Professional Documents
Culture Documents
LTF Interpretation
LTF Interpretation
LTF Interpretation
This article forms part of our Tests and results series for 2011 which aims to provide information
about common tests that general practitioners order regularly. It considers areas such as indications,
what to tell the patient, what the test can and cannot tell you, and interpretation of results.
Reprinted from Australian Family Physician Vol.40, No. 3, march 2011 113
AST
ALT
Haem metabolite
Conjugated in liver
Synthesised in liver: half life about 20 days
Includes albumin, immunoglobulins and carrier proteins:
variable proportion synthesised in liver
Originates from the canalicular (bile) surface of hepatocyte
Originates from the canalicular (bile) surface of hepatocyte
Also from bone (produced during bone formation), intestine
and placenta
Originates from the hepatocyte cytoplasm, hepatocyte
mitochondria and from muscle (skeletal and cardiac)
Originates from the hepatocyte cytoplasm
Examples
Laboratory features
Common causes
Cholestasis
Hepatocellular
damage
Biliary obstruction
Pregnancy (needs further assessment)
Drugs (eg. erythromycin, oestrogen)
Infiltration (eg. malignancy)
Infection (eg. hepatitis B, C, A; EBV;
CMV)
Alcohol (AST often >2 times ALT)
Fatty liver
Drugs (eg. paracetamol*)
Metal overload (eg. hereditary
haemochromatosis, copper overload)
Hypoxia (LD usually >1.5 times AST)
Autoimmune
* Patients with pre-existing liver disease, including alcohol abuse, are vulnerable to
paracetamol toxicity even at a standard dose5
114 Reprinted from Australian Family Physician Vol.40, No. 3, march 2011
Next steps?
Follow up investigations are certainly
recommended for patients with severe or
persistent abnormalities, or with relevant clinical
findings. These investigations are context
specific. However, in a hepatotoxic picture
investigations such as hepatitis serology, ferritin
and transferrin saturation are first line. Further
investigation may include tests for less common
causes such as copper overload and autoimmune
liver disease. In contrast, for cholestatic results
the initial emphasis is usually on hepatic
imaging with ultrasound.
Case study 1
A woman, 35 years of age, complained
of abdominal pain and dark urine. She
was clinically mildly jaundiced. Her liver
function tests were as follows:
Albumin
36 g/L (3448)
Protein
83 g/L (6585)
Total bilirubin
45 mol/L (224)
GGT
ALP
ALT
49 U/L (<55)
AST
43 U/L (<45)
Case study 2
A man, 39 years of age, had the following
results as part of an insurance medical:
Albumin
37 g/L (3448)
Protein
72 g/L (6585)
Total bilirubin
13 mol/L (224)
GGT
46 U/L (<60)
ALP
81 U/L (30110)
ALT
76 U/L (<55)
AST
44 U/L (<45)
Case study 3
A man, 66 years of age, presented with
weight loss and fatigue. He had a normocytic
anaemia. His LFTs were as follows:
Albumin
22 g/L (3448)
Protein
59 g/L (6585)
Total bilirubin
12 mol/L (224)
GGT
ALP
527 U/L(30110)
ALT
AST
96 U/L (<45)
Author
References
1
Resources
Reprinted from Australian Family Physician Vol.40, No. 3, march 2011 115