Professional Documents
Culture Documents
Cosmetic Personal Care Cleaner
Cosmetic Personal Care Cleaner
(12)
(54)
Lee et al.
4,994,414 A
5,034,216 A
5,074,916 A
US 7,250,174 B2
Jul. 31, 2007
7/1991 Barone et a1
12/1991 Hench et al.
5,290,544 A * 3/1994 Shimono et al.
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5380360
5,614,489
5,658,332
5,735,942
5,766,611
(73)
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Notice:
(65)
Noguchi et 31'
Mohammadi et al.
Ducheyne et al.
Litkowski et a1.
Shimono etal.
5827882 A
10/1998 Yu et 31'
11/1998 Greenspan et al.
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5,990,380 A
5,997,887 A
12/1999 Ha et al.
6,010,713 A
6,086,374 A
]u1_ 4, 2002
(60)
1/ 1995
3/ 1997
8/1997
4/ 1998
6/1998
5,834,008 A
5,874,101 A
5,891,233 A
5,891,470 A
A
A
A
A
A *
6,224,888 B1 *
6,517,863 B1*
(51)
Int. Cl.
A61K 6/00
A61]; 9/00
A61K 25/34
A61K 8/00
(200601)
(200601)
(2006.01)
(200691)
A61K 8/18
(2006.01)
(52)
(58)
EP
W0
W0
W0
0 261 593
WO 97/27148
WO 98/11853
WO 98/46164
3/1988
7/1997
3/1998
10/1998
OTHER PUBLICATIONS
References Cited
3,922,155 A
3,981,736 A
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Frankel LLP
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(57)
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ABSTRACT
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4,698,318 A
3/1987 Kasuga
10/1987 Vogel et a1.
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4,777,041 A
4,783,429 A
4,786,555 A
4,814,165 A *
4,851,046 A
(Continued)
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10/1989 Kasuga
4,965,071 A
10/1990 Kawan
14 Claims, N0 Drawings
US 7,250,174 B2
Page 2
FOREIGN PATENT DOCUMENTS
W0
W0
W0
WO 98/46170
WO 99/13852
WO 99/16423
WO
W0
W0
W0
W0
W0
W0
9937287
WO
WO
WO
WO
WO
WO
99/37287
00/15167
00/42977
00/76486
01/03650
01/72145
10/1998
3/1999
4/1999
*
7/1999
7/1999
3/2000
7/2000
12/2000
1/2001
10/2001
OTHER PUBLICATIONS
* cited by examiner
US 7,250,174 B2
1
20
compositions.
BACKGROUND OF THE INVENTION
30
35
40
Component
Wt. Percent
$102
40490
CaO
445
Na2O
P205
Cal:2
B203
K20
MgO
0435
2416
0425
04
048
045
needed.
45
50
55
$102
Wt. Percent
40468
CaO
5430
Na2O
P205
10435
1412
60
Component
65
US 7,250,174 B2
3
and 150 um, and more preferably, betWeen about 50 and 100
glasses.
Particulate, non-interlinked bioactive glass is preferred
for many embodiments of the present invention. That is, the
glass is in the form of small, discrete particles, rather than a
particle siZes.
30
35
be used.
40
45
50
55
US 7,250,174 B2
5
Alternatively, the frit or ribbons may be ground using a
Component
SiO2
59
5435
P205
49472
CaO
Wt. Percent
step yields larger pore siZe in the ?nal product and permits
development of HCA very rapidly for both high and loW
silicon dioxide content gels. Indeed, these compositions
form HCA more rapidly than other gels When exposed to
35
large extent.
A sol-gel process is any process that includes the use of
formly.
Component
Wt. Percent
60
SiO2
49490
CaO
542
P205
1412
illary force inside the pore structure of the gel Which results
in large pore siZe. Gels are netWorks of small colloid
particles. The netWorks includes voids Which become pores
US 7,250,174 B2
7
20
25
Cosmetics
General
30
35
50
sun-screening applications.
55
from the skin in such a Way that skin Wrinkles become less
visible to the human eye. Further, the scatter of UV light is
65
focusing effect.
