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Science of The Total Environment: Susan Ann Eick, George Richardson
Science of The Total Environment: Susan Ann Eick, George Richardson
a r t i c l e
i n f o
Article history:
Received 1 March 2010
Received in revised form 1 June 2011
Accepted 6 June 2011
Available online 13 July 2011
Keywords:
Asthma
Ventilation
Respiratory health
Anti-allergy
Indoor environment
Housing
a b s t r a c t
During 2001 to 2004, a study was conducted to assess the indoor environmental and health impact of
installing allergen-reducing interventions in the homes of asthmatic children. Based on the results of a pilot
study, to determine an intervention that would provide improved symptom scores and a reduction in house
dust mite allergen (Der p 1), mechanical ventilation and heat recovery (MVHR) systems were installed in 16
homes. Environmental and respiratory health assessments were conducted before and after the installation of
the MVHR systems. The results indicated that the installation of MVHR systems reduced Der p 1
concentrations in living room carpets and mattresses. There were signicant reductions in symptom scores
for breathlessness during exercise, wheezing, and coughing during the day and night. Although, there was not
a parallel control group for the main study, the lack of change in the pilot study control group (who did not
receive an intervention), indicated that the changes in symptom scores were in part to do with the
intervention. Larger scale trials are needed to determine the efcacy of MVHR systems in homes to improve
indoor air quality and reduce asthma symptoms.
2011 Elsevier B.V. All rights reserved.
1. Introduction
Housing conditions are very important for human health, particularly for children who might remain indoors for up to 78% of their time
(WHO, 2001; Bonnefoy et al., 2003; US DHHS, 2009). There is a
correlation between the changes in indoor environments, particularly in
the home, over the last 50 to 60 years and the increasing incidence of
asthma (Ashmore, 1998; Howieson et al., 2003; Jacobs et al., 2009).
Increased indoor temperatures, reduced natural ventilation and
increasing energy efciency requirements have altered the indoor
environment (Richardson and Eick, 2006; Crump et al., 2009). The home
environment is a source of exposure to various indoor and outdoor
generated pollutants that have health implications (NAS, 2001; SCHER,
2007; CLG, 2008).
Physical changes can be made to the home environment to make it
more healthy and interventions have been developed to this effect, for
example, ventilation, anti-allergy products, deep cleaning, and in addition,
projects designed to change behaviours that lead to exposure to asthma
triggers (NAS, 2001; Richardson et al., 2005; Krieger et al., 2005).
dent study (the Breath of Fresh Air Project) in Cornwall, UK, to identify
possible interventions to reduce children's medically documented
respiratory symptoms through the introduction of interventions to
their home environment.
The inclusion criteria for participation were that at least one
asthmatic child (clinically diagnosed) under the age of 12 years permanently lived in the household and that the household received
income related, state funded benets.
3. Methods
3.1. Study design
The Breath of Fresh Air Project had two phases. A pilot study was
conducted to determine a suitable allergen reducing intervention,
which could then be investigated further in a larger study (herein
referred to as the main study). Indoor environmental and health
assessments were conducted before and after the installation of an
intervention in each home. Participants could not be blinded due to
the nature of the interventions.
2. Background
3.2. Recruitment strategy
The West of Cornwall Primary Care Trust, Kerrier and Penwith
District councils, and Enact Energy initiated and designed an indepen Corresponding author.
E-mail address: susan.eick@plymouth.ac.uk (S.A. Eick).
0048-9697/$ see front matter 2011 Elsevier B.V. All rights reserved.
doi:10.1016/j.scitotenv.2011.06.011
S.A. Eick, G. Richardson / Science of the Total Environment 409 (2011) 36283633
medical treatments. No nancial incentives were offered for participation or towards the long-term operating costs of the interventions. A
representative from each participating family was asked to sign a
consent form and agree for anonymous data to be shared for research
purposes.
3.3. Demographics
All homes were in southwest Cornwall with an assortment of
heating systems (Table 1). All homes were naturally ventilated (open
windows, inltration). Some had basic forms of passive ventilation,
for example trickle vents in windows. The homes were a mixture of
social rented (public sector tenant), private rented (tenant of
independent landlord), and privately owned (owner-occupied).
In total, 126 children were recruited into the study (pilot study= 70;
main study = 56). There were no signicant differences between the
pilot study and main study at baseline apart from outdoor conditions,
which were adjusted for. There were no signicant differences between
the dropouts and completers of the study at baseline (Table 2).
3.4. Interventions
Table 3 shows the distribution of the following interventions and
control homes in the pilot study.
3.4.1. MVHR
Retrotted, whole-house mechanical ventilation with heat recovery (MVHR) system (Model WH320, ADM Systems, Skipton, UK and
an equivalent Model VVX-200, Villavent Ltd., Oxon, UK). The MVHR
systems provided a low-level continuous supply of fresh air (~ 90 m 3
h -1 equal to ~0.5 ac h 1, for a 90 m 2 house with a volume of
~ 200 m 3), ltration of coarse particles from the input air (EU3 type
lter 510 m with 85% efciency) and recycling of latent heat in the
exhaust air (~70% efciency) to the input air. Stale air was extracted
from kitchens and bathrooms and fresh preheated outdoor air was
vented into living rooms and bedrooms.
