Professional Documents
Culture Documents
tmp7102 TMP
tmp7102 TMP
tmp7102 TMP
Academic qualifications
MA St Catharines College Cambridge, UK, June 1968
MB, BChir St Catharines College Cambridge, UK, June 1968
MRCP(UK) Royal College of Physicians, London, Feb 1971
MD University of Cambridge, UK, June 1985
FRCP Royal College of Physicians, London, Dec 1985
FMedSci Academy of Medical Sciences, London (Founder) July 1997
Distinctions
Open Scholarship, St Catharines College, Cambridge, 1965
First Class, Cambridge University Tripos, 1967
Essay Prize, Birmingham 1970: National Sickness Service.
Invited founder member of Academy of Medical Sciences, London, 1997
Deans Medal, University of Liverpool, 1998
OBE UK New Year Honours, January 2007
Sir Rickard Christophers Medal, Royal Society of Tropical Medicine and
Hygiene, London June 2009
Appointments
1968-70: Pre-registration and SHO posts, Medicine, London, Gloucester and
Birmingham
1971-72: Registrar, Liver Unit (Dame Sheila Sherlock), Royal Free Hospital, London
1972-73: Registrar, Communicable Diseases (Dr David Tyrrell), Northwick Park
Hospital, London
1974-1984: Medical Specialist, Government of Malawi
1984-93: Senior Lecturer and Hon Consultant Physician, University of Liverpool and
Liverpool School of Tropical Medicine
1993 Dec 2008: Professor of Tropical Medicine, University of Liverpool and
Liverpool School of Tropical Medicine
2009 current: Emeritus Professor of Medicine, University of Liverpool, UK.
[Resident in Malawi 1974-1984 and 1995-2015 (ongoing)]:
1995-July 2007:
- Director, Malawi-Liverpool-Wellcome Trust Clinical Research Programme (MLW)
(a Wellcome Trust Major Overseas Programme), College of Medicine, University of
Malawi, Blantyre, Malawi.
- Co-Director, Wellcome Trust Tropical Centre, University of Liverpool
1995-2011:
Hon consultant physician and Professor of Medicine, College of Medicine, University
of Malawi 2007-2012:
Hon Senior Clinical Scientist, MLW, College of Medicine, Blantyre, Malawi, 20072015 (ongoing)
Other appointments
Founding Editor, Medical Quarterly (Journal of the Medical Association of Malawi)
1978-1984 (now Malawi Medical Journal)
Editor, Tropical Doctor (Royal Society of Medicine, London) 1986-94
Editor-in-Chief, Malawi Medical Journal, 1997-present
Chair, Editorial Board of Tropical Doctor, 2008-present
WHO Expert Advisory Panel on Malaria, 1993-2009 (renewed Feb 2007)
WHO Monitor, Field Trials of SPf66 malaria vaccine:
Tanzania 1992
The Gambia 1993
Thailand 1993
Chair, Independent Data Monitoring Committee (formerly Data & Safety Monitoring
Board) for RTS,s malaria vaccine trials(GSK and Malaria Vaccine Initiative) 19992015 (ongoing)
Chair, National Malaria Technical Committee Research Working Group, Ministry of
Health, Malawi, 2001-2011
Member, Scientific Advisory Panel, AMANET (African Malaria Network Trust),
2002-2008
Member, Board of Trustees of the REACH Trust, Lilongwe, Malawi 2003-2010
Member, Board of Trustees of JOSHUA, Blantyre, Malawi 2006-2012
Member, Expert Scientific Advisory Committee (ESAC), Consortium for National
Health Research (CNHR), Kenya, January 2009-2015 (ongoing)
Member, Global Health Network Group of the Academy of Medical Sciences,
London, January 2009-2014 (ongoing)
Deputy Chair, Board of the Worldwide Antimalarial Resistance Network (wWARN),
January 2009-2015 (ongoing)
Member, WHO Joint Technical Expert Group (JTEG) Malaria Vaccines in Pivotal
Phase 3 Trials and Beyond, March 2009-2015 (ongoing)
Member WHO Nutrition Guidance Expert Advisory Committee (NUGAG) - 20092011
Recent activities
In 1995 I moved to Malawi to initiate and direct the Malawi-Liverpool-Wellcome
Trust Clinical Research Programme (MLW), based in the College of Medicine,
University of Malawi. I continued to be on the payroll of the University of Liverpool
(Liverpool School of Tropical Medicine), through which most grants to MLW from
The Wellcome Trust have been channelled. Prof R Heyderman took over as Director
of MLW in August 2007, and I continued to work in MLW and the College of
Medicine as Senior Clinical Scientist and Professor of Clinical Medicine.
MLW aims to apply good science to the study of diseases of local importance in
Malawi, in the place where they occur, and in so doing to build local and international
capacity in health research and to contribute to national health policy development.
International Fellowships and grants (listed below) from The Wellcome Trust,
together with extensive support from the University of Liverpool and LSTM through
sytem: pathogenesis and worldwide impact at the Pasteur Institute, Paris. Opening
Speaker
28 Nov 2008. Invited speaker. Diversity Leaders Award Ceremony, Blantyre, Malawi
2009
07 May 2009 Two invited lectures to Health Interventions in Low-income Countries
course, Jonkoping, Sweden
10 May 2009 Invited Lecture to Swedish Doctors' Bank annual meeting,
Holsbybrun, Sweden
3-5 June 2009 Invited delegate, Joint Technical Exert Group (JTEG), WHO Malaria
Vaccine International Meeting, Dakar, Senegal
12-14 June 2009 Invited delegate and Deputy Chair to WWARN (Worldwide
Antimalarial Resistance Network) workshop at Sanger Institute, Hinxton, Cambridge,
UK
22-24 June 2009 Committee of East African Scientific and Academic Committee
(ESAC),Nairobi, Kenya
30 June 2009 Invited Lecture to Research Methodology Course, Blantyre:
Scientists' Maladies: Some Syndromes to which Scientists are Prone
27-29 July 2009 Invited delegate, meeting of Technical Working Group of the
National Malaria Control Programme - Salima, Malawi
21 August MIM, Lilongwe, Malawi. National Stakeholders' Meeting of National
Malaria Control Programme invited opening address.
15-30 Oct 2009 Co-supervisor, National WHO Training-of-Trainers Course in
recognition and management of severe malaria, Sana'a, Yemen
8-16 November 2009 Supervisor, WHO International Training-of-Trainers Course
in recognition and management of severe malaria, Wad Medani, Sudan
18-22 November 2009 Invited Chair, 2 sessions at Annual Meeting of American
Society of Tropical Medicine and Hygiene, Washington DC, USA.
2010
14 Jan 2010 Technical Working Group of National Malaria Control Pogramme,
Salima.
22-25 Feb 2010 Nutrition Guidance Advisory Group (NUGAG), WHO, Geneva
05 Mar 2010 - Technical Working Group of National Malaria Control Pogramme,
Lilongwe
23-26 March invited delegate, MALERA (Malaria Eradication) meeting,
Washington DC, USA
29 April 2010 invited lecture 'Supporting research in Developing Countries'
Amsterdam Medical Centre, Amsterdam, Netherlands
06 May 2010 Lectures, 'HILL' Course for health staff planning work overseas,
Jonkoping, Sweden
08 May 2010 Lecture 'Emergencies in Clinical Medicine' - Sweden Doctors' Bank,
Holsbybrunn, Sweden
11-12 May 2010 Chair, Independent Data Monitoring Committee for malaria
vaccine programme (WHO, MVI, GSK), London, UK
18 June 2010 speaker at Peer Review Workshop, convened by Malawi Medical
Journal, Blantyre
21-23 June Deputy Chair, annual meeting of wWARN (Worldwide Antimalarial
Resistance Network), Dakar, Senegal
2011
09 Mar 2011 Lilongwe, Malawi, Health Research Institute meeting, invited
participant
14-18 Mar 2011 Geneva, Switzerland, meeting of NUGAG committee member
31 May 1 June 2011 London, meeting of IDMC of the RTSS vaccine programme
(Chair)
28-29 June 2011 London, Christian Medical Fellowship 'Developing Health' Course
invited lecturer
30 June 2011 London Board meeting of Tropical Doctor at Royal Society of
Medicine (Chair)
11 July 2011 Lilongwe, Malawi National Malaria Control Programme meeting
(Chair)
15 Aug 2011 Lilongwe, Malawi Malaria Indicators Survey meeting of NMCP
(Chair)
(1-19 Sept 2011 Cycle ride 'Length and Height of Britain [LAHOB]' to raise money
for patients at QECH, Blantyre lahob.org.uk) [Raised 25,000]
28-30 Sept 2011 Geneva Technical Expert Group of WHO Severe Malaria
(panel member)
3-6 Oct 2011 Barcelona - 7th Annual Meeting of European Societies of Tropical
Medicine. Invited speaker Clinical Trials, and case management of comatose child.
