18/2/2015

UCLBiochemicalandMicrobialEngineering[LBIRC2108]

|agenda|directories|librairies|jobopportunities|campusmaps|

search...

|IntranetUCL|

COURSESDESCRIPTIONFOR20142015
>UCL>TEACHINGANDTRAINING >Studyprogramme>Fiched'activit

LBIRC2108
COURSEDESCRIPTION
> Studyprogramme
> Searchincourses
description
> Printablewebversion
> Document

[Versionfranaise]

BiochemicalandMicrobialEngineering[LBIRC2108]
5.0crditsECTS 30.0h+22.5h 2q >Schedule
Teacher(s)

AgathosSpyridon

Language

French

Place
ofthecourse

LouvainlaNeuve

Online
resources

Icampus
From design to scaleup on a pilot scale of microbial and enzymatic processes. Theoretical and
methodological foundations of applied chemical kinetics and design of chemical reactors with the
characteristics(kineticsandtransportphenomena)ofbiochemicalandmicrobiologicalprocessesinorderto
systematizetheprinciplesunderlyingtheanalysisanddesign/sizingofbioreactors.Specifics:

Mainthemes

(Micro)biologicalprocessescharacterizedkineticallyandthermodynamically:cellgrowth,itsmeasurement
orestimation,useofsubstrate(s),formationofproduct(s).Yields.Productivities.Kineticmodels.Parameter
estimation.Themethodologyofmaterialandenergybalancesfortheanalysisofbiotechnologicalsystems
and of their performance. Batch, continuous, semi continuous reactors. Transport phenomena applied to
theanalysisofaeration,agitation,rheology,scaleupandsterilizationofbioreactors.
a.Contributiondel'activitaurfrentielAA(AAduprogramme)
1.22.12.22.44.14.24.58.5
b.FormulationspcifiquepourcetteactivitdesAAduprogramme

Attheendofthisactivity,thestudentisableto:

Aims

1.Applythemethodologyofmaterialbalancestotheanalysisofbiotechnologicalsystems
2.Applythemethodologyofenergybalancetotheanalysisofbiotechnologicalsystems
3.Applythemethodologyofreactordesigntotheanalysisanddesign/sizingofbioreactors(area
ofbiochemicalandmicrobiologicalprocesses)inthespecificcaseofbatchreactors
4.Applythemethodologyofreactordesigntotheanalysisanddesign/sizingofbioreactorsinthe
specificcaseofCSTR(continuousstirredtankreactor).
5.Applythemethodologyofreactordesigntotheanalysisanddesign/sizingofbioreactorsinthe
specificcaseofsemicontinuousreactors(fedbatch).
6.Applymasstransferphenomenaintheanalysisofdifferentoperations(aeration,agitation,etc.)
thatcantakeplaceinbioreactors.
7. Apply the phenomena of energy transfer to the analysis of different operations (aeration,
agitation,etc.)thatcantakeplaceinbioreactors.
8. Apply the phenomena of transfer of momentum to the analysis of different operations (aeration,
agitation,etc.)cantakeplaceinbioreactors.
9.Applythemethodologyofchemicalkineticsappliedtotheanalysisanddesign/sizingofbioreactors(area
ofbiochemicalandmicrobiologicalprocesses).
10. Search for real values of constants ''or of other parameters in correlations that are essential to the
design/sizingofbiologicalreactors.
11. As part of the design of a new biological reactor propose in a reasoned manner (with its advantages
and limitations) the design of the most appropriate reactor with respect to the industrial context under
consideration.

Evaluation
methods

Teaching
methods

http://www.uclouvain.be/encours2014LBIRC2108.html

Writtenexaminationin2parts
1.Examinationrequiringshortanswersbutbasedonatheoreticaldevelopment
2.Examinationfocusedonproblemsolving
1. Lectures, lectures with guided questions, including presentations of concrete examples from industry
with case analysis by the instructor [conventional lectures, interactive presentations using audiovisual
equipment(videoprojections,powerpoint)]
2. Exercise sessions in teams, guided. These exercises are designed to familiarize the student with the
methodology of solving quantitative problems in the design and analysis of bioprocesses: makes use of
calculationsforsizingorperformance,constructionofflowsheetscombiningunitoperations,searchofreal
values of constants or other parameters of correlations useful in design or modeling / optimization of

1/2

18/2/2015

UCLBiochemicalandMicrobialEngineering[LBIRC2108]
bioprocesses.
Theactivitybeginswithafacetofacepresenceonly

Content

Definitions:Definitionsinbioengineeringquantitiesandreactorsmicrobialprocesses'yieldsofbiological
processes in a reactor. Kinetic models of microbial growth. Modeling of a batch reactor modeling of a
continuous stirred biological system with and without recycling ' twostage continuous stirred systems.
Enzymatic process reactors design and performance. Sterilization processes. Scaleup from laboratory
scale through pilot scale to industrial scale. Bioseparations engineering. Ideal recovery process: primary
separation, isolation, purification and polishing. Separation devices in industrial cell culture: continuous
perfusionreactorwithcellretention.Advantagesandlimitationsofeachdesigninanindustrialcontext.

Bibliography

Mandatory supports(available on icampus): Notes, slides, chapters and sections specified from the
textbooks "Bioprocess Engineering Principles" by Pauline M. Doran 2nd edition (2013) and "Bioprocess
Engineering"byMichaelL.Shuler&FikretKargi2ndedition(2002)
Other supports: video projections, recommended reading: chapters and sections from the above
textbooks

Cycleandyear
ofstudy

>Premireannedemaster[120]bioingnieur:chimieetbioindustries,finalitspcialise

Facultyorentity
incharge

>AGRO

<<<Pageprcdente
|Webmaster:UniversitcatholiquedeLouvain|information:infocontact|privacy|rules|
|adress:1,Placedel'UniversitB1348LouvainlaNeuve(Belgique)Tel:+32(0)10/47.21.11Fax:+32(0)10/47.29.99|

http://www.uclouvain.be/encours2014LBIRC2108.html

2/2