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Table 2
Inter-comparison of groups at baseline: Dropouts vs. Completers.
Pilot study
Main study
Averages
Dropouts
13 children
(11 homes)
Retained
46 children
(33 homes)
Dropouts
42 children
(31 homes)
Retaineda
14 children
(13 homes)
Child's age
Total symptom score
Number of smokers per
home
Outdoor temperature (C)
Outdoor relative humidity
(%)
Living room temperature
(C)
Living room relative
humidity (%)
2.8
24.0
1.1
6.6
16.2
0.7
6.0
23.0
0.6
6.0
19.4
0.6
12.7
47.2
12.3
56.2
12.0
56.0
11.1
57.8
18.0
18.6
19.0
18.5
48.9
49.5
53.0
50.9
a
In addition, 3 control homes from the previous groups were analysed therefore the
total sample in the main study was 17 children in 16 homes.
3.4.2. Surfaces
Laminate ooring (low formaldehyde content, wood composite)
laid in the living room and the asthmatic child's bedroom. An antiTable 1
Summary of housing characteristics.
Characteristics
Age
Type
Volume
Type of heating
Natural gas.
b1930
193049
195069
197089
1990
Mid-terraced
End-terraced
Semi detached
Ground oor at
Upstairs at
Bungalow
1
2
3
b100 m3
100150 m3
150250 m3
N 250 m3
Electric res
Coal red
Gasa central heating
Gasa res only
Bottled butane gas
Gasa & electric res
14
16
30
27
14
57
10
23
5
7
0
9
84
7
9
50
39
2
8
20
48
4
3
2
25
16
21
36
2
61
7
25
2
0
5
9
82
9
7
45
43
5
20
20
52
8
0
0
Table 3
Distribution of interventions in the pilot study.
Intervention
MVHR
Surfaces
Central heating
Control homes
Total
16 (8)
10 (9)
9 (7)
11 (9)
46 (33)
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S.A. Eick, G. Richardson / Science of the Total Environment 409 (2011) 36283633
Table 4
Environmental variables recorded during each one hour assessment.
Variables
Units
Temperature
Relative humidity
Fine particles (0.33.0 m)
Coarse particles (3.07.0 m)
Wall/wall surface moisturea
Dust mite allergen (Der p 1)b
Microbial coloniesc
Carbon dioxided
Carbon monoxidee
C
%
Particles L 1
Particles L 1
WME %
g g 1
number slide 1
ppm
ppm
the children's mainly female (~ 85%), adult guardian during face-toface interviews in their home by a qualied nurse. The number of
children assessed was higher than the number of homes because
there was often more than one asthmatic child.
4. Results
4.1. Response rates
No participants objected to the assessors visiting their homes. In the
pilot study, 22 homes dropped out (11 prior to the start of the study), in
the main study, 42 homes dropped out (due to MVHR system installation delays).
Table 5
Environmental results (median values, signicant statistics in bold).
Pilot study
Variable
Temperature living room
(C)
Temperature bedroom
(C)
Relative humidity living room
(%)
Relative humidity bedroom
(%)
Absolute humidity living room
(g kg1)
Absolute humidity bedroom
(g kg 1)
Airborne microbes bedroom
(number slide 1)
Coarse particles living room
(particles L 1)
Coarse particles bedroom
(particles L 1)
Fine particles living room
(particles L 1 103)
Fine particles bedroom
(particles L 1 103)
Der p1 bedroom mattress
(g g 1)
Der p1 living room carpet
(g g 1)
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
MVHR
(n = 8)
Surfaces
(n = 9)
Central heating
(n = 7)
Control
(n = 9)
Main study
(n = 16)
21
18
0.17
20
19
0.33
44
39
0.12
49
38
0.03
6.87
5.37
0.05
7.21
5.19
0.04
3
1
0.19
377
404
0.67
228
259
0.89
95
108
0.80
83
96
0.64
5.87
2.86
0.31
0.70
0.36
0.35
18
16
0.82
19
17
0.95
47
46
0.05
48
41
0.01
6.90
5.52
0.08
6.46
5.35
0.05
2
5
0.95
294
211
0.31
166
189
0.42
108
61
0.50
92
52
0.72
2.84
3.20
0.36
2.37
0.00
0.32
17
19
0.38
18
19
0.28
56
46
0.05
52
45
0.01
6.74
6.18
0.24
6.15
5.87
0.15
4
5
0.48
387
307
0.47
317
212
0.08
86
67
0.09
91
67
0.93
4.87
8.50
0.13
5.08
2.28
0.76
20
19
0.13
20
19
0.16
46
42
0.04
47
41
0.02
6.83
5.49
0.01
6.60
5.86
0.02
2
7
0.06
302
385
0.16
181
229
0.34
57
118
0.12
57
110
0.01
4.25
4.00
0.97
2.05
9.33
0.10
18
19
0.23
19
19
0.06
49
51
0.90
48
50
0.55
6.73
7.22
0.38
6.60
7.10
0.69
4
4
0.58
368
325
0.35
283
201
0.08
65
276
0.02
54
269
0.02
4.00
0.04
0.24
2.65
0.38
0.07
S.A. Eick, G. Richardson / Science of the Total Environment 409 (2011) 36283633
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Table 6
Symptom scores (median values, signicant values in bold).