19 Oct 2011 invited speaker, Mentoring Course of College of Medicine Blantyre,
Malawi
7-9 Nov 2011 Washington DC, USA NUGAG (Nutrition committee of WHO)
committee member and workshop participant.
14-16 Dec 2011 External examiner, East African Diploma in Tropical Medicine &
Hygiene, Kampala, Uganda
PI: M E Molyneux
US$ 53,300 (~ 31,353)
1 Jan 1998
New research laboratory in Blantyre, Malawi:
The Wellcome Trust.
460,000
31 Jan 2000:
Effects of malaria on markers of HIV disease in an adult Malawian population
PI: M E Molyneux
Wellcome Trust: Ref 057618
89,232
24 March 2000 for 5 years:
renewal of grant to support activities of the
Wellcome Trust Centre for Research in Clinical Tropical Medicine, University of
Liverpool.
M E Molyneux and P AWinstanley
The Wellcome Trust: Project grant 060123/Z/99/Z + B
476,188
1 July 2000 for 5 years
Malaria and concomitant infections in Malawi
M E Molyneux
The Wellcome Trust, UK: Renewal of Research Leave Fellowship
Ref: 058390/Z/99/Z
2,321,494
01 Dec 2001- 30 Nov 2005
'Incidence of common infections in HIV-infected and HIV-uninfected children and
benefit of cotrimoxazole prophylaxis'
Dr S M Graham and M E Molyneux
The Wellcome Trust: extension to Research Leave Fellowship
Grant Ref 058390/Z/99/H
262,650
2003-2006
Anthropological and Bio-ethics Study of Clinical Research
PIs Prof Joseph Mfutso-bengo , M E Molyneux
Wellcome Trust Grant Ref: 029634
160,000
July 2003-June 2006
Analysis of circulating and sequestered populations of Plasmodium falciparum in
fatal paediatric malaria
A G Craig, M E Molyneux & J L Montgomery
The Wellcome Trust: Project Grant
Grant Ref 071376
238,689
Additional grants
Peer-reviewed publications
1. Molyneux ME. National Sickness Service. Lancet 1971;1(7701):693-5.
2. Molyneux ME. Mediastinal reticulosis with hypertrophic pulmonary
osteoarthropathy. Brit J Dis Chest 1973;67(1):66-70.
3. Molyneux ME, Tozer RA, Hutt MSR. Histiocytic medullary reticulosis in Africa.
Lancet 1978;8101:1202-3.
4. Molyneux ME, Beare AS, Callow K, Schild GC. Use of single radial
immunodiffusion test for serological studies in volunteers inoculated with live
attenuated influenza virus. J Hyg (Lond) 1974;73(2):287-95.
5. Molyneux ME. An ABC of prescribing sins. British Medical Journal
1980;281:1698-1699.
6. Supran EM, Molyneux ME, Banatvala JE. IgM responses to hepatitis-A virus
and hepatitis-B core antigen in acute and chronic liver disease in Malawi; possible
role of non-A, non-B, hepatitis. Trans R Soc Trop Med Hyg 1980;74(3):389-92.
7. Cole PJ, Molyneux ME. Immunological sensitisation of human lymphocytes after
influenza vaccination. J Infect 1980;2(1):67-77.
8. Molyneux ME, Supran EM, Islam MN, Banatvala JE, Hutt MSR. Hepatitis-B
virus determinants in patients with liver disease in Malawi. Trans R Soc Trop Med
Hyg 1980;74(3):383-8.
9. Molyneux ME. Straight and crooked thinking about tuberculosis. S Afr Med J
1982;Spec No:34-5.
10. Molyneux ME. Viral hepatitis. Questions and answers. Trop Doctor
1986;16(3):99-104.
11. Karbwang J, Looareesuwan S, Phillips RE, Wattanagoon Y, Molyneux ME,
Nagachinta B, Back DJ, Warrell DA. Plasma and whole blood mefloquine
concentrations during treatment of chloroquine-resistant falciparum malaria with
the combination mefloquine-sulphadoxine-pyrimethamine. Br J Clin Pharmacol
1987;23(4):477-81.
12. Wirima J, Khoromana C, Molyneux ME, Gilles HM. Clinical trials with
halofantrine hydrochloride in Malawi. Lancet 1988;2(8605):250-2.
13. Taylor TE, Molyneux ME, Wirima JJ, Fletcher KA, Morris K. Blood glucose
levels in Malawian children before and during the administration of intravenous
quinine for severe falciparum malaria. N Engl J Med 1988;319(16):1040-7.
14. Cuevas LE, Hart CA, Molyneux M, Mughogho GH. C-reactive protein and
bacterial meningitis. Ann Trop Paediatr 1988;8(4):230-3.
15. Molyneux ME. Malaria - clinical features in children. J Roy Soc Med 1989;82
Suppl 17:35-8. (Review).
16. Cheesbrough JS, Liomba NG, Sutorius FF, Molyneux ME. Histiocytic medullary
reticulosis associated with positive human immunodeficiency virus 1 (HIV-1)
serology in two African patients. Trans R Soc Trop Med Hyg 1989;83(2):259.
17. Molyneux ME, Taylor TE, Wirima JJ, Borgstein A. Clinical features and
prognostic indicators in paediatric cerebral malaria: a study of 131 comatose
Malawian children. Quart J Med 1989;71(265):441-59.
18. Molyneux ME, Looareesuwan S, Menzies IS, Grainger SL, Phillips RE,
Wattanagoon Y, Thompson RP, Warrell DA. Reduced hepatic blood flow and
intestinal malabsorption in severe falciparum malaria. Am J Trop Med Hyg
1989;40(5):470-6.
19. Grau GE, Taylor TE, Molyneux ME, Wirima JJ, Vassalli P, Hommel M, Lambert
PH. Tumor necrosis factor and disease severity in children with falciparum
malaria. N Engl J Med 1989;320(24):1586-91.
20. Burnham G, Harries A, Macheso A, Wirima J, Molyneux M. Chloroquine induced
pruritus in Malawi: lack of association with onchocerciasis. Trans R Soc
Trop Med Hyg 1989;83(4):527-8.
21. Molyneux ME, Taylor TE, Wirima JJ, Harper G. Effect of rate of infusion of
quinine on insulin and glucose responses in Malawian children with falciparum
malaria. BMJ 1989;299:602-3.
22. Molyneux ME. The clinical features of cerebral malaria in children. Med Trop
(Mars) 1990 Jan-Mar;50(1):65-8.
23. Pavone R, Schinaia N, Hart CA, Getty B, Molyneux M, Borgstein A. Viral
gastro-enteritis in children in Malawi. Ann Trop Paediatr 1990;10(1):15-20.