Further, the sol-gel-derived bioactive glass reacts With
aqueous solutions to form a solution that becomes concen
US 7,250,174 B2
10
Applicants have unexpectedly discovered that a combi
nation of bioactive glass With standard skin creams give the
skin a pleasant-non-oily feeling and look When compared
oily/fatty skin.
Bioactive glass and sol-gel derived bioactive glass exhibit
Methods of Making
20
contamination.
Bioactive glass may be added to or included in cosmetic
together.
utiliZed. Agitation may be achieved, for example, With
standard mixing devices. General mixing and blending may
be achieved, for example, With an impeller.
55
60
US 7,250,174 B2
11
12
TABLE II
RaW Materials Combined With Sol-Gel-Derived Bioactive Glass
RaW Material
Dermol M5
While in formulation.
In another embodiment the bioactive glass and/ or sol-gel
derived bioactive glass can be formulated into a dry form
Tergitol NP-9
Coco Hydroxy Sultaine
Crodesta SL-4O
POE2O Sorbitan monooleate
Propylene Glycol
Ethanol
Na Laureth-2 Sulfate
Sorbitan Isostearate
Glycerin
20
Procetyl AWS
Crodafos SG
Glycerox 767
Cocamide DEA
RaW Material
Incromectant AQ
Promyristyl PM-3
Jojoba Oil
Incromectant AQ
25
Dermol DPG 2B
Abil EM-90
Dermol DPG-2B
Transutol CG
Transcutol CG
Octyl Methoxycinnamate
Crodafos N3N
Triethanolamine
Menthyl Anthranilate
Octyl Methoxycinnamate
Crodafos N3N
Triethanolamine
30
Mineral Oil
Incrodet TD7C
Menthyl Anthranilate
Mineral Oil
Incrodet TD7C
35
40
Probutyl l4
GE SF 96 (350 cps)
Probutyl l4
Foamtaine CABG
Dermol MS
Stepanquat ML
Ammonium Lauryl Sulfate
Incromectant LQ
Tergitol NP-9
Coco Hydroxy Sultaine
45
Crodesta SL-40***
POE2O Sorbitan monooleate
Propylene Glycol
Ethanol
Na Laureth-2 Sulfate
Sorbitan Isostearate
following:
Glycerin
Procetyl AWS
Crodafos SG
Glycerox 767
Cocamide DEA
60
Glycerin
Propylene Glycol
Butylene Glycol
Hexylene Glycol
2-methyl propane diol
Jojoba Oil
Abil EM-90
following:
Ethanol
compositions.
65
Isopropanol
n-propanol
lauryl alcohol
US 7,250,174 B2
13
14
TABLE III-continued
TABLE IV-continued
HeXylene Glycol
following:
Isopropyl Myristate
folloWing:
Isopropyl Palmitate
Jojoba Oil
Glyceryl tri caprate/caprylate
Ethanol
Isopropanol
n-propanol
lauryl alcohol
oleyl alcohol
Sorbitan Esters
Diesters of diacids
Cosmetically acceptable Ethoxylated Materials including, but not
limited to the folloWing:
folloWing:
Isopropyl Myristate
Isopropyl Palmitate
Jojoba Oil
Glyceryl tri caprate/caprylate
Ethoxylated Glycerides
Cosmetically acceptable PropoXylated Materials including, but not
limited to the folloWing:
20
Ethoxylated PropoXylates
Cosmetically acceptable anhydrous ionic surfactants including, but
not limited to the folloWing:
25
Ethoxylated Glycerides
Phosphate esters
Sulfaters
Carboxylates
Fatty amine salts
30
Ethoxylated PropoXylates
folloWing:
Dimethicone
Simethicone
35
Phosphate esters
Cyclomethicone
Sulfaters
CarboXylates
Zonyls
folloWing:
Fluorcarbon alcohols
Cosmetically acceptable aerosol propellants including, but not limited
to the folloWing:
Dimethicone
Simethicone
Cyclomethicone
Propane
45
Butane
Pentane
Isobutane
Zonyls
Fluorcarbon alcohols
folloWing:
folloWing:
Polyalkenes
Polyoxethylenes
PolyoXypropylenes
Polyamides
Polyesters
Polyurethanes
TABLE IV
Anhydrous and Hydrous Ingredients Which May Be Used in a TWo
folloWing:
Polyacrylics
