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@contraceptives Drugs
@contraceptives Drugs
@contraceptives Drugs
MALE HORMONAL
Mechanism :
Both FSH and hight
conc of intra-testicular
testerone (+ LH) are
essential for
spermatogenesis in
adult testis
Decrease GnTH
decrease effect of FSH
on sperm production
decrease
intratesticular
testosterone
reversible inhibition of
spermatogenesis
Agents used
1. testosterone alone
- FB inhibition
hypothalamus and
pituitary inhibition of
GnTH release
- produce azospermia
oligospermia
- does not have 100%
contraceptive efficacy
- produce side effects of
high dose of testosterone
2.testosterone combined
with progestin
- less testosterone dose
less side effect
Increase degree of
spermatogenic suppression
P4 act directly on leydig
cells decrease synthesis
of testosterone & decrease
expression of LH receptors
decrease intratesticular
testosterone concentration
3. GnRH antagonist +
testosterone
- prevents hypogonadism