24. Mansor SM, Taylor TE, McGrath CS, Edwards G, Ward SA, Wirima JJ,
Molyneux ME. The safety and kinetics of intramuscular quinine in Malawian
children with moderately severe falciparum malaria. Trans R Soc Trop Med Hyg
1990;84(4):482-7.
25. Molyneux ME. Cerebral malaria in children: clinical implications of
cytoadherence. Am J Trop Med Hyg 1990 Aug;43(2 Pt 2):38-41. (Review).
26. Molyneux ME, Taylor TE, Wirima JJ, Grau GE. Tumour necrosis factor,
interleukin-6, and malaria. Lancet 1991;337:1098 (Letter).
27. Molyneux ME, Taylor TE, Thomas CG, Mansor S, Wirima JJ. Efficacy of
quinine for falciparum malaria according to previous chloroquine exposure.
Lancet 1991;337:1379-80.
28. Mansor SM, Molyneux ME, Taylor TE, Ward SA, Wirima JJ, Edwards G.
Effect of Plasmodium falciparum malaria infection on the plasma concentration of
alpha 1-acid glycoprotein and the binding of quinine in Malawian children.
Br J Clin Pharmacol 1991;32(3):317-21.
29. Cheesbrough JS, Molyneux ME, Green SD. When is fever malaria? Lancet
1991;338(8782-8783):1601 (Letter).
30. Hill AV, Allsopp CE, Kwiatkowski D, Taylor TE, Yates SN, Anstey NM,
Wirima JJ, Brewster DR, McMichael AJ, Molyneux ME, et al. Extensive genetic
diversity in the HLA class II region of Africans, with a focally predominant allele,
DRB1*1304. Proc Natl Acad Sci USA 1992;89(6):2277-81.
31. Goldring JD, Molyneux ME, Taylor T, Wirima J, Hommel M. Plasmodium
falciparum: diversity of isolates from Malawi in their cytoadherence to melanoma
cells and monocytes in vitro. Br J Haematol 1992;81(3):413-8.
32. Taylor TE, Molyneux ME, Wirima JJ, Borgstein A, Goldring JD, Hommel M.
Intravenous immunoglobulin in the treatment of paediatric cerebral malaria.
Clin Exp Immunol 1992 Dec;90(3):357-62.
33. Barry M, Molyneux ME. Ethical dilemmas in malaria drug and vaccine trials: a
bioethical perspective. J Med Ethics 1992 Dec;18(4):189-92.
34. Kwiatkowski D, Molyneux ME, Stephens S, Curtis N, Klein N, Pointaire P, Smit
M, Allan R, Brewster DR, Grau GE, et al. Anti-TNF therapy inhibits fever in
cerebral malaria. Quart J Med 1993 Feb;86(2):91-8.
35. Taylor TE, Borgstein A, Molyneux ME. Acid-base status in paediatric
Plasmodium falciparum malaria. Quart J Med 1993;86(2):99-109.
36. Taylor TE, Wills BA, Kazembe P, Chisale M, Wirima JJ, Ratsma EY, Molyneux
ME. Rapid coma resolution with artemether in Malawian children with cerebral
malaria. Lancet 1993;341:661-2.
37. Phillips RE, Looareesuwan S, Molyneux ME, Hatz C, Warrell DA.
Hypoglycaemia and counterregulatory hormone responses in severe falciparum
malaria: treatment with Sandostatin. Quart J Med 1993 Apr;86(4):233-40.
38. Molyneux ME, Fox R. Diagnosis and treatment of malaria in Britain.
BMJ 1993;306:1175-80. Review.
39. Taylor TE, Molyneux ME. Folate deficiency to protect against malaria. N Engl J
Med 1993;328(15):1127 (Letter)
40. Lewallen S, Taylor TE, Molyneux ME, Wills BA, Courtright P. Ocular fundus
findings in Malawian children with cerebral malaria. Ophthalmology
1993;100(6):857-61.
41. Taylor T, Wills B, Wirima J, Molyneux M. Artemether in cerebral malaria.
Lancet 1993;341:1604 (Letter).
42. Vadas P, Taylor TE, Chimsuku L, Goldring D, Stefanski E, Pruzanski W,
Molyneux ME. Increased serum phospholipase A2 activity in Malawian children
with falciparum malaria. Am J Trop Med Hyg 1993;49(4):455-9.
43. Molyneux ME, Engelmann H, Taylor TE, Wirima JJ, Aderka D, Wallach D, Grau
GE. Circulating plasma receptors for tumour necrosis factor in Malawian
children with severe falciparum malaria. Cytokine 1993;5(6):604-9.
44. Molyneux ME. Malaria--still waiting for a vaccine. Tropical Doctor
1994;24(3):97-8 (Editorial)
45. Jonkman A, Chibwe RA, Khoromana CO, Liabunya UL, Chaponda ME,
Kandiero GE, Molyneux ME, Taylor TE. Cost-saving through microscopy-based
versus presumptive diagnosis of malaria in adult outpatients in Malawi. Bull
World Health Org 1995;73(2):223-7.
46. Taylor TE, Molyneux ME. Something new out of Africa. N Engl J Med
1995;332(21):1441-2.
47. Lewallen S, Bakker H, Taylor TE, Wills BE, Courtright P, Molyneux ME.
Retinal findings predictive of outcome in cerebral malaria. Trans Roy Soc Trop
Med Hyg 1996;90:144-146.
48. Molyneux EM, Walsh AL, Phiri A, Molyneux ME. Acute bacterial meningitis
in children admitted to the Queen Elizabeth Central Hospital, Blantyre, Malawi in
1996-97. Trop Med and Internat Health 1998; 3(8):610-618.
49. Lewallen S, Taylor TE, Molyneux ME, Semba RD, Wills BA, Courtright P.
Association between measures of vitamin A and the ocular fundus findings in
cerebral malaria. Archives of Ophthalmology 1998;116:293-296.
50. Taylor TE, Wills BA, Courval JM, Molyneux ME. Intramuscular artemether vs
intravenous quinine: an open, randomized trial in Malawian children with
cerebral malaria. Trop Med Int Health 1998;3(1):3-8.
51. Hoffman IF, Jere CS, Taylor TE, Munthali P, Dyer JR, Wirima JJ, Rogerson SJ,
Kumwenda N, Eron JJ, Fiscus SA, Chakraborty H, Taha TE, Cohen MS,
Molyneux ME. The effect of Plasmodium falciparum malaria on HIV-1 RNA
blood plasma concentration. AIDS 1999;13:487-494.
52. White NJ, Nosten F, Looareesuwan S, Watkins WM, Marsh K, Snow RW,
Kokwaro G, Ouma J, Hien TT, Molyneux ME, Taylor TE, Newbold CI, Ruebush
(II) TK, Danis M, Greenwood BM, Anderson RM, Olliaro P. Averting a malaria
disaster. (Editorial). Lancet 1999;353:1965-7.
53. Cunliffe NA, Gondwe JS, Broadhead RL, Molyneux ME, Woods PA, Bresee JS,
Glass RI, Gentsch JR, Hart CA. Rotavirus G and P types in children with acute
diarrhoea in Blantyre, Malawi: predominance of novel P[6]G8 strains. J Med
Virol 1999;57:308-312.
54. Rogerson SJ, Tembenu R, Dobano C, Plitt S, Taylor TE, Molyneux ME.
Cytoadherence characteristics of Plasmodium falciparum infected erythrocytes
from Malawian children with severe and uncomplicated malaria. Am J Trop
Med Hyg 1999; 61(3):467-472.
55. Beeson JG, Brown GV, Molyneux ME, Mhango C, Dzinjalamala F, Rogerson SJ.
Plasmodium falciparum isolates from infected pregnant women and children are
associated with distinct adhesive and antigenic properties. J Infect Dis 1999;
180: 464-472.