Polymethacrylics
PolysiloXanes
Cosmetically acceptable copolymers
Glycerin
Propylene Glycol
Butylene Glycol
65
US 7,250,174 B2
15
16
toning and exfoliating products and makeup removal prod
ucts; facial moisturizing, anti-wrinkle, eye treatment, hand
lotion and body lotion products; foot care products; anti-itch
products; anti-bacterial, antiseptic, antibiotic and ?rst aid
products; bath and shower soap in bar, liquid and gel form
and bath salt products; shampoo and hair detangling prod
ucts; hair mousse, hair gel and hair spray products; antiper
spirant and deodorant products in powder, creme, roll-on,
aerosol and stick form; aftershave and shaving lotion prod
ucts; shaving products in creme, gel, powder and soap
TABLE IV-continued
Anhydrous and Hydrous Ingredients Which May Be Used in a Two
Emulsifying Waxes
Lubrajels
Zilgels
Jojoba Glaze
Absorption Bases
Pigmentation Products
TABLE V
Evaporating Ingredients
following:
25
Ethanol
Isopropanol
n-propanol
Cosmetically acceptable Esters including, but not limited to the
following:
30
Ethyl acetate
Butyl acetate
Cosmetically acceptable Ethoxylated Materials including, but not
limited to the following:
Ethoxydiglycol
35
following:
40
following:
Acetone
n-alkanes
branched alkanes
Permethyls
Aerosol propellant gases
Cyclomethicone
Dimethicone
Cosmetically acceptable ketones including, but not limited to the
50
?uoro carbons and hydro chloro ?uoro carbons including, but not
60
diaper, baby wipe and hand wipe, baby powder and body
powder and diaper rash products; nursing pads (for bras);
makeup products; tampon, maxipad and pantiliner products;
acne prevention and treatment products; facial cleansing,
65
US 7,250,174 B2
17
18
(palm oil), jojoba oil, menthyl anthranilate, methylparaben,
EXAMPLE 1
soluble calcium.
20
25
Wt %
Jojoba Glaze
82.5
Octyl Methoxycinnalnate
Benzophenone-3
INGREDIENTS
7.5
5.0
5.0
30
100.0
EXAMPLE 2
35
40
INGREDIENTS
Wt %
Jojoba Glaze
45
82.5
Octyl Methoxycinnalnate
Benzophenone-3
7.5
5.0
5.0
or sulisobenzone.
50
EXAMPLE 3
POI-111111215 CPD3-32, J, K, N, o, R, s
55
60
hexyl
P-methoxycinnamate,
?uoroalkyldimethicone,
65
INGREDIENTS
Jojoba Glaze
87.5
Octyl Methoxycinnalnate
7.5
Benzophenone 3
5.0
100.0
US 7,250,174 B2
19
20
Formulas to be tested
ents.
baby wipe and hand wipe, baby powder and body powder
ingredients.
25
manufacturers.
herbal extracts.
diaper products.
Generally, baby wipe or hand wipe products comprise the
active ingredient disodium cocoamphodiacetae, a protectant
such as silicon oil, mineral oil, fatty acids, fatty alcohols or
plant oils, and a moisturizer such as aloe gel, propylene
glycol and PEG-60.
Common formulations of baby and hand wipe products
comprise water, propylene glycol, PEG-75 lanolin, cocoam
Makeup Products
The present invention includes novel formulations which
55
lipstick, lip gloss, lip treatment, lipliner, nail polish and nail
65
US 7,250,174 B2
21
22
oring agents.
20
30
35
40
50
extracts.
55
diaZolidinyl urea.
Eyeshadow products may also include one or more of the
ingredients.
US 7,250,174 B2
23
24
monate.
ingredients.
Generally, face poWder products comprise talc, a preser
vative, calcium stearate, and coloring agents.
Common formulations of face poWder products comprise
talc, mineral oil, Zinc stearate, kaolin, aluminum starch
35
40
60
agents.
