Professional Documents
Culture Documents
AB Classes
AB Classes
Notes
Class SE
Individual agents
Erythromycin: (+sulfisoxazole-->
Pediazole)
N,V,Burning
For Mycoplasma,
stomach+abdominal cramp, Clarithromycin (biaxin)
Legionella,
Cholestatic hepatitis
Chlamydia,
Azithromycin (zithromax)
Diphtheria,
(estolate form)
Pertusis)
DI: HME inh.
Clindamycin (cleocin or dalacinC)
Macrolides
Inh. Protein synth
by binding to 50s
ribosomal subunit
S.E
Comments
Diarrhea,blood dysc.
Troleadomycin
Natural Penicillin (Penicllinase sensetive) +VE
Extensive cross
reactivity between
Penicillins and
Imipenem
No igE crossreactivity between
penicillins and
aztreonam.
Most patients will
have ampicillin
rash with no crossreactivity with any
other penicillins.
Most common in
patients with
mononucleosis OR
receiving
allopurinol
Penicillin
nafacillin (unipen)
Neutropenia
(Cloxa -Eosinophilia). ( OxaHEPATITIS,Billiary phelbitis)
Oxa,Cloxa,Dicloxa,Flucloxacillin
N,V, Hypersensitivity Rn,
Bone marrow supp,
Pseudomembraneous
colitis, Super infection, If
high level seizures
Ampicillin (Omnipen)
Amoxicillin
(Amox+clav)=AUGMENTIN
(amp.+sulbact)=UNASYN
MILD diarrhea.
to be penicllinase resistant
Bacampicillin
Cyclacillin
Extended spectrum penicllins (All inhibit platlet aggregation)
Carbenicillin
( geocillin )
Ticarcillin
Azlocillin
(ticar)
Piperacillin
CIDAL
Excreted by liver
Mezlocillin
pipercillin + tozbactam->zosyn
CIDA
Aminoglycosides
Cephalospo
rins
Ototoxicity IRR.-Nephrotoxicity
REV.(after 5-7 d of therapy) - Streptomycin
Neuromuscular blockade(with
large doses via interperitoneal
Gentamycin (garamycin)
OR mythenia gravis pt )
Nephrotoxicity ( inc. with nephrotoxic ds) Ototoxicity ( inc. with loop diuretics)
Amikacin (amikin)
C.I PREGNANCY
Each generation
shifted to G - ve
activity but less +
ve and resistance
to B lactamase
Vestibular/cochlear
toxicity.Ataxia.Nystagmus.proteinurea
Netilmicin - Kanamycin
Cephalothin, Cisplatin,
Amphotericin B, Methoxy
flurane: Nephrotoxicity
Neomycin (mycifradin)
N,V,D.
Hypersensitivity
reactions,
Pseudomembraneous
colitis, super infection,
nephrotoxicity
Tobramycin (nebcin)
1st Gen.:Cefadroxil-cefazolincephalexin-cephalothin-cephradine.
2nd Gen:Cefaclor-cefotetancefuroxime-cefpodoxime-cefprozilloracarbef-
CEFACLOR:Serum-Sickness Rn in 1%
of children.CEFUROXIME:diarrhea /
bitter after taste taken e juice or food
cefamandole
3rd :Cefoperazone (Diarrhea)
Hypothrombinemia &
Dislfuram Rn Most
common e'
(cefamandole,cefotetan,c
efoperazole,cefmetazole).
moxalactam
cefixime
Diarrehea
cefotaxime
ceftazidime
DI: Probencid:inhibit
excretion
ceftriaxone
N,V,D,dizziness-Rash,
Liver enzymes-Tendonitis
Ciprofloxacin (cipro)
common in elderly
.Crystalluria at alkaline PH
Oflaxacin (floxin)
.Prolong QT
Fluoroquino
lone
Inhibit DNA gyrase
C.I in
PREGNANCY - C.I
children <18y
arthropathy
Photosensitivity,P.colitis,epatitis,Cartilge
toxicity. / INR if e warfarin
against chlamydia
Norfloxacin (noroxin )
Lomefloxacin (maxaquin)
Enoxacin ( penetrex )
Pefloxacin
Levofloxacin ( levoquin )
Metronidazole ( flagyl)
Tetracycline
Broad Spectrum
static
Sulfonamide
Doxycycline-Tetracycline
Methacycline
Minocycline
antagonize ADH
Pseudo tumor cerebri,Candidiasis.
D.I : Ca,Al,Mg,Fe dec. ABSORPTION
vestibular toxicity
Chloramphen
icol
Meropenem
Vancomycin (vancocin)
-Against
NV,hemolytic
anemia,CNS,Mononuclosis
like synd.
Blood
dysc.,rash,pruritis,exfoliative
dermatitis
M.leprae
Pectinomycin
inh
dihydrofolate
synth.
Static
Linzolide
broad
Dalfopristin/Qu
inupristin
Cidal
Aztreonam
Glycopeptides
Trimethoprim
Demeclocycline
Combine with
Pyrimethamine in ttt of
Chlortetracycline
Penems
Dapsone
N,D,cholestatic hepatitis
Sulfadiazine
(high incidence in AIDS).
C.I PREGNANCY - Blood dyscriasis (heam
C.I in neonates:
Sulfamethoxazole + Trimethoprim-Anemia in G6PD, bone
kernictures
marrow) Hypersensitivity Rn >Cotrimoxazole (cidal)
(caused by inc.
(Exfoliative dermatitis,
unbound drug as
Stevens-johnson synd)Sulfisoxazole
premature liver
Crystalluria & Haematuria
Sulfacytine
cannot conj.
DI: Displacement
Bilirubin )
Phenytoin,oral anti-coagulant- Sulfamethizole
sulfonylureas
(Rifadin)
Discoloratn of urine & tears (contact lens can be stained) + all S.E
xpt diziness
Isoniazid
Rifampin
(isotamine)
Pyrazinamide
Ethambutol
Cycloserine