56. Lewallen S, Harding SP, Ajewole J, Schulenburg WE, Molyneux ME, Marsh K,
Usen S, White NJ, Taylor TE. A review of the spectrum of clinical fundus
findings in P falciparum malaria in African children with a proposed classification
and grading system. Trans Roy Soc Trop Med Hyg 1999;93:619-622
57. Movaffaghy A, Lochhead J, Riva C, Harding SP, Molyneux M, Taylor TE. Optic
nerve head blood flow measurements with a portable laser doppler flowmeter in
children with cerebral malaria. ARVO. Invest Ophthalmol Vis Sci 1999;40:S864.
58. Harding SP, Lochhead J, Movaffaghy A, Falsini B, Riva C, Molyneux M.
Electroretinography of severe malaria in Malawian children. ARVO. Invest
Ophthalmol Vis Sci 1999;40:S148.
59. Brown H, Turner G, Rogerson SJ, Tembo M, Mwenechanya J, Dzinjalamala F,
Molyneux ME, Taylor TE. Cytokine expression in the brain in human cerebral
malaria. J Infect Dis 1999;180:1742-6.
60. Boeree MJ, Harries AD, Zijlstra EE, Taylor TE, Molyneux ME. Co-trimoxazole
in HIV-1 infection. Lancet 1999;354(9175):334 (Letter).
61. Beeson JG, Rogerson SJ, Cooke BM, Reeder JC, Chai W, Lawson AM,
Molyneux ME, Brown GV. Adhesion of Plasmodium falciparum-infected
erythrocytes to hylauronic acid in placental malaria. Nature Medicine 2000;
6(1):86-90.
62. Molyneux ME. Impact of malaria on the brain and its prevention.
(Commentary). Lancet 2000;355:671-2
63. Lewallen S, White VA, Whitten RO, Gardiner J, Hoar B, Lindley J, Lochhead J,
McCormick A, Wade K, Tembo M, Mwenechanya J, Molyneux ME, Taylor TE.
Clinical-histopathological correlation of the abnormal retinal vessels in cerebral
malaria. Arch Ophthalmol 2000;118:924-928
64. Graham SM, Mtitimila EI, Kamanga HS, Walsh AL, Hart CA, Molyneux ME.
Clinical presentation and outcome of Pneumocystis carinii pneumonia in
Malawian children. Lancet 2000;355:369-373.
65. Rogerson SJ, Beeson JG, Mhango C, Dzinjalamala FK, Molyneux ME.
Plasmodium falciparum rosette formation is uncommon in isolates from pregnant
women. Infection and Immunity 2000;68:391-393.
66. Van den Broek NR, Rogerson SJ, Mhango CG, Kambala B, White SA, Molyneux
ME. Anaemia in pregnancy in southern Malawi: prevalence and risk factors.
Brit J Obstetrics & Gynaecology 2000;107:445-451.
67. Rogerson SJ, van den Broek NR, Chaluluka E, Qongwane C, Mhango CG,
Molyneux ME. Malaria and anaemia in antenatal women in Blantyre, Malawi: a
twelve-month survey. Am J Trop Med Hyg 2000; 62(3):335-340.
68. Graham SM, Walsh AL, Molyneux EM, Phiri AJ, Molyneux ME. Clinical
presentation of non-typhoidal salmonella bacteraemia in Malawian children.
Trans Roy Soc Trop Med Hyg 2000;94:310-314.
69. Rogerson SJ, Chaluluka E, Kanjala M, Mkundika P, Mhango C, Molyneux ME.
Intermittent sulphadoxine-pyrimethamine in pregnancy: effectiveness against
malaria morbidity in Blantyre, Malawi, in 1997-99. Trans Roy Soc Trop Med
Hyg 2000;94:549-553.
70. Walsh AL, Phiri AJ, Graham SM, Molyneux EM, Molyneux ME. Bacteremia in
febrile Malawian children: clinical and microbiologic features. Pediatr Infect Dis J
2000;19:312-8.
71. Graham SM, Hart CA, Molyneux EM, Walsh AL, Molyneux ME. Malaria and
Salmonella infections: cause or coincidence? Trans R Soc Trop Med Hyg
2000;94:227.
72. Rogerson SJ, Katundu P, Molyneux ME. Rosette Formation by Clinical Isolates
of Plasmodium Falciparum in Serum-Free Medium. Trans R Soc Trop Med Hyg
2000;94:461-462.
73. Cunliffe NA, Gentsch JR, Kirkwood CD, Gondwe JS, Dove W, Nakagomi O,
Nakagomi T, Hoshino Y, Bresee JS, Glass RI, Molyneux ME, Hart CA.
Molecular and serologic characterization of novel serotype G8 human rotavirus
strains detected in Blantyre, Malawi. Virology 2000;274:309-320.
74. Gordon SB, Walsh AL, Chaponda M, Gordon MA, Soko D, Mbvwinji M,
Molyneux ME, Read RC. Bacterial meningitis in Malawian adults:
pneumococcal disease is common, severe and seasonal. Clin Infect Dis 2000;
31:53-57.
75. Brown GV, Beck H-P, Molyneux ME, Marsh K. Molecular approaches to
epidemiology and clinical aspects of malaria. Parasitology Today 2000;
16:448-451.
76. Graham SM, Molyneux EM, Walsh AL, Cheesbrough JS, Molyneux ME, Hart
CA. Nontyphoidal salmonella infections of children in tropical Africa. Pediatr
Infect Dis J 2000;19:1189-1196.
77. Brown H, Rogerson SJ, Taylor TE, Mwenechanya J, Tembo M, Molyneux ME,
Turner G. Blood-brain barrier function in cerebral malaria in Malawian children.
Am J Trop Med Hyg 2001;64: 207213
78. Clark IA, Whitten R, Molyneux M, Taylor T. Salicylates, nitric oxide, malaria
and Reyes syndrome. (Hypothesis). Lancet 2001;537:625-627.
79. Cunliffe NA, Gondwe JS, Graham SM, Thindwa BDM, Dove W, Broadhead RL,
Molyneux ME, Hart CA. Rotavirus strain diversity in Blantyre, Malawi, from
1997 to 1999. J Clin Microbiol 2001;39:836-843.
80. Gordon MA, Walsh AL, Chaponda M, Soko D, Mbvwinji M, Molyneux ME,
Gordon SB. Bacteraemia and mortality among adult medical admissions in
Malawi predominance of non-typhi salmonellae and Streptococcus pneumoniae.
J Infection 2001;42:44-49.
81. Mathanga D, Molyneux ME. Bednets and malaria in Africa. (Commentary).
Lancet 2001;357:1219-1220.
82. Jere C, Cunliffe NA, Hoffman I, Stewart PW, Kilaru R, Broadhead RL, Molyneux
ME, Hart CA, Fiscus SA. Plasma HIV burden in Malawian children co-infected
with rotavirus. AIDS 2001; 15:1439-1442
83. Cunliffe NA, Gondwe JS, Kirkwood CD, Graham SM, Nhlane N, Thindwa BDM,
Dove W, Broadhead RL, Molyneux ME and Hart CA. Effect of concomitant
HIV infection on presentation and outcome of rotavirus gastroenteritis in
Malawian children. Lancet 2001;358:550-555.
84. Gordon SB, Molyneux ME, Boeree MJ, Kanyanda S, Chaponda M, Squire SB,
Read RC. Opsonic phagocytosis of Streptococcus pneumoniae by alveolar
macrophages is not impaired in HIV-infected Malawian adults. JID 2001;
184:1345-1349.
85. The Artemether-Quinine Meta-analysis Study Group. A meta-analysis using
individual patient data of trials comparing artemether with quinine in the
treatment of severe falciparum malaria. Trans Roy Soc Trop Med Hyg 2001;
95:637-650.
86. Gordon SB, Chaponda M, Walsh AL, Whitty CJM, Gordon MA, Machili CE,
Gilks CF, Boeree MJ, Kampondeni S, Read RC, Molyneux ME. Pneumococcal
disease in HIV-infected Malawian adults: acute mortality and long-term survival.