Pilot study
Symptom
Breathless during the day
when not exercising
Breathless during the day
when exercising
Wheezy during the day
Runny nose
Blocked nose
Hay fever
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
Before
After
p value
MVHR
(n = 16)
Surfaces
(n = 10)
Central heating
(n = 9)
Control
(n = 11)
Main study
(n = 17)
1
1
0.19
0
0
0.32
1
1
0.27
1
1
0.20
2
1
0.05
3
1
0.02
2
1
0.24
0
1
0.52
0
0
0.16
9
6
0.04
6
4
0.02
2
2
0.67
0
1
0.74
0
1
1.00
1
1
1.00
2
1
0.12
2
1
0.43
0
1
0.67
0
0
0.40
0
0
0.32
8
8
0.39
8
6
0.38
2
1
0.03
1
1
0.46
1
1
0.10
1
1
0.68
3
1
0.03
2
1
0.08
3
2
0.02
3
2
0.53
0
0
0.32
14
9
0.02
8
5
0.01
1
2
0.06
1
1
0.74
1
1
0.71
2
1
0.52
2
1
0.21
2
2
0.07
2
1
0.07
0
2
0.13
0
0
0.16
9
11
0.14
9
9
0.76
1
0
0.03
1
0
0.02
1
0
0.01
1
0
0.01
2
0
b 0.01
2
0
b 0.01
1
0
0.01
1
0
b 0.01
0
0
0.18
12
1
b 0.01
9
1
b 0.01
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S.A. Eick, G. Richardson / Science of the Total Environment 409 (2011) 36283633
improve the reliability of the results, data from the pilot homes that
received MVHR systems were included in the analysis (homes = 24;
children = 33). Further signicance tests were conducted. The results
in Table 7 are very similar to the results for the 17 children in the main
study.
4.3.2. Medical events
The data from the combined MVHR group (33 children) indicated
that the number of days lost per month from school/nursery due to
asthma reduced (median number of days lost before = 3, after = 0;
p = 0.03) as did the number of visits made to a GP (median number of
GP visits before = 1, after = 0; p = 0.04).
5. Discussions
The results from the Breath of Fresh Air Project indicated a reduction
in asthma symptoms from the installation of MVHR systems. There were
limitations to the study. The small sample size reduced the sensitivity of
the analysis, only allowing the detection of large changes in the
environmental and health data. The assessors were aware of becoming
an intervention, through their own actions or in conversations with the
participants. Other factors such as: type of house, position of house,
social status (income, psychological welfare etc.), GP's choice of patients,
poor memory of guardian, and biased responses by the guardian to the
assessors, may have inuenced the results. No measurements of outside
of own house inuences were accounted for, such as day-care nurseries,
friends at day-care, school environments, and after school activities, all
possibly inuencing the recorded symptoms. A major consideration was
the variation in the lifestyle and habits of the participants. This may have
had an inuence on the outcomes of the assessments. There were no
changes in smoking or cat ownership, both of which are known asthma
triggers.
There was no parallel control group to compare the main study
results to in 2004, therefore factors such as being involved in a study,
extra attention, and someone taking the participant's opinions seriously
cannot be discounted from inuencing the results. If a Hawthorne or
similar effect (Gillespie, 1991) was the dominant reason for improved
health, it could be expected that all the participants in the pilot study,
including the control households, would have improved in a similar
fashion, since all homes received the same attention. However, the
control and Surfaces group showed no signicant changes.
The symptom questions used in this study have been previously
demonstrated to correlate well with the clinical severity of an adult's
asthma (Steen et al., 1994). Without clinical outcomes it cannot be
conrmed whether or not the reduction in symptom scores really
represent a change in asthma for the participating children. The World
Health Organisation has suggested that despite the subjectivity of the
type of questionnaire used in this study, the measurement of perceived
health is still useful in measuring public health status (WHO, 2001).
When the questionnaires were implemented (each year in April),
the preceding months were not in the high pollen count season. The
Table 7
Symptom scores: combined MVHR group (n = 33).
Symptom
0
0
0
0
0
1
0
0
0
3
3
0.07
0.01
0.01
0.01
b0.01
b0.01
b0.01
0.04
0.6
b0.01
b0.01
S.A. Eick, G. Richardson / Science of the Total Environment 409 (2011) 36283633
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