US 7,250,174 B2
25
Lipstick and lip gloss products may also include one or
-continued
INGREDIENTS
Methyl Paraben
Propyl Paraben
Schott Glass 45s5 (<4 11 ave. part. size)
pentaerythrityl
10.0
i
i
10.0
i
i
10.0
100.0
100.0
glass.
20
tetrabehenate,
30
dipentaerythrityl hexacaprate/hexacaprylate,
0.1
0.2
0.1
Observations:
1) The Talc Formula did not set as well/quickly as either
beeswax,
0.1
0.2
0.1
100.0
sorbitan
Wt % C
Talc USP
20
0.1
0.2
0.1
Wt % B
Part C
Wt % A
fragrance,
EXAMPLE 4
45
Formulas CPD3-33 A, B, C
wt % A
wt % B
wt % C
Red 7 Ca Lake
Red 6 Ba Lake
Red 33 Al Lake
Castor Oil
Part B
3.0
1.0
1.0
15.0
3.0
1.0
1.0
15.0
3.0
1.0
1.0
15.0
Castor Oil
Carnauba Wax
Candellila Wax
Ozokerite Wax
30.6
2.0
7.0
2.0
30.6
2.0
7.0
2.0
30.6
2.0
7.0
2.0
Microcrystalline Wax
Jojoba Oil
3.0
25.0
3.0
25.0
3.0
25.0
Vitamin E
15.0
15.0
15.0
Part A
55
60
US 7,250,174 B2
27
28
EXAMPLE 5
Wt %
Jojoba Glaze
Schott Glass Bioactive Glass (<4 u ave. part. size)
80.0
20.0
100.0
EXAMPLE 6
II
20
oxide.
Nail polish products may also include one or more of the
INGREDIENTS
Wt %
Jojoba Glaze
Schott Glass Bioactive Glass (<4 u ave. part. size)
90.0
10.0
25
100.0
30
Bioactive Glass)
35
INGREDIENTS
Wt %
Glycerin
90.50
Pemulen TR-2
0.45
9.05
40
100.00
45
50
INGREDIENTS
Jojoba Glaze
55
Wt %
91.5
0.5
0.5
Talc - USP
2.5
5.0
100.0
60
nails.
agents.
US 7,250,174 B2
29
30
Products
The present invention includes novel formulations Which
generic manufacturers.
Generally, tampon products comprise cotton and/or rayon
overWrap and cotton cord.
Tampon products may also include one or more of the
ingredients.
25
35
55
65
ingredients.
US 7,250,174 B2
31
32
35
40
45
and hand and body lotion products may also include one or
more of the folloWing: 1-hexadecanol, acemannan hydrogel,
50
55
US 7,250,174 B2
33
34
EXAMPLE 9
INGREDIENTS
20.0
PolaWax
5.0
Glycerin
2.0
Deionized Water
65.4
Jaguar C-14S
Wt %
0.5
Phenobact
1.0
0.1
2.0
4.0
100.0
25
EXAMPLE 10
30
Formulas CPD3-34 A, B, C
35
INGREDIENTS
40 Crodafos CES
3.0
3.0
0.8
0.6
10.0
5.0
0.8
0.6
10.0
5.0
0.8
0.6
10.0
5.0
59.9
0.1
59.9
0.1
59.9
0.1
0.1
7.0
0.1
7.0
0.1
7.0
0.8
0.3
0.1
0.8
0.3
0.1
0.8
0.3
0.1
Propylene Glycol
3.0
3.0
3.0
Jaguar 13S
0.3
0.3
0.3
Part B
45
Deionized Water
NaOH
Volpo 10
TiO2
YelloW Iron Oxide
Red Iron Oxide
50 50/50 BlacldBroWn Iron Oxide Blend
Part C
Part D
55
Talc USP
60 Germaben II
8.0
Wt % C
3.0
Volpo 10
Volpo 3
Jojoba Oil
Cyclomethicone D5
Wt % B
Part A
Wt % A
8.0
8.0
1.0
1.0
100.0
100.0
1.0
100.0
ents.
34 B.
65
US 7,250,174 B2
35
36
manufacturers.
hydrocortisone.
20
25
pumice.
tate.
30
40
45
50
Anti-itch Products
The present invention includes novel formulations Which
60