AIDS 2002;16:1-9.
87. Kublin JG, Dzinjalamala FK, Kamwendo DD, Malkin EM, Cortese JF, Martino
LM, Mukadam RAG, Rogerson SJ, Lescano AG, Molyneux ME, Winstanley PA,
Chimpeni P, Taylor TE and Plowe CV. Molecular markers for treatment
failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone for falciparum
malaria and a model for practical application in Africa. Journal of Infectious
Diseases 2002;185:380-388
88. Sulo J, Chimpeni P, Hatcher J, Kublin JG, Plowe CV, Molyneux ME, Marsh K,
Taylor TE, Watkins WM, Winstanley PA. Randomised clinical trial of
chlorproguanil-dapsone (Lapdap) versus sulfadoxine-pyrimethamine for
sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi.
Lancet 2002;360:1136-1142.
89. Gordon MA, Banda HT, Gordon SB, Boeree M, Walsh AL, Corkhill JE, Hart CA,
Gilks CF, Molyneux ME. Non-typhoidal salmonella bacteraemia among HIVinfected
Malawian adults: high mortality and frequent recrudescence. AIDS 2002;16:16331641.
90. Pisell TL, Hoffman IF, Jere CS, Ballard SB, Molyneux ME, Butera ST, Lawn SD.
Immune activation and induction of HIV-1 replication within CD14+
macrophages during acute Plasmodium falciparum malaria co-infection. AIDS
2002;16(11):1503-1509.
91. Walsh AL, Molyneux EM, Kabudula M, Phiri AJ, Molyneux ME, Graham SM.
Bacteraemia following blood transfusion in Malawian children: predominance of
Salmonella. Trans Roy Soc Trop Med Hyg 2002;96:276-277.
92. Movaffaghy A, Lochhead J, Riva CE, Harding SP, Petrig BL, Molyneux ME,
Taylor TE. Feasibility of LDF measurements of optic nerve head blood flow in
children with cerebral malaria. Microvascular Research 2002; 2424:1-7.
93. Kamwendo DD, Dzinjalamala FK, Snounou G, Kanjala MC, Mhango CG,
Molyneux ME, Rogerson SJ. (2002). Plasmodium falciparum: PCR detection and
genotyping of isolates from peripheral, placental, and cord blood of pregnant
Malawian women and their infants. Trans R Soc Trop Med Hyg 96:145-149.
94. Taylor TE, Molyneux ME. Clinical features of malaria in children. In Essential
Malariology (Warrell DA and Gilles HM, eds) OUP 2002, London and New
York.
95. El Setouhy M, Agbenyega T, Anto F, Clerk CA, Koram KA, English M,
Molyneux CS, Juma R, Kumwenda N, Mfutso-Bengo J, Molyneux ME, Taylor
TE, Diarra DA, Maiga S, Sylla M, Youssouf D, Falade CO, Gabadegesin S, Lie
R, Mugusi F, Ngassapa D, Ecuru J, Talisuna A, Emanuel E, Grady C, Wendler D,
Higgs E, Plowe C, Sugarman J. Fair benefits for research in developing
countries. Science 2002;298(5601):2133-2134.
96. Lewis DK, Peters RPH, Schijffelen MJ, Joaki G, Walsh AL, Kublin JG,
Kumwenda J, Kampondeni S, Molyneux ME, Zijlstra E. Clinical indicators of
mycobacteremia in adults admitted to hospital in Blantyre, Malawi. Int J Tuberc
Lung Dis 2002;6(12):1067-1074.
97. Cunliffe NA, Dove W, Gondwe JS, Thindwa BDM, Greensill J, Holmes JL,
Bresee JS, Monroe SS, Glass RI, Broadhead RL, MolyneuxME, Hart CA.
Detection and characterisation of human astroviruses in children with acute
gastroenteritis in Blantyre, Malawi. J Med Virol 2002;67:563-566.
98. Rogerson SJ, Brown HC, Getachew A, Pollina E, Turner G, Tadesse E, Lema V,
Molyneux ME. Placental TNF- alpha but not IFN-gamma associated with
placental malaria and low birth weight in Malawian women. Infection and
Immunity 2003;71:267-270.
99. Lochhead J, Movaffaghy A, Falsini B, Winstanley PA, Mberu EK, Riva CE,
Molyneux ME, Taylor TE, Harding SP. The effect of quinine on the
electroretinograms of children with paediatric cerebral malaria. J Infect Dis
2003;187(8): 1342-5.
100. Abrams ET, Brown H, Chensue SW, Turner GDH, Tadesse E, Lema VM,
Molyneux ME, Rochford R, Meshnick SR, Rogerson SJ. Host response to
malaria during pregnancy: placental monocyte recruitment is associated with
elevated beta-chemokine expression. J Immunol 2003;170:2759-2764.
101. Ackerman H, Usen S, Mott R, Richardson A, Sisay-Joof F, Katundu P,
Taylor T, Ward R, Molyneux M, Pinder M, Kwiatkowski D. Haplotypic
analysis of the TNF locus by association efficiency and entropy. Genome
Biology 2003;4(4):R24
102. Grau GE, Mackenzie CD, Carr RA, Redard M, Pizzolato G, Allasia C,
Cataldo C, Taylor TE, Molyneux ME. Platelet accumulation in brain
microvessels in fatal paediatric cerebral malaria. J Infect Dis 2003; 187:461-466
103. Clark IA, Awburn M, Whitten RO, Harper CG, Liomba NG, Molyneux
ME, Taylor TE. Systemic and cerebral induction of nitric oxide in fatal cases of
falciparum malaria and sepsis in Malawi. Malaria Journal 2003;2:6
104. Rogerson SJ, Pollina E, Getachew A, Tadesse E, Lema VM, Molyneux
ME. Placental monocyte infiltrates in response to Plasmodium falciparum
malaria infection and their association with adverse pregnancy outcomes. Amer J
Trop Med Hyg 2003; 68: 115-119.
105. Gordon SB, Kanyanda S, Walsh AL, Goddard K, Chaponda M, Atkinson
V, Mulwafu W, Molyneux EM, Zijlstra EE, Molyneux ME, Graham SM. Poor
potential coverage for 7-valent pneumococcal conjugate vaccine, Malawi.
Emerging Infectious Diseases 2003;9(6):747-749.
106. Gordon SB, Miller DE, Day RB, Ferry T, Wilkes DS, Schnizlein-Bick
CT, Zijlstra EE, Read RC, Molyneux ME, Twigg III HL. Pulmonary
immunoglobulin responses to Streptococcus pneumoniae are altered but not
reduced in HIV infected Malawian adults. Journal of Infectious Diseases 2003;
188(5):666-670.
107. Beare NAV, Lewis DK, Kublin JG, Harding SP, Zijlstra EE, Molyneux
ME. Retinal changes in adults with cerebral malaria. Ann Trop Med Parasitol
2003;97(3):313-315.
108. Mwapasa V, Rogerson SJ, Molyneux ME, Abrams E, Kamwendo DD,
Lema VM, Tadesse E, Chaluluka E, Wilson P, Meshnick SR. The Effect of
Plasmodium falciparum Malaria on Peripheral and Placental HIV-1 RNA
Concentrations in Pregnant Malawian Women. AIDS 2004; 18: 1-9
109. Molyneux EM, Forsyth H, Tembo M, Kayira K, Bwanaisa L,
Mwenechanya J, Njobvu A, Rogerson SJ, Walsh AL, Molyneux ME . The effect
of HIV infection on paediatric bacterial meningitis in Blantyre, Malawi. Arch
Dis Child 2003;88(12):1112-8.
