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Show Me Your Nasty Molecule: The Homework
Show Me Your Nasty Molecule: The Homework
Show Me Your Nasty Molecule: The Homework
THE HOMEWORK
THE HOMEWORK
If any
What is a pollutant?
What is a pollutant?
Generally, any substance
introduced into the environment
that adversely affects the
usefulness of a resource or the
health of humans, animals, or
ecosystems.
Fout
Fin
Cin
Cx
Degradation (chemical)
Photolysis
Hydrolysis
Redox
Biodegradation
Cout
Fout
Fin
Cin
Cx
Cout
Fout
Fin
Cx
Cin
Cz
Cout
Fout
Fin
Cx
Cin
Cw
Cz
Cout
C1000
Fin
Cout
C0.1
Cin
C10
C1
Cz
Fout
AIR
WATER
SOIL
PLANTS
NON-CONTAMINATED COMPARTMENTS
ANIMALS
AIR
WATER
SOILS
PLANTS
ANIMALS
Hydrolysis
Phototransformation
Dissociation
Solubility
Sorption
Biodegradation
Metabolism
Accumulation
Bioaccumulation
Volatilization
Respiration
Excretion
Cl
Cl
Cl
p,p-DDT
+
o,p-DDT
Cl
SOIL
SEDIMENT
ORGANISMS
Cl
Cl
Cl
DDT
Cl
Cl
Cl
Cl
DDE
Cl
Cl
DDD
DDMU, DDA, DBP
Rappolt, RT (1973). "Use of oral DDT in three human barbiturate intoxications: hepatic enzyme
induction by reciprocal detoxicants". Clin Toxicol 6 (2): 147-51
Silent Spring
DDT
world-wide distribution
accumulating in organisms
Cl
Cl
Cl
Cl
Cl
2,2-Bis(p-chlorophenyl)-1,1,1-trichloroethane
Woburn, MA (1980s)
TCE
Cl
H
Cl
Cl
wide-spread in groundwater
disputed source
suspected to cause cancer
(leukemia)
A Civil Action
Jonathan Harr (1995)
From The Body Restoration Plan: Eliminate Chemical Calories'" and Repair Your Body's
Natural Slimming System" by Dr. Paula Baillie-Hamilton 2003 by Dr. Paula Baillie-Hamilton 200
biology.queensu.ca/~pearl/taste/tpics/core.jpg
OUR GOALS?
Analytical capabilities
Low concentrations
Specific compounds
Positive identification
No metabolites
Cl
Cl
Cl
Cl
Cl
O
Cl
Cl
Cl
Cl
Cl
Cl
Cl
> 1 g kg-1
>0.1 g kg-1
0.00004 g kg-1
Different structure
causes different
toxicity
reactivity
partitioning
H2
C
H3 C
H2
C
C
H2
H 3C
H2
C
CH
Cl
CH3
Cl
H3C
H3C
~ 1 yr
~ 40 d
C
CH3
~ 30 s
Cl
Different structure
causes different
toxicity
reactivity
partitioning
OH
OH
Cl
Cl
Cl
Cl
Cl
Cl
OH
Cl
Cl
Cl
Cl
pKa:
5.04
Kp: 10 L kg-1
5.40
20 L kg-1
Cl
Cl
6.35
180 L kg-1
air
water
suspended matter
soil and sediment
organisms
etc.
http://www.youtube.com/watch?v=z4lijvIjpRw