademarks owned or

licensed by Eli Lilly and Company, its subsidiaries or afliates.
2014 Elanco Animal Health.
VAC 31892-2
The label contains complete use information, including
cautions and warnings. Always read, understand and follow
the label and use directions. Do not vaccinate within 21 days
of slaughter.
1
Milliken, G. A. 2013. Mannheimia haemolytica efcacy studies demonstrating the absence
of excessive interference of Titanium products with the Mannheimia haemolytica-Pasteurella
multocida bacterin-toxoid.
2
Demonstration of the compatibility of components between APHIS product codes 1181.20
(Establishment 213) and G935.04 (Establishment 315) APHIS product code 45B9.20. Study
No. 2010-01 Rev. 1.
3
Efcacy study for BRSV fraction to demonstrate compatibility of the BRSV component in
APHIS product code: 45B9.20 (unlicensed). Study No. 2011-05 Rev. 1.
4
Porter, M. 2011. Field safety evaluation of bovine rhinotracheitis-virus diarrhea-
parainuenza3-respiratory syncytial virus vaccine, modied live virus, APHIS product code
1181.20 (establishment 213) in combination with Mannheimia haemolytica-Pasteurella
multocida bacterin-toxoid, APHIS product code: G935.04 (establishment 315). Protocol No.
2011-01, Rev. 02.
5
Edwards, A. J. 1996. Respiratory Diseases of Feedlot Cattle in the Central USA. Bovine
Practitioner. 30:5-7.
6
Galyean, M. L., L. J. Perino and G. C. Duff. 1999. Interaction of Cattle Health/Immunity and
Nutrition. J. Anim. Sci. 77:1120-1134.
7
Loneragan, G. H., D. A. Dargatz, P. S. Morley, and M. A. Smith. 2001. Trends in Mortality
Ratios Among Cattle in US Feedlots. J. Am. Vet. Med. Assoc. 219:1122-1127.
8
Chirase, N. K. and L. W. Greene. 2001. Dietary zinc and manganese sources administered
from the fetal stage onwards affect immune response of transit stressed and virus infected
offspring steer calves. Animal Feed Science and Technology. 93:217-228.
9
Smith, R. A. 1998. Impact of Disease on Feedlot Performance: A Review. J. Anim. Sci.
76:272274.
10
Bateman K. G., S. W. Martin, P. E. Shewen and P. I. Menzies. 1990. An evaluation of
antimicrobial therapy for undifferentiated bovine respiratory disease. Can. Vet. J. 31:689-696.
11
Wittum T. E., N. E. Woollen, L. J. Perino and E. T. Littledike. 1996. Relationships among
treatment for respiratory tract disease, pulmonary lesions evident at slaughter, and rate of
weight gain in feedlot cattle. J. Am. Vet. Med. Assoc. Aug 15;209(4):814-8.
USBBUTIT00014
Elanco.us
Learn more about
Titanium 5
+
PH-M
the new single-vaccine solution
thats approved for cattle as
young as 2 months of age.
The Titanium line of vaccines is a brand
youve come to trust the brand that
brought you the rst type 2 BVD
modied-live virus (MLV) vaccine.
Figure 2. Titanium 5 + PH-M Safety Study Injection-Site Evaluation
4
Calves vaccinated on Day 1 and revaccinated on Day 21.
P
e
r
c
e
n
t

o
f

a
n
i
m
a
l
s
Day 4-6 Day 21 Day 25-27 Day 42
100%
80%
60%
40%
20%
0%
Injection-site swelling measurements
0 <1.5 cm >5 cm 1.5 - 5 cm