110. M Gordon, Zijlstra EE, Naus CWA, Visser LG, Molyneux ME, van
Lieshout L. Schistosomiasis does not contribute to death or recurrence in HIVinfected Malawian adults with non-typhoid salmonella (NTS) bacteraemia. Clin
Infect Dis 2003;37:e177-178.
111. Clark IA, Awburn MM, Harper CG, Liomba NG, Molyneux ME.
Induction of HO-1 in tissue macrophages and monocytes in fatal falciparum
malaria and sepsis. Malaria Journal 2003;2:41
112. Gordon SB, Musaya J-L, Wilson L, Phiri A, Zijlstra EE, Molyneux ME.
HIV infected adults do not have an excess of colonising bacteria in their large
airways. BMC Infectious Diseases 2003;3:29
113. Beeson J, Mann E, Elliott S, Lema V, Tadesse E, Molyneux M, Brown G,
Rogerson S. Antibodies to variant surface antigens of Plasmodium falciparum
infected erythrocytes and adhesion inhibitory antibodies are associated with
placental malaria and have overlapping and distinct targets. J Infect Dis 2004;
189:540-551.
114. Plowe CV, Kublin JG, Dzinjalamala FK, Kamwendo DS, Mukadam RAG,
Chimpeni P, Molyneux ME, Taylor TE. Sustained sulfadoxine-pyrimethamine
clinical efficacy for uncomplicated falciparum malaria in Malawi after ten years
as first line therapy: a five year prospective efficacy study. Brit Med J 2004;
328:545-548.
115. Taylor TE, Fu WN, Carr RA, Whitten RO, Mueller JG, Fosiko NM,
Liomba NG, Molyneux ME. Differentiating the pathologies of cerebral malaria
by post mortem parasite counts. Nature Medicine 2004;10(2):143-145.
116. Mount A, Mwapasa V, Elliott SR, Beeson JG, Tadesse E, Lema VM,
Molyneux ME, Meshnick SR, Rogerson SJ. Impairment of humoral immunity to
Plasmodium falciparum malaria in pregnancy by HIV infection Lancet 2004:
363:1860-1867.
117. Maitland K, Molyneux ME. Malaria (Review). Adv Exp Med Biol
2004;549:125-134.
118. Barnes KI, Mwenechanya J, Tembo M, McIlleron H, Folb PI, Ribeiro I,
Little F, Molyneux ME. Efficacy of artesunate administered by suppository in
the initial treatment of moderately severe malaria in African children and adults.
Lancet 2004:363:1598-1605
119. Peters RPH, Zijlstra EE, Schijffelen MJ, Walsh AL, Joaki G, Kumwenda
JJ, Kublin JG, Molyneux ME, Lewis DK. A prospective study of bloodstream
infections as cause of fever in Malawi: clinical predictors and implications for
management. Trop Med Int Health 2004;9(8):928-934.
120. Mwandumba HC, Russell DG, Nyirenda MH, Anderson J, White SA,
Molyneux ME, Squire SB. Mycobacterium tuberculosis resides in non-acidified
vacuoles in endocytically-competent alveolar macrophages from patients with
tuberculosis and HIV-infection. J Immunol 2004;172(7):4592-4598
121. Combes V, Taylor TE, Juhan-Vague I, Mge J-L, Mwenechanya J, Tembo
M, Grau GE, Molyneux ME. Circulating endothelial microparticles in Malawian
children with severe falciparum malaria. JAMA 2004;291:2543-4
122. Beare NA, Southern C, Chalira C, Taylor TE, Molyneux ME, Harding SP.
Prognostic significance and course of retinopathy in children with severe malaria.
Arch Ophthalmol 2004;122:1141-1147.
123. Maitland K, Molyneux ME. Malaria. In: Hot Topics in Infection and
Immunity in Children. Eds Pollard AJ, McCracken GH, Finn A. Kluwer A /
Plenum Publishers, New York, 2004.
124. Abrams ET, Milner D, Kwiek J, Mwapasa V, Kamwendo DD, Tadesse E,
Lema V, Molyneux ME, Rogerson SJ, Meshnick SR. Risk factors and
mechanisms of preterm delivery in Malawi. Am J Reproductive Immunol
2004;52:174-183
125. Dzinjalamala FK, Macheso A, Kublin JG, Taylor TE, Barnes KI,
Molyneux ME, Plowe CV, Smith PJ. Blood folate concentrations and in vivo
sulfadoxine-pyrimethamine failure in Malaian children with uncomplicated
falciparum malaria. Am J Trop Med Hyg 2005;72(3):267-272
126. Kublin JG, Patnaik P, Jere CJ, Miller WC, Hoffman IF, Chimbiya N,
Pendame R, Taylor TE, Molyneux ME. Effect of Plasmodium falciparum
malaria on HIV-1 RNA blood concentration in a cohort of adults in rural Malawi.
Lancet 2005;365:233-240.
127. Milner DA, Dzamalala CP, Liomba NG, Molyneux ME, Taylor TE.
Supra-orbital Sampling of Brain Tissue After Death: Improving upon the Clinical
Diagnosis of Cerebral Malaria. J Infect Dis 2005;191:805-808.
128. Milledge J, Calis JCJ, Graham SM, Phiri A, Wilson LK, Soko D,
Mbvwinji M, Walsh AL, Rogerson SR, Molyneux ME, Molyneux EM.
Aetiology of neonatal sepsis in Blantyre, Malawi: 1996-2001. Ann Trop Paed
2005;25:99-108.
154. Carrol ED, Mankhambo LA, Balmer P, Nkhoma S, Banda DL, Guiver M,
Jeffers G, Makwana N, Molyneux EM, Molyneux ME, Smyth RL, Hart CA, and
the IPD Study Group. Chemokine responses are increased in HIV-infected
Malawian children with invasive pneumococcal disease. J AIDS 2007;
44(4):443-450.
155. Bronzan RN, Taylor TE, Mwenechanya J, Tembo M, Kayira K, Bwanaisa
L, Njobvu A, Kondowe W, Chalira C, Walsh AL, Phiri A, Wilson LK, Molyneux
ME, Graham SM. Bacteremia in Malawian children with severe malaria:
prevalence, etiology, HIV co-infection and outcome. J Infect Dis 2007; 195
(6):895-904
156. Dobao C, Rogerson SJ, Taylor TE, McBride JS, Molyneux ME.
Expression of surface markers by Plasmodium falciparum infected erythrocytes in
peripheral blood and tissues of children with fatal malaria. Infect Immun.
2007;75(2):643-652.
157. Bell DJ, Molyneux ME. Treatment of childhood falciparum malaria
current challenges. In: Expert Review of Anti-infective Therapy 2007;5(1):141-52.
158. Bell DJ, Nyirongo SK, Molyneux ME, Winstanley PA, Ward SA.
Practical HPLC methods for the quantitative determination of common
antimalarials in Africa. J Chromatogr B Analyt Technol Biomed Life Sci
2007;847(2):231-6
159. Mallewa M, Fooks AR, Banda D, Chikungwa P, Mankhambo L,
Molyneux E, Molyneux M, Solomon T. Rabies Encephalitis in a Malaria-Endemic
Area, Malawi, Africa. Emerging Infectious Diseases 2007;13(1):136-9.
160. Koram K, Molyneux ME. When is "malaria" malaria? The different
burdens of malaria infection, malaria disease and malaria-like illnesses. In:
Breman JG, Alilio MS, White NJ (eds). Defining and defeating the intolerable
burden of malaria - III. Progress and perspectives. Am J Trop Med Hyg 2007;
77(6) supplement: 1-327.
161. Jaworowski A, Kamwendo DD, Ellery P, Sonza S, Mwapasa V, Tadesse
E, Molyneux ME, Rogerson SJ, Meshnick SR, Crowe SM. CD16+ monocyte
subset preferentially harbors HIV-1 and is expanded in pregnant Malawian
women with P falciparum malaria and HIV-1 infection. J Infect Dis
2007;196:38-42.
