I see guys spending weeks, months trying to make a girl happy.

I see girls waiting

endlessly for their guys to call. Is that all your life is about? For your lover to
validate you? Or to make a relationship work? Instead, why not focus on yourself working on your goals, learning something, being a more positive person and
helping others. That will boost your self-esteem far more than any lover ever could.
Next time that guy or girl treats you badly, say thank you. Say thank you for
reminding me that I need to make myself the focus of my life, not you.

"Don't blame people for disappointing you . Blame yourself for expecting Too much"

Never beg for any relation... Be brave enough to ACCEPT the one's who wants to be with you,
and REJECT the one's who only show they are with you..!!

Martin Karplus is sort of like the godfather of the field- he was Linus Paulings last
graduate student and theres not an area of molecular simulation which he has not
touched. Undergraduate chemistry students would know his name from the socalled Karplus equation that allows you to relate magnetic resonance properties of
molecules to their geometry; now they will find out that he is more than a textbook
relic. Warshel and Levitt have made key contributions at the boundary between
quantum mechanics and classical mechanics. All three of the recipients have mainly
become well-known for simulating the behavior of small organic molecules like
drugs and proteins, but their techniques have also been equally applicable to
materials like zeolites and solar cells.
As with many Nobel Prizes there are a few other individuals who have contributed
enormously to the field who were inevitably left out. Although little known outside
the field, my personal list would include Norman Allinger, Andrew McCammon, Ken
Houk, Roberto Car, Bill Goddard and Michele Parrinello. Foremost in my mind is
University of George chemist Norman Allinger. Allinger was the first person to
widely develop and apply the force field approach that underlies much of this years
work. A force field is basically a set of simple equations for describing the bonds,
angles, torsional (rotatable) angles and long-range non-bonded interactions in a
molecule (see illustration above). It is a simplified model based on classical
mechanics which regards atoms and bonds as balls and springs. Because it is a
simplified model it needs to be shored up with parameters from experiment or from

rigorous quantum mechanical calculations. Allinger developed two very widely used
versions of a force field initially called MM2 (the method itself is called molecular
mechanics, MM), spent years carefully parametrizing and benchmarking them and
then applied them to a variety of molecules.
Karplus, Warshel and Levitt applied these ideas but also developed their own, and
then went much beyond the initial work by creating hybrid methods that combined
classical with quantum mechanics (QM/MM). This is a major part of the prize
announcement; it took a lot of efforts to refine and troubleshoot such methods and
make them accessible to non-specialist chemists. You could use the quantum
mechanical technique for describing the core part of a molecular system and then
use the classical part for simulating the rest of it. Among other things this would
enormously save time, since doing a quantum mechanical calculation on the entire
system would be prohibitively expensive in terms of time. The three chemists have
also developed purely classical methods to simulate molecular motion. These days
most of us who do the calculations take this work for granted, so thoroughly
ingrained it is in the language and tools of computational chemistry.