162. Nkhoma S, Molyneux ME, Ward SA. In vitro antimalarial susceptibility
profile and pfcrt/pfmdr-1 genotypes of Plasmodium falciparum field isolates from
Malawi. Am J Trop Med Hyg 2007;76(6):1107-1112
163. Gordon SB, Kayhty H, Molyneux ME, Haikala R, Nurkka A, Musaya J,
Zijlstra EE, Lindell D, French N. Pneumococcal conjugate vaccine is
immunogenic in lung fluid of HIV infected and immunocompetent adults.
Journal of Allergy and Clinical Immunology; 2007;120(1):208-10.
165. Molyneux ME, Marsh K, White NJ, Farrar J, French N, Day N, RowlandJones S. UK doctors are already put off by changes in training. (Letter). Brit
Med J 2007;334:709-710
166. MacLennan CA, van Oosterhout JJG, White SA, Drayson MT, Zijlstra EE,
Molyneux ME. Finger-prick blood samples can be used interchangeably with
venous samples for CD4 counting indicating their potential for use in CD4 rapid
tests. AIDS 2007; 21(12):1643-1645
167. Carrol ED, Guiver M, Nkhoma S, Mankhambo LA, Marsh J, Balmer P,
Banda DL, Balmer P, Banda DL, Jeffers G, the IPD Study Group, White SA,
Molyneux EM, Molyneux ME, Smyth RL, Hart CA. High pneumococcal DNA
219. Molyneux EM, Mankhambo LA, Phiri A, Graham SM, Forsyth H, Phiri
A, Walsh AL, Wilson LK, Molyneux ME. The outcome of non-typhoidal
salmonella meningitis in Malawian children, 1997-2006. Ann Trop Paediatr
2009;29(1):13-22.
220. Larru B, Molyneux EM, ter Kuile FO, Taylor TE, Molyneux ME,
Terlouw DJ. Short report. Malaria in infants < 6 months: retrospective
surveillance of hospital admission records in Blantyre, Malawi. Malaria Journal
2009; Dec 29;8:310. doi: 10.1186/1475-2875-8-310.
221. Kingsley RA, Msefula CL, Thomson NR, Kariuki S, Holt K, Gordon
MA, Whitehead S, Sangal V, Marsh K, Achtman M, Molyneux ME, MacLennan
CA, Heyderman RS, Dougan G. Epidemic multiply-drug-resistant Salmonella
Typhimurium causing invasive disease in Sub-Saharan Africa. Genome Res
2009;19:2279-2287.
222. Bell DJ, Wootton D, Mukaka M, Montgomery J, Kayange N, Chimpeni
P, Hughes DA, Molyneux ME, Ward SA, Winstanley PA, Lalloo DG.
Measurement of adherence, drug concentrations and the effectiveness of
artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine
in the treatment of uncomplicated malaria in Malawi. Malar J 2009;26(8):204.
223. Phiri H, Montgomery J, Molyneux M, Craig A. Competitive endothelial
adhesion between Plasmodium falciparum isolates under physiological flow
conditions. Malar J 2009;8:214.
224. Chimalizeni Y, Kawaza K, Taylor TE, Molyneux ME. The platelet
count in cerebral malaria - is it useful to the clinician? Am J Trop Med Hyg
2010;83:48-50
225. Mankhambo L, Phiri A, Mallewa M, Molyneux ME. Management of
severe malaria. Therapy 2010;
226. Mandala WL, MacLennan JM, Gondwe EN, Ward SA, Molyneux ME,
MacLennan CA. Lymphocyte subsets in healthy Malawians: implications for
immunologic assessment of HIV infection in Africa. J Allergy Clin Immunol
2010;125:203-208
227. MacLennan CA, Gilchrist JJ, Gordon MA, Cunningham AF, Cobbold M,
Goodall, Kingsley RM, van Oosterhout JG, Msefula CL, Mandala WL, Leyton
DL, Marshall JL, Gondwe EN, Bobat S, Lpez-Macas C, Henderson IR, Zijlstra
EE, Dougan G, Drayson MT, MacLennan ICM, Molyneux ME. Dysregulated
humoral immunity to nontyphoidal Salmonella in HIV-infected African adults.
Science 2010;328:508-512.
228. Gondwe EN, Molyneux ME, Goodall M, Graham SM, Mastroeni P,
Drayson MT, MacLennan CA. Importance of antibody and complement for
oxidative burst and killing of invasive nontyphoidal Salmonella by blood cells in
Africans. Proc Nat Acad Sci 2010;107:3070-3075
229. Gordon MA, Kankwatira AM, Mwafulirwa G, Walsh AL, Hopkins MJ,
Parry CM, Faragher EB, Zijlstra EE, Heyderman RS, Molyneux ME. Invasive
non-typhoid Salmonellae establish systemic intracellular infection in HIV-infected
adults; an emerging disease pathogenesis. Clin Infect Dis 2010;50.
230. Birbeck GL, Beare N, Lewallen S, Glover SJ, Molyneux ME, Kaplan
PW, Taylor TE. Identification of malaria retinopathy improves the specificity of
the clinical diagnosis of cerebral malaria: findings from a prospective cohort
study. Am J Trop Med Hyg 2010;82(2):231234
231. Bridges D, Bunn J, van Mourik JA, Grau GE, Preston RJS, Molyneux
ME, Combes V, ODonnell JS, de Laat B, Craig AG. Rapid activation of
HIV infection and correlation with clinical outcomes. PLoS One 2011;6(7):e22491.
259. Bell DJ, Nyirongo SK, Mukaka M, Molyneux ME, Winstanley PA, Ward
SA. Population pharmacokinetics of sulfadoxine and pyrimethamine in Malawian
children with malaria. Clin Pharmacol Ther 2011;89(2):268-75.
260. Herricks T, Seydel KB, Turner G, Molyneux M, Heyderman R, Taylor T,
Rathod PK. A microfluidic system to study cytoadhesion of Plasmodium
falciparum infected erythrocytes to primary brain microvascular endothelial cells.
Lab Chip 2011;11(17):2994-3000.
261. Hartung TK, Chimbayo D, van Oosterhout JJ, Chikaonda T, van
Doornum GJ, Claas EC, Melchers WJ, Molyneux ME, Zijlstra EE. Etiology of
suspected pneumonia in adults admitted to a high-dependency unit in Blantyre,
Malawi. Am J Trop Med Hyg 2011;85(1):105-12.
262. Whitten R, Milner DA Jr, Yeh MM, Kamiza S, Molyneux ME, Taylor
TE. Liver pathology in Malawian children with fatal encephalopathy. Hum
Pathol 2011;42(9):1230-9.
263. Ajdukiewicz KM, Cartwright KE, Scarborough M, Mwambene JB,
Goodson P, Molyneux ME, Zijlstra EE, French N, Whitty CJ, Lalloo DG.
Glycerol adjuvant therapy in adults with bacterial meningitis in a high HIV
seroprevalence setting in Malawi: a double-blind, randomised controlled trial.
Lancet Infect Dis 2011;11(4):293-300.
264. Bhanushali M, Taylor TE, Molyneux ME, Sapuwa M, Mwandira E,
Birbeck GL. Evoked potentials in pediatric cerebral malaria. Neurol Int
2011;3(3):e14.
265. Conroy A, Rogerson SJ, Molyneux ME, Liles C, Kain K. Performance
Characteristics of Combinations of Host Biomarkers to Identify Women with
Occult Placental Malaria: A Case-Control Study from Malawi. PloS One
2011;6(12):e28540.
266. Taylor SM, Antonia A, Feng G, Mwapasa V, Chaluluka E, Molyneux M,
Ter Kuile FO, Rogerson SJ, Meshnick SR. Adaptive evolution and fixation of
drug-resistant Plasmodium falciparum genotypes in pregnancy-associated
malaria: 9-year results from the QuEERPAM study. Infect Genet Evol
2012;12(2):282-90.
267. Danny A Milner, Jimmy Vareta, Clarissa Valim, Jacqui Montgomery,
Rachel F Daniels, Sarah K Volkman, Daniel E Neafsey, Daniel J Park, Stephen F
Schaffner, Nira C Mahesh, Kayla G Barnes, David M Rosen, Amanda K Lukens,
Daria Van Tyne, Roger C Wiegand, Pardis C Sabeti, Karl B Seydel, Simon J
Glover, Steve Kamiza, Malcolm E Molyneux, Terrie E Taylor and Dyann F
Wirth. Human cerebral malaria and Plasmodium falciparum genotypes in
Malawi. Malaria Journal 2012;11:35
268. Conroy AL, Glover SJ, Hawkes M, Erdman LK, Seydel KB, Taylor TE,
Molyneux ME, Kain KC. Angiopoietin-2 levels are associated with retinopathy
and predict mortality in Malawian children with cerebral malaria: a retrospective
case-control study. Crit Care Med 2012;40(3):952-959
269. Taylor SM, Antonia A, Chaluluka E, Mwapasa V, Feng G, Molyneux
ME, ter Kuile F, Meshnick SR, Rogerson SJ. Antenatal receipt of sulfadoxinepyrimethamine does not exacerbate pregnancy-associated malaria despite the
expansion of drug-resistant Plasmodium falciparum: clinical outcomes from the
QuEERPAM study. Clin Infect Dis 2012;55(1):42-50.
270. Adam D Irwin, Fiona Marriage, Limangeni A Mankhambo, IPD Study
Group, Graham Jeffers, Ruwanthi Kolamunnage-Dona, Malcolm Guiver, Brigitte
284. Herricks T, Seydel KB, Molyneux M, Taylor T, Rathod PK. Estimating physical
splenic filtration of Plasmodium falciparum-infected red blood cells in malaria
patients. Cell Microbiol 2012;14(12):1880-91.
285. Milner DA Jr, Valim C, Luo R, Playforth KB, Kamiza S, Molyneux ME, Seydel
KB, Taylor TE. Supraorbital postmortem brain sampling for definitive quantitative
confirmation of cerebral sequestration of Plasmodium falciparum parasites.
J Infect Dis 2012;205(10):1601-6.
286. Milner D Jr, Factor R, Whitten R, Carr RA, Kamiza S, Pinkus G, Molyneux M,
Taylor T. Pulmonary pathology in pediatric cerebral malaria. Hum
Pathol 2013;44(12):2719-26.
287. Milner DA Jr, Valim C, Carr RA, Chandak PB, Fosiko NG, Whitten R, Playforth
KB, Seydel KB, Kamiza S, Molyneux ME, Taylor TE. A histological method for
quantifying Plasmodium falciparum in the brain in fatal paediatric cerebral malaria.
Malar J 2013;12:191.
288. Moxon CA, Wassmer SC, Milner DA Jr, Chisala NV, Taylor TE, Seydel KB,
Molyneux ME, Faragher B, Esmon CT, Downey C, Toh CH, Craig AG, Heyderman
RS. Loss of endothelial protein C receptors links coagulation and inflammation to
parasite sequestration in cerebral malaria in African children. Blood 2013;122(5):84251.
289. Chua CL, Brown GV, Hamilton JA, Molyneux ME, Rogerson SJ, Boeuf P.
Soluble CD163, a product of monocyte/macrophage activation, is inversely associated
with haemoglobin levels in placental malaria. PLoS One 2013;8(5):e64127.
290. Band G, Le QS, Jostins L, Pirinen M, Kivinen K, Jallow M, Sisay-Joof F,
Bojang K, Pinder M, Sirugo G, Conway DJ, Nyirongo V, Kachala D, Molyneux M,
Taylor T, Ndila C, Peshu N, Marsh K, Williams TN, Alcock D, Andrews R, Edkins S,
Gray E, Hubbart C, Jeffreys A, Rowlands K, Schuldt K, Clark TG, Small KS, Teo
YY, Kwiatkowski DP, Rockett KA, Barrett JC, Spencer CC; Malaria Genomic
Epidemiology Network. Imputation-based meta-analysis of severe malaria in three
African populations. PLoS Genet 2013;9(5):e1003509.
291. Gordon SB, Jagoe RT, Jarman ER, North JC, Pridmore A, Musaya J, French N,
Zijlstra EE, Molyneux ME, Read RC. The alveolar microenvironment of patients
infected with human immunodeficiency virus does not modify alveolar macrophage
interactions with Streptococcus pneumoniae. Clin Vaccine Immunol 2013;20(6):88291.
292. SanJoaquin MA, Allain TJ, Molyneux ME, Benjamin L, Everett DB, Gadabu O,
Rothe C, Nguipdop P, Chilombe M, Kazembe L, Sakala S, Gonani A, Heyderman
RS. Surveillance Programme of IN-patients and Epidemiology (SPINE):
implementation of an electronic data collection tool within a large hospital in Malawi.
PLoS Med 2013;10(3):e1001400.
292. Mallewa M, Vallely P, Faragher B, Banda D, Klapper P, Mukaka M, Khofi H,
Pensulo P, Taylor T, Molyneux M, Solomon T. Viral CNS infections in children
from a malaria-endemic area of Malawi: a prospective cohort study. Lancet Global
Health 2013 Sep;1(3):e153-60.
293. Conroy AL, Silver KL, Zhong K, Rennie M, Ward P, Sarma JV, Molyneux ME,
Sled J, Fletcher JF, Rogerson S, Kain KC. Complement activation and the resulting
placental vascular insufficiency drives fetal growth restriction associated with
placental malaria. Cell Host Microbe 2013;13(2):215-26.
294. Moxon CA, Chisala NV, Wassmer SC, Taylor TE, Seydel KB, Molyneux ME,
Faragher B, Kennedy N, Toh CH, Craig AG, Heyderman RS. Persistent Endothelial
****
Editorials in Medical Quarterly (MQ) 1980-1984 (later Malawi Medical Journal)
Be Comforted. MQ April 1980
Health Service Shapes. MQ July 1980
The Abana and Farpar Syndrome. MQ Oct 1980
Rabies. MQ Oct 1980
Placebos. MQ Jan 1981
The Captain of the Men of Death. MQ April 1981
The Craft of Medicine. MQ April 1981.
Gastroenteritis. MQ July 1981
Why Meet? MQ July 1981
Malaria. MQ Jan 1982
Diabetes Mellitus. MQ Jan 1982
Between Ourselves MQ April 1982
The Old Mother Hubbard Syndrome. MQ July 1982
Tubercle Centenary. MQ July 1982
Clinical Decisions. MQ October 1982
Ascites. MQ October 1982
Geography, Viruses and Cancer. MQ Jan 1983
Malaria Again. MQ July 1983
Compliance. MQ July 1983
Labels. MQ October 1983
Primary Health Care. MQ Jan 1984
Snakebite. MQ Jan 1984
Burns. MQ April 1984
Medical Research. MQ April 1984
****
EXTRA-CURRICULAR INTERESTS
Amateur conducting of choral/orchestral works (mixed choir, with
Police or Army band and other instrumentalists):
1978 Handel - Messiah
1980 Carl Orff - Carmina Burana (version for choirs, 2 pianos and percussion)
1981 Handel Israel in Egypt
1983 Mozart Vesperae solennes (and miscellaneous items)
1984 Vivaldi Gloria (and miscellaneous items)
1998 Bach Mass in B minor
2000 Handel Messiah
Mountain walking, cycling, squash.
Cycled Land's End to John o'Groats, climbing Ben Nevis on the way ('Length and
Height of Britain') Sept 2011, to raise money ($39,000) for Hospital in Malawi
lahob.org.uk